Lupride 1mg Injection 0.5ml

INTRODUCTION

LUPRIDE 1MG INJECTION contains Leuprolide which belongs to the group of medicines called Gonadotropin Releasing Hormone (GnRH) agonist. It is used for palliative treatment (relieving symptoms and minimize the associated suffering) of advanced prostatic cancer.

Advanced prostatic cancer is the cancer (abnormal cell multiplication and differentiation) that originates in the prostate gland and spreads to the other parts of the body. It is characterized by the symptoms such as painful urination, decreased urine pressure, blood in the semen, bone pain, leg swelling, and weakness.

Do not receive LUPRIDE 1MG INJECTION if you are allergic to Leuprolide and other GnRH, GnRH agonist analogs.

Before receiving this medicine, inform your doctor if you have liver impairment, kidney failure, metastatic vertebral lesions, urinary tract obstruction, diabetes or if you have history of orchiectomy (surgical removal of testes) or have been treated with an LH-RH agonist analog previously also.

LUPRIDE 1MG INJECTION is not recommended for use in pregnant and breastfeeding women. It should be used with caution in children and elderly patients (aged above 65 years). Consult your doctor before receiving.

The common side effects associated with the use of LUPRIDE 1MG INJECTION are hot flashes, impotence, anaemia, bone pain, muscle pain, dizziness, light-headedness, general pain, headache, sleeplessness, sleep disorders, and shortness of breath. Consult your doctor if any of these side effects worsens.

USES OF LUPRIDE 1MG INJECTION

• Used for palliative treatment (relieving symptoms and minimize the associated suffering) of advanced prostatic cancer

HOW LUPRIDE 1MG INJECTION WORKS

LUPRIDE 1MG INJECTION helps in palliative treatment of advanced prostatic cancer where leuprolide works by initial stimulation followed by blocking of secretion of gonadotropin releasing hormone (GnRH), resulting in suppression of production of ovarian and testicular hormones. This thus helps to relieve the symptoms associated with increased testosterone levels in advanced prostatic cancer.

DIRECTIONS FOR USE

LUPRIDE 1MG INJECTION will be administered to you only by a doctor or a nurse subcutaneously (under the skin). Keep changing the site of injection periodically if taken for long term. Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF LUPRIDE 1MG INJECTION

HOW TO MANAGE SIDE EFFECTS

Headache:

Take rest and plenty of water. Avoid taking alcohol and skipping meals. Do not strain your eyes by watching screen for long time. Consult your doctor if the condition persists for long or gets worsened.

Dizziness:

Lie down until the dizziness passes and get up slowly. Do not bend down suddenly. Get a lot of rest. Walk slowly and carefully. Take plenty of fluids. Avoid drinking coffee, alcohol, or smoking. Consult your doctor if the condition persists for long or gets worsened.

Constipation:

Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate treatments for constipation.

WARNING & PRECAUTIONS

PREGNANCY

LUPRIDE 1MG INJECTION is not recommended for use during pregnancy. Consult your doctor before receiving.

BREASTFEEDING

LUPRIDE 1MG INJECTION is not recommended for use in breastfeeding women. Consult your doctor before receiving.

KIDNEY

LUPRIDE 1MG INJECTION should be used with caution in patients with kidney failure. Consult your doctor before receiving.

LIVER

There is no dose adjustment of LUPRIDE 1MG INJECTION is required in patients with hepatic impairment. Consult your doctor before receiving.

ALLERGY

Do not receive LUPRIDE 1MG INJECTION if you are allergic to Leuprolide, GnRH, GnRH agonist analogs, or to any of the other ingredients of this medicine.

HEART DISEASE

LUPRIDE 1MG INJECTION should be used with caution in patients under high cardiovascular risk factors. Consult your doctor before receiving.

INTERACTIONS

A. Drug-Drug Interactions:

Before receiving LUPRIDE 1MG INJECTION, inform your doctor if you are taking any prescription, non-prescription and herbal supplements.

Overdosage:

LUPRIDE 1MG INJECTION will be administered to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. If you or anyone else accidentally receives too much of this medicine, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are shortness of breath, decreased activity, and irritation at the site of injection.

SYNOPSIS

MORE INFORMATION

• Keep LUPRIDE 1MG INJECTION out of reach of children
• Store between 2-8°C

FAQs ABOUT LUPRIDE 1MG INJECTION

What LUPRIDE 1MG INJECTION is used for?

LUPRIDE 1MG INJECTION for palliative treatment (relieving symptoms and minimize the associated suffering) of advanced prostatic cancer. Consult your doctor before receiving.

What side effects are seen with LUPRIDE 1MG INJECTION?

The common side effects associated with the use of LUPRIDE 1MG INJECTION are hot flashes, impotence, anaemia, bone pain, muscle pain, dizziness, light-headedness, general pain, headache, sleeplessness, sleep disorders, and shortness of breath. Consult your doctor if any of these side effects worsens.

Who should avoid receiving LUPRIDE 1MG INJECTION?

Do not receive LUPRIDE 1MG INJECTION if you are allergic to Leuprolide, GnRH, GnRH agonist analogs. It is not recommended for use in pregnant women, breastfeeding women, and children. Consult your doctor before receiving.

Is LUPRIDE 1MG INJECTION safe to use in children?

LUPRIDE 1MG INJECTION should be used with caution in children. Your doctor will administer the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before receiving.

Is LUPRIDE 1MG INJECTION safe to use in pregnant and breastfeeding women?

LUPRIDE 1MG INJECTION is not recommended for use during pregnancy as it may increase the risk for pregnancy loss. It is also not recommended for use in breastfeeding women as it is not known whether it can pass through milk. Consult your doctor before receiving.

What is the method of receiving LUPRIDE 1MG INJECTION?

LUPRIDE 1MG INJECTION will be given to you only by a doctor or a nurse subcutaneously (under the skin). Keep changing the site of injection periodically if taken for long term. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Is LUPRIDE 1MG INJECTION safe to use in heart patients?

LUPRIDE 1MG INJECTION should be used with caution in patients under high cardiovascular risk factors. Consult your doctor before receiving.

REFERENCES

1. KD. Tripathi. Anterior Pituitary Hormones. Essentials of Medical Pharmacology. Seventh edition. 2013. Page – 243.

2. Bethesda, National Institute of Diabetes and Digestive and Kidney Diseases. Leuprolide. NIH. National Library of Medicine. National Centre for Biotechnology Information. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. March 2018. [Accessed on 29th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK548676/

3. K Saruki, T Sekihara, M Mashimo, H Matsuo, H Sekiguchi. Leuprorelin acetate blood levels and dialysance after the administration of sustained release leuprorelin acetate in a dialysis case complicated by prostate cancer. NIH. National Library of Medicine. National Centre for Biotechnology Information. PubMed.gov. February 1998. [Accessed on 29th November 2022] https://pubmed.ncbi.nlm.nih.gov/9492847/

4. Ben Venue Laboratories, Inc. FDA (Food and Drug Administration). [Revised in August 2011] [Accessed on 29th November 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/074728s011lbl.pdf

5. Intas Pharmaceuticals Ltd. LUPRORIN 4. [Accessed on 29th November 2022] https://www.intaspharma.com/products/

AUTHOR DETAILS

Written By Dr. Janet.C, Pharm.D
Last updated on 06 Dec 2022 | 11:42 PM(IST)