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INTRODUCTION
SPECTRAXIME contain cefuroxime which belongs to a group of medicine called cephalosporin antibiotics. It is an antibiotic used in adults and children to treat infections of lungs or chest, urinary tract, skin and soft tissue, abdomen and also helps to prevent infections during surgery. It works by preventing bacteria from forming the bacterial protective covering (cell wall). This causes the cell walls to rupture resulting in the death of the bacteria.
The common side effects are injection site pain, swelling and redness along the vein, increases in substances (enzymes) produced by the liver, neutropenia or eosinophilia, anaemia. This medicine will be administered by a doctor or nurse. SPECTRAXIME will be given as a drip (intravenous infusion) or as an injection directly into a vein or into a muscle. Your doctor will decide the dose and frequency depending on your condition. Before taking this medicine tell your doctor if you have ever had kidney disease, heart disease, liver problems. Pregnant and breastfeeding women should consult their doctor before taking this medicine.
USES OF SPECTRAXIME
- Treat infections of lungs or chest, urinary tract, skin and soft tissue, abdomen
- Helps to prevent infections during surgery
HOW SPECTRAXIME WORKS
SPECTRAXIME works by preventing bacteria from forming the bacterial protective covering (cell wall). This causes the cell walls to rupture resulting in the death of the bacteria.
DIRECTIONS FOR USE
This medicine will be administered by a doctor or nurse. SPECTRAXIME will be given as a drip (intravenous infusion) or as an injection directly into a vein or into a muscle. Your doctor will decide the dose and frequency depending on your condition.
SIDE EFFECTS OF SPECTRAXIME
SERIOUS
- severe allergic reaction (including raised and itchy rash, swelling, sometimes of the face or mouth causing difficulty in breathing)
- skin rash, which may blister, and look like small target (central dark spot surrounded by a paler area, with a dark ring around the edge)
- widespread rash with blisters and peeling skin (sings of Stevens-Johnson syndrome or toxic epidermal necrolysis)
- fungal infections
- severe diarrhoea
COMMON
- pain, swelling and redness along the vein at the site of injection
- increases in substances (enzymes) produced by the liver
- changes in your white blood cell count (neutropenia or eosinophilia)
- low levels of red blood cells (anaemia)
HOW TO MANAGE SIDE EFFECTS
Diarrhoea:
Drink lot of fluids, such as water or squash, to avoid dehydration. Do not take any other medicines without consulting to a doctor.
WARNING & PRECAUTIONS
PREGNANCY
SPECTRAXIME should be used with caution in pregnant women. Consult your doctor before taking this medicine.
BREASTFEEDING
SPECTRAXIME should be used with caution in breast feeding women. Consult your doctor before taking this medicine.
DRIVING AND USING MACHINES
Do not drive or operate any machine while taking this medicine since it may cause feel unwell.
ALCOHOL
Consumption of alcohol is not recommended during treatment with SPECTRAXIME.
KIDNEY
SPECTRAXIME should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.
LIVER
SPECTRAXIME should be used with caution in patients suffering from liver function impairment or active liver diseases. Consult your doctor for advice.
ALLERGY
Do not take SPECTRAXIME if you are allergic (hypersensitive) to cefuroxime or any other ingredients in this medicine.
OTHERS
Tell your doctor if you have or had a condition such as,
- skin rashes and gastrointestinal disorders such as diarrhoea
INTERACTIONS
Talk to your doctor if you are taking,
- antibiotics such as aminoglycoside (used to treat infection)
- water tablets (diuretics)such as furosemide
- probenecid (used to treat Gout)
- oral anticoagulants
- contraceptive pills
SYNOPSIS
| Drug | : | Cefuroxime |
| Pharmacological Category | : | Antibiotic, Cephalosporin (Second Generation) |
| Therapeutic Indication | : | Infections such as lungs or chest, urinary tract, skin and soft tissue, abdomen and infections during surgery |
| Dosage Forms | : | Tablet, Capsule, Injection, Syrup |
MORE INFORMATION
Store below 20-25°C and keep out of reach of children.
FAQs ABOUT SPECTRAXIME
Can I take SPECTRAXIME during pregnancy?
It should be used with caution in pregnant women. Consult your doctor before taking.
Is SPECTRAXIME better than amoxicillin?
It is an antibiotic which is useful in treating bacterial infections. Amoxicillin is also an effective and cheap antibiotic which is used to treat many types of bacterial infections. The only difference among these medicines is the response of the medicine to the infection, as it varies from person to person. The effectiveness of two daily dose of this medicine is same as three daily doses of amoxicillin.
Can I take SPECTRAXIME during kidney disease?
It should be used with caution in patients suffering from active kidney diseases.
REFERENCES
1. KD Tripathi. Beta-Lactam Antibiotics. Essentials of Medical Pharmacology. Seventh Edition,2013. Page-727.
2. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 686-688.
3. J Scott 1, D Ormrod, K L Goa. Cefuroxime axetil: an updated review of its use in the management of bacterial infections. NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov. 2001 [Accessed 02 Dec 2020] https://pubmed.ncbi.nlm.nih.gov/11558834/
4. C M Ginsburg, G H McCracken, Jr, M Petruska, and K Olson. Pharmacokinetics and bactericidal activity of cefuroxime axetil. US National Library of Medicines, National Institutes of Health. Oct 1985. [Accessed 02 Dec 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC180292/
5. FACTA Farmaceutici S.P.A; Electronic Medicines Compendium (EMC); [Revised on Jun 2018] [Accessed 02 Dec 2020] http://www.hpra.ie/img/uploaded/swedocuments/2204203.PA1226_009_002.af47d81e-3068-479b-9c91-8a209488572d.000001Cefuroxime%20PIL.180710.pdf
USEFUL DIAGNOSTIC TESTS
- Complete blood count
- Peripheral smear examination
Manufacturer/Marketer Details
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