Xtandi 40Mg Capsule 112's

Cancer/Oncology Rx required
OUT OF STOCK

Best Price*  ₹ 268,508.00
MRP ₹335,635.00
(Inclusive of all taxes) *This product cannot be returned for a refund or exchange. *112 Capsule(s) in a Container * Mkt: Astellas Pharma India Pvt Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout



INTRODUCTION

XTANDI 40MG contain enzalutamide which belongs to a group of medicine called androgen receptor inhibitors. It is used to treat adult men with prostate cancer that no longer responds to a hormone therapy or surgical treatment to lower testosterone (or) has spread to other parts of the body and responds to a hormone therapy or surgical treatment to lower testosterone.

Prostate cancer is marked by an uncontrolled (malignant) growth of cells in the prostate gland. The prostate is the walnut-sized gland in men, located just below the bladder and in front of the rectum, surrounding the urethra which is the tube that carries urine out of the bladder. It is also called as prostatic carcinoma.

The most common side effects are tiredness, hot flushes, high blood pressure. XTANDI 40MG works by blocking the activity of hormones called androgens (such as testosterone). By blocking androgens, enzalutamide stops prostate cancer cells from growing and dividing. This medicine may cause fertility problems in males, which may affect the ability to father children. Talk to your healthcare provider if you have concerns about fertility.

This medicine is strictly not recommended for use in children and adolescents. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems.

USES OF XTANDI 40MG

  • Treat adult men with prostate cancer

HOW XTANDI 40MG WORKS

XTANDI 40MG works by blocking the activity of hormones called androgens (such as testosterone). By blocking androgens, enzalutamide stops prostate cancer cells from growing and dividing.

DIRECTIONS FOR USE

Always take XTANDI 40MG exactly as your doctor has told you. XTANDI 40MG can be taken with or without food. Try to take XTANDI 40MG at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine. The recommended dose of this medicine is one tablet once a day.

SIDE EFFECTS OF XTANDI 40MG

SERIOUS

  • seizure or loss of consciousness
  • posterior reversible encephalopathy syndrome (PRES) (quickly worsening symptoms such as headache, decreased alertness, confusion, reduced eyesight, blindness, blurred vision, or other visual problems)
  • allergic reactions such as swelling of the face, tongue, lip or throat
  • chest pain or discomfort or shortness of breath

COMMON

  • tiredness or weakness
  • broken bones
  • hot flushes
  • high blood pressure
  • headache
  • falls and fractures
  • feeling anxious
  • dry skin, itching
  • difficulty remembering
  • blockage of the arteries in the heart (ischemic heart disease)
  • breast enlargement in men (gynaecomastia)
  • symptom of restless legs syndrome (an uncontrollable urge to move a part of the body, usually the leg)
  • reduced concentration
  • forgetfulness
  • back pain
  • constipation
  • joint pain
  • decreased appetite
  • diarrhoea

HOW TO MANAGE SIDE EFFECTS

Headache:

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

Constipation: 

Take fibre rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.

Diarrhoea:

Drink lot of fluid such as water or squash, to avoid dehydration. Do not take any other medicines without talking to a doctor.

WARNING & PRECAUTIONS

PREGNANCY

Enzalutamide can cause harm to your unborn baby and loss of pregnancy (miscarriage). XTANDI 40MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING

It is not known if Enzalutamide passes into your breast milk. XTANDI 40MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES

XTANDI 40MG has moderate effect on your ability to drive or use any tools or machines as the side effects include psychiatric and neurological events including seizure. If you are at higher risk of seizures, talk to your doctor.

ALCOHOL

Consumption of alcohol is not recommended during treatment with XTANDI 40MG.

KIDNEY

XTANDI 40MG should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.

LIVER

XTANDI 40MG should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.

ALLERGY

Do not take XTANDI 40MG if you are allergic (hypersensitive) to enzalutamide or any other ingredients in this medicine.

HEART DISEASE

XTANDI 40MG should be used with caution in patients suffering from active heart diseases. Consult your doctor for advice.

OTHERS

Tell your doctor if you have or had a condition such as,

  • have a history of seizures, brain injury, stroke, or brain tumor
  • posterior reversible encephalopathy syndrome (PRES) (symptoms such as worsening headache, confusion, blindness, or other vision problems)
  • have high blood pressure
  • have abnormal amounts of fat or cholesterol in your blood (dyslipidemia)

INTERACTIONS

Talk to your doctor if you are taking,

  • medicines such as aminophylline, theophylline (used to treat asthma and other respiratory diseases)
  • medicines such as clozapine, olanzapine, risperidone, ziprasidone, bupropion, lithium, chlorpromazine, mesoridazine, thioridazine, amitriptyline, desipramine, doxepin, imipramine, maprotiline, mirtazapine, diazepam, midazolam, haloperidol (used to treat certain psychiatric disorders such as severe anxiety, depression, and schizophrenia)
  • pethidine, fentanyl, tramadol (used to treat pain)
  • gemfibrozil, atorvastatin, simvastatin (used for lower cholesterol)
  • carbazitaxel, docetaxel (used to treat cancer)
  • carbamazepine, clonazepam, phenytoin, primidone, valproic acid (used to treat epilepsy)
  • zolpidem (used to treat sleep disorders)
  • bisoprolol, digoxin, diltiazem, felodipine, nicardipine, nifedipine, propranolol, verapamil (used to treat heart conditions or lower blood pressure)
  • dexamethasone, prednisolone (used to treat serious disease related to inflammation)
  • indinavir, ritonavir (used to treat HIV infection)
  • clarithromycin, doxycycline, moxifloxacin (used to treat bacterial infections)
  • levothyroxine (used to treat thyroid disorders)
  • colchicine (used to treat gout)
  • omeprazole (used to treat stomach disorders)
  • dabigatran etexilate (used to prevent heart conditions or strokes)
  • tacrolimus (used to prevent organ rejection)
  • warfarin, acenocoumarol, clopidogrel (used to prevent blood clots)
  • quinidine, procainamide, amiodarone and sotalol (used to treat heart rhythm problems)
  • methadone (used for pain relief and part of drug addiction detoxification)

SYNOPSIS

Drug :   Enzalutamide
Pharmacological Category :   Antineoplastic Agent, Antiandrogen
Therapeutic Indication :   Adult men with prostate cancer
Dosage Forms :   Tablet, Capsule

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT XTANDI 40MG

Can XTANDI 40MG cause Constipation?

Yes, this medicine may cause constipation in some individuals. Take fibre rich foods such as fresh fruit, vegetables and cereals and drink plenty of water. Exercise more regularly.

Can I take XTANDI 40MG during Pregnancy?

No, Enzalutamide can cause harm to your unborn baby and loss of pregnancy (miscarriage). It is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your Doctor.

Can I take XTANDI 40MG during heart disease?

It should be used with caution in patients suffering from active heart diseases. Consult your doctor for advice.

REFERENCES

1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page-1367-1368.

2. Sumanta K Pal 1, Cy A Stein, Oliver Sartor. Enzalutamide for the treatment of prostate cancer. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Apr 2013. [Accessed 25 Jan 2021] https://pubmed.ncbi.nlm.nih.gov/23441761/

3. Astellas Pharma Europe B.V; Electronic Medicines Compendium (EMC); [Revised on Oct 2018] [Accessed 25 Jan 2021] https://www.medicines.org.uk/emc/files/pil.10318.pdf

4. Astellas Pharma US, Inc; U.S. Food & Drug Administration; [Revised on Oct 2020] [Accessed 25 Jan 2021] https://www.astellas.us/docs/us/12A005-ENZ-Patient%20Package%20Insert-WPI.pdf

USEFUL DIAGNOSTIC TESTS

  • Prostate Specific Antigen (Free) PSA
  • Prostate Specific Antigen (Total) PSA

PRODUCT DETAILS

    Net Qty
    1
    Ingredient
    ENZALUTAMIDE 40MG
    Hsn Code
    30049099
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