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INTRODUCTION
PREXOL 0.25 TABLET contains Pramipexole which belongs to the group of medicines called Dopamine agonists. It is used to treat signs and symptoms of idiopathic Parkinson’s disease.
It is also prescribed to treat conditions such as Restless Legs Syndrome.
A disorder of the central nervous system that affects movement, often including tremors. Nerve cell damage in the brain causes dopamine levels to drop, leading to the symptoms of Parkinson's.
PREXOL 0.25 TABLET should not be given in patients with kidney diseases and psychosis. PREXOL 0.25 TABLET is not recommended for use in pregnancy and breastfeeding.
This medicine is strictly for use in adults and should not be used in children and adolescents under 18 years of age.
The common side effects of taking PREXOL 0.25 TABLET include sleepiness, dizziness, dyskinesia, nausea, hallucinations (seeing, hearing or feeling things that are not present), abnormal dreams, confusion, behavioural symptoms (Impulse control and compulsions), headache, double or blurred vision, low blood pressure, constipation, vomiting, swelling of body usually in the legs, decreased weight and appetite. Consult your doctor for advice if any of the above side effects worsen.
USES OF PREXOL 0.25 TABLET
- Used to treat signs and symptoms of idiopathic Parkinson’s disease
HOW PREXOL 0.25 TABLET WORKS
PREXOL 0.25 TABLET is a dopamine agonist which binds to a set of dopamine receptors in the brain. It relieves Parkinsonism by stimulating dopamine receptors present in the striatum (part of the brain that is responsible for cognition, planning, decision-making, motivation, reinforcement, and reward perception).
DIRECTIONS FOR USE
Take PREXOL 0.25 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF PREXOL 0.25 TABLET
COMMON
- sleepiness
- dizziness
- uncontrolled, involuntary movement
- nausea
- abnormal dreams
- confusion
- headache
- double or blurred vision
- low blood pressure
- constipation
- vomiting
- swelling of body usually in the legs
- decreased weight and appetite
- fatigue
- insomnia
UNCOMMON
- paranoia
- delusion
- compulsive shopping, gambling, hypersexuality, delusion, loss of libido, delirium, paranoia, binge eating
- amnesia (loss of memory)
- loss of consciousness
- cardiac failure
- dyspnoea
- hiccups
- rash, itching
- difficulties in breathing
- hyperkinesia (inability to remain still)
- restlessness
- loss of reality (delirium)
RARE
- mania (over-excitedness)
Stop takingPREXOL 0.25 TABLET and contact your doctor immediately if you experience any of the following side effects:
- serious allergic reaction such as sudden wheezing, rash, itching, hives, swelling of the lips, tongue, face or throat causing difficulty in swallowing or breathing
- symptoms of Pneumonia (infection of the lungs) include fever, shivering, sweating, difficulty breathing, chest pain and feeling unwell
- symptoms of heart failure, causing shortness of breath or a persistent cough, extreme tiredness and swelling of the ankles
- decreased sodium levels in the blood, which may cause weakness, confusion muscle pains
- falling asleep while you are doing activities such as talking, eating, driving, or feel sleepier than normal
- hallucinations or other psychotic-like behaviour (seeing visions, hearing sounds or feeling sensations that are not real, confusion, excessive suspicion, aggressive behaviour, agitation, delusional beliefs and disorganized thinking)
- withdrawal symptoms such as fever, confusion, severe muscle stiffness, apathy, anxiety, depression, fatigue, difficulty sleeping, sweating, and pain
HOW TO MANAGE SIDE EFFECTS
Nausea:
Take PREXOL 0.25 TABLET during or after meals to minimise effects. Consult your doctor for advice.
Constipation:
Eat fibre rich food, drink plenty of fluids to avoid constipation. Consult your doctor for advice.
WARNING & PRECAUTIONS
PREGNANCY
Use of PREXOL 0.25 TABLET is not recommended in pregnant women. Contact your doctor before taking.
BREASTFEEDING
PREXOL 0.25 TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Contact your doctor before taking.
DRIVING AND USING MACHINES
Use of PREXOL 0.25 TABLET can cause sleepiness, drowsiness, hallucinations and sudden onset of sleep. Hence, it is not recommended to drive or use machines after taking this medicine.
ALCOHOL
Avoid alcohol consumption while taking PREXOL 0.25 TABLET as it may increase the risk of sleepiness.
KIDNEY
PREXOL 0.25 TABLET should be used with caution in patients with kidneys disease. Contact your doctor before taking.
LIVER
PREXOL 0.25 TABLET should be used with caution in patients with liver diseases. Contact your doctor before taking.
ALLERGY
Do not take PREXOL 0.25 TABLET if you are allergic to Pramipexole or to other ingredients of the medicine.
LUNGS
PREXOL 0.25 TABLET should be used with caution in patients with existing pulmonary diseases. Contact your doctor before taking.
HEART DISEASE
PREXOL 0.25 TABLET should be used with caution in patients with severe heart and blood vessel disease. Contact your doctor before taking.
OTHERS
PREXOL 0.25 TABLET is not recommended for use if you have:
- psychosis (schizophrenia)
Use in pediatrics:
Use of PREXOL 0.25 TABLET is not advisable in children and adolescents under 18 years of age. Contact your doctor before taking.
Use in geriatrics:
PREXOL 0.25 TABLET should be used with caution in elderly patients over 65 years of age. Contact your doctor to get the correct dose.
INTERACTIONS
A. Drug-Drug Interactions:
Before taking PREXOL 0.25 TABLET, inform your doctor if you are taking any of the following medicine:
- cimetidine, ranitidine, pantoprazole, antacids (medicines used to treat excess acid and to treat gastric ulcers)
- amantadine, levodopa, benztropine (medicines used to treat parkinson’s disease)
- mexiletine, procainamide, quinidine (medicines used to treat irregular heartbeats
- zidovudine (medicine used to treat HIV infection)
- cisplatin (medicine used to treat various types of cancers)
- quinine (medicines used to treat malaria)
- any medicines that calm you down (sedative effect)
- phenothiazines, butyrophenones, thioxanthenes (medicines used to treat schizophrenia and psychoses)
- metoclopramide (medicines used to treat nausea and vomiting)
- diltiazem, triamterene, verapamil, hydrochlorothiazide (medicines used to treat high blood pressure and heart diseases)
- cefadroxil, cefaclor, amoxicillin (medicines used for bacterial infections)
- indomethacin (medicines used to treat pain)
- chlorpropamide (medicines used to treat diabetes mellitus)
Overdosage:
If you miss a dose of PREXOL 0.25 TABLET, do not take double dose. If you have accidentally taken too much of this medicine, contact your doctor or nearest hospital immediately for advice. Symptoms of overdosage are vomiting, nausea, agitation, low blood pressure, hallucination, restlessness, confusion.
SYNOPSIS
| Drug | : | Pramipexol |
| Pharmacological Category | : | Dopamine agonists |
| Therapeutic Indication | : | Idiopathic Parkinson’s disease |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep PREXOL 0.25 TABLET out of sight and reach of children
- Store PREXOL 0.25 TABLET at room temperature
FAQs ABOUT PREXOL 0.25 TABLET
What is the most important information I should know about PREXOL 0.25 TABLET?
PREXOL 0.25 TABLET may cause you to fall asleep while you are doing daily activities such as driving, talking with other people, watching TV, or eating. Do not drive a car, operate a machine, or do anything that needs you to be alert until you know how PREXOL 0.25 TABLET affects you. Tell your doctor if this happens.
When is PREXOL 0.25 TABLET used?
PREXOL 0.25 TABLET is used to treat Parkinson’s Disease and Restless Legs Syndrome. Contact your doctor before taking.
Who should not take PREXOL 0.25 TABLET?
Do not take PREXOL 0.25 TABLET if you are allergic to Pramipexole or its constituents.
What should I tell my doctor before taking PREXOL 0.25 TABLET?
Tell your doctor about all of your medical conditions including kidney problems, liver and heart problems or any other medical conditions.
How should I take PREXOL 0.25 TABLET?
Take PREXOL 0.25 TABLET as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
What should I do if I miss a dose of PREXOL 0.25 TABLET?
If you missed a dose, do not double the dose. Skip the missed dose and take your next dose at regular interval. Be sure to tell your doctor right away if you stop taking PREXOL 0.25 TABLET for any reason. Do not start taking this medicine again before speaking with your doctor.
What are the possible side effects of taking PREXOL 0.25 TABLET?
PREXOL 0.25 TABLET can cause side effects such ad dizziness, nausea, falling asleep during normal daily activities, hallucinations, low blood pressure, fainting, or sweating. Contact your physician if any of the symptoms worsen.
REFERENCES
1. KD Tripathi. Drugs acting on Central Nervous System. Page-430 Essentials of Medical Pharmacology.
2. Boehringer Ingelheim Pharmaceuticals, Inc. [Revised in July 2021] [Accessed on 12th July 2022] https://docs.boehringeringelheim.com/Prescribing%20Information/PIs/.pdf
3. McDermott Laboratories Ltd. Pramipexole Dihydrochloride. [Revised in June 2021] [Accessed on 12th July 2022] https://www.medicines.org.uk/emc/files/pil.10327.pdf
4. Pramipexole Dihydrochloride. National Library of Medicine. [Revised in August 2021] [Accessed on 13th July 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=00699692-532a-68fd-8a51-3770a81b2208
AUTHOR DETAILS
Written By Dr. Janet.C, Pharm.D
Last updated on 17 Nov 2022 | 11:00 PM(IST)
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