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Drug Information

What is Methoxsalen used for?

Methoxsalen oral is used for the treatment of psoriasis.

Methoxsalen topical is used along with the exposure to ultraviolet rays to treat skin diseases, such as psoriasis and vitiligo (white patches on the skin).

Methoxsalen may also be prescribed for other conditions as determined by the doctor.

How does Methoxsalen work?

Methoxsalen belongs to a class of drugs called psoralens. It works by enhancing the sensitivity of the skin to ultraviolet light A (UVA), which helps in clearing the disease.

How to use Methoxsalen?

The dosage and the drug form depends on the age, weight and medical condition of an individual.

  • Swallow the tablet/capsule whole. Do not crush or chew the tablet/capsule.
  • For topical application, apply a thin layer of cream/ointment on the affected area and rub it gently.

If you miss a dose of Methoxsalen, consult your doctor immediately.

What are the drugs that interact with Methoxsalen?

The drugs that interact with Methoxsalen topical are:

  • Aminolevulinic acid
  • Betamethasone
  • Methyl aminolevulinate
  • Tretinoin

The drugs that interact with Methoxsalen oral are:

  • Acetaminophen
  • Acitretin
  • Arginine
  • Duloxetine
  • Emtricitabine
  • Levothyroxine
  • Rosuvastatin
  • Sildenafil
  • Tenofovir
  • Varenicline

This is not a comprehensive list of drug interactions. Consult your doctor to know more about other possible drug interactions.

What are the side effects of Methoxsalen?

The following are the most common side effects of Methoxsalen topical:

  • Itching
  • Redness
  • Peeling of skin
  • Blistering of the skin

The following are the most common side effects of Methoxsalen oral:

  • Nausea
  • Trouble sleeping
  • Darkening of skin
  • Dizziness

This is not a complete list of side effects and others may occur. Please consult your doctor to know more about other possible side effects.

What special precautions should be followed while using Methoxsalen?

  • Seek doctor’s advice before taking any other drug or herbal products while on Methoxsalen
  • Keep the medicine away from children.
  • Do not apply any cream on the moist skin. Wash and dry the affected area before applying Methoxsalen
  • Do not apply the cream on injured or bruised area.

What should you tell your doctor before using Methoxsalen?

  • Tell your doctor if you are allergic to Methoxsalen.
  • Inform the doctor if you are taking any other drugs, OTC medications, herbal products or nutritional supplements.
  • Inform your doctor if you have any pre-existing skin disorders, liver or heart diseases.

Frequently asked questions about Methoxsalen

  1. Can I use a larger dose of Methoxsalen for faster recovery?
  2. No, do not exceed the prescribed dosage as it result in severe skin problems.

  3. What are the overdose symptoms of Methoxsalen?
  4. The overdose symptoms of Methoxsalen include unusual weakness, mouth sores, nausea, vomiting, bloody stools, and easy bruising. Consult your doctor if you experience any of the above symptoms.

  5. Does Methoxsalen treat mycosis fungoides?
  6. Yes, Methoxsalen also helps in the treatment of mycosis fungoides, which is a type of lymphoma. However, please consult your doctor before using Methoxsalen.


The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment.  Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

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