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Introduction About LUPRIDE DEPOT 45MG INJECTION
LUPRIDE DEPOT 45MG INJECTION contains Leuprolide which belongs to the group of medicines called Gonadotropin Releasing Hormone (GnRH) Agonist. It is used for palliative management (relieving symptoms and minimising the associated suffering) of advanced prostatic cancer.
Advanced prostatic cancer is a cancer (abnormal cell multiplication and differentiation) that originates in the prostate gland and spreads to the other parts of the body. It is characterized by the symptoms such as painful urination, decreased urine pressure, blood in the semen, bone pain, leg swelling, and weakness.
Do not receive LUPRIDE DEPOT 45MG INJECTION if you are allergic to Leuprolide, GnRH, GnRH agonist analogs.
Before receiving this medicine, inform your doctor if you have liver impairment, kidney impairment, congenital long QT syndrome, congestive heart failure, frequent electrolyte abnormalities, metastatic vertebral lesions, urinary tract obstruction, or diabetes.
Before receiving this medicine, inform your doctor if you have a history of seizures, epilepsy, cerebrovascular disorders, or central nervous system anomalies/tumours. LUPRIDE DEPOT 45MG INJECTION is not recommended for use in pregnant women, breastfeeding women, and children.
It should be used with caution in elderly patients (aged above 65 years). Consult your doctor before receiving.
The most common side effects associated with the use of LUPRIDE DEPOT 45MG INJECTION are general pain, reactions at the site of injection, hot flashes/sweating, gastrointestinal disorders, joint disorders, shrinking of testes, urinary disorders, infections in upper respiratory tract, and fatigue. Consult your doctor if any of these side effects worsens.
Uses Of LUPRIDE DEPOT 45MG INJECTION
- Used for palliative management (relieving symptoms and minimize the associated suffering) of advanced prostatic cancer
How LUPRIDE DEPOT 45MG INJECTION Works
LUPRIDE DEPOT 45MG INJECTION helps in palliative management of advanced prostatic cancer where leuprolide works by blocking the secretion of gonadotropin releasing hormone (GnRH) following an initial stimulation, resulting in suppression of ovarian and testicular steroidogenesis (process of synthesis of steroid hormones), thereby relieving the symptoms associated with increased testosterone levels in advanced prostatic cancer.
How to use LUPRIDE DEPOT 45MG INJECTION
For intramuscular use:
LUPRIDE DEPOT 45MG INJECTION will be administered to you only by a doctor or a nurse intramuscularly (into the muscle) or subcutaneously (under the skin). Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of LUPRIDE DEPOT 45MG INJECTION
Common
- hot flashes, sweating
- general pain in the body (especially joint pain and back pain)
- pain at the site of injection
- gastrointestinal disorders
- respiratory disorders
- urinary disorders
- shrinking of testicles
- extreme weakness
- headache
- joint disorders
- dizziness
- other sleep disorders
- neuromuscular disorders
- skin reactions
- flu-syndrome
- dehydration
- muscle pain
- sensation of pins and needles
- lethargy
- constipation
- sinus headache
- influenza-like illness including influenza, nasopharyngitis, nasal congestion, upper respiratory tract infection, rhinorrhea, and viral upper respiratory tract infection
- cough
- hemorrhagic cystitis
- high blood pressure
- rash
- urinary tract infection
- cystitis (an inflammatory condition of bladder)
- decreased haemoglobin
- COPD (chronic obstructive pulmonary disease)
- breathlessness especially on exertion
- increased frequency of urination in night
- peripheral/pitting oedema (swelling in legs and feet due to water retention)
- coronary artery disease ( heart disease) characterized by angina (chest pain)
- itching
- hair loss
- pain in testicles
- clamminess
- breast enlargement in males
- reduced libido
Rare
Stop receiving LUPRIDE DEPOT 45MG INJECTION and contact your doctor if you experience any of the following side effects:
- COPD (chronic obstructive pulmonary disease)
- coronary artery disease (heart disease) is characterized by angina (chest pain)
- cerebrovascular accident/transient ischemic attack (life-threatening events related to impaired heart function)
- pneumonia (a life-threatening lung disease)
- second primary neoplasm (cancer) including basal cell carcinoma, lung neoplasm, bladder transitional cell carcinoma, malignant melanoma, squamous cell carcinoma, non-Hodgkin’s lymphoma
How To Manage Side Effects
Headache:
Take rest and plenty of water. Avoid taking alcohol and skipping meals. Do not strain your eyes by watching the screen for a long time. Consult your doctor if the condition persists for long or gets worsens.
Dizziness:
Lie down until the dizziness passes and get up slowly. Do not bend down suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids. Avoid drinking coffee, alcohol, or smoking. Consult your doctor if the condition persists for long or gets worsens.
Constipation:
Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate managements for constipation.
Warning & Precautions
Pregnancy
LUPRIDE DEPOT 45MG INJECTION is not recommended for use during pregnancy. Consult your doctor before receiving.
Breastfeeding
LUPRIDE DEPOT 45MG INJECTION is not recommended for use in breastfeeding women as it can pass through milk. Consult your doctor before receiving.
Driving and Using Machines
Do not receive LUPRIDE DEPOT 45MG INJECTION if you are allergic to Leuprolide, GnRH, GnRH agonist analogs, or to any of the other ingredients of this medicine.
Kidney
LUPRIDE DEPOT 45MG INJECTION should be used with caution in patients with renal impairment. Consult your doctor before receiving.
Liver
LUPRIDE DEPOT 45MG INJECTION should be used with caution in patients with hepatic impairment. Consult your doctor before receiving.
Heart Disease
LUPRIDE DEPOT 45MG INJECTION should be used with caution in patients with congenital long QT syndrome and congestive heart failure only if clearly necessary. Consult your doctor before receiving.
Others
Before receiving LUPRIDE DEPOT 45MG INJECTION, inform your doctor if you:
- have frequent electrolyte abnormalities
- have metastatic vertebral lesions
- have urinary tract obstruction
- have diabetes
- have a history of seizure
- have a history of epilepsy
- have a history of cerebrovascular disorders
- have a history of central nervous system anomalies or tumours
Use in pediatrics:
LUPRIDE DEPOT 45MG INJECTION is not recommended for use in children. Consult your doctor before receiving.
Use in geriatrics:
LUPRIDE DEPOT 45MG INJECTION should be used with caution in elderly patients (above 65 years). Consult your doctor before receiving.
Interactions
A. Drug-Drug Interactions
Before receiving LUPRIDE DEPOT 45MG INJECTION, inform your doctor, if you are taking any of the following medicine:
- medicines that prolong the QT interval (Ex. haloperidol, amiodarone, erythromycin)
Overdosage:
LUPRIDE DEPOT 45MG INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. If you or anyone else accidentally receives too much of this medicine, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are shortness of breath, decreased activity, and increased scratching.
Synopsis
| Drug | : | Leuprolide |
| Pharmacological Category | : | Gonadotropin Releasing Hormone (GnRH) Agonist |
| Therapeutic Indication | : | Palliative management for advanced prostatic cancer |
| Dosage Forms | : | Injection, Injection depot |
More Information
- Keep LUPRIDE DEPOT 45MG INJECTION out of reach of children
- Store between 2-8°C
FAQs About LUPRIDE DEPOT 45MG INJECTION
What LUPRIDE DEPOT 45MG INJECTION is used for?
LUPRIDE DEPOT 45MG INJECTION for palliative management (relieving symptoms and minimize the associated suffering) of advanced prostatic cancer. Consult your doctor before receiving.
What side effects are seen with LUPRIDE DEPOT 45MG INJECTION?
The most common side effects associated with the use of LUPRIDE DEPOT 45MG INJECTION are general pain, reactions at the site of injection, hot flashes/sweating, gastrointestinal disorders, joint disorders, shrinking of testes, urinary disorders, infections in the upper respiratory tract, and fatigue. Consult your doctor if any of these symptoms worsens.
Who should avoid receiving LUPRIDE DEPOT 45MG INJECTION?
Do not receive LUPRIDE DEPOT 45MG INJECTION if you are allergic to leuprolide, GnRH, GnRH agonist analogs. It is not recommended for use in pregnant women, breastfeeding women, and children. Consult your doctor before receiving.
Is LUPRIDE DEPOT 45MG INJECTION safe to use in children?
LUPRIDE DEPOT 45MG INJECTION is not recommended for use in children because the safety and effectiveness of this medicine have not been established in this population. Consult your doctor before receiving.
Is LUPRIDE DEPOT 45MG INJECTION safe to use in pregnant and breastfeeding women?
LUPRIDE DEPOT 45MG INJECTION is not recommended for use during pregnancy as it may increase the risk for pregnancy loss. It is also not recommended for use in breastfeeding women as it can pass through milk. Consult your doctor before receiving.
What happens if you take more LUPRIDE DEPOT 45MG INJECTION than your required dose?
LUPRIDE DEPOT 45MG INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. If you or anyone else accidentally receives too much of this medicine, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are shortness of breath, decreased activity, and increased scratching.
Is LUPRIDE DEPOT 45MG INJECTION safe to use in heart patients?
LUPRIDE DEPOT 45MG INJECTION should be used with caution in patients with congenital long QT syndrome and congestive heart failure only if clearly necessary. Consult your doctor before receiving.
References
1. KD. Tripathi. Anterior Pituitary Hormones. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 243.
2. Dallas V. Swayzer, Valerie Gerriets. Leuprolide. NIH. National Library of Medicine. National Centre for Biotechnology Information. StatPearls [Internet]. October 2015. [Accessed on 28th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK551662/
3. AbbVie Inc. FDA (Food and Drug Administration). [Revised in June 2014] [Accessed on 28th November 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/020517s036_019732s041lbl.pdf
4. Dailymed. ELIGARD- leuprolide acetate. [Revised in April 2019] [Accessed on 28th November 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b78d1919-9dee-44fa-90f9-e0a26d32481d&audience=consumer
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