Nitroplus 50mg Injection 10ml

Angina Rx required
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MRP ₹66.45
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INTRODUCTION

NITROPLUS 50MG contains Nitroglycerin (glyceryl trinitrate) which belongs to a group of medicines called vasodilators. It is used to treat peri-operative hypertension, in controlling of congestive heart failure secondary to acute myocardial infarction and in the treatment of angina pectoris in patients who have not responded to sublingual nitroglycerin and beta-blockers and for induction of intraoperative hypotension. Nitroglycerin relaxes vascular smooth muscles and blood vessels in your body which increases the amount of blood and oxygen flow to the heart which reduces the workload of the heart. This helps in relieving chest pain (angina) and in the management of blood pressure.

The most common side effect of taking this medicine are headache, light-headedness, sleepiness, fast or irregular heartbeat, dizziness when standing up suddenly or weakness. Your doctor will decide the correct dose of glyceryl trinitrate for you depending upon your medical condition and how often it must be given. Treatment should not last for more than 3 days. During therapy, your blood pressure and pulse must be monitored.

Do not take this medicine, if you have marked anemia, raised intracranial pressure, arterial hypoxaemia, low blood volume or severe hypotension. Before taking this medicine, inform your doctor, if you have severe liver or kidney problems or heart disease apart from angina. If you are pregnant or breast-feeding, ask your doctor for advice before taking this medicine. This medicine is generally not recommended for use in children. Consult your doctor before taking.

USES OF NITROPLUS 50MG

  • Controls blood pressure in perioperative hypertension
  • Controls congestive heart failure secondary to acute myocardial infarction
  • Treats angina pectoris in patients who have not responded to sublingual nitroglycerin and beta-blockers
  • Induces intraoperative hypotension

HOW NITROPLUS 50MG WORKS

After administration, nitroglycerin is converted into free radical nitric oxide which activates the enzyme guanylate cyclase. Activation of this enzyme leads to dephosphorylation, which relaxes vascular smooth muscles and blood vessels in your body which increases the amount of blood and oxygen flow to the heart. It reduces cardiac preload and afterload and also reduces spasm of coronary artery, decreasing systemic vascular resistance and blood pressure. This helps in relieving chest pain (angina) and in the management of blood pressure.

DIRECTIONS FOR USE

NITROPLUS 50MG will be given to you by a doctor or a nurse in a hospital into a vein as intravenous infusion drip (intravenously). Your doctor will decide the correct dose for you depending upon your condition. Treatment should not last for more than 3 days. During therapy, your blood pressure and pulse must be monitored continuously.

SIDE EFFECTS OF NITROPLUS 50MG

SERIOUS

  • allergic skin reaction (such as skin rash, redness, itch, burning sensation, irritation)

COMMON

  • headache
  • dizziness, light-headedness
  • sleepiness
  • fast or irregular heartbeat
  • weakness

HOW TO MANAGE SIDE EFFECTS

Headache: 

Try to rest and relax. Drink plenty of fluids. Consult your doctor for advice if the pain still persists.

Dizziness or drowsiness:

Try to rest and relax. Avoid travelling, driving or standing for a long time. If symptoms worsen, consult your doctor immediately.

WARNING & PRECAUTIONS

PREGNANCY

NITROPLUS 50MG should be used with caution in pregnant women. Consult your doctor before taking this medicine.

BREASTFEEDING

NITROPLUS 50MG should be used with caution in breastfeeding women. Consult your doctor before taking this medicine.

DRIVING AND USING MACHINES

Do not drive or operate any machines if your ability is affected by this medicine.

ALCOHOL

Consumption of alcohol is not recommended during treatment with this medicine.

KIDNEY

NITROPLUS 50MG should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.

LIVER

NITROPLUS 50MG should be taken with caution in patients with severe liver disease. Consult your doctor for advice.

ALLERGY

Do not take this medicine if you are allergic (hypersensitive) to nitroglycerin.

HEART DISEASE

NITROPLUS 50MG should be taken with caution in patients with severe heart disease. Consult your doctor for advice.

OTHERS

Do not take this medicine, if you have:

  • low blood pressure, low blood volume, increased intracranial pressure, cerebral haemorrhage, anemia or low oxygen levels in your blood
  • an under active thyroid gland, hypothermia (low body temperature), malnutrition (poor nutrition due to an unbalanced diet) or glaucoma

INTERACTIONS

Talk to your doctor, if you are taking,

  • medicines used to treat erectile dysfunction
  • medicines to treat hypertension
  • tricyclic antidepressants (e.g. amitriptyline)
  • other similar guanylate cyclase stimulators (riociguat)
  • morphine-like painkillers

SYNOPSIS

Drug :   Nitroglycerin (Glyceryl trinitrate)
Pharmacological Category :   Vasodilators
Therapeutic Indication :  

Angina pectoris, High blood pressure, Congestive heart failure

Dosage Forms :  

Tablet, Capsule, Sublingual Tablet, Injection, Ointment, Patch, Spray

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT NITROPLUS 50MG

Can NITROPLUS 50MG cause dizziness?

Yes. It may cause dizziness in some individuals, although not everybody gets them. Try to rest and relax. Avoid travelling, driving or standing for a long time. If symptoms worsen, consult your doctor.

Can NITROPLUS 50MG be used in children?

It is not recommended for use in children. Consult your doctor before taking this medicine.

REFERENCES

1. KD. Tripathi. Antianginal and Other Anti-ischaemic Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 542-543.

2. Thomas Michel and Brian B. Hoffman. Treatment of myocardial ischemia and Hypertension. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 747-750.

3. Gerald G. Briggs and Roger K. Freeman. N. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 2770-2775.

4. Kasr El Aini Hospital. The Effect of Periradial Injection of Papaverine Versus Nitroglycerine on Radial Artery Diameter. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on September 2020] [Accessed 17th November 2020] https://clinicaltrials.gov/ct2/show/NCT04030663

5. Cairo University. Effects of Nitroglycerin Versus Labetalol on Tissue Perfusion During Deliberate Hypotension. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on April 2020] [Accessed 17th November 2020] https://www.clinicaltrials.gov/ct2/show/NCT03809065

6. E.F.McNiff, A.Yacobi, F.M.Young-Chang, L.H.Golden, A.Goldfarb, Ho-LeungFung. Nitroglycerin Pharmacokinetics After Intravenous Infusion in Normal Subjects. Journal of pharmaceutical sciences. Sciencedirect.com. January 2016. [Accessed 17th November 2020] https://www.sciencedirect.com/science/article/abs/pii/S0022354915438730#!

7. Hameln pharma ltd. Electronic Medicines Compendium (EMC); [Revised on April 2020] [Accessed 17th November 2020] https://www.medicines.org.uk/emc/files/pil.6296.pdf

8. Hospira UK Limited. Electronic Medicines Compendium (EMC); [Revised on July 2018] [Accessed 17th November 2020] https://www.medicines.org.uk/emc/files/pil.3792.pdf

9. Baxter Healthcare Corporation. U.S. Food & Drug Administration. [Revised on October 2014] [Accessed 17th November 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/019970s015lbl.pdf

PRODUCT DETAILS

    Net Qty
    1
    Ingredient
    GLYCERYL TRINITRATE(NITROGLYCERIN) 50MG
    Hsn Code
    30049099
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