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INTRODUCTION
LUPRORIN 3.75MG INJECTION contains Leuprolide which belongs to the group of medicines called Gonadotropin Releasing Hormone (GnRH) agonist. It is used to manage endometriosis, relieving pain and reducing endometriotic lesions. It is also used for preoperative hematologic improvement in women having fibroids (abnormal growth in uterus) induced anaemia for whom hormonal suppression is considered necessary for three months.
Endometriosis is a chronic disease in which a tissue like the uterus lining grows outside the uterus, resulting in pain and/or infertility. It is characterized by symptoms such as pain during periods, pelvic pain, pain associated with sexual intercourse, painful urination, fatigue, depression, bloating and nausea.
Do not receive LUPRORIN 3.75MG INJECTION if you are allergic to Leuprolide, GnRH, or GnRH agonist analogs.
Before receiving this medicine, inform your doctor if you have liver impairment, kidney impairment, or undiagnosed abnormal uterine bleeding.
Inform your doctor if you are chronic alcohol or tobacco user or have strong family history of osteoporosis or chronic use of medicines.
LUPRORIN 3.75MG INJECTION is not recommended for use in pregnant women. It should be used with caution in breastfeeding women only if considered necessary. It is not recommended for use in premenarcheal children and postmenopausal women. Consult your doctor before receiving.
The common side effects associated with the use of LUPRORIN 3.75MG INJECTION are hot flashes/sweating, general pain, headache, gastrointestinal disorders, swelling due to water retention, nausea, vomiting, reduced libido, and dizziness. Consult your doctor if any of these side effects worsens.
USES OF LUPRORIN 3.75MG INJECTION
It is used:
- to manage endometriosis, relieving pain and reducing endometriotic lesions
- for preoperative hematologic improvement in women having fibroids induced anaemia for whom hormonal suppression is considered necessary for three months
HOW LUPRORIN 3.75MG INJECTION WORKS
LUPRORIN 3.75MG INJECTION contains Leuprolide which helps in managing endometriosis and fibroids. It works by blocking the secretion of gonadotropin releasing hormone (GnRH) following an initial stimulation, resulting in suppression of ovarian and testicular steroidogenesis (process of synthesis of steroid hormones), thereby relieving the symptoms associated with increased levels of sex hormones.
DIRECTIONS FOR USE
LUPRORIN 3.75MG INJECTION will be administered to you only by a doctor or a nurse intramuscularly (into the muscle). Your doctor will adminster the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF LUPRORIN 3.75MG INJECTION
COMMON
- hot flashes/sweating
- headache
- vaginitis (inflammation in the vagina)
- depression/emotional lability
- general pain
- weight gain or loss
- nausea
- vomiting
- reduced libido
- dizziness
- acne
- skin reactions
- joint disorder
- oedema (swelling due to water retention)
- paraesthesia (sensation of burning and pricking)
- gastrointestinal disturbances
- neuromuscular disorders
- breast changes or breast pain
- nervousness
- extreme weakness
- urinary tract infection
Stop receiving LUPRORIN 3.75MG INJECTION and contact your doctor if you experience any of the following side effects:
- signs of pituitary apoplexy such as sudden headache, visual changes, vomiting, weakened eye muscles, altered mental status, sudden loss of heart function
- urinary tract infection
- renal calculus (kidney stones)
- depression
HOW TO MANAGE SIDE EFFECTS
Dizziness Or Drowsiness
Lie down until the dizziness passes and get up slowly. Do not bend down suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids. Avoid drinking coffee, alcohol, or smoking. Consult your doctor if the condition persists for long or gets worsened.
Nausea And Vomiting
Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.
Headache
Take rest and plenty of water. Avoid taking alcohol and skipping meals. Do not strain your eyes by watching screen for long time. Consult your doctor if the condition persists for long or gets worsened.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedLUPRORIN 3.75MG INJECTION is not recommended for use during pregnancy as it may increase the risk of pregnancy complications such as early pregnancy loss and foetal harm. Consult your doctor before receiving.
BREASTFEEDING
Monitoring requiredLUPRORIN 3.75MG INJECTION should be used with caution breastfeeding women only if considered necessary because it is not known whether it can pass through milk. Consult your doctor before receiving.
KIDNEY
Use with CautionLUPRORIN 3.75MG INJECTION should be used with caution in patients with renal impairment. Consult your doctor before receiving.
LIVER
Use with CautionLUPRORIN 3.75MG INJECTION should be used with caution in patients with hepatic impairment. Consult your doctor before receiving.
ALLERGY
ContraindicatedDo not receive LUPRORIN 3.75MG INJECTION if you are allergic to Leuprolide, GnRH, GnRH agonist analogs, or to any of the other ingredients of this medicine.
USE IN PEDIATRICS
ContraindicatedLUPRORIN 3.75MG INJECTION is not recommended for use in premenarcheal children and adolescents (below 18 years). Consult your doctor before receiving.
USE IN GERIATRICS
ContraindicatedLUPRORIN 3.75MG INJECTION is not recommended for use in postmenopausal women. Consult your doctor before receiving.
OTHERS
LUPRORIN 3.75MG INJECTION is not recommended for use if you:
- have undiagnosed abnormal uterine bleeding
Before receiving LUPRORIN 3.75MG INJECTION, inform your doctor if you:
- have strong family history of osteoporosis
INTERACTIONS
A. Drug-Drug Interactions:
Before receiving LUPRORIN 3.75MG INJECTION, inform your doctor, if you are taking any of the following medicine:
- medicines used to treat convulsions (Ex. carbamazepine)
- corticosteroids (Ex. dexamethasone)
Overdosage:
LUPRORIN 3.75MG INJECTION will be administered to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. If you or anyone else accidentally receives too much of this medicine, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Leuprolide |
| Pharmacological Category | : | Gonadotropin Releasing Hormone (GnRH) agonist |
| Therapeutic Indication | : | Endometriosis, Fibroids |
| Dosage Forms | : | Injection, Injection depot |
MORE INFORMATION
- Keep LUPRORIN 3.75MG INJECTION out of reach of children
- Store between 2-8°C
FAQs ABOUT LUPRORIN 3.75MG INJECTION
Q: What is LUPRORIN 3.75MG INJECTION used for?
A: LUPRORIN 3.75MG INJECTION is used to manage endometriosis, relieving pain, and reducing endometriotic lesions. It is also used for preoperative hematologic improvement in women having fibroids (abnormal growth in uterus) induced anaemia for whom hormonal suppression is considered necessary for three months. Consult your doctor before receiving.
Q: What side effects are seen with LUPRORIN 3.75MG INJECTION?
A: The common side effects associated with the use of LUPRORIN 3.75MG INJECTION are hot flashes/sweating, general pain, headache, gastrointestinal disorders, swelling due to water retention, nausea, vomiting, reduced libido, and dizziness. Consult your doctor if any of these side effects worsens.
Q: Who should avoid receiving LUPRORIN 3.75MG INJECTION?
A: Do not receive LUPRORIN 3.75MG INJECTION if you are allergic to Leuprolide, GnRH, or GnRH agonist analogs. It is not recommended for use in pregnant women, premenarcheal children and postmenopausal women. Consult your doctor before receiving.
Q: Is LUPRORIN 3.75MG INJECTION safe to use in children?
A: LUPRORIN 3.75MG INJECTION is not recommended for use in premenarcheal children and adolescents (below 18 years). However, the efficacy of this medicine is expected to be the same for post pubertal adolescents (below 18 years) as for women (aged 18 years or older). Consult your doctor before receiving.
Q: Is LUPRORIN 3.75MG INJECTION safe to use in elderly patients?
A: LUPRORIN 3.75MG INJECTION is not recommended for use in postmenopausal women. Menopause is natural cessation of menstrual cycles that marks the end of reproductive life in females. Consult your doctor before receiving this medicine.
Q: Is LUPRORIN 3.75MG INJECTION safe to use in pregnant women?
A: LUPRORIN 3.75MG INJECTION is not recommended for use during pregnancy as it may increase the risk of pregnancy complications such as early pregnancy loss and foetal harm. Consult your doctor before receiving.
Q: Is LUPRORIN 3.75MG INJECTION safe to use in breastfeeding women?
A: LUPRORIN 3.75MG INJECTION should be used with caution breastfeeding women only if considered necessary because it is not known whether it can pass through milk. Consult your doctor before receiving.
REFERENCES
1. KD. Tripathi. Anterior Pituitary Hormones. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 243.
2. Dallas V. Swayzer, Valerie Gerriets. Leuprolide. NIH. National Library of Medicine. National Centre for Biotechnology Information. StatPearls [Internet]. October 2015. [Accessed on 30th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK551662/
3. AbbVie Inc. FDA (Food and Drug Administration). [Revised in March 2020] [Accessed on 30th November 2022] https://www.rxabbvie.com/pdf/lupron3_75mg.pdf
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