INTRODUCTION

SILOTRIF 8MG contains silodosin which belongs to the group of medicines called selective alpha-1 adrenergic receptor antagonist. It is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia in men. Benign prostate hyperplasia (BPH) is a non-cancerous enlargement of the prostate gland in men. Symptoms of Benign prostate hyperplasia (BPH) may include difficulty in urination, urinary frequency and an inability to complete bladder emptying.

Silodosin blocks the alpha-1 adrenoreceptors present in tissues of human prostate and bladder and relax the smooth muscle in these tissues, resulting in improvement of symptoms of BPH. The side effect occurs most commonly while taking this medicine is an orgasm with reduced or no semen. This side effect is reversible with discontinuation of the product. Silodosin can cause postural hypotension, with or without dizziness, so do not drive, operating machinery, or perform any hazardous tasks while taking this medicine if you feel so.

Always take this medicine as directed by your physician. Swallow the medicine as a whole with water and do not crush or chew the medicine. Do not take this medicine if you are suffering from any kidney disease or liver disease. Consult your doctor before taking. Your doctor will decide the correct dose for you depending upon your medical condition and response to treatment. To get the most benefit, try taking this medication regularly with the same meal each day.

USES OF SILOTRIF 8MG

• Treat signs and symptoms of benign prostatic hyperplasia in men

HOW SILOTRIF 8MG WORKS

Silodosin works by blocking the alpha-1 adrenoreceptors where the smooth muscle in these tissues relax, resulting in an improvement in urine flow and a reduction in symptoms of benign prostatic hyperplasia.

DIRECTIONS FOR USE

Always take this medicine as directed by your physician. Swallow the medicine as a whole with water and do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your medical condition and response to treatment. To get the most benefit, try taking this medication regularly with the same meal each day.

SIDE EFFECTS OF SILOTRIF 8MG

HOW TO MANAGE SIDE EFFECTS

Diarrhea:

Drink lots of fluids to avoid dehydration. Avoid taking any other medicines for diarrhoea without speaking to a doctor.

Headache:  

Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.

Dizziness:

Lie down and close your eyes. Drink plenty of water and take rest. If still dizziness persists, consult your physician.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor, if you are taking,

• medicines used to treat infections (e.g. clarithromycin, telithromycin, itraconazole, ketoconazole, posaconazole or voriconazole)
• medicines used to treat heart problems (nicardipine, quinidine, digoxin)
• medicine used to treat viral infection like hepatitis C or HIV/AIDS
• medicine used to treat impotence or erectile dysfunction (e.g. tadalafil, sildenafil)
• other medicines similar to silodosin (e.g. alfuzosin, doxazosin, prazosin, tamsulosin, or terazosin)
• cyclosporine (used to reduce graft rejection)
• imatinib (used to treat certain type of blood cancer)
• isoniazid (used to treat tuberculosis)
• nefazodone (used to treat depression)

SYNOPSIS

MORE INFORMATION

Do not store above 30°C and keep out of reach of children.

FAQs ABOUT SILOTRIF 8MG

Can SILOTRIF 8MG be used for impotence?

No. This medicine is only indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia in men and does not has any influence in increasing sexual performance.

Can we consume alcohol while taking SILOTRIF 8MG?

Avoid consumption of alcohol while taking this medicine, because it may make you feel dizzier.

REFERENCES

1. Thomas C. Westfall and David P. Westfall. Adrenergic agonist and antagonist. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 307.

2. David Robertson and Italo Biaggioni. Adrenoceptor Antagonist Drugs. Basic and Clinical Pharmacology. 14th Edition. New York McGraw Hill Education 2018.  Page – 160.

3. RECORDATI GROUP. Evaluation of the Efficacy and Safety of Silodosin in the Treatment of the Signs and Symptoms of BPH. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on February 2009] [Accessed 17th November 2020] https://clinicaltrials.gov/ct2/show/NCT00359905

4. Watson Pharmaceuticals. A Study of Silodosin 8 mg Daily for the Treatment of Nocturia in Men with Benign Prostatic Hyperplasia. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on March 2012] [Accessed 17th November 2020] https://clinicaltrials.gov/ct2/show/NCT00793819

5. Jae Hung Jung, Jiye Kim, Roderick MacDonald, Balaji Reddy, Myung Ha Kim, and Philipp Dahm. Silodosin for the treatment of lower urinary tract symptoms in men with benign prostatic hyperplasia. NCBI; PMC US National Library of Medicine, National Institute of Health. November 2017. [Accessed 17th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486059/

6. Hee Ju Cho and Tag Keun Yoo. Silodosin for the treatment of clinical benign prostatic hyperplasia: safety, efficacy, and patient acceptability. NCBI; PMC US National Library of Medicine, National Institute of Health. September 2014. [Accessed 17th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199653/

7. Watson Laboratories, Inc. U.S. Food & Drug Administration. [Revised on January 2013] [Accessed 17th November 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/022206s012lbl.pdf