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INTRODUCTION
SILODERM MIXI CREAM is a combination of Beclomethasone dipropionate, Clotrimazole, and Gentamicin which belongs to the group of medicines called Corticosteroids, Imidazoles, and Aminoglycoside antibiotics, respectively. SILODERM MIXI CREAM is used to treat contact dermatitis (itchy rash), atopic dermatitis, eczematous dermatitis, napkin rash (diaper rash), dermatophytosis (fungal infection of skin or scalp), intertrigo (type of inflammatory skin reaction), and onychomycosis (nail fungus) in affected individuals.
SILODERM MIXI CREAM is not recommended for use in patients allergic to Beclomethasone, Clotrimazole, and/or Gentamicin. It is also not recommended for use in patients with skin problems such as acne, rosacea (severe flushing of skin), perioral dermatitis (spotty red rash around mouth), viral & fungal infections, and/or varicose ulcers caused by swollen veins.
Before applying SILODERM MIXI CREAM, inform your doctor if you are a smoker, and/or have psoriasis (itchy skin) or allergic reaction to any substance.
SILODERM MIXI CREAM should be used with caution during pregnancy and in breastfeeding women only if it is necessary. It is not recommended for use in children (aged below 1 year) and should be used with caution in children and adolescents (aged 2 to 18 years). The medicine is also advised to be used with caution in elderly patients (aged 65 years and above) after consulting the doctor.
The most common symptoms of applying SILODERM MIXI CREAM are irritation, burning or stinging sensation, itchy rash, red,itchy skin, and blistering at the site of application. Consult your doctor if any of these symptoms gets worse.
USES OF SILODERM MIXI CREAM
It is used to treat the following conditions:
- contact dermatitis (itchy rash due to allergic reaction)
- atopic dermatitis (red,itchy skin)
- eczematous dermatitis (dry, red, itchy skin)
- napkin rash (diaper rash)
- dermatophytosis (fungal infection of skin or scalp)
- intertrigo (type of inflammatory skin reaction)
- onychomycosis (nail fungus)
HOW SILODERM MIXI CREAM WORKS
SILODERM MIXI CREAM helps to treat allergic and fungal skin infections, where Beclomethasone dipropionate works by blocking the production of certain chemical messengers (prostaglandins) that makes the skin red, swollen and itchy, Clotrimazole works by causing destruction to fungi by preventing it to form their own protective, and Gentamicin causes destruction and prevents bacterial growth by inhibiting their protein synthesis resulting in bacteriostatic effect.
DIRECTIONS FOR USE
Always apply SILODERM MIXI CREAM, as directed by your physician. It is for external use only. On the affected area, apply a thin layer of this medicine. Treated areas on the face need not be covered with a plaster or bandage. Do not apply SILODERM MIXI CREAM on your face beyond 5 days. Avoid applying SILODERM MIXI CREAM around your eyes, including eyelids.
SIDE EFFECTS OF SILODERM MIXI CREAM
COMMON
- irritation
- burning or stinging sensation
- itchy rash
- red,itchy skin
- blistering at the site of application
RARE
Stop applying SILODERM MIXI CREAM and contact your doctor if you experience any of the following side effects:
- signs of allergic reaction such as itching, rash, blisters, burning/pricking/tickling sensation, discomfort, swelling of the lips, face, throat or tongue irritation, redness or peeling of skin, swallowing or breathing problems, weakness, feeling dizzy or faint, and or nausea
- if irritation, sensitization or superinfection develops due to overgrowth of nonsusceptible organisms such as fungi
HOW TO MANAGE SIDE EFFECTS
Itchy Skin:
Avoid scratching your skin. Cool your skin by holding onto a damp towel. Try to have cool or warm baths. Wear loose clothing and do not wear tight clothes. Try to avoid using perfumed soaps, deodorants or moisturizers and always use unperfumed moisturizer.
WARNING & PRECAUTIONS
PREGNANCY
SILODERM MIXI CREAM should be used with caution during pregnancy and in women planning for pregnancy. Consult your doctor before applying SILODERM MIXI CREAM.
BREASTFEEDING
SILODERM MIXI CREAM should be used with caution in breastfeeding women. Consult your doctor before applying SILODERM MIXI CREAM.
DRIVING AND USING MACHINES
SILODERM MIXI CREAM is unlikely to affect your ability to drive or operate machines. Consult your doctor before applying SILODERM MIXI CREAM.
ALLERGY
SILODERM MIXI CREAM is not recommended for use if you are allergic to Beclomethasone, Clotrimazole, Gentamicin or any other ingredients of this medicine.
OTHERS
SILODERM MIXI CREAM is not recommended for use if you:
- have skin problems such as acne (pimples), rosacea (severe flushing of skin on and around your nose), perioral dermatitis (spotty red rash around your mouth)
- itching around your back passage or private parts
- viral infections such as cold sores, herpes or chickenpox
- fungal infections, such as ringworm infection, athlete’s foot or thrush
- skin blisters or sores that are caused by an infection
- varicose ulcers caused by swollen veins
- stasis ulcers caused by reduced blood or body fluid flow
Before applying SILODERM MIXI CREAM, inform your doctor if you:
- medicine planned to be applied under an airtight dressing such as child's nappy.
- have psoriasis (itchy skin)
- smoke
- suffered or have allergic reaction to any substance
Use in Pediatrics:
SILODERM MIXI CREAM is not recommended for use in children (below 1 year). It should be used with caution in children and adolescents (aged 2 to 18 years). Consult your doctor before applying SILODERM MIXI CREAM.
Use in Geriatrics:
SILODERM MIXI CREAM should be used with caution in elderly patients (aged 65 years or above). Consult your doctor before applying SILODERM MIXI CREAM.
INTERACTIONS
A. Drug-Drug Interactions:
Inform your doctor about all the medicines you use including prescription, non-prescription, and/or herbal medicines before using this medicine.
Overdosage:
If you or anyone else accidentally applys too much SILODERM MIXI CREAM, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Beclomethasone dipropionate, Clotrimazole, Gentamicin |
| Pharmacological Category | : | Corticosteroids, Imidazoles, and Aminoglycoside antibiotics |
| Therapeutic Indication | : | Contact dermatitis (itchy rash due to allergic reaction), atopic dermatitis (red,itchy skin), eczematous dermatitis (dry, red, itchy skin), napkin rash (diaper rash), dermatophytosis (fungal infection of skin or scalp), intertrigo (type of inflammatory skin reaction), onychomycosis (nail fungus) |
| Dosage Forms | : | Cream |
MORE INFORMATION
- Keep SILODERM MIXI CREAM out of reach in children
- Store SILODERM MIXI CREAM at room temperature
FAQs ABOUT SILODERM MIXI CREAM
What SILODERM MIXI CREAM is used for?
SILODERM MIXI CREAM is used to contact dermatitis (itchy rash due to allergic reaction), atopic dermatitis (red,itchy skin), eczematous dermatitis (dry, red, itchy skin), napkin rash (diaper rash), dermatophytosis (fungal infection of skin or scalp), intertrigo (type of inflammatory skin reaction), and onychomycosis (nail fungus)
What happens if you forget to apply SILODERM MIXI CREAM?
If you forget to apply SILODERM MIXI CREAM then try to apply it as soon as you remember. If the time is for the next application then carry on as normal. Try to remember to apply SILODERM MIXI CREAM as per its application time to avoid the risks of returning infection.
Is SILODERM MIXI CREAM safe to be used in children?
SILODERM MIXI CREAM is not recommended for use in children (below 1 year). It should be used with caution in children and adolescents (aged 2 to 18 years). Consult your doctor before applying SILODERM MIXI CREAM.
Who should avoid applying SILODERM MIXI CREAM?
SILODERM MIXI CREAM is not recommended for use in patients with skin problems such as acne (pimples), rosacea (severe flushing of skin on and around your nose), perioral dermatitis (spotty red rash around your mouth), itching around your back passage or private parts, viral infections, fungal infections, and varicose ulcers caused by swollen veins.
Is SILODERM MIXI CREAM safe to be used in pregnant and breastfeeding women?
SILODERM MIXI CREAM should be used with caution during pregnancy and in childbearing potential & breastfeeding women only if it is clearly necessary. Consult your doctor before applying SILODERM MIXI CREAM.
REFERENCES
1. KD. Tripathi. Aminoglycoside Antibiotics, Antifungal Drugs & Drugs Acting on Skin and Mucous Membranes. Essentials of medical pharmacology. Seventh edition. 2013. Page – 747, 792, & 895
2. Patrick T. McKeny; Trevor A. Nessel; Patrick M. Zito. Antifungal Antibiotics. NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. [Revised in November 2021] [Accessed on 6th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK538168/
3. Sarah N Hilmer, Kim Tran, Patrick Rubie, Jason Wright, Danijela Gnjidic, Sarah J Mitchell,Slade Matthews, and Peter R Carroll. Gentamicin pharmacokinetics in old age and frailty. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in February 2011] [Accessed on 6th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040542/
4. Purna Pharmaceuticals NV. Electronic medicines compendium (EMC). [Revised in September 2021 [Accessed on 6th July 2022] https://www.medicines.org.uk/emc/files/pil.12941.pdf
5. Mylan UK Healthcare Limited. Electronic medicines compendium (EMC). [Revised in February 2022] [Accessed on 6th July 2022] https://www.medicines.org.uk/emc/files/pil.2598.pdf
6. GENTAMICIN SULFATE cream. DailyMed. NIH U.S. National Library of Medicine. [Revised in June 2022] [Accessed on 6th July 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9e550dc9-509e-da05-8a97-ecbd0f5dd633
7. PokuPharma Limited. Clonem G-P Antimicrobial Cream. [Accessed on 6th July 2022] https://pokupharmagh.com/product-details/clonem-gp-cream/
8. Alvizia Healthcare. ATMOBEC-CG CREAM. [Accessed on 6th July 2022] https://alviziahealthcare.com/ATMOBEC-CG.html
USEFUL DIAGNOSTIC TESTS
- Patch test
- Potassium hydroxide (KOH) microscopy
PRODUCT DETAILS
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