INTRODUCTION

REZ Q 300MG INJECTION contains Quinine which belongs to the group of medicines called Antimalarials. It is used to treat malaria caused by an organism called Plasmodium falciparum.

Malaria is a serious disease caused by a parasite that commonly infects a specific type of mosquito which feeds on humans, causing high fevers, shaking chills, and flu-like symptoms.

REZ Q 300MG INJECTION is not recommended for use if you have a prolonged QT interval, glucose-6-phosphate dehydrogenase (G6PD) deficiency, muscle weakness, optic neuritis (swelling of optic nerve), galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption.

Before receiving REZ Q 300MG INJECTION, inform your doctor if you have any heart problems. REZ Q 300MG INJECTION is not recommended for use in pregnant and breastfeeding women unless considered clearly necessary.

The most common side effects of receiving REZ Q 300MG INJECTION are vomiting, headache, dizziness and injection site reactions such as pain, swelling, redness. Contact your doctor if any of the side effects gets worse.

USES OF REZ Q 300MG INJECTION

• Used to treat malaria

HOW REZ Q 300MG INJECTION WORKS

REZ Q 300MG INJECTION works by increasing the levels of haeme in the blood, a substance toxic to the malarial parasite. This kills the parasite and stops the infection from spreading.

DIRECTIONS FOR USE

REZ Q 300MG INJECTION will be administered to you only by a doctor or a nurse as intramuscularly or intravenously. Your doctor will decide the correct dose and duration for you based upon your age, body weight and disease condition.

SIDE EFFECTS OF REZ Q 300MG INJECTION

HOW TO MANAGE SIDE EFFECTS

Nausea or Vomiting:

Take regular sips of a cold drink. Have ginger or peppermint tea. Stick to simple meals. Avoid eating oily or spicy foods. If you still feel nauseous, contact your doctor.

Headache:

Drink plenty of water and get adequate rest. Try to be relaxed and stress free. Check with your doctor before taking any medicine for headache. If headache does not get better, consult your doctor.

Dizziness:

Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if the symptom did not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions:

Before receiving REZ Q 300MG INJECTION, inform your doctor if you are taking any of the following medicines:

• medicines used to treat fungal infections (Ex. fluconazole, ketoconazole)
• medicines used to treat HIV (Ex. nevirapine, ritonavir)
• medicines used to treat bacterial infections (Ex. rifampicin, moxifloxacin)
• medicines used in epilepsy (Ex. phenobarbital, carbamazepine, phenytoin)
• amantadine (used to treat Parkinson’s disease)
• levacetylmethadol (used to relieve pain)
• medicines used to stop your blood from clotting (Ex. warfarin, rivaroxaban)
• medicines used for allergic reactions (Ex. astemizole, terfenadine)
• other medicines used to treat malaria (Ex. chloroquine, mefloquine halofantrine)
• medicines used to treat certain mental disorders (Ex. pimozide, thioridazine)
• medicines used to treat heart conditions like heart insufficiency or irregular heartbeat (Ex. digoxin, digitalis, flecainide, amiodarone)
• cimetidine (used to treat stomach ulcers or acid reflux)
• ciclosporin (used to prevent transplant rejection)
• medicines used to treat diabetes (Ex. metformin, glimepiride)
• suxamethonium (used as a muscle relaxant)

Overdosage:

REZ Q 300MG INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms irreversible vision loss, vomiting, ringing in ears, headache, visual disturbance, fits, breathlessness, heart rhythm disturbances.

SYNOPSIS

MORE INFORMATION

• Keep REZ Q 300MG INJECTION out of reach of children
• Store below 25°C

FAQs ABOUT REZ Q 300MG INJECTION

Is REZ Q 300MG INJECTION safe in pregnancy?

REZ Q 300MG INJECTION is generally not recommended for use in pregnant unless considered clearly necessary. It should not be used for cramps during pregnancy. If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before receiving REZ Q 300MG INJECTION.

What is REZ Q 300MG INJECTION used for?

REZ Q 300MG INJECTION is used to treat malaria caused by an organism called Plasmodium falciparum (a serious disease caused by a parasite that commonly infects a specific type of mosquito which feeds on humans, causing high fevers, shaking chills, and flu-like symptoms). Consult your doctor before receiving it.

Can I take other medicines with REZ Q 300MG INJECTION?

Before receiving REZ Q 300MG INJECTION, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, over-the-counter or any herbal medicine, as these might interact with each other and cause serious side effects.

Can REZ Q 300MG INJECTION cause headache?

Headache is a common side effect of REZ Q 300MG INJECTION. In such case, drink plenty of water and get adequate rest. Try to be relaxed and stress free. Check with your doctor before taking any medicine for headache. If headache does not get better, consult your doctor.

Is REZ Q 300MG INJECTION safe?

REZ Q 300MG INJECTION is safe if used in the dose and duration advised by your doctor. Follow your doctor's instructions carefully and let your doctor know if any of the side effects bother you.

REFERENCES

1. KD. Tripathi. Antimalarial Drugs. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 825.

2. Achan, J., Talisuna, A. O., Erhart, A., Yeka, A., Tibenderana, J. K., Baliraine, F. N., Rosenthal, P. J., & D'Alessandro, U. Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. May 2011. [Accessed on 4th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121651/

3. Cipla Ltd. Quinine. [Revised in April 2014] [Accessed on 4th August 2022] https://www.ciplamed.com/content/qinarsol-tabetsinjection

USEFUL DIAGNOSTIC TESTS

• Malarial Falciparum & Vivax Antigen
• Malarial Parasite Identification
• Peripheral Smear Examination
• Peripheral Smear for Malaria