INTRODUCTION

RECOGEST N 200MG INJECTION contains Progesterone which belongs to the group of medicines called Steroid hormones. It is used to treat amenorrhea (missed periods) and abnormal uterine bleeding (abnormal bleeding from the womb cavity) due to hormonal imbalance in the absence of organic pathology like submucous fibroids or uterine cancer.

It can also be used as a progesterone supplementation in women (34 years of age and younger) who cannot use vaginal preparations and undergoing in vitro fertilization (IVF) or treatment in an Assisted Reproductive Technology (ART) program.

Before receiving RECOGEST N 200MG INJECTION inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have diabetes, asthma, epilepsy or migraine headaches before receiving RECOGEST N 200MG INJECTION as a precaution.

RECOGEST N 200MG INJECTION is not recommended for use in patients with breast cancer, ovarian cancer, uterine cancer, blood clot problems or unusual vaginal bleeding. RECOGEST N 200MG INJECTION is not recommended for use in breast-feeding women, children and adolescents (below 18 years of age).

RECOGEST N 200MG INJECTION can be used during the first three months of pregnancy. However, it should not be used in women who have ectopic pregnancy (pregnancy outside the womb) and in women who had a history of idiopathic jaundice or other skin problems during their earlier pregnancies.

The most common side effects of receiving RECOGEST N 200MG INJECTION are pain, redness, itching, irritation or swelling at the injection site, vaginal bleeding, headache, bloating, nausea and constipation. Inform your doctor if any of these side effects bothers you.

Talk to your doctor immediately if you experience any changes in body weight or feel depressed while receiving RECOGEST N 200MG INJECTION.

USES OF RECOGEST N 200MG INJECTION

It is used:

• to treat amenorrhea and abnormal uterine bleeding due to hormonal imbalance
• as a progesterone supplementation in women (34 years of age and younger) who cannot use vaginal preparations and undergoing IVF or treatment in an assisted reproductive Technology (ART) program

HOW RECOGEST N 200MG INJECTION WORKS

RECOGEST N 200MG INJECTION helps you to become pregnant and to stay pregnant by increasing uterine wall receptivity for implantation of an embryo and maintaining the pregnancy after an embryo is implanted. It also regulates hormonal balance in the body and corrects abnormal uterine bleeding.

DIRECTIONS FOR USE

RECOGEST N 200MG INJECTION will be given to you only by a doctor or a nurse either into the muscles (as intramuscular injection) or under the skin (as subcutaneous injection). Your doctor will decide the correct dose and duration of therapy for you according to your age, body weight and disease condition.

SIDE EFFECTS OF RECOGEST N 200MG INJECTION

HOW TO MANAGE SIDE EFFECTS

Nausea:

Take regular sips of cold drink. Stick to simple meals. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. If nausea does not improve, inform your doctor.

Headache:

Apply hot or cold-water bag on your head. Drink plenty of fluids. Try taking rest in a quiet and dark room. Apply pain relieving balm on your forehead if necessary. Inform your doctor if your headache does not reduce.

Constipation:

Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals and drink plenty of water. Do minimal exercises (such as walking). If the symptom does not improve, inform your doctor.

Stomach pain:

Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. If the symptom gets worse inform your doctor.

Bloating:

Try to increase your physical activity during daytime. Do not or limit the intake of carbonated drinks. Avoid eating foods which causes bloating such as beans, lentils and others. Always eat smaller and frequent meals and chew your food properly while eating. Inform your doctor if the symptom does not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before receiving RECOGEST N 200MG INJECTION, inform your doctor if you are taking any of the following medicines:

• medicines used to treat epilepsy (Ex. carbamazepine, phenytoin, phenobarbital)
• rifampicin (used to treat bacterial infections)
• medicines used to treat fungal infections (Ex. griseofulvin, ketoconazole)
• St. john’s wort (used to treat depression)
• cyclosporine (used to suppress immune function to prevent rejection of transplanted organ)
• medicines used to treat diabetes (Ex. glimepiride, metformin)

 Overdosage:

RECOGEST N 200MG INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor if you experience any unusual symptoms such as drowsiness after receiving RECOGEST N 200MG INJECTION.

SYNOPSIS

MORE INFORMATION

• Store RECOGEST N 200MG INJECTION at room temperature

FAQs ABOUT RECOGEST N 200MG INJECTION

Does RECOGEST N 200MG INJECTION cause weight gain?

Yes, RECOGEST N 200MG INJECTION might cause weight gain due to overstimulation of ovaries in some individuals. Stop receiving RECOGEST N 200MG INJECTION and consult your doctor as soon as you notice that your weight has increased abnormally.

Does RECOGEST N 200MG INJECTION make you feel tired?

Yes, RECOGEST N 200MG INJECTION may cause tiredness in some individuals. To manage this, drink plenty of fluids and eat balanced diet and frequent meals. Get enough rest and follow regular sleep schedule.

How is RECOGEST N 200MG INJECTION administered?

RECOGEST N 200MG INJECTION will be given to you only by a doctor or a nurse either into the muscles (as intramuscular injection) or under the skin (as subcutaneous injection). Your doctor will decide the correct dose and duration of RECOGEST N 200MG INJECTION for you according to your age, body weight and disease condition.

Why is RECOGEST N 200MG INJECTION necessary for pregnancy?

RECOGEST N 200MG INJECTION supplements your body with sufficient levels of progesterone that is required for a successful implantation of fertilized egg in the uterus and for the maintenance of an early pregnancy. It sustains pregnancy among infertile women and in women who face repeated/threatened abortions by increasing the thickness of uterine wall.

When is progesterone produced in the reproductive cycle?

The typical menstrual cycle takes approximately 28 to 32 days and is divided into three distinct phases namely the follicular phase, the ovulatory phase and the luteal phase. The luteal phase is the period when the body produces progesterone, the hormone that makes the uterus prepare its lining to receive the egg.

What are the common side effects of RECOGEST N 200MG INJECTION?

The most common side effects of receiving RECOGEST N 200MG INJECTION are injection site reactions (pain, swelling, redness and itching), stomach pain, breast pain or tenderness, nausea, bloating, headache, vaginal bleeding or discharge and extreme tiredness. Inform your doctor if any of these side effects bothers you.

REFERENCES

1. KD. Tripathi. Estrogens, Progestins, and Contraceptives. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 316.

2. Michaela Jewson, Prashant Purohit, Mary Ann Lumsden. Progesterone and abnormal uterine bleeding/menstrual disorders. ScienceDirect. November 2020. [Accessed on 21st July 2022] https://www.sciencedirect.com/science/article/abs/pii/S152169342030081X

3. Lei Jiang, Zhuo-Ye Luo, Gui-Min Hao,corresponding author and Bu-Lang Gao. Effects of intramuscular and vaginal progesterone supplementation on frozen-thawed embryo transfer. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. October 2019. [Accessed on 21st July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6813338/

4. Institut Biochimique SA. Progesterone. Product Monograph. Inprosub (Progesterone Injection) [Revised in June 2021] [Accessed on 21st July 2022] https://pdf.hres.ca/dpd_pm/00062667.PDF

5. Pharmasure Limited. Lubion 25 mg solution for injection. Progesterone. [Revised in March 2018] [Accessed on 21st July 2022] https://www.pharmasure.co.uk/uploads/uk-PIL-Lubion-UI.pdf

USEFUL DIAGNOSTIC TESTS

• Saline-infusion sonography
• Ultrasound
• Anti-mullerian hormone