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Medley Pharmaceuticals Ltd

Oncet 3D Tablet 10'S

Asthma/COPD
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    Introduction About ONCET 3D TABLET

    ONCET 3D TABLET is a combination of Acebrophylline, Fexofenadine and Montelukast which belongs to the group of medicines called Bronchodilators, Antihistamines and Leukotriene Receptor Blockers respectively. It is used in the management of asthma and chronic obstructive pulmonary disease (COPD). It can also be used to manage inflammation of the airways (such as bronchitis) and can provide relief from the symptoms of seasonal allergic rhinitis (nasal congestion, repeated sneezing, nasal itching or a red, watery, and itchy eyes) among asthmatic patients.

    Before taking ONCET 3D TABLET inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have fits, stomach ulcers, viral infections, hypertension or hyperthyroidism as a precaution.

    ONCET 3D TABLET is not recommended for use in pregnant or breastfeeding women. The most common side effects of taking ONCET 3D TABLET are epigastric pain, stomach discomfort, nausea, vomiting, dizziness, headache and respiratory tract infections. Consult your doctor if any of these side effects trouble you.

    Uses Of ONCET 3D TABLET

    It is used to manage and prevent:

    • Asthma & COPD
    • Bronchitis (inflammation of the airways)
    • Seasonal allergic rhinitis (nasal congestion, repeated sneezing, nasal itching or a red, watery, and itchy eyes)

    How ONCET 3D TABLET Works

    ONCET 3D TABLET is a bronchodilator with anti-inflammatory properties. It blocks the release of certain chemicals (such as phosphodiesterase, leukotrienes) in the respiratory tract that triggers airway inflammation, swelling and narrowing. As a result, it widens the airways, and reduces airway inflammation. This allows the air to pass through more freely through the airways which makes breathing easier.

    How to use ONCET 3D TABLET

    Take ONCET 3D TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.

    Your doctor will decide the correct dose, duration of therapy and number of doses per day depending upon your age, body weight and disease condition.

    Do not stop taking ONCET 3D TABLET once your symptoms subside without consulting your doctor.

    Side Effects Of ONCET 3D TABLET

    Common

    • stomach pain or discomfort, heartburn, loss of appetite
    • headache
    • transient nausea, dizziness
    • vomiting, diarrhoea, constipation
    • drowsiness
    • upper respiratory tract infection
    • skin rash or itching
    • fever
    • breathing difficulties
    • nasal inflammation
    • increased liver enzymes

    Uncommon

    • nosebleed
    • dry mouth, indigestion
    • bruising
    • joint pain, muscle cramps
    • bedwetting in children
    • weakness, tiredness, feeling unwell
    • oedema
    • tiredness/sleepiness

    Rare

    • numbness of arm and legs
    • lack of sleep
    • fast heart rate
    • high or low blood pressure
    • high blood sugar levels

    Stop taking ONCET 3D TABLET and contact your doctor immediately if you experience any of the following side effects:

    • allergic reactions (swelling of the face, lips, tongue and/or throat which may cause difficulty in breathing or swallowing)
    • behaviour and mood related changes (anxiety, aggressive behaviour or hostility, depression, suicidal thoughts, hallucinations)
    • fits
    • increased bleeding tendency
    • feeling shaky (tremor)
    • strong, fast or irregular heartbeats
    • flu-like symptoms accompanied with pins and needles, numbness of arms or legs, worsening of pulmonary symptoms, and/or rash

    How To Manage Side Effects

    Nausea and Vomiting:

    Take ONCET 3D TABLET with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your symptom worsens.

    Headache:

    Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.

    Dizziness:

    Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

    Warning & Precautions

    Pregnancy

    ONCET 3D TABLET is not recommended for use in pregnancy. Therefore, consult your doctor before taking it.

    Breastfeeding

    ONCET 3D TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.

    Driving and Using Machines

    ONCET 3D TABLET usually does not affect your ability to drive or operate any machinery. However, do not drive or handle any heavy tools or machines if you feel dizzy or drowsy after taking ONCET 3D TABLET.

    Kidney

    ONCET 3D TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.

    Liver

    ONCET 3D TABLET should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.

    Allergy

    Do not take ONCET 3D TABLET if you are allergic to Montelukast, Fexofenadine, Acebrophylline or to any other methylxanthines (such as theophylline, doxophylline).

    Heart Disease

    ONCET 3D TABLET is not recommended for use in patients suffering from myocardial infarction or arrythmias. It should be used with caution in patients with heart failure or any other heart problems. Therefore, consult your doctor before taking it.

    Others

    ONCET 3D TABLET is not recommended for use if you:

    • have an asthma attack
    • have hypotension (low blood pressure)
    • have fluid and electrolyte imbalance

    Before taking ONCET 3D TABLET, inform your doctor if you:

    • have chronic alcoholism (addiction to alcohol)
    • have any viral infections
    • have an over-active thyroid gland
    • have hypertension (high blood pressure)
    • have ulcers in the stomach and/or intestines
    • have fits (seizures)

    Use in paediatrics:

    ONCET 3D TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.

    Use in geriatrics:

    ONCET 3D TABLET should be used with caution in the elderly patients. Therefore, consult your doctor before taking it.

    Interactions

    A. Drug-Drug interactions:

    Before taking ONCET 3D TABLET, inform your doctor if you are taking any of the following medicines such as:

    • medicines used to manage fits (Ex. phenobarbital, phenytoin)
    • rifampicin (a medicine used to manage tuberculosis)
    • medicines used to relieve fever, pain and inflammation (Ex. aspirin, ibuprofen)
    • gemfibrozil (a medicine used to control blood cholesterol levels)
    • allopurinol (a medicine used to manage gout)
    • cimetidine (a medicine used to manage stomach ulcers)
    • medicines used to manage bacterial infections (such as ciprofloxacin, erythromycin, doxycycline, amoxicillin)
    • corticosteroids (used to manage pain and inflammation) such as prednisolone
    • diltiazem, verapamil (a medicine used to manage heart problems)
    • frusemide (a medicine used to reduce edema and blood pressure by increasing urine output)
    • isoprenaline (a medicine used to manage slow heart rate)
    • oral contraceptives (birth control pills) such as ethinylestradiol
    • thiabendazole (a medicine used to manage worm infections)
    • medicines used to manage indigestion (such as aluminium hydroxide, magnesium hydroxide)
    • ketoconazole (a medicine used to manage fungal infection)
    • medicines used to manage HIV infections (such as ritonavir, lopinavir)

    Overdosage:

    If you or anyone else accidentally took more ONCET 3D TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include nausea, vomiting, upper stomach pain, restlessness, dizziness, tiredness, dry mouth, fits, fast heart rate, fast heart rate, sleepiness, thirst, headache and hyperactivity.

    Synopsis

    Drug :   Acebrophylline, Fexofenadine, Montelukast
    Pharmacological Category :   Methylxanthines, Second Generation Antihistamines, Leukotriene receptor antagonists
    Therapeutic Indication :   Asthma, COPD, Bronchitis, Allergic rhinitis      
    Dosage Forms :   Tablet, Combipack

    More Information

    • Keep ONCET 3D TABLET out of reach of children
    • Store ONCET 3D TABLET at room temperature

    FAQs About ONCET 3D TABLET

    Q: How ONCET 3D TABLET works?

    A: ONCET 3D TABLET is a bronchodilator with anti-inflammatory properties. It blocks the release of certain chemicals (such as phosphodiesterase, leukotrienes) in the respiratory tract that triggers airway inflammation, swelling and narrowing. As a result, it widens the airways, and reduces airway inflammation. This allows the air to pass through more freely through the airways which makes breathing easier.

    Q: What is the use of ONCET 3D TABLET?

    A: ONCET 3D TABLET is used to manage asthma, COPD, inflammation of the airways (such as bronchitis) and seasonal allergic rhinitis.

    Q: Can I take ONCET 3D TABLET daily?

    A: ONCET 3D TABLET is generally prescribed as one or two doses per day. However, your doctor will decide the number of doses per day depending upon your age, body weight and disease condition.

    Q: How long does it take for ONCET 3D TABLET to start working?

    A: ONCET 3D TABLET may start working within 2 hours of oral administration. However, it may take 2 weeks for ONCET 3D TABLET to show improvements in your condition. Therefore, take ONCET 3D TABLET regularly as informed by your doctor without fail to achieve better results.

    Q: Is ONCET 3D TABLET effective?

    A: Yes. ONCET 3D TABLET effectively controls the symptoms of asthma and allergic rhinitis, by blocking the release of certain chemicals (phosphodiesterase, leukotrienes) in the respiratory tract that triggers the allergic and inflammatory response. It also manages the narrowing of the airway tract which makes breathing easier.

    Q: What will happen if I consume a high dose of ONCET 3D TABLET than prescribed by my doctor?

    A: Do not consume a higher dose of ONCET 3D TABLET than the one prescribed by your doctor, as it may lead to unwanted side effects. Your doctor will decide the correct dose for you, depending on your age and disease condition. If the prescribed dose, is not working for you, consult your doctor for advice.

    Q: Is ONCET 3D TABLET safe?

    A: ONCET 3D TABLET is considered safe at doses prescribed by the physician. However, it may cause few side effects such as epigastric pain, stomach discomfort, nausea, vomiting, dizziness, headache or respiratory tract infections in some individuals. Consult your doctor if any of these side effects trouble you.

    Q: What should I do if I forgot to take a dose of ONCET 3D TABLET?

    A: If you forgot to take a dose of ONCET 3D TABLET, take it as soon as possible. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of ONCET 3D TABLET to compensate the missed dose.

    Q: Will taking a higher dose of ONCET 3D TABLET be more effective?

    A: No. Do not take a higher dose of ONCET 3D TABLET than prescribed by your doctor, as it could lead to toxicity. Always consume the dose prescribed by your doctor. If you feel that the prescribed dose is not working for you, consult your doctor for advice.

    Q: Can the use of ONCET 3D TABLET make me feel dizzy?

    A: ONCET 3D TABLET may cause dizziness in some individuals. If you experience dizziness, try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.

    Q: I’m pregnant. Can I take ONCET 3D TABLET?

    A: ONCET 3D TABLET is generally not recommended for use in pregnant women. Therefore, consult your doctor before taking it.

    Q: Can ONCET 3D TABLET be used in children?

    A: ONCET 3D TABLET is generally not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before taking it.

    Q: Can ONCET 3D TABLET make you sleepy?

    A: Yes. This medicine may make you feel sleepy or drowsy. Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.

    Q: Can ONCET 3D TABLET be used on an asthma attack?

    A: No. ONCET 3D TABLET is only used to manage or manage the symptoms of asthma. If your asthma or breathing gets worse suddenly, contact your doctor immediately or go to the hospital straight away to avoid further exacerbation of the attack. Meanwhile use a fast-acting rescue inhaler along with ONCET 3D TABLET.

    Q: Can I stop using ONCET 3D TABLET once my symptoms subside?

    A: No. Continue to use ONCET 3D TABLET as long as your doctor prescribes it to you. Do not stop using this medicine or reduce the dose suddenly without consulting your doctor as it may make it less effective.

    References

    1. KD. Tripathi. Histamines and Antihistamines. Drugs for Cough and Bronchial Asthma. Essentials of medical pharmacology. Seventh edition. 2013. Page – 166, 224 & 228.

    2. David Axelrod and Leonard Bielory. Fexofenadine hydrochloride in the treatment of allergic disease: a review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. September 2008. [Accessed on 27th December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3121339/

    3. Ajitha Sharma, Shalini Adiga, Bharti Chogtu, Aswini Kumar Mohapatra, and Rahul Magazine. Comparing the Efficacy and Influence on the Quality of Life of Three Classes of Drugs Used in Bronchial Asthma - A Prospective Study. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. September 2014. [Accessed on 27th December 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225908/

    4. Accord Healthcare Limited. Electronic Medicines Compendium (EMC) [Revised in September 2020] [Accessed on 27th December 2022] https://www.medicines.org.uk/emc/files/pil.1243.pdf

    5. Cipla Ltd. Mucophylin Capsules (Acebrophylline). [Revised in November 2013] [Accessed on 27th December 2022] https://www.ciplamed.com/print-product-pdf/24147

    6. Chanelle Medical. Electronic Medicines Compendium (EMC) [Revised in September 2020] [Accessed on 27th December 2022] https://www.hpra.ie/img/uploaded/swedocuments/75618f0e-570f-4613-9d9a-74e9b0667183.pdf

    7. Central Drugs Standard Control Organization. Acebrophylline capsules 100mg. May 2008. Acebrophylline SR Tablet 200 mg. November 2010. [Accessed on 27th December 2022] https://cdsco.gov.in/opencms/resources/UploadCDSCOWeb/2018/UploadApprovalMarketingFDC/LIST%20OF%20APPROVED%20DRUG%20FROM%2001-01-2008%20to%2031-12-2008.pdf

    8. Minolast FXA. Leeford Healthcare Pvt Ltd. [Accessed on 27th December 2022] https://www.leeford.in/product/745/minolast-fxa

     

    Author Details

    Written By Srilekha. R - B.Pharm
    Reviewed For Accuracy By Dr. Rajnikant - MBBS, MD (Physiology)
    Last updated on 29 Dec 2022 | 03:18 PM(IST)
    Lab updated