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Introduction About LORVAS 2.5MG TABLET
LORVAS 2.5MG TABLET contains Indapamide which belongs to the group of medicines called Thiazide like diuretics. It is used to manage high blood pressure (hypertension). It can also be used alone or in combination with other medicines to manage high blood pressure (hypertension) in adults.
Hypertension is a condition in which the force of the blood against the blood vessel wall is too high, resulting in early morning headaches, nosebleeds, irregular heartbeat, changes in vision, and buzzing in the ears.
Your doctor may advise to have a test to check how well your parathyroid gland is working and blood tests to check for low sodium or potassium levels or high calcium levels before taking LORVAS 2.5MG TABLET.
LORVAS 2.5MG TABLET should be avoided in patients with severe liver disease or conditions like hepatic encephalopathy (liver problems affect your brain and central nervous system), severe kidney disease and low level of potassium in blood.
Before taking LORVAS 2.5MG TABLET, inform your doctor if you have heart rhythm problems, diabetes, gout, muscle disorders, eye pain or decrease in vision due to choroidal effusion (fluid collection in the vascular layer of the eye) or earlier penicillin or sulphonamide allergy and are an athlete.
LORVAS 2.5MG TABLET is not recommended among pregnant and breastfeeding women. LORVAS 2.5MG TABLET is generally not recommended for use in children and need to be used with caution among elderly patients with impaired kidney function.
The most common side effect of taking LORVAS 2.5MG TABLET is skin rashes. Contact your doctor if the side effects gets worsen.
Uses Of LORVAS 2.5MG TABLET
- Used to manage high blood pressure (hypertension)
How LORVAS 2.5MG TABLET Works
LORVAS 2.5MG TABLET lowers blood pressure by removing the extra water and salt from the body through acting on kidney. It also widens the blood vessel and makes the blood flow easy through blood vessels. This combined effect lowers blood pressure more effectively.
How to use LORVAS 2.5MG TABLET
Take LORVAS 2.5MG TABLET as advised by your physician. Swallow LORVAS 2.5MG TABLET with a glass of water. Do not crush or chew. Your doctor will determine the correct dose and duration for you depending upon your age, body weight and disease condition.
Side Effects Of LORVAS 2.5MG TABLET
Common
- skin rash
- allergic reactions in the form of skin rashes (especially patients who are more prone to allergic and asthmatic reactions)
- signs of low potassium in blood (constipation, skipped heartbeat feeling, muscle weakness or spasms)
Uncommon
- vomiting
- red pinpoints on skin (purpura)
- signs of low sodium in blood (headache, confusion, irritability, muscle weakness or cramps)
- impotence
Rare
- tiredness
- headache
- paraesthesia (burning, prickling, numbness, itching and painful sensation)
- vertigo
- nausea or constipation, dry mouth
- signs of low magnesium and chlorine in the blood (numbness, tingling sensation with muscle cramps)
Stop taking LORVAS 2.5MG TABLET and consult your doctor immediately if you experience any of the following side effects:
- angioedema and/or urticaria signs (swelling of the skin of extremities or face, swelling of the lips or tongue, swelling of the mucous membranes of the throat or airways resulting in breathing or swallowing difficulty)
- severe skins reactions like stevens-johnson syndrome (intense skin rash, reddening of the skin over the whole body, severe itching, blistering, peeling and swelling of the skin, inflammation of mucous membranes)
- irregular heartbeat
- severe abdominal and back pain accompanied with feeling sick due to inflamed pancreas
- inflammation of the brain caused by liver illness (hepatic encephalopathy)
- inflammation of the liver (hepatitis)
- abnormal muscle breakdown causes muscle weakness, cramps, tenderness or pain and particularly while having a high temperature
How To Manage Side Effects
Skin rash:
Just tap the skin dry after a bath or shower. Don't scratch the affected skin. Leave the rash open and avoid using harsh soaps, lotions and other creams to soothe the irritated skin. If the symptom does not improve, contact your doctor immediately.
Warning & Precautions
Pregnancy
LORVAS 2.5MG TABLET is not recommended for use in pregnant women. Consult your doctor before taking this medicine.
Breastfeeding
LORVAS 2.5MG TABLET is not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking this medicine.
Driving and Using Machines
Do not drive or operate any machines if you feel dizzy or tired after taking LORVAS 2.5MG TABLET.
Alcohol
Avoid consumption of alcohol while taking LORVAS 2.5MG TABLET because it might make you dizzier.
Kidney
LORVAS 2.5MG TABLET is not recommended in patients with severe kidney disease. It should be used with caution in patients with mild to moderate kidney problems. Consult your doctor before taking this medicine.
Liver
LORVAS 2.5MG TABLET is not recommended in patients with severe liver disease or hepatic encephalopathy (liver problems affect your brain and central nervous system). It should be used with caution in patients with mild to moderate liver problems. Consult your doctor before taking the medicine.
Allergy
Do not take LORVAS 2.5MG TABLET if you are allergic to Indapamide or any other ingredients of this medicine.
Heart Disease
LORVAS 2.5MG TABLET should be taken with caution in patients with heart rhythm problems. Consult your doctor before this medicine.
Others
LORVAS 2.5MG TABLET is not recommended for use if you:
- have hypokalaemia (low levels of potassium in blood)
Before taking LORVAS 2.5MG TABLET, inform your doctor if you:
- experience a decrease in vision or eye pain due to choroidal effusion (fluid collection in the vascular layer of the eye)
- have muscle disorders
- have diabetes
- have gout
- have or had photosensitivity reactions
- are an athlete
Use in pediatrics:
LORVAS 2.5MG TABLET is generally not recommended for use in children. Consult your doctor before taking this medicine.
Use in geriatrics:
LORVAS 2.5MG TABLET should be used with caution in elderly patients, especially in those with impaired kidney function. Consult your doctor before taking this medicine.
Interactions
A. Drug-Drug interactions:
Before taking LORVAS 2.5MG TABLET, inform your doctor if you are taking any of the following medicine:
- medicines for heart rhythm problems (Ex. quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, ibutilide, dofetilide or digitalis)
- bepridil (used in the management of angina pectoris, a condition that causes chest pain)
- stimulant laxatives (medicines used in the management of constipation Ex. bisacodyl, senna, sodium picosulfate)
- medicines used to manage mental disorders such as depression, anxiety or schizophrenia (such as tricyclic antidepressants, antipsychotic drugs, neuroleptics Ex. amisulpride, sulpride, sultopride, tiapride, haloperidol, lithium and droperidol)
- sparfloxacin, moxifloxacin, erythromycin by injection (medicines used in the management of bacterial infections)
- vincamine by injection (medicine used to manage symptomatic cognitive disorders in elderly including memory loss)
- pentamidine (medicine used in management of certain types of pneumonia)
- halofantrine (medicine used in the management of parasitic infection such as malaria)
- mizolastine (medicine used in the management of allergic reactions, such as hay fever)
- medicines used to relieve pain (such as non-steroidal anti-inflammatory drugs (NSAIDs) Ex. Ibuprofen or high doses of acetylsalicylic acid)
- medicine used to manage high blood pressure and heart failure (such as angiotensin converting enzyme (ACE) inhibitors)
- amphotericin B by (medicines used to manage fungal infections)
- oral corticosteroids used to manage various conditions including severe asthma and rheumatoid arthritis (Ex. prednisone, prednisolone, methylprednisolone, dexamethasone)
- allopurinol (medicine used in the management of gout)
- baclofen (used to manage muscle stiffness occurring in diseases such as multiple sclerosis)
- potassium-sparing diuretics (amiloride, spironolactone, triamterene)
- metformin (used in diabetes management)
- iodinated contrast media (used as dye in tests involving X-rays)
- calcium supplements (manageing and managing weak and easily broken bones)
- medicines used to suppress the immune system (Ex. cyclosporin, tacrolimus)
- tetracosactide (medicine used in the management of Crohn’s disease)
- cisapride (medicine used to manage reduced movement of the gullet and stomach)
- diphemanil (used in the management of gastro-intestinal problems such as ulcers, too much acid, overactive digestive system)
- methadone (medicine used in the management of drug addiction)
Overdosage:
If you or anyone else accidentally take too much of LORVAS 2.5MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are nausea or vomiting, low blood pressure, cramps, dizziness, drowsiness, confusion and changes in the amount of urine produced by the kidneys due to severe dehydration.
Synopsis
| Drug | : | Indapamide |
| Pharmacological Category | : | Thiazide like diuretics |
| Therapeutic Indication | : | High blood pressure |
| Dosage Forms | : | Tablet, Capsule |
More Information
- Keep LORVAS 2.5MG TABLET out of reach of children
- Store at room temperature
FAQs About LORVAS 2.5MG TABLET
How do LORVAS 2.5MG TABLET lower blood pressure?
LORVAS 2.5MG TABLET contains Indapamide, which acts as diuretic (water pill) medication that works in the kidneys to remove extra water and certain electrolytes (like sodium and potassium), which help lowers blood pressure. It also relaxes your blood vessels, which lowers your blood pressure more.
What precautions do I need to follow while taking LORVAS 2.5MG TABLET?
Patients taking LORVAS 2.5MG TABLET must inform their doctor about their pre-existing disease conditions like severe liver disease, kidney disease, heart problems, diabetes, gout, muscle weakness and problems in the vision.
Does LORVAS 2.5MG TABLET affect fertility?
LORVAS 2.5MG TABLET does not affect fertility. Even the toxicity studies showed no effect on fertility. No effects on fertility are anticipated till now. However, consult your doctor if you are planning for pregnancy.
What happens if I stopped taking LORVAS 2.5MG TABLET?
Keep taking LORVAS 2.5MG TABLET until your doctor tells you to stop taking it. Medicines usually control your blood pressure and does not manage it. If you have any discomfort on the use of this medicine, talk to your doctor immediately.
Will lifestyle changes helps along with LORVAS 2.5MG TABLET?
You can control your blood pressure by making some key lifestyle changes such as quitting smoking, cutting down on alcohol intake, making exercise a regular habit and consuming a healthy diet with less salt intake. Apart from these changes, staying away from stress is also important for maintaining blood pressure.
References
1. KD. Tripathi. Antihypertensive drugs. Essentials of medical pharmacology. seventh edition. 2013. Page – 561.
2. Avuloglu-Yilmaz, Ece, Deniz Yuzbasioglu, and Fatma Unal. "Assessment of the genotoxic effects of antihypertensive drug active ingredient indapamide in human lymphocytes." Drug and Chemical Toxicology. [Revised on January 2022] [Accessed on 9th May 2022] https://www.tandfonline.com/doi/abs/10.1080/01480545.2022.2026375
3. Robinson, Dean M. and Keri Wellington.NIH National Library of Medicine Indapamide sustained release: a review of its use in the treatment of hypertension. [Revised on January 2006] [Accessed on 9th May 2022] https://pubmed.ncbi.nlm.nih.gov/16451099/
4. S.C. Zentiva S.A. Electronic Medicines Compendium (EMC). [Revised in September 2021] [Accessed on 9th May 2022] https://www.medicines.org.uk/emc/files/pil.4188.pdf
5. Servier Industries. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on 9th May 2022] https://www.medicines.org.uk/emc/files/pil.1152.pdf
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