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Introduction About MUZIKA TABLET
MUZIKA TABLET is a combination of Hydralazine and Isosorbide dinitrate which belongs to the group of medicines called Vasodilators. It is used to manage heart failure along with standard therapy in patients to improve survival, delay hospitalization for heart failure and to improve patient-reported functional status.
Heart failure is defined as a progressive clinical disorder where your heart is unable to pump sufficient blood to meet the body’s metabolic needs, characterized by shortness of breath and extreme tiredness.
During course of the management your doctor might regularly monitor your blood pressure to avoid any untoward side effects. The safety and effectiveness of MUZIKA TABLET in children have not been established.
Before taking MUZIKA TABLET, inform your doctor if you have any kidney, heart, lung or liver problems, too much sweating, fluid loss, vomiting or diarrhea or if you consume alcohol.
MUZIKA TABLET is not studied in pregnant and breastfeeding women, so consult your doctor before taking it. The most common side effects of taking MUZIKA TABLET are headache and dizziness. Consult your doctor if any of the side effects worsen.
Uses Of MUZIKA TABLET
- Manage heart failure
How MUZIKA TABLET Works
MUZIKA TABLET helps in the management of heart failure, where hydralazine relaxes the smooth muscles of arteries and isosorbide dinitrate acts by releasing nitric oxide and subsequently activating guanylyl cyclase and ultimately relaxes smooth muscles of both arteries and veins.
How to use MUZIKA TABLET
Take MUZIKA TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of MUZIKA TABLET
Common
- headache
- dizziness
Rare
Stop taking MUZIKA TABLET and consult your doctor immediately if you experience any of the following side effects:
- allergic reaction (signs include rash, hives, itching, red, swollen, blistered or peeling skin, wheezing, tightness in the chest or throat, difficulty breathing, swallowing or talking, unusual hoarseness or swelling of the mouth, face, lips, tongue or throat)
- lupus-like rash on the cheeks or other body parts, easy sunburn, muscle or joint pain, chest pain or breathlessness or swelling in the arms or legs
- low blood pressure (very bad dizziness or passing out)
- fever
- insufficient oxygen supply to heart muscle and angina (chest pain or pressure or a fast heartbeat)
- peripheral neuritis (numbness, prickling and tingling sensation)
How To Manage Side Effects
Headache:
Drink ample amount of water. Get adequate rest. Try to be relaxed and stress free. Ask your doctor before taking any medicine for headache.
Dizziness:
When you start taking MUZIKA TABLET, you may feel dizzy. If this happens, resting or lying down for some time can help. Rise slowly after sitting or lying down. Be careful while going up and down stairs. Consult your doctor if you experience persistent dizziness.
Warning & Precautions
Pregnancy
MUZIKA TABLET is not studied in pregnant women. Consult your doctor before taking it.
Breastfeeding
MUZIKA TABLET is not studied in breastfeeding women. Consult your doctor before taking this medicine as it is not known if it passes into breast milk.
Driving and Using Machines
Do not drive or use any machines until you see how MUZIKA TABLET affects you.
Alcohol
Avoid consumption of alcohol during management with MUZIKA TABLET as it may increase the risk of vasodilating effects of this medicine.
Kidney
MUZIKA TABLET is not studied in patients with kidney impairment. Consult your doctor before taking it.
Liver
MUZIKA TABLET is not studied in patients with liver impairment. Consult your doctor before taking it.
Allergy
Do not take MUZIKA TABLET if you are allergic to Hydralazine or Isosorbide dinitrate.
Heart Disease
MUZIKA TABLET should be used with caution in patients with hypertrophic cardiomyopathy. Consult your doctor before taking it.
Others
Before taking MUZIKA TABLET, inform your doctor if you:
- have too much sweating, fluid loss, vomiting or diarrhea
Use in pediatrics:
Safety and effectiveness of MUZIKA TABLET in children and adolescents (aged less than 18 years) have not been established. Consult your child’s doctor for advice.
Use in geriatrics:
MUZIKA TABLET should be used with caution in elderly patients. Consult your doctor before taking it.
Interactions
A. Drug - Drug interactions:
Before taking MUZIKA TABLET, inform your doctor if you are taking any of the following medicines:
- medicines used to manage erectile dysfunction (Ex. avanafil, sildenafil, tadalafil, vardenafil)
- riociguat (used to manage high blood pressure in the vessels that carry blood to the lungs)
Overdosage:
If you or anyone else accidentally took too much of MUZIKA TABLET, contact your doctor immediately. Symptoms of overdose include headache, confusion, fast heartbeat, generalized skin flushing, reduced cardiac output, low blood pressure, irregular heartbeat and shock.
Synopsis
| Drug | : | Hydralazine, Isosorbide dinitrate |
| Pharmacological Category | : | Vasodilators |
| Therapeutic Indication | : | As adjunct to standard management in heart failure |
| Dosage Forms | : | Tablet |
More Information
- Keep MUZIKA TABLET out of reach of children
- Store at room temperature
FAQs About MUZIKA TABLET
Q: What do I need to inform my doctor before taking MUZIKA TABLET?
A: Before taking MUZIKA TABLET, inform your doctor about all the medicines that you are taking (prescription or OTC, herbal products, vitamins) and your health problems. This is necessary to make sure that it is safe for you to take this medicine with all your other medicines and health problems. Do not start, stop or change the dose of any medicine without consulting your doctor.
Q: How does MUZIKA TABLET work?
A: MUZIKA TABLET helps in the management of heart failure, where hydralazine relaxes the smooth muscles of arteries and isosorbide dinitrate acts by releasing nitric oxide and subsequently activating guanylyl cyclase and ultimately relaxes smooth muscles of both arteries and veins.
Q: Can MUZIKA TABLET make me feel dizzy?
A: MUZIKA TABLET may cause a drop in your blood pressure that may make you feel dizzy. If this happens, resting or lying down for some time can help. Rise slowly after sitting or lying down. Be careful while going up and down stairs. Consult your doctor if you experience persistent dizziness.
Q: Does MUZIKA TABLET cause headache?
A: Yes, headache is a side effect of MUZIKA TABLET. Drink ample amount of water. Get adequate rest. Try to be relaxed and stress free. Ask your doctor before taking any medicine for headache.
Q: Can MUZIKA TABLET be used in children?
A: The safety and effectiveness of MUZIKA TABLET in children and adolescents (aged less than 18 years) have not been established. Your child’s doctor will select a suitable alternative therapy for your child to manage the condition.
References
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Heart Failure. Pharmacotherapy Handbook. Ninth edition. Page- 75
2. Anne L Taylor, Susan Ziesche, Clyde Yancy, Peter Carson, Ralph D'Agostino Jr, Keith Ferdinand, Malcolm Taylor, Kirkwood Adams, Michael Sabolinski, Manuel Worcel, Jay N Cohn; African-American Heart Failure Trial Investigators. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. November 2004. [Accessed on 30th May 2022] https://pubmed.ncbi.nlm.nih.gov/15533851/
3. Arbor Pharmaceuticals. LLC. U.S. Food & Drug Administration. [Revised in April 2015] [Accessed on 30th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020727s005lbl.pdf
4. Memorial Sloan Kettering Cancer Centre. Hydralazine + Isosorbide dinitrate. [Revised in September 2020] [Accessed on 30th May 2022] https://www.mskcc.org/pdf/cancer-care/patient-education/isosorbide-dinitrate-and-hydralazine
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