New Revised MRP, 100% GST benefit passed OTRIFRESH O 0.05% Nasal Drops 10ml
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Introduction About OTRIFRESH O 0.05% NASAL DROPS
OTRIFRESH O 0.05% NASAL DROPS contains Oxymetazoline which belongs to the group of medicines called Nasal decongestants. It is used in adults and in adolescents (aged 12 years or above) to provide relief from nasal congestion, itching and discomfort caused due to common cold, sinusitis (inflammation of the sinuses) or allergic rhinitis (an allergic condition).
Always use OTRIFRESH O 0.05% NASAL DROPS as directed by your physician. It is for intranasal use only. Do not use OTRIFRESH O 0.05% NASAL DROPS for more than 7 days without consulting your doctor.
Before using OTRIFRESH O 0.05% NASAL DROPS inform your doctor if you have diabetes, hypertension, glaucoma, hyperthyroidism, or any heart problems. You must also inform your doctor if you have any other problems in nasal tract apart from nasal congestion such as chronic nasal inflammation with very dry nasal passages (rhinitis sicca or atrophic rhinitis).
Consult your doctor before using OTRIFRESH O 0.05% NASAL DROPS if you are pregnant, think you may be pregnant or breastfeeding. The most common side effects of using OTRIFRESH O 0.05% NASAL DROPS are irritation or burning sensation after application and nasal dryness. Consult your doctor if any of these side effect worsens.
Uses Of OTRIFRESH O 0.05% NASAL DROPS
It is used in adults and in adolescents (aged 12 years or above) to provide relief from:
- Nasal congestion (blocked nose)
- Symptoms of Allergic rhinitis (such as nasal itching, discomfort, runny nose)
- Sinusitis (inflammation of nasal passages)
How OTRIFRESH O 0.05% NASAL DROPS Works
OTRIFRESH O 0.05% NASAL DROPS opens and clears the nasal passages. It works by narrowing down the blood vessels supplying the nasal passage. This helps swollen blood vessels of the nasal tract to return to its normal size which allows the air to pass through the nostrils more freely. It also reduces the excessive nasal secretions and provides temporary relief from nasal inflammation, swelling and discomfort.
How to use OTRIFRESH O 0.05% NASAL DROPS
Always use OTRIFRESH O 0.05% NASAL DROPS as directed by your physician. It is for intranasal use only.
For Nasal Drops: Gently instil few drops of this medicine into each nostril. Clean the dropper after application.
For Nasal Spray: Insert the spray nozzle inside the affected nostril. Press the pump to release the spray and sniff at the same time. Repeat the same to the other nostril if required. Clean the nozzle after application.
To avoid possible spread of infection, this pack should only be used by a single person. Do not use OTRIFRESH O 0.05% NASAL DROPS for more than 7 days without consulting your doctor. Discard the unused portion after 28 days of opening it.
Side Effects Of OTRIFRESH O 0.05% NASAL DROPS
Common
- dry nose
- nose discomfort
- headache
- nausea
- irritation or burning sensation after application
Uncommon
- nosebleeds
Rare
Stop using OTRIFRESH O 0.05% NASAL DROPS and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions (such as swelling of the face, lips, tongue, and/or throat which can lead to difficulty in breathing or swallowing)
- severe itching of the skin, with red rash or raised spots on the skin
How To Manage Side Effects
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Nausea And Vomiting
Take OTRIFRESH O 0.05% NASAL DROPS with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.
Warning & Precautions
Pregnancy
Consult your doctorConsult your doctor before using OTRIFRESH O 0.05% NASAL DROPS if you are pregnant or think you may be pregnant.
Breastfeeding
Consult your doctorConsult your doctor before using OTRIFRESH O 0.05% NASAL DROPS if you are breastfeeding.
Driving and Using Machines
Use with CautionDo not drive or operate any tools or machines if your ability is affected by OTRIFRESH O 0.05% NASAL DROPS.
Allergy
ContraindicatedDo not use OTRIFRESH O 0.05% NASAL DROPS if you are allergic to Oxymetazoline or to any other ingredients of this medicine.
Heart Disease
Use with CautionOTRIFRESH O 0.05% NASAL DROPS should be used with caution in patients with heart disease (such as hypertension, prolonged QT syndrome). Therefore, consult your doctor before using it.
Use In Pediatrics
Consult your doctorOTRIFRESH O 0.05% NASAL DROPS can be used in children and adolescents aged 12 years or above. You must consult your doctor before using OTRIFRESH O 0.05% NASAL DROPS if your child is aged 6 years or above. It is not recommended for use in children aged below 6 years. Therefore, consult your doctor for advice before administration.
Use In Geriatrics
Use with CautionOTRIFRESH O 0.05% NASAL DROPS should be used with caution in elderly patients. Therefore, consult your doctor for advice.
Others
OTRIFRESH O 0.05% NASAL DROPS is not recommended for use if you:
- have had a recent neurosurgery
- have narrow angle glaucoma (increased pressure within the eyes)
- have any problems in nasal tract such as chronic nasal inflammation with very dry nasal passages (rhinitis sicca or atrophic rhinitis)
- have an enlarged prostate gland
- have phaeochromocytoma (a rare tumor of the adrenal glands)
Before using OTRIFRESH O 0.05% NASAL DROPS, inform your doctor if you:
- have diabetes
- have hyperthyroidism (overactive thyroid gland)
Interactions
A. Drug-Drug interactions:
Before using OTRIFRESH O 0.05% NASAL DROPS, inform your doctor if you are taking any of the following medicines:
- antidepressants (used to manage depression) such as monoamine oxidase inhibitors (Ex. moclobemide, isocarboxazid, phenelzine and tranylcypromine), tricyclic antidepressants (Ex. amitriptyline, nortriptyline), lithium, fluoxetine, sertraline, citalopram, escitalopram etc.
- medicines used to control blood pressure such as alpha blockers (Ex. prazosin, terazocin), beta blockers (Ex. propranolol, atenolol) or bethanidine, debrisoquine and guanethidine timolol, betaxolol (used to manage glaucoma in the eye)
- medicines used to manage parkinsonism (such as bromocriptine and rasagiline)
- medicines used for irregular heart rate (such as digoxin)
- medicines used for migraine headache (such as ergotamine or methysergide)
Overdosage:
If you or anyone else accidentally applied too much of OTRIFRESH O 0.05% NASAL DROPS, consult your doctor immediately.
Synopsis
| Drug | : | Oxymetazoline |
| Pharmacological Category | : | Alpha-Adrenergic Agonist |
| Therapeutic Indication | : | Nasal congestion, sinusitis, perennial allergic rhinitis |
| Dosage Forms | : | Nasal drops, Nasal spray, Eye drops |
More Information
- Keep OTRIFRESH O 0.05% NASAL DROPS out of reach to children
- Store OTRIFRESH O 0.05% NASAL DROPS at room temperature
FAQs About OTRIFRESH O 0.05% NASAL DROPS
Q: What is the use of OTRIFRESH O 0.05% NASAL DROPS?
A: OTRIFRESH O 0.05% NASAL DROPS is used to provide relief from nasal congestion, itching and discomfort caused due to common cold, sinusitis or allergic rhinitis.
Q: Can OTRIFRESH O 0.05% NASAL DROPS be used every day?
A: Use OTRIFRESH O 0.05% NASAL DROPS for the duration prescribed by your doctor. Do not use OTRIFRESH O 0.05% NASAL DROPS for more than 7 days without consulting your doctor. Prolonged use of OTRIFRESH O 0.05% NASAL DROPS may worsen your condition.
Q: Is it safe to use OTRIFRESH O 0.05% NASAL DROPS?
A: Yes. OTRIFRESH O 0.05% NASAL DROPS is one of the safe and well tolerated medicine. It does not cause any harmful side effects. It may cause local irritation or burning sensation after application which is quite normal and disappears after few minutes.
Q: What are the side effects of OTRIFRESH O 0.05% NASAL DROPS?
A: The most common side effects of using OTRIFRESH O 0.05% NASAL DROPS are irritation or burning sensation after application and nasal dryness. Consult your doctor if they bother you.
Q: Can OTRIFRESH O 0.05% NASAL DROPS be used in children?
A: OTRIFRESH O 0.05% NASAL DROPS can be used in children and adolescents aged 12 years or above. You must consult your doctor before using OTRIFRESH O 0.05% NASAL DROPS if your child is aged 6 years or above. It is not recommended for use in children aged below 6 years. Therefore, consult your doctor for advice before administration.
Q: Is OTRIFRESH O 0.05% NASAL DROPS an antihistamine?
A: OTRIFRESH O 0.05% NASAL DROPS is a sympathomimetic agonist. It directly acts on the alpha-adrenergic receptors of the blood vessels supplying the nasal tract and narrows them down. This reduces swelling of the nasal tract and allows the air to pass through the nostrils more freely.
Q: How long it takes for OTRIFRESH O 0.05% NASAL DROPS to work?
A: OTRIFRESH O 0.05% NASAL DROPS may show its therapeutic effect after 5 to 10 minutes of application. It works by narrowing of blood vessels in the affected lining of the nose and helps to provide relief from congestion.
Q: Can OTRIFRESH O 0.05% NASAL DROPS cause rebound congestion?
A: Yes, OTRIFRESH O 0.05% NASAL DROPS may cause rebound congestion (worsening of congestion due to nasal decongestant sprays) if you use for more than the duration recommended by your doctor.
References
1. K.D. Tripathi. Adrenergic System and Drugs. Essential of Medical Pharmacology. 7th Edition. Page – 136.
2. H M Druce, D L Ramsey, S Karnati, A N Carr. Topical nasal decongestant oxymetazoline (0.05%) provides relief of nasal symptoms for 12 hours. NIH. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. December 2018. [Accessed on 11th February 2023]. https://pubmed.ncbi.nlm.nih.gov/29785414/
3. Galpharm Healthcare Ltd. Decongestant 0.05% w/v Nasal Spray (Oxymetazoline Hydrochloride). Boots. Electronic Medicines Compendium (EMC). [Revised in September 2020] [Accessed on 11th February 2023]. https://www.medicines.org.uk/emc/files/pil.11520.pdf
4. GlaxoSmithKline. Otrivine. Adult Nasal Drops Xylometazoline Hydrochloride. Electronic Medicines Compendium (EMC). [Revised in August 2021] [Accessed on 11th February 2023]. https://www.medicines.org.uk/emc/files/pil.1412.pdf
5. Nasivion Classic Adult Nasal Spray 10ml. [Accessed on 11th February 2023]. https://www.nasivion.com/en_IN/home/products/nasivion-classic-nose-spray.html
6. Central Drugs Standard Control Organization. Oxymetazoline Hydrochloride Nasal Spray50mcg/0.05%w/w. August 2009. [Accessed on 11th February 2023]. https://cdscoonline.gov.in/CDSCO/Drugs
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