Soranib Tablet 30'S

Cancer/Oncology Rx required

Best Price*  ₹ 1,655.28
MRP ₹2,069.10
(Inclusive of all taxes) *30 Tablet(s) in a Container * Mkt: Cipla Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

SORANIB contains Sorafenib which belongs to the group of medicines called antineoplastic agents. It is used to treat liver and thyroid cancer. It can also be used to treat advanced cancer of kidney, when standard therapy cannot cure the disease. Sorafenib works by slowing down the rate of growth of tumor cells and arrests blood supply to them.

This medicine can be taken either without food or with a low-to-moderate fat meal. Do not take this medicine with high fat meals, because this may make SORANIB less effective. It is important to take this medicine at same time each day, so that there is a steady concentration in your bloodstream. During the treatment, your doctor would monitor your blood pressure and blood sugar levels regularly to avoid any unwanted side effects.

The most common side effects of taking this medicine are nausea, vomiting, diarrhea, hair loss, headache, muscle pain and mouth sores. Before taking this medicine, inform your doctor if you have severe kidney or liver impairment. While taking this medicine, avoid becoming pregnant. If you could become pregnant use an adequate contraceptive method. Do not breastfeed while taking this medicine, because it may interfere with the growth and development of your baby. This medicine is generally not recommended for use in children. Consult your doctor before taking.

USES OF SORANIB

  • Treats liver cancer (hepatocellular carcinoma)
  • Treats thyroid cancer (differentiated thyroid carcinoma)
  • Treats advanced uncontrollable kidney cancer (advanced renal cell carcinoma)

HOW SORANIB WORKS

Sorafenib is a tyrosine kinase inhibitor that acts by decreasing the proliferation of tumor cells. It inhibits various intracellular and cell surface kinases, that are responsible for tumor growth, tumor cell signaling, angiogenesis and arrests blood supply to the cancer cells which results in apoptosis (death of cells).

DIRECTIONS FOR USE

Take this medicine as directed by your physician. It can be taken either without food or with a low-to-moderate fat meal. Try to take this medicine at same time each day. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.

SIDE EFFECTS OF SORANIB

COMMON

  • diarrhea, nausea or vomiting
  • feeling weak or tired
  • mouth pain, tongue pain, abdominal pain
  • headache
  • joint pain or tumor pain
  • hair loss
  • painful palms or soles
  • dry skin, rash or itching
  • high blood pressure
  • fever or infections
  • loss of appetite, indigestion, constipation, weight loss
  • difficulty in swallowing
  • depression
  • sexual impotence
  • dysphonia (change in voice)
  • chest pain
  • tinnitus (ringing in the ear)
  • anemia (decrease in red blood cells)
  • underactive thyroid gland
  • dysgeusia (distortion of sense of taste)
  • flushing (redness in face and often other areas of skin)
  • runny nose
  • heartburn

RARE

  • allergic reaction (such as skin rash, painful blisters and fever, swelling of skin, difficulty in breathing or swallowing)
  • symptoms of liver damage (nausea, vomiting, abdominal pain and jaundice)

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Try taking this medicine with, or just after meal. Stick to simple meals. Do not eat rich or spicy food.

Constipation: 

Eat fibre rich foods like fresh fruit, vegetables and cereals. Drink plenty of water. Exercise more regularly.

Diarrhea:

Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.

Stomach pain:

Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.

WARNING & PRECAUTIONS

PREGNANCY

SORANIB is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING

SORANIB is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.

DRIVING AND USING MACHINES

Do not drive or operate any machines if your ability is affected by this medicine.

ALCOHOL

Avoid consumption of alcohol while taking this medicine.

KIDNEY

SORANIB should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.

LIVER

SORANIB should be taken with caution in patients with severe liver disease. Consult your doctor for advice.

ALLERGY

Do not take this medicine if you are allergic to sorafenib.

HEART DISEASE

SORANIB should be taken with caution in patients with high blood pressure or other heart disorders. Consult your doctor for advice.

INTERACTIONS

Talk to your doctor, if you are taking,

  • rifampicin, neomycin or other medicines used to treat infections
  • St John’s wort (a herbal treatment used to treat depression)
  • medicines used to treat epilepsy (e.g. phenytoin, carbamazepine or phenobarbital)
  • dexamethasone (a corticosteroid used for various conditions)
  • anticoagulants used to prevent blood clots (e.g. warfarin or phenprocoumon)
  • other medicines used to treat cancer (doxorubicin, capecitabine, docetaxel, paclitaxel and irinotecan)
  • digoxin (used to treat mild to moderate heart failure)

SYNOPSIS

Drug :   Sorafenib
Pharmacological Category :   Antineoplastic Agents, Tyrosine Kinase Inhibitors
Therapeutic Indication :   Liver cancer, Thyroid cancer, Advanced kidney cancer
Dosage Forms :   Tablet

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT SORANIB

Can SORANIB cure hepatocellular carcinoma?

Yes. This medicine is intended to cure liver cancer (hepatocellular carcinoma) in adult patients.

Does SORANIB cause hair loss?

Yes. This medicine may cause hair loss and if this symptom bothers you contact your physician.

Can SORANIB be used in children?

No. This medicine is generally not recommended for use in children. Consult your doctor before taking.

REFERENCES

1. Bruce A. Chabner, Jeffery Barnes, Joel Neal, Erin Olson, Hamza Mujagic, Lecia Sequist, Wynham Wilson, Dan L. Longo, Constantine Mitsiades and Paul Richardson. Targeted therapies: Tyrosine kinase inhibitors, Monoclonal antibodies and Cytokines. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York Mc Graw Hill Medical 2011. Page – 1740.

2. Gerald G. Briggs and Roger K. Freeman. S. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation, Tenth Edition. 2015. Page – 3562-3563.

3. Bayer. A Phase III Randomized, Placebo-controlled Study of Sorafenib in Patients with Advanced Hepatocellular Carcinoma. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on October 2014] [Accessed 3rd November 2020] https://clinicaltrials.gov/ct2/show/NCT00105443

4. Giorgia Marisi, Alessandro Cucchetti, Paola Ulivi, Matteo Canale, Giuseppe Cabibbo, Leonardo Solaini, Francesco G Foschi, Serena De Matteis, Giorgio Ercolani, Martina Valgiusti, Giovanni L Frassineti, Mario Scartozzi, and Andrea Casadei Gardini. Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers? NCBI; PMC, National Library of Medicine, National Institute of Health. September 2018. [Accessed 3rd November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6158485/

5. Bayer AG. Electronic Medicines Compendium (EMC); [Revised on September 2019] [Accessed 3rd November 2020] https://www.medicines.org.uk/emc/files/pil.226.pdf

6. Bayer HealthCare Pharmaceuticals Inc. U.S. Food & Drug Administration; [Revised on October 2010] [Accessed 3rd November 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021923s008s009lbl.pdf

7. Bayer HealthCare Pharmaceuticals Inc. U.S. Food & Drug Administration; [Revised on December 2018] [Accessed 3rd November 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021923s020lbl.pdf

USEFUL DIAGNOSTIC TESTS

  • Alpha-fetoprotein (AFP) L3 Fraction
  • Complete Blood Count
  • Thyroid Profile Free

PRODUCT DETAILS

    Net Qty
    1 N
    Item Weight
    40 g
    Ingredient
    SORAFENIB TOSYLATE 200MG
    Hsn Code
    30049049
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DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Soranib Tablet 30'S

Soranib Tablet 30'S Mkt: Cipla Ltd

M.R.P.: Rs.2,069.10
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