INTRODUCTION

VALENT 160MG contains Valsartan which belongs to a group of medicines called angiotensin II receptor blocker. It is indicated for the treatment of hypertension and a recent heart attack (myocardial infarction) in both adults and in children aged above 6 years. It can also be used to provide symptomatic relief from heart failure. Valsartan antagonizes the hypertensive effects of angiotensin II at angiotensin receptor 1 (AT1) binding sites and reduces the risk of cardiovascular outcomes. Along with the treatment, your doctor might recommend you make certain lifestyle changes such as quitting alcohol and smoking, improve your sleep at night, eating a healthy diet and manage weight.

Always take this medicine as directed by your physician. It can be taken with or without food. Swallow the medicine as a whole with a glass of water. The main side effect of taking this medicine is dizziness. Avoid travelling, driving or operate any machine while taking this medicine. Your doctor might monitor your kidney function, blood pressure, and the electrolytes (e.g. potassium) in your blood at regular intervals. Do not take this medicine if you are pregnant, breastfeeding or diabetic. Consult your doctor for advice.

USES OF VALENT 160MG

• Treats high blood pressure and a recent heart attack (myocardial infarction) in both adults and in children aged above 6 years
• Provides symptomatic relief from heart failure

HOW VALENT 160MG WORKS

VALENT 160MG blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. This relaxes the blood vessel and lowers the blood pressure which can increases the supply of blood and oxygen to the heart.

DIRECTIONS FOR USE

Always take this medicine as directed by your physician. It can be taken with or without food. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF VALENT 160MG

HOW TO MANAGE SIDE EFFECTS

Dizziness:

Try to rest and relax. Drink plenty of fluids. Do not drink too much alcohol. Avoid travelling, riding bike or operate any machine while taking this medicine. If the symptoms worsens, contact your doctor.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor, if you are taking,

• other medicines used to lower blood pressure such as diuretics (e.g. furosemide), ACE inhibitors (e.g. captopril, enalapril), beta-blockers (e.g. atenolol, propranolol) or renin inhibitors (e.g. aliskiren)
• medicines that increase the amount of potassium in your blood (e.g. spironolactone, eplerenone and heparin)
• non-steroidal anti-inflammatory medicines (used to treat pain) e.g. aspirin, ibuprofen
• rifamycin (used to treat tuberculosis)
• ciclosporin (used to suppress graft rejection)
• ritonavir (used to treat HIV/AIDS infection)
• lithium (used to treat psychiatric illness)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT VALENT 160MG

Can VALENT 160MG cause dizziness?

Yes. This medicine may cause dizziness in some individuals, although not everybody gets them. Try to rest and relax. Drink plenty of fluids. Do not drink too much alcohol. Avoid travelling, driving or operate any machine while taking this medicine. If the symptoms worsen, contact your doctor.

Can VALENT 160MG be used in children?

This medicine can be used in children aged between 6-18 years.

REFERENCES

1. KD. Tripathi. Drugs Affecting Renin Angiotensin System and Plasma Kinins. Essentials of medical pharmacology. Seventh edition. 2013. Page – 507.

2. KD. Tripathi. Antihypertensive Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page - 561-562.

3. Randa Hilal-Dandan. Renin and Angiotensin. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 738-739.

4. Thomas Michel & Brian B. Hoffman. Treatment of Myocardial Ischemia and Hypertension. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 778-779.

5. Gerald G. Briggs and Roger K. Freeman. V. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 4071-4074.

6. Novartis. The VALIDATE Study of Valsartan for Patients with Early-Stage Heart Failure. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on November 2011] [Accessed 25th November 2020] https://clinicaltrials.gov/ct2/show/NCT00241098

7. Novartis. Efficacy and Safety of Valsartan Versus Placebo on Exercise Tolerance in Patients With Heart Failure. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on November 2016] [Accessed 25th November 2020] https://clinicaltrials.gov/ct2/show/NCT00171106

8. Ivo Abraham, Karen MacDonald, Christine Hermans, Ann Aerts, Christopher Lee, Heidi Brié and Stefaan Vancayzeele. Real-world effectiveness of valsartan on hypertension and total cardiovascular risk: review and implications of a translational research program. NCBI; PMC US National Library of Medicine, National Institute of Health. March 2011. [Accessed 25th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072745/

9. McDermott Laboratories Ltd, Generics [UK] Limited, Mylan Hungary Kft and Mylan UK Healthcare Limited. Electronic Medicines Compendium (EMC); [Revised on July 2019] [Accessed 25th November 2020] https://www.medicines.org.uk/emc/files/pil.8178.pdf

10. Novartis Pharmaceuticals Corp. U.S. Food & Drug Administration; [Revised on December 2011] [Accessed 25th November 2020]https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021283s033lbl.pdf

USEFUL DIAGNOSTIC TESTS

• Electrocardiogram (ECG)
• Echocardiogram
• Coronary angiography
• Chest MRI scan
• Chest CT scan