Oxra 10mg Tablet 14'S

Introduction About OXRA 10MG TABLET

OXRA 10MG TABLET is a prescription medicine used to manage type 2 diabetes mellitus by improving blood sugar control. It is prescribed only when diet and lifestyle changes does not result in adequate blood glucose control. It contains an antidiabetic ingredient called Dapagliflozin which is Sodium-Glucose Co-transporter-2 (SGLT2) Inhibitor. It works by blocking the glucose reabsorption in the kidneys, leading to excretion of glucose, sodium (salt) and water from the body via the urine.

OXRA 10MG TABLET is also prescribed for management of heart failure and chronic kidney disease (CKD). It reduces the risk of hospitalization due to heart failure and slows the progression of diabetic and non-diabetic kidney disease. By reducing fluid retention, protecting kidney function, and improving cardiovascular outcomes, this tablet serves a dual purpose in high-risk diabetic patients.

OXRA 10MG TABLET is generally taken once daily, with or without food, at the same time each day. It is suitable for adults and elderly patients but is not recommended for children under 10 years. Regular monitoring of blood sugar, kidney function, and hydration status is advised.

OXRA 10MG TABLET is not advised during pregnancy or breastfeeding, as its safety has not been established in these conditions. Common side effects include urinary tract infections, genital infections, increased urination, low blood pressure, and dehydration. In rare cases, it may cause serious conditions like ketoacidosis or acute kidney injury. Always follow your doctor’s instructions for dosage and inform them of any other medications you are taking to avoid interactions.

Uses Of OXRA 10MG TABLET

• Type II diabetes mellitus (in adults and in children aged 10 years or older)
• Heart failure
• Chronic Kidney Disease (or CKD)

Benefits of OXRA 10MG TABLET

OXRA 10MG TABLET for Diabetes

• OXRA 10MG TABLET, containing Dapagliflozin 10 mg, is a prescription medication used to manage type 2 diabetes mellitus.
• It works by increasing glucose excretion through the urine, helping to lower blood sugar levels effectively.
• As an SGLT2 inhibitor, OXRA 10MG TABLET improves glycemic control in adults when used along with proper diet and exercise.
• It may also be prescribed in combination with other antidiabetic medications like metformin or insulin for better results.

OXRA 10MG TABLET for Weight Loss

• One of the added benefits of OXRA 10MG TABLET (Dapagliflozin) is moderate weight loss in patients with type 2 diabetes.
• By promoting the loss of excess glucose through urine, OXRA 10MG TABLET indirectly supports calorie loss and fat reduction.
• It is especially helpful for overweight diabetic patients aiming to manage both blood sugar and body weight simultaneously. However, it should not be used solely as a weight-loss medication.

OXRA 10MG TABLET Kidney Benefits

• OXRA 10MG TABLET has shown potential renal protective effects in diabetic patients. It helps reduce the risk of progression of diabetic kidney disease by lowering albuminuria (protein in urine) and improving overall renal function.
• Clinical studies suggest that SGLT2 inhibitors like dapagliflozin reduce the risk of end-stage kidney disease (ESKD), making OXRA 10MG TABLET a valuable choice in managing diabetic nephropathy.

OXRA 10MG TABLET Heart Health

• OXRA 10MG TABLET not only controls blood sugar but also supports cardiovascular health in people with type 2 diabetes. It has been proven to lower the risk of heart failure hospitalization and cardiovascular death in high-risk patients.
• It is diuretic-like action helps reduce blood pressure and fluid overload, easing the burden on the heart. As a result, OXRA 10MG TABLET is often preferred in patients with coexisting heart disease and diabetes.

How OXRA 10MG TABLET Works

OXRA 10MG TABLET belongs to a class of medicines called SGLT2 inhibitors. It works by blocking the sodium-glucose co-transporter 2 (SGLT2) in the kidneys, which prevents glucose from being reabsorbed into the bloodstream. Instead, excess sugar is flushed out through the urine, helping to lower blood sugar levels, reduce body weight, and mildly lower blood pressure.

How OXRA 10MG TABLET Helps in Diabetes?

OXRA 10MG TABLET helps manage type 2 diabetes mellitus by removing excess glucose from the body via urine, without depending on insulin. This not only helps control blood sugar levels but also contributes to weight loss, improved insulin sensitivity, and reduced cardiovascular risks when used along with diet and exercise.

How OXRA 10MG TABLET Works for Heart Failure Patients?

In heart failure patients, OXRA 10MG TABLET reduces the volume overload by increasing the excretion of both glucose and sodium through urine, acting like a mild diuretic. This helps decrease fluid buildup, lower blood pressure, and reduce the heart's workload. Clinical trials show that dapagliflozin significantly lowers the risk of hospitalization for heart failure and improves quality of life in people with reduced ejection fraction (HFrEF).

How OXRA 10MG TABLET Works for CKD?

For patients with chronic kidney disease (CKD), OXRA 10MG TABLET offers renal protection by reducing pressure inside the kidney's filtering units (glomeruli) and decreasing proteinuria (protein in the urine), a key marker of kidney damage. It slows down the progression of kidney disease, even in non-diabetic individuals, and lowers the risk of reaching end-stage kidney disease (ESKD) or needing dialysis.

How to use OXRA 10MG TABLET

• Take OXRA 10MG TABLET exactly as prescribed by your doctor.
• Swallow the tablet whole with a glass of water—do not crush, chew, or break it.
• Follow your doctor's advice regarding diet, exercise, and other medications while taking OXRA 10MG TABLET for best results.

OXRA 10MG TABLET Dosage Guidelines

Usual Dosage:

• Initial dose: 10 mg once daily, typically taken in the morning, with or without food.
• Maintenance dose: The dose can be increased depending on the individual’s response to treatment, with a common adjustment to 20 mg once daily.
• Maximum dose: The maximum recommended dose is 20 mg per day.

2. Adjustment for Specific Conditions:

• Elderly patients (over 65): Typically start at 5 mg daily due to potential increased sensitivity to the medication.
• Patients with liver or kidney impairment: A lower starting dose (such as 5 mg daily) and gradual adjustments may be required.
• Patients with reduced renal function or moderate hepatic impairment: The dose may be adjusted or carefully monitored.

OXRA 10MG TABLET Dosage for Adults and Elderly

• For adults and elderly patients, the standard dose is 10 mg once daily, which can be taken with or without other diabetes medications.
• However, in elderly patients or those with reduced kidney function, close monitoring is advised to avoid dehydration or urinary tract infections.

How to Take OXRA 10MG TABLET?

• Take OXRA 10MG TABLET once daily, preferably at the same time each day.
• It can be taken with or without food.
• Maintain adequate fluid intake and monitor your blood sugar regularly as advised by your doctor.

When and How Often to Take OXRA 10MG TABLET?

OXRA 10MG TABLET should be taken once a day, ideally at the same time every day to maintain consistent drug levels in the body. Your doctor will decide the duration of therapy depending on your response and clinical condition.

Can OXRA 10MG TABLET Be Taken with Food?

Yes, OXRA 10MG TABLET can be taken with or without food. Taking it with food may help reduce the chance of stomach discomfort, but it is not mandatory. Always follow your doctor’s instructions.

What if I forgot to take OXRA 10MG TABLET

If you miss a dose of OXRA 10MG TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to make up for the missed one, as it may lead to low blood sugar or dehydration.

Side Effects Of OXRA 10MG TABLET

Like all medicines, OXRA 10MG TABLET may cause certain side effects in some individuals, although not everybody gets them.

Common Side Effects of OXRA 10MG TABLET:

• fungal infections of genital (thrush) causing itching, irritation, unusual discharge, odor
• back pain
• passing more urine, increased urine frequency
• dizziness
• skin rash
• dehydration, thirst
• constipation
• dry mouth

When to Seek Medical Attention?

Stop taking OXRA 10MG TABLET and contact your doctor immediately if you experience any of the following side effects such as:

• signs of allergic reaction (skin rash, itching, swelling of the face, tongue or throat, causing difficulty in breathing and swallowing)
• signs of diabetic ketoacidosis (nausea or vomiting, stomach pain, excessive thirst, fast and deep breathing, confusion, unusual sleepiness or tiredness, a sweet smell to breath, a sweet or metallic taste in the mouth or a different odor to urine or sweat, and rapid weight loss)
• pain, swelling, redness or tenderness of the genitals or the areas between the genitals and the anus accompanied with high fever or a feeling generally unwell (sign of necrotizing fasciitis of the perineum)
• signs of urinary tract infection (such as fever and/or chills, burning sensation while passing urine, pain in the back or side)
• bloody urine
• signs of low blood sugar levels (shaking, sweating, anxiety, hunger, fast heartbeat, headache, change in vision, mood swings, confusion)

Warning & Precautions

Other Warnings for OXRA 10MG TABLET

Before taking OXRA 10MG TABLET, inform your doctor if you:

• have type I diabetes (insulin-dependent diabetes)
• have diabetes related kidney problem
• have low blood pressure
• have uncontrollably high levels of blood glucose levels
• have fever, nausea, vomiting or if you are unable to eat or drink anything
• often get infections of the urinary tract
• are on fasting
• are dehydrated (due to recent vomiting, diarrhea or other reasons)
• have any serious illness or had a major surgery recently

Diet and Lifestyle Advice

Best Foods to Eat (Low-Carb & Diabetes-Friendly)

1. High-Fiber Vegetables
   • Spinach, kale, broccoli, cauliflower, bell peppers
   • Why? Low in carbs, rich in fiber, slow digestion to prevent sugar spikes
2. Healthy Proteins
   • Eggs, fish (salmon, tuna), chicken, turkey
   • Why? No impact on blood sugar, keeps you full longer
3. Healthy Fats
   • Avocados, nuts (almonds, walnuts), olive oil
   • Why? Helps manage insulin resistance
4. Low-Carb Fruits
   • Berries (strawberries, blueberries), lemon, grapefruit
   • Why? Lower sugar content compared to bananas and mangoes
5. Whole Grains (in Moderation)
   • Quinoa, brown rice, whole wheat bread
   • Why? Provides slow-releasing carbs
6. Dairy (Low-Carb Options)
   • Greek yogurt, cheese, almond milk
   • Why? High protein, low sugar
7. Hydration is Important!
   • Drink at least 2.5-3 liters of water daily
   • Why? OXRA 10MG TABLET increases urination, so dehydration risk is high

 Foods to Avoid (High-Carb & Sugar Spikes)

• Refined Carbs & Sugar (White bread, rice, pasta, sweets)
• Sugary Drinks (Soda, fruit juices, flavored coffee)
• Processed Foods (Fast food, packaged snacks)
• High-Sodium Foods (Pickles, processed meats)

Exercise Tips for Better Blood Sugar Control

 Best Exercises for Diabetes Management

1. Walking (30-45 min daily)
   • Why? Lowers blood sugar and improves circulation
2. Strength Training (2-3 times a week)
   • Light weights or resistance bands
   • Why? Helps muscles absorb glucose better
3. Yoga & Stretching
   • Why? Reduces stress (which can spike blood sugar)
4. Cycling & Swimming
   • Why? Good for heart health & fat loss

Exercise Precautions While on OXRA 10MG TABLET

• Stay hydrated (risk of dehydration is high)
• Monitor blood sugar (especially if combining with insulin or sulfonylureas)
• Have a snack if needed (avoid hypoglycemia)

Drug - Drug interaction

1. Major Interactions (Avoid Use or Monitor Closely)

a) Monoamine Oxidase Inhibitors (MAOIs) – Risk of Serotonin Syndrome

Examples:

• Phenelzine, Selegiline, Isocarboxazid, Rasagiline, Linezolid, Methylene Blue
• Effect: Increases serotonin levels excessively, leading to serotonin syndrome (agitation, confusion, rapid heart rate, fever, seizures, and even death).

b) Other SSRIs, SNRIs, or Serotonergic Drugs

Examples:

• Fluoxetine, Paroxetine, Sertraline (SSRIs)
• Venlafaxine, Duloxetine (SNRIs)
• Tryptophan supplements, Tramadol, Lithium, St. John’s Wort, MDMA (Ecstasy), Dextromethorphan
• Effect: Increases the risk of serotonin syndrome.

c) Blood Thinners & Antiplatelet Drugs – Increased Bleeding Risk

Examples:

• Warfarin, Heparin, Dabigatran, Rivaroxaban (anticoagulants)
• Aspirin, Clopidogrel, NSAIDs (Ibuprofen, Naproxen, Diclofenac)
• Effect: Increases the risk of bleeding or bruising, especially in the stomach.

d) Antipsychotic Medications – Risk of QT Prolongation & Heart Arrhythmia

Examples:

• Haloperidol, Quetiapine, Ziprasidone, Chlorpromazine
• Effect: May lead to irregular heart rhythm (QT prolongation), dizziness, fainting, and sudden death in severe cases.

2. Moderate Interactions (Use with Caution & Monitor Closely)

a) Drugs Affecting Liver Enzymes (CYP2C19 & CYP3A4)

• Some drugs affect how OXRA 10MG TABLET (Escitalopram) is broken down in the liver.
• CYP2C19 Inhibitors (Increase Escitalopram Levels – Higher Risk of Side Effects):
  • Omeprazole, Esomeprazole, Cimetidine, Fluconazole
  • Effect: Increased sedation, drowsiness, nausea, and serotonin-related side effects.
• CYP2C19 Inducers (Decrease Escitalopram Levels – Reduced Effectiveness):
  • Rifampin, Carbamazepine, Phenytoin
  • Effect: Reduced effectiveness in treating depression and anxiety.

b) Opioid Painkillers – Increased Sedation & Risk of Respiratory Depression

Examples:

• Codeine, Morphine, Oxycodone, Fentanyl, Methadone
• Effect: Increased drowsiness, dizziness, and respiratory depression.

c) Alcohol – Increased Drowsiness & Impaired Judgment

• Effect: Escitalopram can enhance the sedative effects of alcohol, leading to increased dizziness, drowsiness, and impaired judgment.

d) Anti-Seizure Medications – Lower Effectiveness of Escitalopram

Examples:

• Carbamazepine, Phenytoin, Phenobarbital
• Effect: These drugs reduce Escitalopram’s effectiveness by increasing its metabolism.

3. Minor Interactions (Low Risk but Monitor)

a) Herbal Supplements – Risk of Serotonin Syndrome or Side Effects

Examples:

• St. John’s Wort (Serotonin Syndrome Risk)
• Valerian Root (Increased Drowsiness)
• Kava (Risk of Liver Damage)
• Effect: Increased side effects like drowsiness, agitation, and confusion.

b) Caffeine – Increased Anxiety or Restlessness

• Effect: High caffeine intake may worsen anxiety and jitteriness in patients taking Escitalopram.

Synopsis

Drug	:	Dapagliflozin
Pharmacological Category	:	SGLT-2 Inhibitors
Therapeutic Indication	:	Type II Diabetes Mellitus, Heart Failure, Chronic Kidney Disease
Dosage Forms	:	Tablet

More Information

FAQs About OXRA 10MG TABLET

Q: What is OXRA 10MG TABLET used for?

A: OXRA 10MG TABLET is used to manage type II diabetes mellitus in adults and in children (aged 10 years or older) when diet and exercise does not result in adequate control on blood glucose levels. It can also be used to manage heart failure and chronic kidney disease (reduced kidney function) in adults.    

Q: Is OXRA 10MG TABLET safe to use in children?

A: There are limited for the use of OXRA 10MG TABLET in pregnant women Therefore, the use of this medicine is not recommended during the second and third trimesters of pregnancy.

Q: Can the use of OXRA 10MG TABLET cause weight loss?

A: OXRA 10MG TABLET may cause weight loss in some individuals. It is because of excessive loss of fluid from the body in the form of urine. However, consult your doctor if this side effect troubles you.

Q: Can OXRA 10MG TABLET affects pregnancy?

A: There are limited for the use of OXRA 10MG TABLET in pregnant women Therefore, the use of this medicine is not recommended during the second and third trimesters of pregnancy.

Q: Can OXRA 10MG TABLET cause urinary tract infection?

A: Yes, taking OXRA 10MG TABLET may cause urinary tract infections in few peoples. Not every individual gets the side effect, so it is always better to practice good hygiene. Contact your doctor for advice.

Q: How does OXRA 10MG TABLET work?

A: OXRA 10MG TABLET is a SGLT-2 inhibitor. It works by blocking the action of a protein called SGLT-2 in the kidneys. This action manages the reabsorption of glucose and sodium ions in the kidneys. As a result, it excretes excess glucose and from the body in the form urine leading to decrease in blood sugar levels. It also protects kidney function and manages it from further damage. Additionally, it reduces the strain on the heart and helps it to pump blood more efficiently with less pressure.

Q: How and when to take OXRA 10MG TABLET?

A: Take OXRA 10MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. It can be taken with or without meals.

Q: How long should I take OXRA 10MG TABLET?

A: You need to take OXRA 10MG TABLET as long as your doctor prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.

Q: What to do if I forgot to take a dose of OXRA 10MG TABLET?

A: If you forgot to take a dose of OXRA 10MG TABLET take it as soon as you remember. However, if it is time for the next dose of OXRA 10MG TABLET, skip the missed dose and take the next one regularly.

Q: What are the most common side effects of taking OXRA 10MG TABLET?

A: The most common side effects of taking OXRA 10MG TABLET are genital infections, back pain, passing more urine, constipation, dizziness and rash. Contact your physician if any of these side effect worsens.

Q: Will taking a higher dose of OXRA 10MG TABLET be more effective?

A: No, taking a higher dose of OXRA 10MG TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy. 

Q: What precautions do I need to follow while taking OXRA 10MG TABLET?

A: Before taking OXRA 10MG TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have severe low blood pressure or are severely dehydrated due to excessive vomiting or diarrhea. Along with the therapy, follow the diet and lifestyle changes advised by your doctor to achieve better results.

Q: Can OXRA 10MG TABLET be taken with insulin?

A: Co-administration of OXRA 10MG TABLET with insulin is considered risky as they increase the chance of hypoglycemia (decreased blood sugar levels). Therefore, consult your doctor before taking it.

Q: Can OXRA 10MG TABLET cause constipation?

A: Yes. Constipation is a common side effect of taking OXRA 10MG TABLET. Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly while taking this medicine. Contact your doctor if this side effect bothers you.

Q: Is OXRA 10MG TABLET safe for people with kidney disease?

• OXRA 10MG TABLET (Dapagliflozin) is not recommended for patients with severe kidney disease (eGFR < 30 mL/min/1.73m²) or end-stage kidney disease.
• It can help slow kidney damage in early-stage kidney disease, but in advanced kidney failure, it is ineffective.

Q: Is it safe to consume alcohol while taking OXRA 10MG TABLET?

A: Alcohol can increase the risk of dehydration and low blood sugar. It can also worsen dizziness and increase the risk of ketoacidosis (dangerous blood acid buildup). If consuming alcohol, stay hydrated and monitor blood sugar closely.

Q: Is OXRA 10MG TABLET available over the counter?

A: No, it requires a prescription. OXRA 10MG TABLET is a prescription-only medication and should be taken under a doctor's supervision.

Q: How does OXRA 10MG TABLET work for diabetes?

A: Dapagliflozin (OXRA 10MG TABLET) is an SGLT2 inhibitor that helps remove excess sugar through urine. It lowers blood sugar levels without increasing insulin levels. It also helps with weight loss and reduces heart/kidney risks in diabetic patients.

Q. What should I avoid while taking OXRA 10MG TABLET?

A: High-carb and sugary foods (White bread, sweets, soda), Alcohol and caffeine (Dehydration risk), Skipping meals (Can cause low blood sugar), Not drinking enough water (Increases dehydration risk)

Q: Does OXRA 10MG TABLET interact with blood pressure medications?

A: Possible interaction. OXRA 10MG TABLET lowers blood pressure naturally due to fluid loss. If taken with diuretics or BP medications (ACE inhibitors, ARBs, beta-blockers), it may cause excessive low blood pressure (dizziness, fainting). Regular BP monitoring is recommended.

Q: Are there any food interactions with OXRA 10MG TABLET?

A: No direct food interactions, but consider: Low-carb diet for better results, Stay hydrated with electrolyte-rich foods, Avoid high-sodium foods (Dehydration risk) and Limit sugary foods & drinks

Q: Is it safe for long-term use?

A: Yes, if monitored properly.

• Safe for long-term use in people with Type 2 Diabetes.
• Regular kidney function tests are needed.
• Watch for signs of UTIs, dehydration, and ketoacidosis.

References

1. KD. Tripathi. Insulin, oral hypoglycaemic drugs, and glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 278.

2. Sarah L. Anderson. Dapagliflozin efficacy and safety: a perspective review. National Institute of Health. NLM. National Centre for Biotechnology Information. PMC. Pubmed Central. December 2014. [Accessed on 24th July 2025] 

3. John J.V. McMurray, Scott D. Solomon, Silvio E. Inzucchi, Lars Kober, Mikhail N. Kosiborod, Felipe A. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction. The New England Journal of Medicine. November 2019. [Accessed on 24th July 2025 

4. Feng, Miao MM, Lv, Haihong PhD, Xu, Xia MM, Wang, Jue MM, Lyu, Wenyi MA, Fu, Songbo MM, Li., Sheyu. Efficacy and safety of dapagliflozin as monotherapy in patients with type 2 diabetes mellitus. Journal of Medicines. July 2019. [Accessed on 24th July 2025] 

5. AstraZeneca UK Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on 24th July 2025] 

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

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