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Drug Information

What is Rasagiline used for?

Rasagiline is used for the treatment of Parkinson's disease.

Rasagiline may also be prescribed for other conditions as determined by the doctor.

How does Rasagiline work?

Rasagiline belongs to the class of drugs called monoamine oxidase (MAO) inhibitors. Rasagiline works by inhibiting the MAO enzyme from breaking down the neurotransmitters called dopamine and norepinephrine. This causes an increase in the levels of these neurotransmitters in the brain, which reduces the symptoms associated with Parkinson’s disease.

How to take Rasagiline?

The dosage and the drug form depends on the age, weight and medical condition of an individual. Take Rasagiline as prescribed by your doctor.

Swallow the tablet whole. Do not crush or chew the tablet. Take Rasagiline with or without food. You must take the tablet at the same time each day.

If you miss a dose of Rasagiline, please take it immediately once you remember. However, if it is almost time for your next dose, then skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed dose.

What are the drugs that interact with Rasagiline?

The drugs that interact with Rasagiline are:

  • Acetaminophen
  • Aspirin
  • Atorvastatin
  • Cholecalciferol
  • Cyanocobalamin
  • Dutasteride
  • Levodopa
  • Metoprolol
  • Ropinirole
  • Rotigotine
  • Sertraline
  • Sildenafil
  • Solifenacin
  • Tadalafil

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Rasagiline?

The following are the most common side effects of Rasagiline:

  • Dizziness
  • Joint pain
  • Heartburn
  • Nausea
  • Dry mouth
  • Weight loss
  • Abdominal pain
  • Vomiting
  • Diarrhoea

The following are the severe side effects and you may require immediate medical attention:

  • Depression
  • Hallucinations
  • Confusion
  • Muscle stiffness
  • Swollen ankles
  • Easy bruising

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions should be followed while taking Rasagiline?

  • Seek doctor’s advice before taking any other drug or herbal products while on Rasagiline
  • Inform your doctor if you have rapid swelling of lips, throat and tongue.
  • Do not stop using the medication abruptly unless instructed by the doctor. Discontinuing the medication suddenly may cause the illness to return.
  • Do not exceed the dose more than what is prescribed.
  • Avoid smoking as it may decrease the blood levels of the drug and makes it less effective.
  • Be cautious while taking Rasagiline if you have any history of decreased liver function.
  • Do not drive or operate heavy machinery if Rasagiline causes dizziness or blurred vision.

You are advised not to take Rasagiline if

  • it has passed the expiry date of the medicine printed on the pack.
  • the foil or packaging is torn or shows signs of tampering or there is discolouration.

What should you tell your doctor before taking Rasagiline?

  • Tell your doctor if you are allergic to Rasagiline.
  • Inform your doctor about the pre-existing heart, liver or kidney problems.
  • Inform the doctor if you are taking any other drugs, OTC medications, herbal products or nutritional supplements.
  • Inform your doctor if you are pregnant or breastfeeding.

Frequently asked questions about Rasagiline

  1. Is it safe to consume alcohol while taking Rasagiline?
  2. It is not advisable to consume alcohol while taking Rasagiline as it may cause excessive dizziness.

  3. Is it common to develop mood disorders while taking Rasagiline?
  4. Mood disorders, such as depression, bipolar disorder and schizophrenia are the severe side effects of Rasagiline. Therefore, immediately inform your doctor if you experience any symptoms associated with those conditions.

  5. Can I take Fluoxetine while on Rasagiline?
  6. It is not safe to take anti-depressants, such as Fluoxetine with Rasagiline, as it may increase the levels of serotonin. Excessive levels of serotonin may cause serotonin syndrome, which may be fatal.

  7. How is Rasagiline stored?
  8. Rasagiline is stored at room temperature (15 – 30°C) and in a dry place, away from direct sunlight, heat and moisture.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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