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Introduction About TRIKA FORTE TABLET
TRIKA FORTE TABLET is a combination of Alprazolam and Sertraline which belongs to the group of medicines called Anxiolytics and Antidepressants respectively. It is used to manage depression, anxiety, post-traumatic stress disorder, panic attacks, phobias, obsessive-compulsive disorder (OCD) and other mixed psychiatric conditions.
Before taking TRIKA FORTE TABLET inform your doctor if you have any problems in your liver, kidneys or heart. You must also inform your doctor if you have diabetes, muscle weakness, breathing problems, depression with suicidal thoughts, any mental illnesses, history of alcoholism or drug abuse, mania, bleeding problems or epilepsy as a precaution.
Do not take TRIKA FORTE TABLET without consulting your doctor if you are pregnant or breastfeeding. Avoid drinking alcohol or grape fruit juice while taking this medicine as it may increase the risk of side effects.
The most common side effects of taking this medicine are depression, headache, dizziness, drowsiness, forgetfulness, constipation, dry mouth, decreased sex drive, problems in erection, blurred vision, problems in sleeping, weight gain or weight loss, changes in taste and sore throat. Consult your doctor if any of these side effects trouble you.
You must also inform your doctor immediately if you experience any worsening of depression with suicidal thoughts or any other unusual changes in behaviour (such as agitation, restlessness, aggressiveness, irritability, violence or anger).
Uses Of TRIKA FORTE TABLET
It is used to manage:
- Depression
- Anxiety
- Post-traumatic stress disorder
- Panic attacks or phobias (fears)
- Obsessive-compulsive disorder
How TRIKA FORTE TABLET Works
TRIKA FORTE TABLET contains two medicines namely alprazolam and sertraline. Alprazolam is a hypnotic medicine. It suppresses the abnormal electrical activity within the brain and induces sleep.
Sertraline is an antidepressant medicine. It works by regulating the release and uptake of certain chemical messengers (dopamine and serotonin) within the brain that affects thoughts, emotions, body movements, and behaviour. As a result, it improves your ability to think, controls your emotions and stabilizes your mental health.
How to use TRIKA FORTE TABLET
Take TRIKA FORTE TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not take this medicine for more than 4 weeks without consulting your doctor.
Side Effects Of TRIKA FORTE TABLET
Common
- depression
- headache, dizziness, drowsiness or sleepiness
- jerky movements or unsteadiness
- forgetfulness
- slurred speech, nervousness
- constipation, dry mouth, loss of appetite, stomach pain, bloating
- tiredness, irritability, confusion, disorientation, loss of alertness
- sexual problems, low sex drive, problems in erection and ejaculation
- inability to sleep or disturbed sleep
- shakiness or trembling
- double or blurred vision
- nausea, diarrhea
- weight gain or weight loss
- joint pain, muscle pain, fever
- changes in taste
- skin rash, itching, flushing, excessive sweating
- fast or irregular heartbeat
- sore throat, chest cold, runny nose
- teeth grinding
- ringing in ears
Uncommon
- abnormally excited
- hallucinations
- dizziness while standing up
- hair loss
- enlarged (dilated) pupils
- breathing problems
- tarry stools
- hemorrhoids or gut inflammation
- unusual vaginal bleeding
Rare
- low RBC, WBC and platelet count in blood
- high blood cholesterol levels
- high or low blood sugar levels
- mouth ulcers, sore tongue
- low urine output
- breast enlargement and discharge, dry vagina
- red painful penis and foreskin
- prolonged erection
Stop taking TRIKA FORTE TABLET and contact your doctor immediately if you experience any of the following side effects:
- suicidal thoughts and behavior
- changes in behavior (such as feeling agitated, restless, aggressive, irritable, violent or angry, false beliefs, nightmares and hallucinations or other inappropriate behavior)
- memory loss (amnesia)
- yellowing of the skin and the whites of the eye (jaundice)
- increased sweating, faster breathing, muscle stiffness, drowsiness or sleepiness
- signs of serotonin syndrome (feeling agitated, hallucinations, confusion, loss of consciousness, fast heartbeat, feeling dizzy, increased sweating, flushing, tremors, stiff muscles, or muscle twitching, loss of coordination, nausea, vomiting, diarrhea or seizures)
- severe allergic skin reactions with blistering and peeling of skin
- feeling restless, urge to move, increased irritation
- fits (seizures)
How To Manage Side Effects
Constipation
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Nausea And Vomiting
Take TRIKA FORTE TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Sleepiness
Try to have a regular bedtime schedule. Avoid having naps during the daytime. Limit caffeine intake and reduce watching TV before bedtime. If the symptom does not improve, consult your doctor.
Warning & Precautions
Pregnancy
ContraindicatedTRIKA FORTE TABLET is generally not recommended for use in pregnant women unless considered necessary by the physician, as it may harm the growing baby. Therefore, inform your doctor before taking TRIKA FORTE TABLET if you are pregnant, think you might be pregnant or planning to have a baby.
Breastfeeding
ContraindicatedTRIKA FORTE TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk to the nursing infant. Therefore, consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or handle any heavy tools or machines if you experience dizziness or drowsiness after taking TRIKA FORTE TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking TRIKA FORTE TABLET as it might make you feel dizzier and drowsier.
Kidney
Use with CautionTRIKA FORTE TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
Liver
Consult your doctorTRIKA FORTE TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with other mild liver problems. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take TRIKA FORTE TABLET if you are allergic to sertraline, alprazolam or to any other sedative or hypnotic medicines (such as midazolam, nitrazepam, clonazepam).
Lungs
ContraindicatedTRIKA FORTE TABLET is not recommended for use in patients suffering from asthma, chronic bronchitis, emphysema, COPD or bronchospasm. Therefore, consult your doctor before taking it.
Heart Disease
Use with CautionTRIKA FORTE TABLET should be used with caution in patients with heart problems (such as slow or abnormal heart rate). Therefore, consult your doctor before taking it.
Others
TRIKA FORTE TABLET is not recommended for use if you:
- suffer from myasthenia gravis (severe muscle weakness)
- have sleep apnea (breathing stops and starts during sleep)
- have recently taken other anti-depressant medicines (MAOI)
Before taking TRIKA FORTE TABLET, inform your doctor if you:
- have previously experienced depression with thoughts of committing suicide
- have any mental illnesses that required hospitalization
- have a previous experience of drug abuse or alcoholism
- have used any hypnotic medicine earlier
- have mania (sudden extreme sense of excitement and hyperactivity)
- have schizophrenia (disorder of thinking)
- have bipolar disorder (alternative episodes of mania and depression)
- have suicidal thoughts
- have low blood sodium levels
- have any bleeding disorders
- are in any on-going electroconvulsive therapy
- have fits (epilepsy)
- have diabetes
- have dehydration or electrolyte imbalance (due to recent vomiting, diarrhea or usage of diuretics)
- have low potassium or magnesium levels in blood
- have glaucoma
Use in Pediatrics:
TRIKA FORTE TABLET is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor before taking it.
Use in geriatrics:
TRIKA FORTE TABLET should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it.
Interactions
A. Drug-Drug interactions:
Before taking TRIKA FORTE TABLET, inform your doctor if you are taking any of the following medicine:
- medicine used to manage depression like monoamine oxidase inhibitors (Ex. tranylcypromine, moclobemide iproniazid, nialamide, isocarboxazid, toloxatone), fluvoxamine, lithium, selegiline, amitriptyline, imipramine, bupropion, St. John’s wort
- other medicines used to manage psychiatric disorders (such as pimozide, haloperidol, risperidone, thioridazine, perphenazine, levomepromazine and olanzapine)
- other medicines used to reduce anxiety and to induce sleep (such as midazolam, clonazepam, nitrazepam)
- medicines used to manage epilepsy (such as phenytoin, carbamazepine)
- medicines used for blood thinning (such as heparin, warfarin)
- diuretics (used to reduce edema and blood pressure) such as hydrochlorothiazide, furosemide
- medicines used to manage diabetes (such as metformin, glimepiride, glibenclamide, insulin, pioglitazone, tolbutamide)
- opioid analgesic medications (such as buprenorphine, morphine, pethidine, fentanyl etc.)
- medicines used to manage allergic reactions (such as azelastine, cyproheptadine, mequitazine)
- medicines used to manage fungal infections (such as fluconazole, ketoconazole, itraconazole, posaconazole, voriconazole)
- oral contraceptives (birth control pill) such as ethinylestradiol, drospirenone
- medicines used to manage bacterial infection (such as sparfloxacin, moxifloxacin, erythromycin IV, pentamidine)
- medicines used for managing stomach ulcers (such as cimetidine, omeprazole, lansoprazole, pantoprazole, rabeprazole)
- medicines used to manage HIV infection (such as ritonavir, nelfinavir, atazanavir, saquinavir, indinavir)
- general anaesthetic (used to create of loss of consciousness before surgery) such as methoxyflurane and trichloroethylene
- medicines used for pain relief (such as tramadol, ibuprofen, diclofenac)
- medicines used to manage migraine headache (such as sumatriptan)
- tryptophan (a medicine used to manage mental illness)
- medicines used to manage abnormal heart rhythm and other heart problems (such as digoxin, quinidine, amiodarone, diltiazem, amlodipine, metoprolol, flecainide, propafenone, nebivolol or encainide)
- amphetamines (a brain stimulant)
- muscle relaxants used prior to surgery (such as mivacurium and suxamethonium)
- aprepitant (a medicine used to manage nausea and vomiting after an operation or chemotherapy)
- metamizole (a medicine used to manage pain and fever)
B. Drug-Food interaction:
Avoid drinking grapefruit juice while taking this medicine, as it may increase the risk of side effects.
Overdosage:
If you or anyone else accidentally took more TRIKA FORTE TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include low blood pressure, dizziness, drowsiness, confusion, feeling cold, slurred speech, breathing difficulties, nausea, vomiting, fast heart rate, shaking, and agitation.
Synopsis
| Drug | : | Alprazolam, Sertraline |
| Pharmacological Category | : | Benzodiazepines, Selective serotonin reuptake inhibitors |
| Therapeutic Indication | : | Anxiety, Depression, OCD, Panic disorder |
| Dosage Forms | : | Tablet |
More Information
- Keep TRIKA FORTE TABLET out of reach of children
- Store TRIKA FORTE TABLET at room temperature
FAQs About TRIKA FORTE TABLET
Q: What is the use of TRIKA FORTE TABLET?
A: TRIKA FORTE TABLET is used to manage depression, anxiety, post-traumatic stress disorder, panic attacks, phobias, obsessive-compulsive disorder (OCD) and other mixed psychiatric conditions.
Q: How TRIKA FORTE TABLET works in my body?
A: TRIKA FORTE TABLET suppresses the abnormal electrical activity within the brain and induces sleep. It also regulates the release and uptake of certain chemical messengers (dopamine and serotonin) within the brain that affects thoughts, emotions, body movements, and behaviour. As a result, it improves your ability to think, controls your emotions and stabilizes your mental health.
Q: Can TRIKA FORTE TABLET be used in children?
A: TRIKA FORTE TABLET is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety data. Therefore, consult your doctor before taking it.
Q: Can TRIKA FORTE TABLET be used during pregnancy?
A: TRIKA FORTE TABLET is generally not recommended for use in pregnant women unless considered necessary by the physician, as it may harm the growing baby. Therefore, inform your doctor before taking TRIKA FORTE TABLET if you are pregnant, think you might be pregnant or planning to have a baby.
Q: Will the use of TRIKA FORTE TABLET cause sleepiness?
A: Yes, TRIKA FORTE TABLET can make your feel sleepy, drowsy, or tired. Therefore, do not drive or handle heavy machines or tool if you feel drowsy or sleepy. Avoid consumption of alcohol as it can aggravate your drowsiness.
Q: Can I consume alcohol while taking TRIKA FORTE TABLET?
A: Avoid consumption of alcohol while taking this medicine as it may make you feel more dizzy or drowsy.
Q: What to do if I forget to take a dose of TRIKA FORTE TABLET?
A: If you forget to take a dose of TRIKA FORTE TABLET, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of TRIKA FORTE TABLET to compensate a missed dose, as it could lead to toxicity.
Q: Will taking a higher dose of TRIKA FORTE TABLET than the prescribed one be beneficial?
A: No, taking a higher dose of TRIKA FORTE TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: Can I stop taking TRIKA FORTE TABLET once my symptoms subside?
A: No. Do not stop taking TRIKA FORTE TABLET without consulting your doctor even if you feel better during the mid-way of the therapy. Sudden discontinuation of therapy may cause withdrawal symptoms such as headaches, muscle pain, tension, restlessness, confusion, mood changes, difficulty in sleeping, irritability, dizziness, tingling sensation, tiredness or weakness, nausea, vomiting and tremors.
Q: Can TRIKA FORTE TABLET be taken daily?
A: Yes. TRIKA FORTE TABLET can be taken daily as per your doctor’s instruction. However, if you are doubtful, consult your doctor.
Q: How to take TRIKA FORTE TABLET?
A: Take TRIKA FORTE TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Q: What are the common side effects of taking TRIKA FORTE TABLET?
A: The most common side effects of taking this medicine are depression, headache, dizziness, drowsiness, forgetfulness, constipation, dry mouth, decreased sex drive, problems in erection, blurred vision, problems in sleeping, weight gain or weight loss, changes in taste and sore throat. Consult your doctor if any of these side effects trouble you.
Q: Can TRIKA FORTE TABLET cause weight gain?
A: Yes. Weight gain is one of the common side effects of taking TRIKA FORTE TABLET. If this side effect bothers you, contact your doctor.
Q: Will TRIKA FORTE TABLET reduce my sex drive?
A: Yes. TRIKA FORTE TABLET may affect your sexual life. It may decrease sex drive or cause problems in orgasm, ejaculation or erection. Therefore, consult your doctor if you experience any such symptoms.
References
1. KD. Tripathi. Drugs Used in Mental Illness: Antidepressant and Antianxiety Drugs. Sedative-Hypnotics. Essentials of Medical Pharmacology. 7th Edition. Page – 405 & 461.
2. Fisekovic Saida and Loga-Zec Svjetlana. SERTRALINE AND ALPRAZOLAM IN THE TREATMENT OF PANIC DESORDER. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. May 2005. [Accessed on 25th January 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214076/
3. Hardeep K. Singh; Abdolreza Saadabadi. Sertraline. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. May 2022. [Accessed on 25th January 2023] https://www.ncbi.nlm.nih.gov/books/NBK547689/#:~:text=Sertraline%20is%20a%20medication%20used,the%20SSRI%20class%20of%20medications
4. Pfizer Italia S.r.l. Xanax® 250 microgram and 500 microgram Tablets alprazolam. Electronic Medicines Compendium. [Revised in November 2022]. [Accessed on 25th January 2023] https://www.medicines.org.uk/emc/files/pil.1656.pdf
5. Milpharm Limited. Sertraline 50 mg film-coated tablets Sertraline 100 mg film-coated tablets (sertraline). Electronic Medicines Compendium. [Revised in June 2022]. [Accessed on 25th January 2023] https://www.medicines.org.uk/emc/files/pil.5760.pdf
6. Central Drugs Standard Control Organization. Alprazolam SR 0.25mg + Sertraline (As Hcl) 25mg/50mg tablet. August 2005. [Accessed on 25th January 2023] https://cdscoonline.gov.in/CDSCO/Drugs
7. Leeford Healthcare Pvt Ltd. Spilane A. [Accessed on 25th January 2023] https://www.leeford.in/product/806/spilane-a
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