INTRODUCTION
MEFPREX SUSPENSION contains Mefenamic acid which belongs to the group of medicines called Non-steroidal Anti-inflammatory drugs. It is used to relieve the symptoms of inflammation such as redness and swelling. It can be used to treat pain and discomfort caused due to arthritis (inflammation of joints) muscular diseases or rheumatoid disorders (inflammatory disorders affecting the muscles and joints). It can also be used in the treatment of headache, muscle pain, tooth ache, post operative pain, childbirth pain, fever in children and painful or heavy periods.
Your doctor may monitor your kidney or liver function before and during the treatment to make sure they are functioning properly. Your doctor may also suggest you perform blood tests during the treatment to check your health condition.
MEFPREX SUSPENSION is not recommended for use in patients have or ever had stomach or intestinal conditions such as stomach ulcer, bleeding in the stomach, severe gastritis (inflammation of lining of the stomach) and inflammatory diseases of the intestine such as ulcerative colitis or Crohn’s disease.
Avoid consumption of alcohol and smoking while taking MEFPREX SUSPENSION as it may irritate your stomach and worsen the side effects.
MEFPREX SUSPENSION is not recommended in patients having severe kidney, liver and heart problems. Consult your doctor before taking it.
MEFPREX SUSPENSION is not recommended for use in pregnant women particularly in the last 3 months of pregnancy as this may delay the onset of labour and prolong its duration. It is not recommended among breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.
Your doctor will give the right dose depends on your child’s age, body weight and disease condition. Consult your doctor for advice before taking MEFPREX SUSPENSION.
However, MEFPREX SUSPENSION should be used with caution in elderly patients (aged over 65 years). Consult your doctor before taking.
The most common side effects of MEFPREX SUSPENSION are abdominal pain, nausea, vomiting, diarrhoea and constipation. Consult your physician if any of the side effects worsen or persists for a longer time.
USES OF MEFPREX SUSPENSION
It is used to treat pain and inflammatory conditions such as:
- redness and swelling caused due to swelling in the body
- pain and discomfort caused due to arthritis, muscular disorders and rheumatoid disorders
- headache or tooth ache
- post operative pain
- fever
- heavy and painful periods
HOW MEFPREX SUSPENSION WORKS
MEFPREX SUSPENSION works by binding to certain receptors in the body where it blocks the action of a particular chemical called prostaglandins in the body. Thus, it relieves pain, redness and swelling associated with various inflammatory conditions of the body.
DIRECTIONS FOR USE
Take MEFPREX SUSPENSION as advised by your physician. Shake well before use. Your doctor will determine the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF MEFPREX SUSPENSION
COMMON
- abdominal pain
- constipation
- diarrhoea
- nausea and vomiting
- dyspepsia (indigestion)
- bleeding, perforations and ulcers of stomach and intestines
- heart burn
- abnormal kidney function
- anaemia (low red blood cell count)
- dizziness
- headache
- oedema (fluid retention)
- elevated liver enzymes
- pruritus (severe itching of the skin) and rashes
- ringing in ears
RARE
Stop taking MEFPREX SUSPENSION and contact your doctor immediately if you experience any of the following side effects:
- signs of allergic reactions (such as difficulty in breathing or swallowing, swelling of the face, lips tongue or throat, severe skin itching, red rashes or raised lumps, blistering of the mouth, eyes and genital area, patchy areas of rash, peeling of skin)
- diarrhoea, passing blood in the stools, passing black tarry stools
- vomiting of blood or dark particles similar to coffee grounds
- signs of stomach problems (such as indigestion or heartburn, abdominal pain, nausea and vomiting)
- signs of anaemia (such as feeling tired, breathless and paleness, sore throat, mouth ulcers, repeated infections)
- signs of low sodium levels (such as headache, nausea, vomiting, tiredness, muscle cramps
- sudden headache, stiff neck, fever, sensitivity to bright light, drowsiness, muscle pain, with or without a rash
- signs of kidney problems (such as fever, rash, nausea, aches and pains, passing more or less urine than usual, passing red urine or urination during night)
- sudden loss or blurring of vision, loss of colour vision, eye pain which increases with eye movement)
- signs of high blood pressure (such as headache, in particular on waking in the morning)
- signs of inflammation of pancreas (such as pain behind the ribs radiating towards the back, often worse when lying down, nausea, vomiting, fever)
- signs of liver problems (such as yellowing of your skin or eyes, pale faeces, dark urine, unexplained persistent nausea, stomach problems, loss of appetite or unusual tiredness)
- worsening of colitis (inflammation of colon) and Crohn’s disease (inflammation of digestive tract)
HOW TO MANAGE SIDE EFFECTS
Nausea or Vomiting:
Take this medicine with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods.
Flatulence:
Eat smaller and frequent meals. Eat and drink slowly and exercise regularly. If the symptoms are not going consult your doctor.
Constipation:
Eat plenty of fibre rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Exercise more regularly.
Diarrhoea:
Drink plenty of fluids, to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.
Stomach pain:
Try to rest and relax. Eat and drink slowly. Keep a heat pad on your stomach. If the symptom does not improve, contact your doctor.
Skin rash:
Avoid hot bathing because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if the symptom worsens.
WARNING & PRECAUTIONS
PREGNANCY
MEFPREX SUSPENSION is not recommended for use in women who are planning to become pregnant or pregnant women particularly in the last 3 months of pregnancy as they may delay the onset of labour and prolong its duration. Consult your doctor for advice before taking the medicine.
BREASTFEEDING
MEFPREX SUSPENSION is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you feel dizziness, drowsiness, fatigue or vision problems after taking MEFPREX SUSPENSION.
ALCOHOL
Avoid consumption of alcohol while taking MEFPREX SUSPENSION because it may irritate your stomach.
KIDNEY
MEFPREX SUSPENSION is not recommended for use in patients having severe kidney problems. Consult your doctor taking it.
LIVER
MEFPREX SUSPENSION is not recommended for use in patients having severe liver problems. Consult your doctor taking it.
ALLERGY
Do not take MEFPREX SUSPENSION if you are allergic to Mefenamic acid or any other anti-inflammatory medicines such as aspirin, ibuprofen, celecoxib.
HEART DISEASE
MEFPREX SUSPENSION is not recommended for use in patients having severe heart problems or have just had any heart bypass surgery. It should be used with caution in patients having high blood pressure. Consult your doctor before taking.
OTHERS
MEFPREX SUSPENSION is not recommended for use if you:
- have or ever had stomach or intestinal conditions such as stomach ulcer, bleeding in the stomach or severe gastritis
- have any inflammatory bowel diseases such as ulcerative colitis or Crohn’s disease
Before taking MEFPREX SUSPENSION, inform your doctor if you:
- have a history asthma
- have any connective tissue disorder such as systemic lupus erythematosus
- have epilepsy (fits)
- have a history of stroke (condition causing blood clots in the brain due to reduced supply of blood and oxygen to the brain)
- have smoking habit
- have diabetes (high blood sugar)
- have high cholesterol (increased accumulation of fat in the blood)
Use in paediatrics:
Your doctor will give the right dose depends on your child’s age, body weight and disease condition. Consult your doctor for advice before taking MEFPREX SUSPENSION.
Use in geriatrics:
MEFPREX SUSPENSION should be used with caution in elderly patients (aged over 65 years). Consult your doctor before taking.
INTERACTIONS
A. Drug - Drug interactions:
Before taking MEFPREX SUSPENSION tell your doctor if you’re taking any of the following medicine:
- corticosteroids (medicines used to treat inflammation) Ex. prednisone, hydrocortisone
- anti-platelets (medicine used to treat clotting of blood) Ex. warfarin, aspirin, clopidogrel
- anti-depressants (medicines used to treat depression and mood swings) Ex. paroxetine, lithium, mifepristone
- anti-inflammatory agents (medicines used to treat inflammation) Ex. dicofenac, celecoxib
- medicines used to treat high blood pressure and other heart problems (Ex. atenolol, ramipril, valsartan, digoxin, sotalol, diltiazem
- diuretics (medicines used to treat water retention) Ex. Furosemide
- medicines used to treat diabetes (high blood sugar) Ex. glipizide, glibenclamide
- medicines used to suppress immune system (Ex. ciclosporin, tacrolimus, methotrexate)
- quinolone antibiotics (medicines used to treat bacterial infections) Ex. moxifloxacin, ciprofloxacin
- aminoglycoside antibiotics (medicines used to treat bacterial infections) Ex. gentamycin, neomycin
- medicine used to treat HIV (Ex. zidovudine)
- probenecid (medicine used to treat gout)
Overdosage:
If you or anyone else accidentally takes too much of MEFPREX SUSPENSION, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are headache, abdominal pain (pain in your stomach) or other abnormal stomach symptoms, nausea, vomiting, tiredness, fainting and ringing in ears.
SYNOPSIS
| Drug | : | Mefenamic acid |
| Pharmacological Category | : | Non-steroidal anti-inflammatory drugs |
| Therapeutic Indication | : | Treats mild to moderate pain |
| Dosage Forms | : | Oral suspension, Suspension, Syrup, Tablet, Dispersible Tablet, Injection |
MORE INFORMATION
- Keep MEFPREX SUSPENSION out of the sight and reach of children
- Store below 30°C
FAQs ABOUT MEFPREX SUSPENSION
How to take MEFPREX SUSPENSION?
Take MEFPREX SUSPENSION as advised by your physician. Shake well before use. Your doctor will determine the correct dose and duration for you depending upon your age, body weight and disease condition.
How MEFPREX SUSPENSION works on my body?
MEFPREX SUSPENSION works by blocking certain chemicals called prostaglandins in the body thus relieves pain, redness and swelling caused due to inflammatory conditions of the body.
Can MEFPREX SUSPENSION taken along with alcohol?
No. You are not advised to consume alcohol while taking MEFPREX SUSPENSION because it may increase your risk of stomach bleeding.
Is MEFPREX SUSPENSION advised to be taken during pregnancy?
MEFPREX SUSPENSION is not recommended for use in pregnant women particularly in the last 3 months of pregnancy as they may delay the onset of labour and prolong its duration. It may also cause bleeding in mother and the baby. Consult your doctor to check whether you can take this medicine during the first 6 months of pregnancy.
Can MEFPREX SUSPENSION be taken more than the recommended dose?
No. Do not take a higher dose of MEFPREX SUSPENSION without consulting your doctor. Taking a higher dose of MEFPREX SUSPENSION may cause affect your stomach and kidneys. You may also get seizures (fits). Symptoms of taking higher dose of MEFPREX SUSPENSION include headache, abdominal pain or other abnormal stomach symptoms, nausea, vomiting. Talk to your doctor right away if you accidently took higher dose of medicine.
Does MEFPREX SUSPENSION affects my mensural bleeding?
MEFPREX SUSPENSION is used to relieve pain that happens before or during a menstrual period. It will not stop periods or bleeding. Consult your doctor regarding its dose and usage during mensural pain.
Is MEFPREX SUSPENSION advised to be taken for children?
Your doctor will give the right dose depends on your child’s age, body weight and disease condition. Consult your doctor for advice before taking MEFPREX SUSPENSION.
REFERENCES
1. KD Tripathi. NSAIDS and Anti-pyretic drugs. Essentials of Medical Pharmacology. Eighth Edition, 2019. Page – 218.
2. Khullar R, Kumar D, Seth N, Saini S. Formulation and evaluation of mefenamic acid emulgel for topical delivery. NIH National Library of Medicine, National center for biotechnology information. [Accessed on 29th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3745000/
3. Dr. Safila Naveed. Estimation and analysis of Mefenamic acid suspension: A proportional investigation. [Accessed on 29th July 2022] https://www.researchgate.net/publication/305870765_Estimation_and_Analysis_of_Mefenamic_Acid_Suspension_A_Proportional_Investigation
4. Delpharm Bladel BV. (EMC). [Revised in November 202] [Accessed 29th July 2022] https://www.medicines.org.uk/emc/files/pil.13316.pdf
5. USFDA. Ponstel (Mefenamic Acid Capsules, USP). [Revised in October 2020 [Accessed 29th July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/015034s040lbl.pdf
USEFUL DIAGNOSTIC TESTS
- Complete blood count
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