Zeptol CR 400mg Tablet 10'S

Epilepsy/Convulsion Rx required

Best Price*  ₹ 30.60
MRP ₹34.00
(Inclusive of all taxes) *10 Tablet(s) in a Strip * Mfr: Sun Pharmaceutical Industries Ltd * Country of Origin: India
TOTAL AMOUNT ₹ 34.00

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INTRODUCTION

ZEPTOL CR 400MG contains carbamazepine which belongs to the group of medicines called anti-convulsants. It is used to treat certain forms of epilepsy and trigeminal neuralgia (painful condition of face). It can also be used to control bipolar disorder if other medicines are not effective. Carbamazepine treats seizure and symptoms of trigeminal neuralgia by inhibiting voltage-dependent sodium channels and preventing action potentials. It is capable of decreasing mania symptoms in bipolar disorder by increasing dopamine turnover and increase GABA transmission.

Prior to the treatment, your doctor may want you to have a several blood tests to find your condition. Inform your doctor, if you have ever had problems with your bone marrow, porphyria or glaucoma before taking this medicine. The most common side effects of taking this medicine are nausea, vomiting, headache, blurred vision and fluid retention. Avoid drinking alcohol or grapefruit juice while taking this medicine, as it may increase your chance of experiencing side effects. ZEPTOL CR 400MG should be used with caution in pregnant, breastfeeding and in elderly patients.

USES OF ZEPTOL CR 400MG

  • Treats epilepsy and trigeminal neuralgia
  • Controls bipolar disorders if other medicines are not effective

HOW ZEPTOL CR 400MG WORKS

Carbamazepine inhibits and prolongs the inactivation of voltage-dependent sodium channels at the synapse by lowering polysynaptic nerve response and inhibiting post-tetanic potentiation. Blockade of sodium channels, decreases the abnormal excitability of neurons and therefore controls seizures.

It acts as a specific analgesic for trigeminal neuralgia, by inhibiting lingual mandibular reflex and by reducing pain caused by stimulation of nerves in the face. It decreases mania symptoms in bipolar disorder by increasing dopamine turnover and GABA transmission.

DIRECTIONS FOR USE

Always take this medicine as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your condition.

SIDE EFFECTS OF ZEPTOL CR 400MG

SERIOUS

  • allergic reactions (such as rash, blistering of lips, eyes or mouth or skin peeling with fever)
  • sore mouth or throat, fever
  • jaundice (yellowing of your skin or whites of your eyes)
  • muscle pain or joint pain
  • breathing problems
  • pain in area near stomach

COMMON

  • feeling or being sick
  • dizziness
  • lack of coordination
  • bruising or bleeding
  • fluid retention and swelling
  • confusion
  • headache
  • blurred vision
  • dry mouth

RARE

  • hallucinations, depression, aggression
  • speech disorders
  • high or low blood pressure
  • irregular heartbeat
  • loss of appetite

HOW TO MANAGE SIDE EFFECTS

Feeling sick or being sick:

Try taking this medicine with, or just after meal. Stick to simple meals.

Headache:  

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

WARNING & PRECAUTIONS

PREGNANCY

ZEPTOL CR 400MG should be used with caution in pregnant women. Consult your doctor before taking this medicine.

BREASTFEEDING

ZEPTOL CR 400MG should be used with caution in breastfeeding women. Consult your doctor before taking this medicine.

DRIVING AND USING MACHINES

Do not drive or operate any machines, because this medicine may make you feel dizzy or drowsy or may cause blurred vision.

ALCOHOL

Avoid consumption of alcohol while taking this medicine.

KIDNEY

ZEPTOL CR 400MG should be taken with caution in patients with kidney disease. Consult your doctor for advice.

LIVER

ZEPTOL CR 400MG should be taken with caution in patients with liver disease. Consult your doctor for advice.

ALLERGY

Do not take this medicine if you are allergic to carbamazepine or any other similar ingredients like oxcarbazepine, amitriptyline or imipramine.

HEART DISEASE

ZEPTOL CR 400MG should be taken with caution in patients with heart disease. Consult your doctor for advice.

OTHERS

Before taking this medicine, inform your doctor, if you have:

  • any eye problems such as glaucoma (increased pressure in eye) or any other mental illness
  • ever had problems with your bone marrow or porphyria (an inherited blood disorder)

INTERACTIONS

Talk to your doctor, if you are taking,

  • medicines used to relieve pain and inflammation
  • medicines used to treat fungal infections (fluconazole, voriconazole)
  • medicines used to treat HIV (e.g. adenofovir, tenofovir)
  • medicines for high blood pressure or heart problems (propranolol, captopril, digoxin, diltiazem)
  • medicines to treat allergy such as hay fever or itching (e.g. fluticastone, mometasone)
  • medicine which reduces nausea or vomiting (e.g. metoclopramide or aprepitant)
  • medicines to treat stomach ulcers (cimetidine or omeprazole)
  • medicines used to treat asthma (e.g. theophylline or aminophylline)
  • medicines used to treat mental illnesses
  • other medicines to treat epilepsy (e.g. phenytoin)
  • medicines to avoid graft rejection (e.g. ciclosporin, tacrolimus)
  • isotretinoin (used to treat acne)
  • acetazolamide (used to treat glaucoma)
  • danazol or gestrinone (used to treat endometriosis)
  • cancer drugs (e.g. temsirolimus, cyclophasphamide, lapatinib)
  • mefloquine (used to treat malaria)
  • levothyroxine (used to treat hypothyroidism)
  • tadalafil (used to treat impotence)
  • albendazole (used to treat worms)
  • bupropion (used to help stop smoking)
  • supplements containing Vitamin B (nicotinamide)

SYNOPSIS

Drug :   Carbamazepine
Pharmacological Category :   Anticonvulsant
Therapeutic Indication :  

Epilepsy, Trigeminal neuralgia, Bipolar disorder

Dosage Forms :   Tablet, Syrup

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT ZEPTOL CR 400MG

Can ZEPTOL CR 400MG cause Stevens-Johnson syndrome?

This medicine may rarely cause allergic reactions like Stevens-Johnson syndrome. Stop the treatment and consult your doctor immediately, if you experience it.

Can [GBNKEYORD] cause missed periods?

This medicine may cause menstrual irregularities. Consult your doctor for advice.

REFERENCES

1. KD. Tripathi. Antiepileptic drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 415-416.

2. Johnathan M. Meyer. Pharmacotherapy of Psychosis and Mania. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 444-451.

3. James O. McNamara. Pharmacotherapy of the Epilepsies. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 594-596.

4. Gerald G. Briggs and Roger K. Freeman. C. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 581-592.

5. Lundbeck LLC. A Study of the Pharmacokinetics (PK) and Safety of IV Carbamazepine Relative to Oral Carbamazepine in Adults with Epilepsy. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on April 2010] [Accessed 26th November 2020] https://clinicaltrials.gov/ct2/show/NCT01079351

6. Zahra Tolou-Ghamari, Mohammad Zare, Jafar Mehvari Habibabadi, and Mohammad Reza Najafi. A quick review of carbamazepine pharmacokinetics in epilepsy from 1953 to 2012. NCBI; PMC US National Library of Medicine, National Institute of Health. March 2013. [Accessed 26th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743329/

7. Novartis Pharmaceuticals UK Limited and Novartis Farma S.p.A. Electronic Medicines Compendium (EMC); [Revised on October 2020] [Accessed 26th November 2020] https://www.medicines.org.uk/emc/files/pil.1040.pdf

8. Novartis Pharmaceuticals Corporation. U.S. Food & Drug Administration. [Revised on February 2009] [Accessed 26th November 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/016608s101,018281s048lbl.pdf

USEFUL DIAGNOSTIC TESTS

  • Electroencephalogram (EEG)

Manufacturer/Marketer Details

    Net Qty
    1
    Shelf Life
    NA
    Item Weight
    17.5
    No. of Units in a Kit
    NA
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DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Zeptol CR 400mg Tablet 10'S

Zeptol CR 400mg Tablet 10'S Mfr: Sun Pharmaceutical Industries Ltd

M.R.P.: Rs.34.00
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