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INTRODUCTION
METOZ 2.5MG contains metolazone which is a diuretic antihypertensive drug used for the treatment of edema. They are usually prescribed to treat high blood pressure, fluid retention (oedema) or heart failure. It removes fluid from the body by increasing urine production. It works by causing you to urinate more which helps to remove excess fluid and salt from your body. Removing this excess fluid and salt also helps to lower your blood pressure. It effectively increases the excretion of phosphate and magnesium ions, and sodium in patients with severely compromised glomerular filtration.
Take this medicine with same meal each day or as directed by physician. Swallow the medicine whole with water. Do not chew the medicine. The most common side effects include constipation, dry mouth, diarrhea, headache, stomach pain, and blurred vision. It is contraindicated in anuria, in hepatic coma or pre-coma, and in cases of known allergy and hypersensitivity to metolazone.
USES OF METOZ 2.5MG
- Treat oedema (fluid retention)
HOW METOZ 2.5MG WORKS
It works by causing you to urinate more which helps to remove excess fluid and salt from your body. Removing this excess fluid and salt also helps to lower your blood pressure.
DIRECTIONS FOR USE
Take this medicine with same meal each day or as directed by physician. Swallow the medicine whole with water. Do not chew the medicine.
SIDE EFFECTS OF METOZ 2.5MG
SERIOUS
- flu-like symptoms, sore throat/pharynx/mouth, fatigue or urinary problems which may be caused by decrease in your white blood cells (agranulocytosis)
- a severe skin reaction, starting with a painful red area, developing into large blisters then peeling of layers of the skin (toxic epidermal necrolysis)
COMMON
- allergic reactions may occur, such as skin reactions, inflamed or reddened skin, hives, itching or skin rashes
- nausea, vomiting
- congestion, diarrhea
- muscle cramps
- headache, dizziness and tiredness
- low levels of potassium, sodium and chloride in the blood
- high levels of uric acid, urea and creatinine and sugar in the blood
- glucose in the urine
HOW TO MANAGE SIDE EFFECTS
Nausea and vomiting:
Keep try taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
Skin redness:
Avoid hot showers or baths because hot water can irritate the skin. Moisturizers can be used regular basis to soothe and hydrate the affected area.
Muscle cramps:
Stretching and massaging the muscle may help it to relax. Applying heat or cold to that area may also help to prevent muscle cramp. Avoid dehydration.
Headache:
Rest and drink plenty of fluids. Apply a cold, wet cloth or ice pack to your forehead. Rest in a quiet, comfortable, dark room.
Constipation:
Eat fiber rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.
Diarrhea:
Drink lots of fluids, such as water or squash, to avoid dehydration. Do not take any other medicines without speaking to a doctor.
WARNING & PRECAUTIONS
PREGNANCY
METOZ 2.5MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
BREASTFEEDING
METOZ 2.5MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
DRIVING AND USING MACHINES
It may cause adverse reactions affecting the ability to drive a vehicle or to operate machines, such as tiredness and dizziness. If you feel tired or drowsy, you should not drive or use machines.
ALCOHOL
Consumption of alcohol is not recommended during treatment with this medicine.
KIDNEY
METOZ 2.5MG should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.
LIVER
METOZ 2.5MG should be taken with caution in patients with severe liver disease. Consult your doctor for advice.
ALLERGY
Do not take if you are allergic (hypersensitive) to this medicine or any other ingredients in this medicine.
HEART DISEASE
METOZ 2.5MG should be taken with caution in patients with severe heart disease. Consult your doctor for advice.
INTERACTIONS
Tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following:
- Lithium (used for treatment of a particular kind of depression)
- Digoxin (used for treatment of heart insufficiency)
- NSAIDs (used for treatment of pain, fever and inflammation)
- Ciclosporin (a drug that affects the immune system)
- Diuretics (for treatment of kidney diseases, high blood pressure, heart failure and liver cirrhosis)
- ACE inhibitors (used for treatment of high blood pressure and heart failure)
- Warfarin (used to prevent blood clotting)
- Insulin or oral antidiabetics
SYNOPSIS
| Drug | : | Metolazone |
| Pharmacological Category | : | Antihypertensive agent, Diuretic |
| Therapeutic Indication | : | Oedema |
| Dosage Forms | : | Tablet |
MORE INFORMATION
Store at room temperature 15-25°C and keep it out of reach of children.
FAQs ABOUT METOZ 2.5MG
How long does it take for METOZ 2.5MG to work?
It usually takes 3 to 4 days for this medicine to start reducing edema, and 3 to 6 weeks to start reducing blood pressure.
What is METOZ 2.5MG?
It is a prescription drug and is a "water pill" (diuretic) that increases the amount of urine you make, which causes your body to get rid of excess water. It is used to treat high blood pressure.
REFERENCES
1. Domenic A. Sica MD; Metolazone and Its Role in Edema Management; [Revised on 2007] [Accessed on 30 Sep 2020] https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1527-5299.2003.01907.x
2. K.D.Tripathi, Essentials of medical pharmacology, Drugs acting on kidney, Chapter 41 –Diuretics, Page – 583.
3. Aine McManus WUTH; U.K. NHS; [Revised on Aug 2020] [Accessed on 30 Sep 2020] https://mm.wirral.nhs.uk/document_uploads/shared-care/Metolazone-for-CKD-SCG-v2.pdf
4. sanofi-aventis Canada Inc; Zaroxolyn Product Monograph; [Revised on Feb 2018] [Accessed on 30 Sep 2020] http://products.sanofi.ca/en/zaroxolyn.pdf
USEFUL DIAGNOSTIC TESTS
- Kidney function test
PRODUCT DETAILS
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