ZERODOL MR Tablet 10's

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Drug Information for ZERODOL MR Tablet 10's

What is Aceclofenac + Tizanidine used for?

Aceclofenac + Tizanidine is used to relieve:

  • Acute low back pain;
  • Muscle spasms associated with spondylosis;
  • Stiffness and restriction of muscles resulting from multiple sclerosis, injury or diseases of the spinal cord;
  • Tension headaches;
  • Muscular cramps;
  • Osteoarthritis flare-up (arthritis of joints);
  • Traumatic injury;
  • Fibromyalgia (musculoskeletal pain).

Aceclofenac + Tizanidine may also be prescribed for other conditions as determined by your doctor.

How does Aceclofenac + Tizanidine work?

  • Aceclofenac is a NSAID (non-steroidal anti-inflammatory drug), analgesic (pain reliever) and anti-pyretic (reduces fever) medicine.
    • Aceclofenac inhibits an enzyme cyclo-oxygenase, which is responsible of production of prostaglandins in our body. (prostaglandins are natural chemicals in our body which promote inflammation).
    • Aceclofenac increases glycosaminoglycans (GAG) synthesis which helps in repair and regeneration of articular cartilage.
  • Tizanidine is a centrally acting skeletal muscle relaxant. Its main site action is on the spinal cord. Tizanidine blocks the nerve impulses through pre-synaptic inhibition of motor neurons, thereby decreasing spasticity without reducing muscle strength.

How to take Aceclofenac + Tizanidine?

  • The dosage of oral tablet of Aceclofenac + Tizanidine depends on the age, weight and medical condition of an individual. Take Aceclofenac + Tizanidine as prescribed by your doctor.
  • You are advised to take the tablet with or after food.
  • Swallow the whole tablet with water.
  • Do not discontinue the medication without consulting a doctor.
  • Aceclofenac + Tizanidine tablets are not recommended for use in children and adolescents.
  • If you miss a dose of Aceclofenac + Tizanidine, please take it immediately once you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.

What should you do when you have taken an overdose of Aceclofenac + Tizanidine?

If you have taken an overdose of Aceclofenac + Tizanidine, please contact your doctor immediately.

Symptoms of overdose of Aceclofenac + Tizanidine are:

  • Headache
  • Nausea, vomiting
  • Pain abdomen
  • Dizziness, hypotension
  • Sweating
  • Somnolence (sleepiness), stupor or coma
  • Pancreatitis (abdominal pain radiating to the back, abdominal pain exaggerated by eating, fever, rapid pulse, nausea, vomiting, pain in pancreas region)
  • Hepatic failure (jaundice, malaise, nausea, vomiting, confusion, abdominal swelling, sleepiness)
  • Acute renal failure (swelling in legs, ankle and feet, shortness of breath, fatigue, chest pain, confusion, disorientation, coma)

What are the drugs that interact with Aceclofenac + Tizanidine?

Drugs that interact with Aceclofenac:

  • Antihypertensives
  • Aspirin and other NSAIDs (non-steroidal anti-inflammatory drugs)
  • Cardiac glycosides
  • Corticosteroids
  • Cyclosporin, Tacrolimus
  • Digoxin
  • Diuretics
  • Lithium
  • Methotrexate
  • Mifepristone
  • Quinolones
  • Warfarin
  • Zidovudine

Drugs that interact with Tizanidine:

  • Amiodarone, Mexiletine, Propafenone
  • Antihypertensives
  • Cimetidine
  • Enoxacin, Ciprofloxacin, Pefloxacin, Norfloxacin
  • Fluvoxamine
  • Oral contraceptives
  • Rofecoxib
  • Ticlopidine

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Aceclofenac + Tizanidine?

Most common side effects of Aceclofenac + Tizanidine are:

  • Nausea
  • Dyspepsia (pain or uncomfortable feeling in stomach)
  • Abdominal pain
  • Diarrhoea or constipation
  • Skin rash
  • Peptic ulcer
  • Urticaria (hives)

Please stop your tablets and contact your physician immediately if you have

  • hypersensitivity reaction (breathing difficulty, bronchospasm, skin rashes, swelling of the face, tongue, larynx);
  • increased blood pressure readings;
  • chest pain;
  • swelling of legs, ankle and feet.

This is not a comprehensive list of side effects. Consult your doctor to know more about other possible side effects.

What special precautions should be followed while taking Aceclofenac + Tizanidine?

  • Seek doctor’s advice before taking any other drug or herbal products while on Aceclofenac + Tizanidine.
  • You are advised to regularly monitor your renal function tests, liver function test and blood tests, if you are on a long-term treatment of Aceclofenac + Tizanidine.

You are advised not to take Aceclofenac + Tizanidine if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering or there is discolouration.
  • you are feeling drowsy

What should you tell your doctor before taking Aceclofenac + Tizanidine?

Tell your doctor if

  • you are allergic to Aceclofenac + Tizanidine or to any ingredients of this medicine.
  • you are taking any other drugs, OTC medications, herbal products or nutritional supplements.
  • you are taking sodium oxybate (GHB), as the sedative effects of Tizanidine may be increased.
  • you had a head injury recently.
  • you have a tumour in the brain.
  • Heart problems, stroke, high blood pressure (hypertension), diabetes, high cholesterol.
  • you have liver disease, kidney disease.
  • you have peptic ulcer.
  • you have history of gastro-intestinal ulceration, bleeding or perforation.
  • you have ulcerative colitis or crohn’s disease.
  • you have SLE (systemic lupus erythematosus)
  • you have bleeding diathesis.
  • you have acute rhinitis.
  • you have asthma.
  • you are planning a surgery or any procedure.
  • you are pregnant or trying to conceive or are breastfeeding.

Frequently asked questions about Aceclofenac + Tizanidine

  1. How should Aceclofenac + Tizanidine be stored?
  2. Aceclofenac + Tizanidine should be stored in a cool, dry place. Keep the medicine away from sunlight and do not freeze the medicine. Keep the medicine out of reach from children.

  3. Can I drive while taking Aceclofenac + Tizanidine?

  4. Aceclofenac + Tizanidine causes drowsiness and dizziness in some individuals. Avoid driving if you are taking Aceclofenac + Tizanidine.

  5. Should I follow any special dietary instructions while taking Aceclofenac + Tizanidine?
  6. There are no dietary restrictions if you are taking Aceclofenac + Tizanidine.

  7. Is Aceclofenac + Tizanidine addictive?
  8. No, Aceclofenac + Tizanidine is not addictive. However, do not take it without consulting your doctor.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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