INTRODUCTION

SITAZIT DM 1000 TABLET is a combination of Dapagliflozin, Metformin and Sitagliptin which belongs to the group of medicines called Antidiabetics. It is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Prior to the treatment, your doctor may want you to take several blood tests to understand your existing kidney condition.  SITAZIT DM 1000 TABLET is not recommended for use in patients with type 1 diabetes. Contact your doctor before taking the medicine. Alcohol is not suggested during treatment with SITAZIT DM 1000 TABLET due to the grown risk of critical adverse effects. SITAZIT DM 1000 TABLET is not suggested for use in children and adolescents since the safety and efficacy of use are not clinically established.

There are no proper information available for the use of SITAZIT DM 1000 TABLET during pregnancy. Contact your doctor before taking. There are no proper information available for the use of SITAZIT DM 1000 TABLET during breastfeeding. Contact your doctor before taking. SITAZIT DM 1000 TABLET should be used with caution in elderly patients (aged 65 years or above). Contact your doctor before taking the medicine. The most common side effects of this medicine are hypoglycemia. Contact your physician if any of the symptoms worsen.

USES OF SITAZIT DM 1000 TABLET

• Used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus

HOW SITAZIT DM 1000 TABLET WORKS

SITAZIT DM 1000 TABLET is a combination of Dapagliflozin, Metformin and Sitagliptin. Dapagliflozin increases urinary glucose excretion and reduces blood glucose levels. Metformin decreases the amount of glucose you absorb from your food and the amount of glucose made by the liver. It also increases the body's response to insulin, a natural substance that controls the amount of glucose in the blood. Sitagliptin helps control blood sugar levels by increasing substances (incretins) in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood.

DIRECTIONS FOR USE

Take SITAZIT DM 1000 TABLET as advised by your physician. Swallow this medicine as whole with a glass of water and do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF SITAZIT DM 1000 TABLET

HOW TO MANAGE SIDE EFFECTS

Nausea And Vomiting

Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Contact your doctor if nausea and vomiting did not improve.

WARNING & PRECAUTIONS

PREGNANCY

Consult your doctor

There are no proper information available for the use of SITAZIT DM 1000 TABLET during pregnancy. Contact your doctor before taking.

BREASTFEEDING

Consult your doctor

There are no proper information available for the use of SITAZIT DM 1000 TABLET during breastfeeding. Contact your doctor before taking.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or operate any machines if you experience symptoms of hypoglycaemia such as weakness, dizziness, increased sweating, fast heartbeat, change in vision, difficulty in concentration, weakness, sleepiness, light-headedness after taking SITAZIT DM 1000 TABLET.

ALCOHOL

Contraindicated

Avoid consumption of alcohol while taking SITAZIT DM 1000 TABLET due to the grown risk of critical adverse effects.

ALLERGY

Contraindicated

Do not take SITAZIT DM 1000 TABLET if you are allergic to Dapagliflozin, Metformin, Sitagliptin or to any other ingredients of this medicine.

OTHERS

Others:

SITAZIT DM 1000 TABLET is not recommended for use if you have:

• type 1 diabetes mellitus

Use in Pediatrics:

SITAZIT DM 1000 TABLET is not suggested for use in children and adolescents since the safety and efficacy of use are not clinically established. Contact your doctor before taking.

Use in Geriatrics:

SITAZIT DM 1000 TABLET should be used with caution in elderly patients (aged 65 years or above). Contact your doctor before taking.

INTERACTIONS

A. Drug - Drug interactions:

Before taking SITAZIT DM 1000 TABLET inform your doctor if you are taking prescription, non-prescription and herbal supplements.

Overdosage:

If you or anyone else accidentally took too much of this medicine, consult your doctor immediately. Symptoms of overdose are hypoglycaemia.

SYNOPSIS

MORE INFORMATION

• Keep SITAZIT DM 1000 TABLET out of reach of children
• Store at room temperature

FAQs ABOUT SITAZIT DM 1000 TABLET

Q: What is SITAZIT DM 1000 TABLET used for?

A: It is used to treat type-2 diabetes mellitus along with diet and exercise when diabetes cannot be controlled with other medicines.

Q: Who should not take SITAZIT DM 1000 TABLET?

A: SITAZIT DM 1000 TABLET is not recommended for use in patients with allergic history to dapagliflozin, metformin, sitagliptin, or patients with type 1 diabetes mellitus.

Q: Can I take alcohol while using SITAZIT DM 1000 TABLET?

A: No. Avoid consumption of alcohol while taking SITAZIT DM 1000 TABLET as it may cause adverse effects.

Q: How does SITAZIT DM 1000 TABLET work?

A: SITAZIT DM 1000 TABLET is a combination of Dapagliflozin, Metformin and Sitagliptin. Dapagliflozin increases urinary glucose excretion and reduces blood glucose levels. Metformin decreases the amount of glucose you absorb from your food and the amount of glucose made by the liver. It also increases the body's response to insulin, a natural substance that controls the amount of glucose in the blood. Sitagliptin helps control blood sugar levels by increasing substances (incretins) in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood.

Q: Can I use SITAZIT DM 1000 TABLET with other diabetic medications?

A: Your doctor may advise SITAZIT DM 1000 TABLET with or without other medications to control your blood sugar levels. However, it is advised to maintain a proper diet and exercise to achieve the controlled blood sugar levels while using this medicine with or without other antidiabetic medications.

Q: Does SITAZIT DM 1000 TABLET cause low blood sugar?

A: Yes. SITAZIT DM 1000 TABLET may cause low blood sugar. Stop taking SITAZIT DM 1000 TABLET and contact your doctor if you experience any unusual symptoms like weakness, shaking, sweating, drowsiness, dizziness, feeling very anxious, fast heartbeat, hunger, headache, change in vision, change in mood or confusion, and irritability.

REFERENCES

1. K.D. Tripathi. Insulin, oral hypoglycaemic drugs and glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page - 278, 275.

2. Clifford J Bailey, Jorge L Gross, Delphine Hennicken, Nayyar Iqbal, Traci A Mansfield, James F List. Uses of metformin and dapagliflozin. Biomed Central (BMC). February 2013. [Accessed on Jan 30th 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606470/

3. La Renon Healthcare. [Accessed on Jan 30th 2023] https://www.larenon.com/wp-content/uploads/2022/11/SITAHENZ-DM-SP-LBL.pdf

4. Emsita Trio Forte. [Accessed on Jan 30th 2023] https://www.medyinfo.com/2022/12/emsita-trio-forte-tablet.html

USEFUL DIAGNOSTIC TESTS

• Blood glucose levels