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Introduction About METOSARTAN LN 25 TABLET
METOSARTAN LN 25 TABLET is a combination of Cilnidipine, Metoprolol and Telmisartan which belongs to the group of medicines called Antihypertensive agents. It is used to manage hypertension (high blood pressure). It can also be used to reduce the risk of heart attack (myocardial infarction), stroke, chest pain (angina) or uneven heartbeat (arrhythmia).
Before taking METOSARTAN LN 25 TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have diabetes, thyroid problems, asthma, low blood pressure, poor blood circulation, psoriasis, allergic reactions, dehydration or gout as a precaution.
METOSARTAN LN 25 TABLET is not recommended for use in patients with severe heart problems apart from hypertension (such as uncontrollable heart failure or heart block). Do not take this medicine without consulting your doctor if you are pregnant or breastfeeding.
The most common side effects of taking this medicine are low blood pressure, slow heart rate, cold hands and feet, racing heartbeat, swelling of ankles or other body parts, flushing, headache, dizziness, nausea, diarrhoea and constipation. Consult your doctor if any of these side effect worsens.
Uses Of METOSARTAN LN 25 TABLET
It is used to:
- Manage Hypertension (high blood pressure)
- Prevent heart attack, stroke, angina (chest pain) or arrhythmia (uneven heartbeat)
How METOSARTAN LN 25 TABLET Works
METOSARTAN LN 25 TABLET is an antihypertensive medicine. It contains three medicines namely, metoprolol, cilnidipine and telmisartan. Metoprolol reduces the heart rate and force of contraction of heart muscles.
How to use METOSARTAN LN 25 TABLET
Take METOSARTAN LN 25 TABLET as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition. Do not stop taking this medicine without consulting your doctor.
Side Effects Of METOSARTAN LN 25 TABLET
Common
- swelling of the ankles or other body parts
- headache, dizziness, sleepiness
- low blood pressure
- slow or fast heart rate
- flushing (redness and warmth of the skin)
- stomach pain, nausea, vomiting, diarrhea, constipation, indigestion
- shortness of breath even with mild physical activity
- changes in bowel habit
- tiredness, weakness
- gingival hyperplasia (enlargement of gums with inflammation)
Uncommon
- chest pain
- weight gain
- depression
- concentration problems, nightmares
- inability to sleep
- drowsiness
- tingling in the skin
- rashes
- increased sweating, fluid retention
- muscle cramps
- low or high blood potassium levels
- vertigo (spinning sensation)
- fast or irregular heartbeat
- low blood pressure causing dizziness while standing up
- dry mouth
- back pain, muscle spasm or pain
- erectile dysfunction (inability to get or keep an erection)
- increased blood uric acid levels
- sore throat, sinus inflammation, common cold, cough
- urinary tract infections
- anaemia
- kidney problems
Rare
- worsening of diabetes
- dry mouth, runny nose, hair loss
- nervousness, anxiety
- visual disturbances
- dry or irritated eyes
- bending of penis on erection (peyronie’s syndrome)
- low blood sugar levels
- low blood platelet count (causing unusual bleeding or bruising)
- high blood calcium levels
Stop taking METOSARTAN LN 25 TABLET and contact your doctor immediately if you experience any of the following side effects:
- severe allergic reactions (such as skin rash, itching, swelling of the face, lips, mouth, or throat which can lead to difficulty in breathing or swallowing)
- severe skin reactions (such as skin rash with itching and redness, blistering and peeling of skin, skin swelling and inflammation of mucous membrane)
- sepsis (infection of blood characterized by sever signs of illness and fever)
How To Manage Side Effects
Constipation
Eat plenty of fibre rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Headache
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Nausea And Vomiting
Take METOSARTAN LN 25 TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if your nausea worsens.
Warning & Precautions
Pregnancy
ContraindicatedMETOSARTAN LN 25 TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing fetus. Therefore, consult your doctor before taking it. If you become pregnant while undergoing therapy with METOSARTAN LN 25 TABLET, stop taking it and consult your doctor immediately.
Breastfeeding
ContraindicatedMETOSARTAN LN 25 TABLET is not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
Driving and Using Machines
Use with CautionDo not drive or operate any machines if your ability is affected by METOSARTAN LN 25 TABLET.
Alcohol
Consult your doctorAvoid consumption of alcohol while taking METOSARTAN LN 25 TABLET as it may make you feel dizzier and drowsier.
Kidney
Consult your doctorMETOSARTAN LN 25 TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems (such as kidney transplant, narrowing of renal arteries). Therefore, consult your doctor before taking it.
Liver
Consult your doctorMETOSARTAN LN 25 TABLET is not recommended for use in patients with severe liver impairment (such as cholestasis, jaundice, biliary obstruction). It should be used with caution in patients with mild to moderate liver problems. Therefore, consult your doctor before taking it.
Allergy
ContraindicatedDo not take METOSARTAN LN 25 TABLET if you are allergic to Metoprolol, Cilnidipine or to Telmisartan.
Lungs
ContraindicatedMETOSARTAN LN 25 TABLET is not recommended for use in patients with severe asthma or chronic obstructive pulmonary disease. Therefore, consult your doctor for advice before taking it.
Heart Disease
Consult your doctorMETOSARTAN LN 25 TABLET is not recommended for use in patients with severe heart problems (such as heart block, uncontrollable heart failure, sick sinus syndrome or a very slow or uneven heartbeat). It should be used with caution in patients with other heart problems (such as a recent heart attack, or angina attack, enlarged heart muscles, or surgery in the heart within the last 4 months). Therefore, consult your doctor before taking it.
Others
METOSARTAN LN 25 TABLET is not recommended for use if you:
- are in shock caused due to poor blood circulation
- have poor blood circulation caused due to blockage in the blood vessels
- have a very low blood pressure
- have metabolic acidosis (too much acidity in blood)
- have unmanageed phaeochromocytoma (tumor present in adrenal glands)
- have diabetes related kidney problems
- have low potassium levels in blood
- have high calcium levels in blood
Before taking METOSARTAN LN 25 TABLET, inform your doctor if you:
- are prone to allergic reactions very often (such as even for insect bites)
- have problems in blood circulation around the body (especially in fingers, arms and feet)
- have diabetes
- have thyrotoxicosis (increased thyroid hormones in the body)
- are severely dehydrated
- have low sodium, potassium, or magnesium levels in the blood
- have gout
- have psoriasis (white scaly patches on the skin)
- have edema (swelling of body parts)
- have primary hyperaldosteronism (problems in adrenal gland)
- are on a low-salt diet
- have had skin cancer
- have an auto-immune disease condition affecting the skin (such as SLS)
- are scheduled for any upcoming surgery
Use in pediatrics:
METOSARTAN LN 25 TABLET is not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor for advice.
Use in geriatrics:
METOSARTAN LN 25 TABLET should be used with caution in the elderly patients. Therefore, consult your doctor before taking it.
Interactions
A. Drug - Drug interactions:
Before taking METOSARTAN LN 25 TABLET, inform your doctor if you are taking any of the following medicines such as:
- medicines used to manage advanced renal cell carcinoma (Ex. aldesleukin)
- medicines used to manage epilepsy (Ex. carbamazepine, phenytoin, phenobarbital)
- medicines used for bacterial infections (Ex. erythromycin)
- medicines used to manage tuberculosis (Ex. rifampicin)
- medicines used to manage hypertension (Ex. aliskiren, propranolol, amlodipine, diltiazem, verapamil, propafenone, captopril, enalapril, losartan, valsartan, clonidine, moxonidine, methyldopa, rilmenidine)
- medicines used for psychosis (Ex. risperidone, thioridazine, quetiapine, olanzapine)
- medicines used to manage diabetes (such as insulin, metformin, glimepiride, teneligliptin, pioglitazone)
- cimetidine (a medicine used to manage stomach ulcers)
- medicines used to manage uneven heartbeat (such as digoxin, disopyramide, quinidine or amiodarone)
- medicines used for pain and inflammation (such as ibuprofen, indomethacin, sulindac, diclofenac)
- medicines used to manage depression (such as fluoxetine, paroxetine, bupropion, lithium)
- ritonavir (a medicine used to manage HIV infection)
- antihistamines (used to manage allergic reactions) such as diphenhydramine
- medicines used to manage malaria (such as hydroxychloroquine, mefloquine)
- terbinafine (a medicine used to manage fungal infection)
- adrenaline (a medicine used to stimulate heart functions)
- phenylpropanolamine (a medicine used to reduce the swelling of the nasal mucosa)
- beta blockers used for glaucoma (such as timolol, pindolol, labetalol)
- ergotamine (a medicine used for migraine headache)
- medicines used to manage angina (such as nitroglycerin)
- anaesthetics (used to cause numbness or loss of sensation) such as lidocaine, sevoflurane, halothane
- alpha blockers (used to manage high blood pressure and benign prostatic hyperplasia) such as prazosine, tamsulosin, terazosine, doxazosine
- antacids (medicines used to neutralise stomach acid) such as aluminium hydroxide, magaldrate
- potassium supplements or potassium-sparing diuretics such as spironolactone, triamterene or amiloride (used to retain or increase potassium levels in the body)
- heparin (a medicine used to manage or manage blood clots)
- medicines used to manage bacterial infections (Ex. trimethoprim)
- medicines used to suppress immune functions (such as ciclosporin, tacrolimus)
- diuretics (used to reduce edema and blood pressure) such as furosemide, hydrochlorothiazide
Overdosage:
If you or anyone else accidentally took more METOSARTAN LN 25 TABLET, consult your doctor immediately. Overdosage may cause low blood pressure, decreased heartbeat, problems in breathing, vomiting, feeling faint and fits.
Synopsis
| Drug | : | Cilnidipine, Metoprolol, Telmisartan |
| Pharmacological Category | : | Calcium Channel Blockers, Beta-blockers, Angiotensin II Receptor Blockers |
| Therapeutic Indication | : | Hypertension, Angina, Heart attack, Stroke |
| Dosage Forms | : | Tablet |
More Information
- Keep METOSARTAN LN 25 TABLET out of the sight and reach of children
- Store METOSARTAN LN 25 TABLET at room temperature
FAQs About METOSARTAN LN 25 TABLET
Q: What are the uses of METOSARTAN LN 25 TABLET?
A: METOSARTAN LN 25 TABLET is used to manage hypertension. It can also be used to manage the risk of heart attack, stroke, angina and arrhythmia.
Q: What type of a medicine is METOSARTAN LN 25 TABLET?
A: METOSARTAN LN 25 TABLET is an antihypertensive medicine. It slows down your heartbeat and reduces force of contraction of the heart. It also relaxes blood vessels supplying the heart which reduces the strain on the heart and helps the heart to pump more blood with lesser force.
Q: What happens when I stop taking METOSARTAN LN 25 TABLET?
A: Do not stop taking METOSARTAN LN 25 TABLET without consulting your doctor as your blood pressure may raise once again. Make sure to take METOSARTAN LN 25 TABLET for the stipulated duration recommended by your doctor to achieve maximum results.
Q: What is the best time to take METOSARTAN LN 25 TABLET?
A: METOSARTAN LN 25 TABLET can be taken with or without meals. Your doctor will decide the best time for you to take METOSARTAN LN 25 TABLET based on your age, body weight and disease condition.
Q: What to do if I forgot to take a dose of METOSARTAN LN 25 TABLET?
A: If you forgot to take a dose of METOSARTAN LN 25 TABLET, take it as soon as you remember. However, if it is time for the next dose of METOSARTAN LN 25 TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of METOSARTAN LN 25 TABLET to compensate the missed ones.
Q: What precautions should be followed while taking METOSARTAN LN 25 TABLET?
A: Before taking METOSARTAN LN 25 TABLET inform your doctor if you have any liver or kidney problems. You must also inform your doctor if you have diabetes, thyroid problems, asthma, low blood pressure, poor blood circulation, dehydration or gout as a precaution. Do not take this medicine without consulting your doctor before if you are pregnant or breastfeeding. Regularly visit your doctor and take all the necessary blood test recommended by your doctor without fail.
Q: Can I consume alcohol while taking METOSARTAN LN 25 TABLET?
A: Avoid consumption of alcohol while taking METOSARTAN LN 25 TABLET as it might make you feel dizzier and drowsier.
Q: What happens if I accidentally take more METOSARTAN LN 25 TABLET?
A: If you or anyone else accidentally took more METOSARTAN LN 25 TABLET, consult your doctor immediately. Overdosage may cause low blood pressure, decreased heartbeat, problems in breathing, vomiting, feeling faint and fits.
Q: Can I take METOSARTAN LN 25 TABLET daily?
A: Take METOSARTAN LN 25 TABLET as advised by your physician. Your doctor will evaluate your health condition and suggests whether can you take METOSARTAN LN 25 TABLET every day or not.
Q: Is METOSARTAN LN 25 TABLET safe to use in diabetic patients?
A: METOSARTAN LN 25 TABLET may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before taking METOSARTAN LN 25 TABLET as a precaution. Your doctor will closely monitor you blood sugar levels to avoid the risk of side effects.
Q: What are the side effects of METOSARTAN LN 25 TABLET?
A: The most common side effects of taking this medicine are low blood pressure, slow heart rate, cold hands and feet, racing heartbeat, headache, dizziness, nausea, diarrhoea and constipation. Consult your doctor if any of these side effect worsens.
Q: Can I stop taking METOSARTAN LN 25 TABLET once my symptoms subside?
A: No. Do not stop taking METOSARTAN LN 25 TABLET without consulting your doctor. As hypertension is a chronic condition, long term management may be necessary to control its symptoms. Therefore, take METOSARTAN LN 25 TABLET as advised by your doctor for the stipulated duration. Premature discontinuation of therapy may increase your blood pressure once again.
Q: Can METOSARTAN LN 25 TABLET be taken during pregnancy?
A: METOSARTAN LN 25 TABLET is not recommended for use in pregnant women as it may cause serious harm to the growing fetus. Therefore, inform your doctor before taking METOSARTAN LN 25 TABLET if you are pregnant, think you may be pregnant or planning to have a baby. If you become pregnant while undergoing therapy with METOSARTAN LN 25 TABLET, stop taking it and consult your doctor immediately.
Q: Is METOSARTAN LN 25 TABLET safe to use in kidney disease?
A: METOSARTAN LN 25 TABLET is not recommended for use in patients with severe kidney problems. It should be used with caution in patients with other kidney problems (such as kidney transplant, narrowing of renal arteries). Your doctor will access your health condition and suggest a suitable dose for you. Therefore, it is important to inform your doctor if you have any kidney problems before taking METOSARTAN LN 25 TABLET as a precaution.
Q: Can the use of METOSARTAN LN 25 TABLET affect the liver?
A: Yes. METOSARTAN LN 25 TABLET may affect the way your liver work. It can elevate the levels of certain liver enzymes in your body. Therefore, it is strictly not recommended for use in patients with severe liver diseases. It should be used with caution in patients with other minor liver problems. Consult your doctor before taking it.
References
1. KD. Tripathi. Antiadrenergic Drugs (Adrenergic Receptor Antagonists) and Drugs for Glaucoma & Cardiovascular drugs. Drugs Affecting Renin-Angiotensin System and Plasma Kinins. Antihypertensive Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 148 & 507.
2. Lionel H. Opie. Calcium channel blockers. Drugs for the heart. 8th Edition. 2013. Page- 88-89.
3. Junichi Minami, Yuhei Kawano, Yuriko Makino, Hiroaki Matsuoka and Shuichi Takishita. Effects of cilnidipine, a novel dihydropyridine calcium antagonist, on autonomic function, ambulatory blood pressure and heart rate in patients with essential hypertension. NIH. National Library of Medicine, National Center for biotechnology information. PMC. PubMed Central. September 2016. [Accessed on 3rd February 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2015014/
4. Jason Morris; Alexis Dunham. Metoprolol. StatPearls. NIH. National Library of Medicine, National Center for biotechnology information. PMC. PubMed Central. October 2022. [Accessed on 3rd February 2023]. https://www.ncbi.nlm.nih.gov/books/NBK532923/
5. Zentiva k.s. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on 3rd February 2023] https://www.medicines.org.uk/emc/files/pil.12971.pdf
6. APL Swift Services (Malta) Limited. Electronic Medicines Compendium (EMC). [Revised in November 2020] [Accessed on 3rd February 2023] https://www.medicines.org.uk/emc/files/pil.5199.pdf
7. Glenmark Arzneimittel GmbH. Electronic Medicines Compendium (EMC). [Revised in November 2019] [Accessed on 3rd February 2023] https://www.medicines.org.uk/emc/files/pil.9981.pdf
8. Unique pharmaceutical laboratories. Cilacar 20mg. September 2017. [Accessed on 3rd February 2023] https://medicaldialogues.in/uploads/2020/05/20/file_upload-129064.pdf
9. Cilnidipine. Centaurpharma.com. [Accessed on 3rd February 2023] https://www.centaurpharma.com/downloads/CENTAPRES.pdf
10 Cilocab. Cilnidipine. ACL limited. [Accessed on 3rd February 2023] https://www.acipharma.net/assets/files/product-pdf/cilocab.pdf
11. Leeford Healthcare Pvt Ltd. Cilnep TM. [Accessed on 3rd February 2023] https://www.leeford.in/product/1500/cilnep-tm
Useful Diagnostic Tests
- Kidney Function Test
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