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Monocef SB 500/250mg Injection 1's
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INTRODUCTION
MONOCEF SB 500/250MG INJECTION is a combination of Ceftriaxone and Sulbactam which belongs to the group of medicines called Antibiotics. It is used in the treatment of infections of the brain (meningitis), lungs, middle ear, abdomen and abdominal wall (peritonitis), urinary tract and kidneys, bones and joints, skin or soft tissues, blood, and heart.
MONOCEF SB 500/250MG INJECTION can also be used to treat specific sexually transmitted infections (gonorrhoea and syphilis), patients with low white blood cell counts (neutropenia) who have fever due to bacterial infection, Lyme disease (caused by tick bites) and to prevent infections during surgery
MONOCEF SB 500/250MG INJECTION is not recommended for use in premature babies and new-born babies having jaundice. Before receiving MONOCEF SB 500/250MG INJECTION, inform your doctor if you have liver or kidney diseases, colitis, haemolytic anaemia, gall stones or kidney stones, upcoming surgeries, pancreatitis.
MONOCEF SB 500/250MG INJECTION should be used with caution in pregnancy and breast feeding. Contact your doctor before receiving. MONOCEF SB 500/250MG INJECTION is not recommended for use in premature babies. Contact your child’s doctor. MONOCEF SB 500/250MG INJECTION should be used with caution in elderly patients (aged above 65 years or above). Contact your doctor before receiving.
The most common side effects of receiving MONOCEF SB 500/250MG INJECTION are, diarrhoea, rash, itching, pain at the site of injection, inflammation of a vein caused by a blood clots. Contact your doctor if any of the symptoms worsen.
USES OF MONOCEF SB 500/250MG INJECTION
Treat bacterial infections involving:
- brain (meningitis)
- lungs
- middle ear
- abdomen and abdominal wall (peritonitis)
- urinary tract and kidneys
- bones and joints
- skin or soft tissues
- blood
- heart
- sexually transmitted infections (gonorrhoea and syphilis)
- low white blood cell counts (neutropenia)
- Lyme disease (caused by tick bites)
Prevents,
- infections during surgery
HOW MONOCEF SB 500/250MG INJECTION WORKS
MONOCEF SB 500/250MG INJECTION helps to treat infections, where Ceftriaxone is a cephalosporin antibiotic which works by inhibiting the synthesis of bacterial cell wall, leading to destruction of the bacteria and sulbactam is a beta-lactamase inhibitor which works by binding and inhibiting beta-lactamase (an enzyme that destroys antibiotic activity) produced by bacterial cells and thereby prevents the reduction in antibacterial activity.
DIRECTIONS FOR USE
MONOCEF SB 500/250MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous injection or infusion or into a muscle as intramuscular injection. Your doctor will decide the correct dose and duration of MONOCEF SB 500/250MG INJECTION for you depending upon your age, body weight and severity of disease condition.
SIDE EFFECTS OF MONOCEF SB 500/250MG INJECTION
COMMON
- pain, tenderness, warmth, tightness at the injection site
- rash
- low count of the blood cells
- diarrhoea
- changes in liver function tests characterised by abdominal pain, yellowing of skin or eyes, dark urine, pale stools
UNCOMMON
- inflammation of the vein
- itching
- fever, chills
- genital fungal infections
- nausea, vomiting
- changes in taste
- headache
- dizziness
RARE
Stop receiving MONOCEF SB 500/250MG INJECTION and contact your doctor immediately if you experience any of the following side effects:
- allergic reaction such as rash, red skin, blistering of lips, eyes, and mouth, skin peeling, high fever, flu-like symptoms, increased level of liver enzymes and increase in eosinophils and enlarged lymph nodes.
- sudden swelling of the throat or face causing difficulty in breathing or swallowing, sudden swelling of the hands, feet and ankles
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes and apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom did not improve.
Nausea:
Stick to simple meals while receiving MONOCEF SB 500/250MG INJECTION. Avoid eating rich or spicy food. Do not take any medication on your own. Ask for your doctor’s advice if nausea doesn’t improve.
Vomiting:
Eat light, bland foods and avoid fried, oily, or sweet foods. Avoid carbonated drinks. Ask for your doctor’s advice if vomiting doesn’t improve.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for treating diarrhea. Contact your doctor if the symptom did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if the symptom did not improve.
Stomach pain:
Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on your stomach. If the symptom does not improve, contact your doctor.
WARNING & PRECAUTIONS
PREGNANCY
MONOCEF SB 500/250MG INJECTION should be used with caution in pregnant women. Consult your doctor before receiving MONOCEF SB 500/250MG INJECTION.
BREASTFEEDING
MONOCEF SB 500/250MG INJECTION should be used with caution in breastfeeding women. Consult your doctor before receiving.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel dizziness after receiving MONOCEF SB 500/250MG INJECTION.
KIDNEY
MONOCEF SB 500/250MG INJECTION should be used with caution in patients with kidney disease such as kidney stones. Consult your doctor before receiving MONOCEF SB 500/250MG INJECTION.
LIVER
MONOCEF SB 500/250MG INJECTION should be used with caution in patients with liver disease. Consult your doctor before receiving.
ALLERGY
Do not receive MONOCEF SB 500/250MG INJECTION if you are allergic to ceftriaxone, sulbactam or to penicillin or similar antibiotics like carbapenems or monobactams or lidocaine or to any of the other ingredients of this medicine.
OTHERS
Tell your physician before receiving MONOCEF SB 500/250MG INJECTION if you have or had:
- gut problems like colitis (inflammation of the bowel)
- pancreatitis
- haemolytic anaemia
- low sodium diet
- upcoming surgeries
- gall bladder stones
- blood tests (coombs test) or urine test (for glucose)
Use in paediatrics:
MONOCEF SB 500/250MG INJECTION is not recommended for use in premature babies and new-born babies with jaundice. Ask for the advice of your child’s doctor.
Use in geriatrics:
MONOCEF SB 500/250MG INJECTION should be used with caution in elderly patients (aged 65 years or above). Your doctor might consider lowering your doses depending upon your health condition. Contact your doctor before receiving MONOCEF SB 500/250MG INJECTION.
INTERACTIONS
A. Drug – Drug Interactions:
Before receiving MONOCEF SB 500/250MG INJECTION, inform your doctor if you are taking any of the following medicines:
- medicine used to treat blood cancer (Ex. amsacrine)
- medicines used to treat certain infections (Ex. vancomycin, chloramphenicol, tobramycin, gentamycin)
- medicine used to treat fungal infections (Ex. fluconazole)
- medicines used to prevent pregnancy, oral contraceptives (Ex. ethinyl estradiol, levonorgestrel)
- medicines used to treat blood clots (Ex. dabigatran, rivaroxaban)
- medicines used to treat gout (Ex. probenecid)
- calcium containing diluents such as ringers’ solution and Hartman’s solution
Overdosage:
MONOCEF SB 500/250MG INJECTION will be administered only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if there are any unusual symptoms.
SYNOPSIS
| Drug | : | Ceftriaxone and Sulbactam |
| Pharmacological Category | : | Cephalosporin antibiotic and Beta-lactamase inhibitors |
| Therapeutic Indication | : | Bacterial infections |
| Dosage Forms | : | Injection |
MORE INFORMATION
- Keep MONOCEF SB 500/250MG INJECTION out of reach of children
- Store MONOCEF SB 500/250MG INJECTION below 30°C
FAQs ABOUT MONOCEF SB 500/250MG INJECTION
How MONOCEF SB 500/250MG INJECTION is given?
MONOCEF SB 500/250MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous injection or infusion or into a muscle as intramuscular injection. Your doctor will decide the correct dose and duration of MONOCEF SB 500/250MG INJECTION for you depending upon your age, body weight and severity of disease condition.
Can MONOCEF SB 500/250MG INJECTION cause diarrhoea?
Yes. MONOCEF SB 500/250MG INJECTION cause diarrhea. Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for treating diarrhoea. Contact your doctor if the symptom did not improve.
Can I stop receiving MONOCEF SB 500/250MG INJECTION on my own?
Do not stop receiving MONOCEF SB 500/250MG INJECTION unless your doctor tells you to. Stopping early may not prove the medicine to be properly effective. If you have any further questions on the use of MONOCEF SB 500/250MG INJECTION, ask your doctor.
Who should avoid receiving MONOCEF SB 500/250MG INJECTION?
MONOCEF SB 500/250MG INJECTION is not recommended for premature babies and new-borns with jaundice, or if you are allergic to ceftriaxone, sulbactam or to penicillin or similar antibiotics like carbapenems or monobactams or lidocaine or to any of the other ingredients of this medicine. Contact your doctor before receiving MONOCEF SB 500/250MG INJECTION.
Does MONOCEF SB 500/250MG INJECTION cause kidney stones?
Yes. MONOCEF SB 500/250MG INJECTION might cause kidney stones. Also, MONOCEF SB 500/250MG INJECTION should be used with caution in patients with kidney stones Consult your doctor before receiving.
REFERENCES
1. KD. Tripathi. Beta lactam antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 727 to 728.
2. Patil UN, Jambulingappa KL. A Combination Strategy of Ceftriaxone, Sulbactam and Disodium Edetate for the Treatment of Multi-Drug Resistant (MDR) Septicaemia: A Retrospective, Observational Study in Indian Tertiary Care Hospital. NIH National Library of Medicine National Centre for Biotechnology Information. Pubmed Central. November 2015. [Accessed on 16th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4668432/
3. Masoumeh Mohkam, Abdollah Karimi, Atoosa Gharib, Hamid Daneshmand, Alireza Khatami, Nozar Ghojevand, Mostafa Sharifian. Ceftriaxone associated nephrolithiasis: a prospective study in 284 children. NIH National Library of Medicine National Centre for Biotechnology Information. Pubmed.gov. May 2007. [Accessed on 16th May 2022] https://pubmed.ncbi.nlm.nih.gov/17226043/
4. Sanjay Mohan Shrivastava, Rajkumar Singh, Abu Tariq, Masoom Raza Siddiqui, Jitendar Yadav, P. S. Negi, Manu Chaudhary. A novel high performance liquid chromatographic method for simultaneous determination of ceftriaxone and sulbactam in sulbactomax. NIH National Library of Medicine National Centre for Biotechnology Information. Pubmed Central. March 2009. [Accessed on 16th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614746/
5. Lupin Pharmaceuticals. Ceftriaxone Injection. Dailymed. [Revised in November 2021]. [Accessed on 16th May 2022] https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=dac396fb-748d-45ea-9830-17c6eeb8834f&type=display
6. Cipla Ltd. Sulbacip IV Injection (Sulbactam Sodium). Ciplamed. [Revised in September 2013]. [Accessed on 16th May 2022] https://www.ciplamed.com/content/sulbacip-iv-injection
7. Cipla Ltd. Cefbact- S injection (Ceftriaxone + sulbactam). Ciplamed. [Revised in April 2022] [Accessed on 16th May 2022] https://www.ciplamed.com/content/cefbact-s-injection
8. Cipla Ltd. Elores injection (Ceftriaxone + sulbactam). Ciplamed. [Revised in October 2019] [Accessed on 16th May 2022] https://www.ciplamed.com/content/elores-powder-for-infusion
9. Leeford Healthcare. Biocef – s (Ceftriaxone + sulbactam). [Accessed on 16th May 2022] https://www.leeford.in/product/164/biocef-s-375
10. Taj Pharma. Ceftriaxone + sulbactam for injection. [Accessed on 16th May 2022] https://tajpharma.in/portfolio-item/ceftriaxone-sulbactam-for-injection-187-5mg/
11. Nitin Lifesciences Ltd. Extacef XL (Ceftriaxone + sulbactam). Blue Cross Labs. [Revised in September 2022] [Accessed on 16th May 2022] https://bluecrosslabs.com/wp-content/uploads/2021/01/EXTACEF-XL1_5g-Injection-PI-Sep2022.pdf
USEFUL DIAGNOSTIC TESTS
- Complete blood count
- Peripheral smear count
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