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INTRODUCTION
SN 15 PLUS TABLET is a combination of Diclofenac and Serratiopeptidase which belongs to a group of medicines called Nonsteroidal anti-inflammatory drugs and Proteolytic enzymes. SN 15 PLUS TABLET is used in the treatment of pain and inflammatory conditions in adult patients.
SN 15 PLUS TABLET is not recommended for use in patients allergic to diclofenac, aspirin, ibuprofen, other NSAIDs, and/or serratiopeptidase. SN 15 PLUS TABLET is also not recommended for use in patients with active gastric or intestinal ulcer/bleeding/perforation, active/previous history of recurrent peptic ulcer/hemorrhage, peripheral arterial disease (blood circulation disorder), severe liver/kidney impairment, and/or heart diseases (such as congestive heart failure, severe heart failure, ischemic heart disease). SN 15 PLUS TABLET is also not indicated for use to treat pain in patients who had undergone coronary artery bypass graft (CABG) surgery.
Before taking SN 15 PLUS TABLET inform your doctor if you had previously suffered from gastrointestinal ulceration, and/or have ulcerative colitis (inflammation of colon), mixed connective tissue disorders (such as systemic lupus erythematosus), diabetes, high blood pressure, lung problems (such as bronchial asthma, chronic obstructive pulmonary diseases), kidney problems (such as mild to moderate renal impairment), and/or liver problems (such as mild to moderate liver impairment).
SN 15 PLUS TABLET is generally not recommended for use during third trimester of pregnancy which is also not recommended for use in women planning for pregnancy. SN 15 PLUS TABLET should be used with caution during first and second trimester of pregnancy only if it is clearly necessary. SN 15 PLUS TABLET is also not recommended for use in breastfeeding women since it may pass through breastmilk. Consult your doctor before taking the medicine.
SN 15 PLUS TABLET is not recommended for use in children and adolescents (aged below 18 years) at higher doses which should be used with caution in children and adolescents (aged above 14 years) at lower doses after consulting the doctor. SN 15 PLUS TABLET should also be used with caution in elderly patients (aged above 65 years) after consulting the doctor.
The most common side effects of taking SN 15 PLUS TABLET are headache, dizziness, abdominal pain, indigestion, nausea, vomiting, and/or diarrhea. Consult your doctor if any of these symptoms worsen.
USES OF SN 15 PLUS TABLET
- Treats pain and inflammatory conditions in adult patients
HOW SN 15 PLUS TABLET WORKS
SN 15 PLUS TABLET provides relief from pain and inflammation in affected individuals where diclofenac works by inhibiting the release of certain chemical messengers (responsible for pain and inflammation) in the brain and serratiopeptidase reduces inflammatory reaction by breaking down abnormal proteins at the site of inflammation thus providing relief from inflammation and pain in affected individuals.
DIRECTIONS FOR USE
Capsule, Tablet:
Take SN 15 PLUS TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose, duration and frequency for you depending on your age, body weight and disease condition.
Orally Disintegrating Tablet:
Take SN 15 PLUS TABLET as advised by your physician. Place SN 15 PLUS TABLET inside your mouth and allow it to dissolve completely. Do not swallow or chew the medicine. Your doctor will decide the correct dose, duration and frequency for you depending on your age, body weight and disease condition.
SIDE EFFECTS OF SN 15 PLUS TABLET
COMMON
- Headache, dizziness, internal spinning sensation
- Nausea, vomiting, diarrhea, indigestion, abdominal pain, flatulence, anorexia (eating disorder), loss of appetite
- Rash, red itchy welts
UNCOMMON
- Heart attack, cardiac failure, racing heartbeat, chest pain
RARE
- Signs of hypersensitivity and anaphylactic reactions (life threatening allergic reactions) such as low blood pressure, red itchy welts, flushed/pale skin, shortness of breath, and/or wheezing
- Excess sleepiness, tiredness
- Asthma, difficulty in breathing
- Stomach inflammation, gastrointestinal bleeding, dark stools, bloody diarrhea, stomach ulcer with/without bleeding/perforation
- Inflammation of liver, jaundice, liver disorders
- Bullous eruptions, skin inflammation, skin redness, erythema multiforme (type of allergic skin reaction)
- Swelling in arms and legs
Stop taking SN 15 PLUS TABLET and contact your doctor immediately if you experience any of the following side effects:
- Skin rash, mucosal lesions, hypersensitivity reaction (associated with signs such as red itchy welts, skin rash, shortness of breath, wheezing, and/or fever)
- Stomach pain, indigestion, heartburn, wind, nausea, vomiting
- Signs of bleeding in the stomach/intestine such as abdominal cramps, black/tarry stool, bright red blood in vomit, and/or dizziness/faintness
- Signs of allergic reactions such as skin rash, itching, bruising, painful red areas, peeling/blistering
- Wheezing/shortness of breath
- Swollen face, lips, hands or fingers
- Signs of jaundice such as yellowing of your skin or the whites of your eyes
- Persistent sore throat/high temperature
- change in quantity of urine and its appearance
- Mild cramping and tenderness of abdomen followed by rectal bleeding/bloody diarrhea usually within 24 hours of the onset of abdominal pain
- Signs of Stevens-Johnson syndrome (serious skin disorder) such as blistering of the skin, mouth, eyes and genitals
- Chest pain due to Kounis syndrome (serious allergic reaction)
HOW TO MANAGE SIDE EFFECTS
Headache:
If SN 15 PLUS TABLET causes headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Headaches should usually go away after the first week of taking SN 15 PLUS TABLET. If it lasts more than a week or severe, inform your doctor.
Diarrhea:
If SN 15 PLUS TABLET causes diarrhea, then drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhea. Consult your doctor and inform them if the symptom gets worse.
Dizziness:
If SN 15 PLUS TABLET causes dizziness, then try to take rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.
Nausea and vomiting:
If SN 15 PLUS TABLET causes nausea and vomiting, then try to take SN 15 PLUS TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if symptom gets worse.
Indigestion:
If SN 15 PLUS TABLET causes indigestion, then try to have smaller and more frequent meals and drink slowly. Reduce consumption of coffee, cola, tea, or alcohol and lose weight if you are obese. Try to avoid smoking and don’t have rich, fatty or spicy foods. Consult your doctor and inform if the symptom does not improve.
WARNING & PRECAUTIONS
PREGNANCY
SN 15 PLUS TABLET is generally not recommended for use during third trimester of pregnancy. It is also not recommended for use in women planning for pregnancy. SN 15 PLUS TABLET should be used with caution during first and second trimester of pregnancy only if it is clearly necessary. Consult your doctor before taking SN 15 PLUS TABLET.
BREASTFEEDING
SN 15 PLUS TABLET is not recommended for use in breastfeeding women since it may pass through breastmilk. Consult your doctor before taking SN 15 PLUS TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel/experience visual disturbances, dizziness, spinning sensation, excess sleepiness, drowsiness, and/or tiredness after taking SN 15 PLUS TABLET.
ALCOHOL
Avoid consumption of alcohol while taking SN 15 PLUS TABLET as it increases the risk of gastrointestinal bleeding.
KIDNEY
SN 15 PLUS TABLET is not recommended for use in patients with severe renal impairment. It should be used with caution in patients with mild to moderate renal impairment. Consult your doctor before taking SN 15 PLUS TABLET.
LIVER
SN 15 PLUS TABLET is not recommended for use in patients with severe hepatic impairment and liver failure. It should be used with caution in patients with mild to moderate hepatic impairment and hepatic porphyria. Consult your doctor before taking SN 15 PLUS TABLET.
ALLERGY
Do not take SN 15 PLUS TABLET if you are allergic to diclofenac, aspirin, ibuprofen, other NSAIDs, serratiopeptidase, and/or any other ingredients of this medicine.
LUNGS
SN 15 PLUS TABLET should be used with caution in patients with lung problems such as bronchial asthma, chronic obstructive pulmonary diseases, and/or chronic infections of the respiratory tract. Consult your doctor before taking SN 15 PLUS TABLET.
HEART DISEASE
SN 15 PLUS TABLET is not recommended for use in patients with established congestive heart failure, severe heart failure, and/or ischemic heart disease, It is also not recommended for use in patients who had undergone coronary artery bypass graft (CABG) surgery. Consult your doctor before taking SN 15 PLUS TABLET.
OTHERS
SN 15 PLUS TABLET is not recommended for use if you:
- Have active gastric or intestinal ulcer/bleeding/perforation
- Previously suffered from gastrointestinal bleeding/perforation (due to NSADIS therapy)
- Have active/previous history of recurrent peptic ulcer/hemorrhage (with two or more bleeding episodes)
- Previously suffered from angio-oedema, red itchy welts, acute rhinitis gastrointestinal (due to NSAIDS therapy)
- Previously had stomach/bowel problems (after taking other NSAIDs)
- Have/had peripheral arterial disease (blood circulation disorder).
- other cerebrovascular diseases (such as stroke, ministroke).
- Have rare hereditary problems of galactose intolerance, severe lactase deficiency/glucose-galactose malabsorption.
Before taking SN 15 PLUS TABLET, inform your doctor if you:
- Have previously suffered from gastrointestinal ulceration
- Have ulcerative colitis (inflammation of colon) or crohn’s disease (inflammatory bowel disease)
- Suffer from mixed connective tissue disorders such as systemic lupus erythematosus (type of autoimmune disease)
- Have diabetes, high blood pressure, hyperlipidemia (high cholesterol level in blood)
- Are a smoker
- Suffer from defective hemostasis (process to prevent/stop bleeding), bleeding diathesis/ hematological abnormalities (increased susceptibility to bleed).
Use in Pediatrics:
SN 15 PLUS TABLET is not recommended for use in children and adolescents (below 18 years) at higher doses. It should be used with caution in children and adolescents (aged above 14 years) at lower doses. Consult your doctor before taking the medicine who shall decide the correct dose, duration and frequency depending on the child’s age, body weight and disease condition.
Use in Geriatrics:
SN 15 PLUS TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking the medicine.
INTERACTIONS
A. Drug-Drug interactions:
Before taking SN 15 PLUS TABLET, inform your doctor, if you are taking any of the following medicine:
- lithium (used for depression)
- digoxin, quinidine (medicines used to treat heart disease)
- medicines used for hypertension such as diuretics (Ex. chlorothiazide, chlorthalidone), beta blockers (Ex. acebutolol, atenolol), angiotensin-converting enzyme inhibitors (Ex. benazepril, captopril)
- potassium-sparing diuretic (used to treat hypertension, cirrhosis, congestive heart failure) Ex. amiloride, eplerenone
- ciclosporin (used to prevent transplant organ rejection)
- tacrolimus (used to treat moderate to severe atopic dermatitis)
- trimethoprim (used to prevent urinary tract infections)
- anticoagulants (medicines used to prevent blood clot) Ex. aspirin, warfarin
- other NSAIDS (medicines used to reduce pain and inflammation) such as cox 2 selective inhibitors (Ex. celecoxib, valdecoxib), corticosteroids (Ex. cortisone, hydrocortisone)
- selective serotonin reuptake inhibitors (medicines used to treat depression) Ex. citalopram, dapoxetine
- antidiabetics (medicines used to treat diabetes) Ex. metformin, glipizide, glyburide
- methotrexate (used to treat inflammatory conditions)
- quinolone (used to treat bacterial infections)
- phenytoin (used to treat seizures)
- colestipol, Cholestyramine (medicines used to lower high cholesterol in blood)
- cardiac glycosides (medicines used to treat heart failure and certain irregular heartbeats) Ex. acetyldigitoxin, deslanoside
- mifepristone (used to end early pregnancy)
Overdosage:
If you or anyone else accidentally take too much of SN 15 PLUS TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are headache, nausea, vomiting, epigastric pain, GI hemorrhage, diarrhea, dizziness, disorientation, excitation, coma, drowsiness, tinnitus, fainting, and/or convulsions.
SYNOPSIS
| Drug | : | Diclofenac, Serratiopeptidase |
| Pharmacological Category | : | Non-steroidal anti-inflammatory drug and Proteolytic Enzyme |
| Therapeutic Indication | : | Pain and inflammatory conditions |
| Dosage Forms | : | Capsule, Tablet, Orally Disintegrating Tablet |
MORE INFORMATION
- Keep out of reach from children
- Store below 25°C
FAQs ABOUT SN 15 PLUS TABLET
What is SN 15 PLUS TABLET and why it is used?
SN 15 PLUS TABLET is a combination of Diclofenac and Serratiopeptidase which belongs to a group of medicines called Nonsteroidal anti-inflammatory drugs and Proteolytic enzymes, which is generally indicated in adult patients to treat pain and inflammatory conditions.
How SN 15 PLUS TABLET works?
SN 15 PLUS TABLET provides relief from pain and inflammation in affected individuals where diclofenac works by inhibiting the release of certain chemical messengers (responsible for pain and inflammation) in the brain and serratiopeptidase reduces inflammatory reaction by breaking down abnormal proteins at the site of inflammation thus providing relief from inflammation and pain in affected individuals.
What are the most common side effects of taking SN 15 PLUS TABLET?
The most common side effects of taking SN 15 PLUS TABLET are headache, dizziness, abdominal pain, indigestion, nausea, vomiting, and/or diarrhea. Consult your doctor if any of these symptoms worsen.
What happens if more dose of SN 15 PLUS TABLET is taken than the required dose?
If you or anyone else accidentally take too much of SN 15 PLUS TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are headache, nausea, vomiting, epigastric pain, GI hemorrhage, diarrhea, dizziness, disorientation, excitation, coma, drowsiness, tinnitus, fainting, and/or convulsions.
Can SN 15 PLUS TABLET be used during pregnancy?
No, SN 15 PLUS TABLET is not recommended for use in pregnant women especially during third trimester stage. It is also not recommended for use in women planning for pregnancy. However, it can be used with caution during first and second trimester of pregnancy provided if it is clearly necessary. Consult your doctor before taking the medicine.
REFERENCES
1. KD Tripathi. Nonsteroidal Antiinflammatory Drugs & Antipyretic-Analgesics and Aspects of Pharmacotherapy, Clinical Pharmacology & Drug Development. Essentials of medical pharmacology. Seventh edition. 2013. Page – 71, 204.
2. Supakanya Wongrakpanich, Amaraporn Wongrakpanich, Katie Melhado, and Janani Rangaswam. A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in February 2018] [Accessed on 5th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772852/
3. B. Pramod Krishna, B. Praveen Reddy, D.S. Yashavanth Kumar, M. Ummar, Vijay Shekhar, and Rahul Vinay Chandra Tiwari. Role of Serratiopeptidase and Dexamethasone in the Control of Postoperative Swelling. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in June 2020] [Accessed on 5th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7433958/
4. Dexcel Pharma Ltd. D. Electronic medicines compendium (EMC). [Revised in March 2022] [Accessed on 5th April 2022] https://www.medicines.org.uk/emc/files/pil.2662.pdf
5. CiplaMed. CIPZEN D Tablets. [Revised in March 2017] [Accessed on 5th April 2022] https://www.ciplamed.com/content/voltanec-sp-tablets
6. Innovative Pharmaceuticals. Geozen-D Tablets. [Accessed on 5th April 2022] https://www.innovativepharma.in/product/geozen-d-tablets/
7. Serum Institute of India Pvt. Ltd. SD-15 TABLETS. [Accessed on 5th April 2022] https://www.seruminstitute.com/product_ind_sdtablets.php
8. Lincoln Pharmaceuticals Ltd. Aldase OD TABLETS. [Accessed on 5th April 2022]. https://www.lincolnpharma.com/international/international-products/
USEFUL DIAGNOSTIC TESTS
- Blood tests, CRP tests
- Kidney function test
- Liver function test
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