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INTRODUCTION
VERMISOL contain levamisole which belongs to a group of medicine called immune-modulating agents. It is used to treat Steroid Sensitive Nephrotic Syndrome (SSNS). It is used during and following a therapy with prednisone or prednisolone.
Steroid Sensitive Nephrotic Syndrome is a rare primary glomerulopathy of unknown cause characterized by edema, nephrotic-range proteinuria and hypoalbuminemia that responds to standard prednisone treatment within 4-6 weeks.
The common side effects are nervousness, sleepiness, depression, nausea, vomiting, reduced appetite, diarrhoea, constipation, inflammation of the pancreas (pancreatitis) (symptoms such as stomach pain), skin rash and inflammation, malformations of the skin such as red swollen spots, muscle and joint pain, inflammation of the mouth, change to your odour.
VERMISOL works by restoring depressed immune function rather than to stimulate response to above-normal levels. This medicine can be taken with some water or, if necessary, with custard or any appropriate liquid.
Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine.
USES OF VERMISOL
- Treat Steroid Sensitive Nephrotic Syndrome (SSNS)
HOW VERMISOL WORKS
VERMISOL works by restoring depressed immune function rather than to stimulate response to above-normal levels.
DIRECTIONS FOR USE
Always take VERMISOL exactly as your doctor has told you. VERMISOL can be taken with or without food. Try to take this medicine at the same time each day. It should be swallowed whole with water. Do not crush or chew the medicine.
SIDE EFFECTS OF VERMISOL
SERIOUS
- changes in white blood cells (neutropaenia). This change might cause flu-like symptom such as chills, fever, fatigue
- changes in blood platelets (trombocytopenia)
- disorders of the brain and nerves (leukoencephalopathy) (symptoms such as confusion, loss of memory, unusual sleepiness, an unusual itching or tingling feeling that occurs without a clear reason, weakness of the muscle, seizures, coma or speech disturbances)
- hypersensitive reactions such as skin rash, itching, a swollen face or tightness of the chest
COMMON
- nervousness, sleepiness, depression
- nausea, vomiting, reduced appetite, diarrhoea, constipation
- inflammation of the pancreas (pancreatitis) (symptoms such as stomach pain)
- skin rash and inflammation, malformations of the skin such as red swollen spots
- muscle and joint pain
- inflammation of the mouth, change to your odour
HOW TO MANAGE SIDE EFFECTS
Sleepiness:
Get up and move around to feel awake. Take a nap to take the edge off the sleepiness. Give your eyes a break to avoid weakness.
Nausea and vomiting:
Try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
Diarrhoea:
Drink lot of fluid such as water or squash, to avoid dehydration. Do not take any other medicines without talking to a doctor.
Constipation:
Take fibre rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.
Stomach pain:
Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Applying heat pad or covered hot water bottle on your stomach. If still pain persists, speak to your doctor.
WARNING & PRECAUTIONS
PREGNANCY
VERMISOL is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
VERMISOL is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
ALCOHOL
Consumption of alcohol is not recommended during treatment with VERMISOL.
KIDNEY
VERMISOL should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
LIVER
VERMISOL should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take VERMISOL if you are allergic (hypersensitive) to levamisole or any other ingredients in this medicine.
OTHERS
Tell your doctor if you have or had a condition such as,
- changes in the blood cells occur (influenza-like symptoms, such as fever and shiverings)
INTERACTIONS
Talk to your doctor if you are taking,
- anticoagulants (blood-thinners)
- phenytoin (used for epilepsy)
- other medicines that effect the formation of blood cells (hematopoiese)
SYNOPSIS
| Drug | : | Levamisole |
| Pharmacological Category | : | Immune-modulating agents |
| Therapeutic Indication | : | Steroid Sensitive Nephrotic Syndrome (SSNS) |
| Dosage Forms | : | Tablet |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT VERMISOL
Is VERMISOL effective?
Yes, it is effective if used in the dose and duration as advised by your doctor.
Can VERMISOL cause constipation?
Yes, this medicine may cause constipation in some individuals. Take fibre rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.
Can I take VERMISOL during pregnancy?
No, it is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
REFERENCES
1. KD Tripathi. Anthelmintic Drugs. Essentials of Medical Pharmacology. Seventh Edition, 2013. Page - 852-853.
2. Lulu Jiang 1, Ishita Dasgupta 1, Jenny A Hurcombe 1, Heather F Colyer 1, Peter W Mathieson 1, Gavin I Welsh 1. Levamisole in steroid-sensitive nephrotic syndrome: usefulness in adult patients and laboratory insights into mechanisms of action via direct action on the kidney podocyte. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. Jun 2015. [Accessed 23 Jan 2021] https://pubmed.ncbi.nlm.nih.gov/25626449/
3. TAJ PHARMACEUTICALS Ltd; Electronic Medicines Compendium (EMC); [Revised on Aug 2015] [Accessed 23 Jan 2021] https://tajpharmaindia.com/wp-content/uploads/2015/09/PIL-FINITOR-LEVAMISOLE-HCL-TAB.pdf
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