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OPGLIM M1 is a combination of Glimepiride and Metformin which belongs to a group of medicines called Antidiabetic agents. It is used to treat type II diabetes mellitus when diet, exercise and treatment with other single agents did not result in adequate response. Type II diabetes mellitus is a chronic medical condition in which the body cannot properly utilize the circulating sugars (glucose) from the blood to make energy. As a result, the patient experience sudden unintentional weight loss, extreme tiredness, increased urination, thirst or hunger and slow healing ulcers. If left untreated, it can cause permanent damage to the nerves in the body and may to lead to other life-threatening complications.
Glimepiride is a sulfonylurea which acts by making the pancreas secrete more insulin to digest the circulating glucose and metformin is biguanide which acts by blocking the production of glucose by the liver. OPGLIM M1 decrease blood glucose levels and makes the body respond better to insulin.
While taking OPGLIM M1, patients must continue to take carbohydrate-regularized diet as instructed by their doctor to obtain better results. Before taking OPGLIM M1 inform your doctor if you have type 1 diabetes mellitus, severe liver or kidney diseases, or heart problems. OPGLIM M1 is not recommended for use in pregnant and breastfeeding women. The common side effects of OPGLIM M1 are nausea, vomiting, diarrhea, stomach pain and changes in taste.
OPGLIM M1 effectively reduces elevated blood glucose levels, where glimepiride acts by making the pancreas secrete more insulin to digest the circulating glucose and metformin acts by blocking the production of glucose by the liver. They collectively decrease the elevated blood glucose levels and makes the body respond better to insulin.
Take OPGLIM M1 as instructed by your doctor. Swallow it as whole and do not crush or chew it. Do not stop taking OPGLIM M1 unless your doctor tells you to stop.
Stop taking OPGLIM M1 and consult your doctor immediately, if you experience
Nausea and vomiting:
Try to take OPGLIM M1 with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. This side effect can be seen usually while taking OPGLIM M1 and would stop within two weeks of therapy. However, consult your doctor if they persist longer.
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. This side effect can be seen usually while taking OPGLIM M1 and would stop within two weeks of therapy. However, consult your doctor if they persist longer
Low blood sugar:
During signs of low blood sugar levels, immediately consume a meal or a snack which is rich in sugars like sweets, biscuits, or fruit juice. Follow the carbohydrate-regularized diet as instructed by your doctor to obtain better results. Consult your doctor if the signs of low blood sugar levels do not improve.
OPGLIM M1 is generally not recommended for use in pregnant women. Consult your doctor before taking.
OPGLIM M1 is generally not recommended for use in breast feeding women. Consult your doctor before taking.
Do not drive or operate any tools or machines if you experience signs of low blood sugar levels (like dizziness or fainting) while taking OPGLIM M1.
Avoid alcohol consumption while taking OPGLIM M1 as it could further increase blood glucose levels.
OPGLIM M1 is not recommended for use in patients who have severe kidney impairment. Consult your doctor before taking.
OPGLIM M1 is not recommended if you have severe liver disease. Consult your doctor before taking.
Do not take OPGLIM M1 if you are allergic to Metformin, Glimepiride or other sulphonylureas (such as glibenclamide, gliclazide) or sulfonamides (Ex. sulphamethoxazole).
OPGLIM M1 is not recommended for use in patients having severe infection in the lungs or in the respiratory tract. Consult your doctor before taking.
OPGLIM M1 is not recommended for use if you:
Before taking OPGLIM M1, inform your doctor if you:
Use in Pediatrics:
Use in Geriatrics:
A. Drug - Drug interactions:
Before taking OPGLIM M1, inform your doctor if you are taking,
If you or anyone else accidentally take too much of OPGLIM M1, consult your doctor immediately. Overdose may cause signs of lactic acidosis (such as generalized weakness and tiredness, vomiting, stomach pain, muscle pain, difficulty in breathing, reduced body temperature and decreased heartbeat).
|Pharmacological Category||:||Sulfonylurea, Biguanide|
|Therapeutic Indication||:||Type II diabetes mellitus|
Can I consume alcohol while taking OPGLIM M1?
No. Do not consume alcohol while taking OPGLIM M1 as it can increase your blood sugar levels further.
Can OPGLIM M1 cause vitamin B12 deficiency?
Yes. The use of OPGLIM M1 can cause alternation in blood count. It can cause decrease in number of red blood cells making your skin look pallor and can make you feel tired and weak. Consult your doctor if you experience any of these symptoms.
What are the precautions do I need to follow while taking OPGLIM M1?
Before taking OPGLIM M1 inform your doctor if you are pregnant or breastfeeding or if you have type I diabetes or any other conditions affecting your liver, kidney, or heart function. Inform your doctor if you have any signs of infections. Make sure to drink plenty of fluids to avoid dehydration and urinary infections. While taking OPGLIM M1, always carry a sugary snack or meal with you, so that it can help you to cope up sudden episodes of dizziness or fainting caused due to low blood sugar levels. Regularly monitor your blood glucose levels and kidney functions as instructed by your doctor without fail.
Can I stop taking OPGLIM M1 once my symptoms are relieved?
No, do not stop taking OPGLIM M1 without consulting your doctor. Continue to take OPGLIM M1 as instructed by your doctor to obtain better results.
What are the possible side effects of OPGLIM M1?
OPGLIM M1 can cause nausea, vomiting, diarrhea, stomach pain and changes in taste sensation. However, these side effects are usually temporary and gets resolved within two weeks of time. If they persist for longer period, contact your doctor.
1. KD Tripathi MD. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Hormones and related drugs. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 270 — 273 & 275-276.
2. Rakesh Kumar Sahay, Vinod Mittal, G Raja Gopal, Sunil Kota, Ghanshyam Goyal, Mahesh Abhyankar, Santosh Revenkar. Glimepiride and Metformin Combinations in Diabetes Comorbidities and Complications: Real-World Evidence. Cureus. September 28, 2020. [Accessed on 26th March 2022] https://www.cureus.com/articles/37779-glimepiride-and-metformin-combinations-in-diabetes-comorbidities-and-complications-real-world-evidence
3. Hye-soon Kim, Doo-man Kim, Bong-soo Cha, Tae Sun Park, Kyoung-ah Kim, Dong-lim Kim, Choon Hee Chung, Jeong-hyun Park, Hak Chul Jang and Dong-seop Choi. Efficacy of glimepiride/metformin fixed-dose combination vs metformin uptitration in type 2 diabetic patients inadequately controlled on low-dose metformin monotherapy: A randomized, open label, parallel group, multicenter study in Korea. NCBI; PMC US National Library of Medicine, National Institute of Health. November 2014. [Accessed 26th March 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234234/
4. Torrent pharmaceuticals Ltd. [Revised in June 2019] [Accessed on 26th March 2022] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2642.pdf
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