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INTRODUCTION
NETASUDIL EYE DROPS contains Netarsudil which belongs to the group of medicines known as Rho Kinase Inhibitor. NETASUDIL EYE DROPS is indicated for reduction of elevated intraocular pressure in adult patients with primary open angle glaucoma or ocular hypertension.
Primary open angle glaucoma is a type of glaucoma which develops over the period of time due to clogging of drainage channels of the eye. Glaucoma is an irreversible and progressive condition in which optic nerve gets damaged due to several reasons such as increased pressure caused by fluid build-up in front region of eye. Ocular hypertension can be defined as high intraocular (inside the eye) pressure due to disturbance in balance between production and outflow of aqueous humour (fluid inside the eye).
Inform your doctor before using NETASUDIL EYE DROPS if you have trauma to eye, planned eye surgery, dry eyes, concurrent eye disease or if you have ocular epithelial surface disruption as risk of bacterial keratitis (bacterial infection of outer layer of eye) is increased in such cases.
NETASUDIL EYE DROPS is not recommended for use in pregnant women unless clearly necessary. Consult your doctor before using. NETASUDIL EYE DROPS should be used with caution in breast feeding women. Consult your doctor before using.
NETASUDIL EYE DROPS is not recommended for use in children and adolescents below 18 years of age. Consult your doctor before using.
If you wear contact lenses, it should be removed prior to instillation of this medicine and can be reinserted 15 minutes following its administration.
NETASUDIL EYE DROPS may cause some side effects such as conjunctival hyperaemia (dilation of vessels of conjunctiva due to inflammation), corneal verticillate (condition in which corneal deposits form faint golden-brown whorl pattern), conjunctival haemorrhage, instillation site pain and erythema. Consult your doctor immediately in case any of the above side effects worsens.
USES OF NETASUDIL EYE DROPS
- Used to reduce elevated intraocular pressure in adult patients with primary open angle glaucoma or ocular hypertension
HOW NETASUDIL EYE DROPS WORKS
NETASUDIL EYE DROPS is a rho kinase inhibitor, works by reducing intraocular pressure (IOP) by increasing the outflow of aqueous humour (transparent fluid in eye which is important for maintaining pressure inside eye and nourishment of our natural lens) through relaxation of trabecular meshwork.
DIRECTIONS FOR USE
Instil NETASUDIL EYE DROPS into the affected eye as directed by your doctor. NETASUDIL EYE DROPS is for ophthalmic use only. Do not inject or swallow the medicine. Wash your hands before using and avoid touching the nozzle/dropper while using the medicine as it may contaminate the medicine.
Your doctor will decide exact dose and duration according to your disease condition, body weight, and age. The tip of the dispensing container should avoid contacting the eye, surrounding structures, fingers, or any other surface in order to avoid contamination of the solution.
SIDE EFFECTS OF NETASUDIL EYE DROPS
COMMON
- conjunctival hyperaemia (dilation of vessels and redness of conjunctiva due to inflammation)
- corneal verticillata (condition in which corneal deposits form faint golden-brown whorl pattern)
- conjunctival haemorrhage
- eye dryness, breaks in protective surface fluid layer of eye
- eye discharge, itching in eyes or eyelids, eye irritation
- pain in the eye
- feeling of grittiness in the eye
- sensitivity to light
- instillation site pain, discomfort and erythema
- reduced visual acuity
- blurred vision, swelling around eye and eyelid
- headache
- staining of cornea due to dye
- increased tear formation
- punctate keratitis (an eye disorder caused by death of cells on the corneal surface)
- conjunctival oedema (swelling of the membrane that covers the white part of the eye)
- foreign body sensation in eyes
- corneal opacity (loss of transparency of the cornea) and decreased vision
- increase in intraocular pressure
- spots or patches of eye redness
UNCOMMON
- inflammation of iris (coloured part of eye), budging of iris
- eyelash growth
- eye diseases related to diabetes
- blindness
- cataract
- small, coloured spots on the eye surface
- glassy eyes
- loss of eyelashes, eyebrows
- tiredness
- increased allergic symptoms
- dizziness
- nasal discomfort, pain
- rash, inflammation, itching of skin, picking of skin
- inflammation of cartilage
- ocular hyperaemia
- corneal or eyelid disorder
- conjunctival follicles
- meibomian gland dysfunction
- corneal pigmentation
- lenticular opacities
- non-infective conjunctivitis
- abnormal sensation in the eye
- episcleral hyperaemia
- refraction disorder
- anterior chamber flare, inflammation
- eczema eyelids
- iris adhesions
- iris bombe (change in position of iris to the lens)
- visual impairment
- corneal dystrophy
- oedema, paraesthesia
- optic nerve cup/disc ration increased
- allergic dermatitis, contact dermatitis
- lichenification, petechiae
RARE
Stop using NETASUDIL EYE DROPS and contact your doctor immediately if you experience any of the following side effects:
- development of eye infections or eye reactions such as conjunctivitis, eye lid reactions
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and relax. Drink plenty of water and electrolytes. Apply a pain-relieving balm on the head if needed. Do not consume alcohol. Contact your doctor if your headache did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operate machinery if you feel dizziness. Avoid alcohol consumption as it aggravates dizziness. Contact your doctor if dizziness worsens.
WARNING & PRECAUTIONS
PREGNANCY
NETASUDIL EYE DROPS is not recommended for use in pregnant women unless clearly necessary. Consult your doctor before using.
BREASTFEEDING
It is unknown whether NETASUDIL EYE DROPS is excreted in human milk, consult your doctor before using the medicine. Your doctor will decide whether to discontinue breast-feeding or to discontinue the therapy by taking the account of breast feeding for the child and the benefit of therapy for the woman.
DRIVING AND USING MACHINES
NETASUDIL EYE DROPS may cause blurred vision which can affect your ability to drive and operate machines. Do not drive or operate machines until symptoms are cleared.
ALLERGY
Do not use NETASUDIL EYE DROPS if you are allergic to Netarsudil or benzalkonium chloride and other ingredients of this medicine.
OTHERS
Before using NETASUDIL EYE DROPS inform your doctor if you have:
- trauma to the eyes
- eye surgery
- dry eyes
- concurrent eye disease
- disruption of ocular surface
Use in paediatrics:
The safety and efficacy of NETASUDIL EYE DROPS in children and adolescents below the age of 18 years have not been established. Consult your doctor before using.
Use in geriatrics:
NETASUDIL EYE DROPS can be used in elderly patients. Consult your doctor before using.
INTERACTIONS
A. Drug-Drug interactions:
Before using NETASUDIL EYE DROPS, inform your doctor if you are taking or using any prescription medicine, non-prescription medicine, or any herbal medicine.
Overdosage:
In case you or anybody else use too much of NETASUDIL EYE DROPS wash your eyes immediately and consult your doctor. In case of accidental ingestion contact your physician immediately.
SYNOPSIS
| Drug | : | Netarsudil |
| Pharmacological Category | : | Rho Kinase Inhibitor |
| Therapeutic Indication | : | Elevated Intraocular Pressure (In Ocular Hypertension or Open Angle Glaucoma) |
| Dosage Forms | : | Eye Drops |
MORE INFORMATION
- Keep NETASUDIL EYE DROPS out of reach of children
- Store in a refrigerator at 2-8°C
FAQs ABOUT NETASUDIL EYE DROPS
What is NETASUDIL EYE DROPS?
NETASUDIL EYE DROPS contains Netarsudil which belongs to group of medicines known as Rho-kinase Inhibitor. It is indicated for the reduction of elevated intraocular pressure in adult patients with primary open-angle glaucoma or ocular hypertension.
What is the mechanism of NETASUDIL EYE DROPS?
NETASUDIL EYE DROPS is a rho kinase inhibitor, works by reducing IOP by increasing the outflow of aqueous humour (transparent fluid in eye which is important for maintaining pressure inside eye and nourishment of our natural lens) through relaxation of trabecular meshwork. Hence, reducing intraocular pressure.
Can I use NETASUDIL EYE DROPS with other eye medications?
If you are using other eye medications as well then there must be at least 15 minutes gap between usage of both. Consult your doctor before using NETASUDIL EYE DROPS with other medications.
Can I operate machinery or drive after using NETASUDIL EYE DROPS?
No, as NETASUDIL EYE DROPS may cause blurring of vision or decreased visual acuity which can affect your ability to drive and operate machinery.
Can I use contact lenses while using NETASUDIL EYE DROPS?
Yes, but contact lenses should be removed before using NETASUDIL EYE DROPS and should be reinserted only after 15 minutes of instillation.
How to use NETASUDIL EYE DROPS?
Instil NETASUDIL EYE DROPS into the affected eye as directed by your doctor. NETASUDIL EYE DROPS is for ophthalmic use only. Do not inject or swallow the medicine. Wash your hands before using and avoid touching the nozzle/dropper while using the medicine as it may contaminate the medicine.
REFERENCES
1. Robert J. Kizior, Keith J. Hodgson. Antiglaucoma agents. Saunders Nursing Drug Handbook 2021. 29th edition. 2021. Page- 88.
2. Preeti Patel, Bhupendra C. Patel. Netarsudil Ophthalmic Solution. National Institute of Health. NLM. National Centre for Biotechnology. May 2022. [Accessed on 30th August 2022] https://www.ncbi.nlm.nih.gov/books/NBK572105/#article-133789.s5
3. Sheridan M Hoy. Netarsudil Ophthalmic Solution 0.02%: First Global Approval. National Institute of Health. NLM. National Centre for Biotechnology. March 2018. [Accessed on 30th August 2022] https://www.ncbi.nlm.nih.gov/books/NBK572105/#article-133789.s5
4. Mansi Batra, Sumeet Gupta, Anroop Nair, Meenakshi Dhanawat. Netarsudil: A new ophthalmic drug in the treatment of chronic primary open angle glaucoma and ocular hypertension. European Journal of Ophthalmology. April 2021. [Accessed on 30th August 2022] https://www.researchgate.net/publication/350796642_Netarsudil_A_new_ophthalmic_drug_in_the_treatment_of_chronic_primary_open_angle_glaucoma_and_ocular_hypertension
5. Aerie Pharmaceuticals. Food and Drug Administration. [Revised in December 2017] [Accessed on 30th August 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208254lbl.pdf
6. Aerie Pharmaceuticals Ireland, Limited. European Medicines Agency. [Revised in November 2019] [Accessed on 30th August 2022] https://www.ema.europa.eu/en/documents/product-information/rhokiinsa-epar-product-information_en.pdf
USEFUL DIAGNOSTIC TESTS
- Tonometry
- Fundus examination
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