Lorsaid Injection 2ml

Pain relief Rx required

Best Price* ₹ 81.38 MRP ₹ 101.73
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INTRODUCTION

LORSAID contains Lornoxicam which belongs to the group of medicines called Non-steroidal anti-inflammatory drugs (NSAIDs). It is used for short term relief of acute mild to moderate pain when oral administration is not appropriate.

LORSAID is not recommended for use in patients with severe kidney or liver impairment, severe heart failure, low blood platelet count (which increases risk of bleeding or bruising), gastro-intestinal bleeding, cerebrovascular bleeding or other bleeding disorders, history of gastrointestinal bleeding or perforation (related to previous therapy with non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen) and varicella (chickenpox) infection.

Before receiving LORSAID inform your doctor if you have impaired kidney function, history of high blood pressure or heart failure, ulcerative colitis or crohn’s disease, peripheral artery or cerebrovascular disease, history of bleeding tendency or asthma, systemic lupus erythematosus (rare immunological disease) or mixed connective tissue disorders and may be at increased risk of developing diabetes or high cholesterol. Your doctor may recommend you to take relevant tests to understand your existing condition.

LORSAID is not recommended for use during the last 3 months of pregnancy, and in first and second trimester of pregnancy it should be used only if clearly advised by the doctor and it is not recommended for use in breastfeeding women. LORSAID is not recommended for use in children and adolescents (less than 18 years of age).

LORSAID should be used with caution in elderly patients (aged 65 years and above), especially in patients with impaired liver or kidney function. The common side effects of receiving LORSAID are dizziness, nausea, vomiting, stomach pain, indigestion and diarrhea. Inform your doctor immediately if any of the side effect worsens or persist for a long period of time.

USES OF LORSAID

  • For short-term relief of acute mild to moderate pain 

HOW LORSAID WORKS

LORSAID has an anti-inflammatory and analgesic activity that works by preventing the release of chemical messengers by inhibiting an enzyme called cyclooxygenase and also inhibits the prostaglandin synthesis that results in relieving pain and swelling associated with various conditions.    

DIRECTIONS FOR USE

LORSAID will be given to you only by a doctor or a nurse into a vein as an intravenous injection or into your muscles as an intramuscular injection. Your doctor will decide the dose, duration and frequency of LORSAID therapy for you depending on your age, body weight and severity of the condition.

SIDE EFFECTS OF LORSAID

COMMON

  • nausea, vomiting
  • diarrhoea
  • stomach pain
  • indigestion
  • mild and transient headache, dizziness

UNCOMMON

  • weight changes
  • anorexia (eating disorder)
  • inability to sleep
  • irritation or inflammation of the conjunctiva
  • vertigo (head spinning sensation), ringing sensation in the ears (tinnitus)
  • palpitations (sensation of pounding hearbeat), increased heart rate
  • heart failure, edema (fluid retention)
  • constipation, flatulence, belching, gastritis
  • flushing
  • stuffy nose
  • facial edema, general feeling of discomfort
  • skin rash, itching, excessive sweating, redness, hives and angioedema (painless swelling under skin)
  • dry mouth, mouth ulcers
  • peptic or duodenal ulcer
  • upper stomach pain
  • hair loss
  • joint pain

RARE

  • sore throat
  • anemia
  • allergic reaction
  • weakness
  • confusion, nervousness or agitation
  • feeling sleepy, tingling sensation
  • abnormal taste sensation
  • tremor, migraine
  • visual disturbances  
  • hot flush, bleeding or collection of blood outside the blood vessel
  • shortness of breath, cough, bronchospasm (lungs airway tighten)
  • difficulty swallowing, swollen tongue or oesophagus
  • perforated peptic ulcer
  • vomiting of blood, gastrointestinal bleeding, black or red-coloured stools
  • stomach acid reflux
  • skin eczema, dermatitis, rash of purple spots
  • bone pain, muscle pain or spasm, weakness
  • urination at nighttime (nocturia), urinary disorders

Inform your doctor immediately if you experience any of the following side effects while receiving LORSAID:

  • difficulty in breathing, chest pain, appearance of ankle swelling or it get worse
  • severe continuous stomach pain or black colored stool or abdominal bleeding
  • signs of liver problems (such as yellowish discoloration of the skin or white part of the eyes (jaundice))
  • allergic reaction (signs include ulcer or blistering, or swelling of the face, lips, tongue or throat which may cause difficulty in breathing)
  • fever, blistering eruption in the skin or swelling of hands and feet or in the mouth area (stevens-johnson syndrome)
  • severe skin infection in case of varicella (chickenpox)
  • skin reactions (signs include skin rash, damage to the internal lining of the nostrils, mouth, eyelids, ears, genitals or anus)

HOW TO MANAGE SIDE EFFECTS

Nausea or vomiting:

Stick to simple meals while receiving LORSAID. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Inform your doctor if the symptom does not improve.

Headache:

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Inform your doctor if the symptom does not improve.

Constipation:

Try to eat more high-fiber foods such as fresh fruit, vegetables, cereals, and drink plenty of water. If this does not help, inform your doctor for receiving alternate treatment for constipation.

Diarrhoea:

Drink lot of fluids, such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Inform your doctor if the symptom gets worse.

Dry mouth:

Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Inform your doctor if the symptom does not improve.

Stomach pain:

Try to rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, inform your doctor.

WARNING & PRECAUTIONS

PREGNANCY

LORSAID is not recommended for use in the third trimester of pregnancy. It should be used with caution during the first and second trimester of pregnancy, unless considered clearly necessary. Consult your doctor before receiving LORSAID.

BREASTFEEDING

LORSAID is not recommended for use in breastfeeding women. Consult your doctor before receiving LORSAID.

DRIVING AND USING MACHINES

Do not drive or use machines after receiving LORSAID if you experience sleepiness or dizziness. Consult your doctor for advice.

KIDNEY

LORSAID is not recommended for use in patients with severe kidney impairment. It should be used with caution in patients with mild to moderate kidney impairment and your doctor may adjust the dose depending upon your kidney function. Consult your doctor before receiving LORSAID.    

LIVER

LORSAID is not recommended for use in patients with severe liver impairment. It should be used with caution in patients with moderate liver impairment (Ex. liver cirrhosis) and your doctor may adjust the dose. Consult your doctor before receiving LORSAID. 

ALLERGY

Do not receive LORSAID if you are allergic to Lornoxicam or other non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, or any other ingredients of this medicine.  

LUNGS

LORSAID should be used with caution in patients with history of asthma. Consult your doctor before receiving LORSAID.

HEART DISEASE

LORSAID is not recommended for use in patients with severe heart failure. It should be used with caution in patients with a history of high blood pressure or heart failure, ischemic heart disease, peripheral arterial disease and cerebrovascular disease. Consult your doctor before receiving LORSAID.        

OTHERS

LORSAID is not recommended for use if you:

  • have low blood platelet count (which increases the risk of bleeding or bruising)
  • have gastro-intestinal bleeding, cerebrovascular bleeding or other bleeding disorders
  • have a history of gastrointestinal bleeding or perforation (related to previous therapy with non-steroidal anti-inflammatory drugs (NSAIDs)) 
  • have active or history of recurrent stomach ulcer/hemorrhage (two or more episodes of proven ulceration or bleeding)
  • varicella (chickenpox) infection

Before receiving LORSAID inform your physician if you:

  • have ulcerative colitis or crohn’s disease
  • have blood coagulation disorders or increased bleeding tendency
  • have diabetes or cholesterol
  • are a smoker
  • have systemic lupus erythematosus or mixed connective tissue disorders

Use in pediatrics:

LORSAID is not recommended for use in children and adolescents (less than 18 years of age) due to lack of safety and effectiveness. Consult child’s doctor for advice.

Use in geriatrics:

LORSAID should be used with caution in elderly patients (aged 65 years and above) especially in patients with impaired kidney or liver function and due to increased risk of gastrointestinal adverse effects. Consult your doctor before receiving LORSAID.

INTERACTIONS

A. Drug-Drug interactions:

Before receiving LORSAID inform your doctor if you are taking any of the following medicines:

  • warfarin, phenprocoumon or heparin (used to prevent or treat blood clots)
  • cimetidine (used to treat heartburn and stomach ulcer)
  • methotrexate, pemetrexed (used to treat cancer)
  • selective serotonin reuptake inhibitors (SSRIs) Ex. fluoxetine, fluvoxamine, paroxetine, sertraline or lithium (used to treat depression)
  • tacrolimus, cyclosporin (used to decrease the action of the immune system to prevent organ rejection)
  • rifampicin, quinolone antibiotics such as moxifloxacin, ciprofloxacin, gemifloxacin, ciprofloxacin (used to treat bacterial infection)
  • sulphonylureas such as glibenclamide (used to treat diabetes)
  • digoxin (used to treat heart disease)
  • corticosteroids such as prednisolone, methylprednisolone, dexamethasone (used to treat the inflammatory condition)
  • diuretics such as furosemide, chlorthalidone, spironolactone, beta-blockers (Ex. metoprolol, atenolol), angiotensin II receptor blockers (ARBs) (Ex. telmisartan, losartan) and angiotensin-converting enzyme (ACE) inhibitors such as captopril, lisinopril (used to lower blood pressure)
  • anti-platelets (Ex. clopidogrel, ticlopidine) medicines used to prevent heart attack and stroke
  • other non-steroidal anti-inflammatory drugs (NSAIDs) (Ex. aspirin, ibuprofen) (used to treat pain and inflammation)

Overdosage:

LORSAID will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms such as include nausea, vomiting, dizziness or impaired vision, impaired coordination ascending to coma and cramps, liver and kidney damages or coagulation disorders.

SYNOPSIS

Drug :  

Lornoxicam

Pharmacological Category :  

Non-steroidal anti-inflammatory drugs

Therapeutic Indication :   Treats acute mild to moderate pain
Dosage Forms :  

Tablet, Injection

MORE INFORMATION

  • Keep out of reach of children
  • Store LORSAID at room temperature

FAQs ABOUT LORSAID

What is LORSAID used for?

LORSAID contains Lornoxicam which belongs to the group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It is used for short term relief of acute mild to moderate pain when oral administration is not appropriate. Consult your doctor before receiving LORSAID.

How does LORSAID work?

LORSAID has an anti-inflammatory and analgesic activity that works by preventing the release of chemical messengers by inhibiting an enzyme called cyclooxygenase and also inhibits the prostaglandin synthesis that results in relieving pain and swelling associated with various conditions.    

Is LORSAID safe to use in pregnant women?

LORSAID is not recommended for use in the third trimester of pregnancy. It should be used with caution during the first and second trimester of pregnancy, unless clearly advised by the doctor. Consult your doctor before receiving LORSAID.

Can LORSAID be used in elderly patients?

LORSAID should be used with caution in elderly patients (aged 65 years and above) especially in patients with impaired kidney or liver function and due to increased risk of gastrointestinal adverse effects. Consult your doctor before receiving LORSAID.

Is [GBNKEYWORD] safe to use in patients with kidney problems?

LORSAID is not recommended for use in patients with severe kidney impairment. It should be used with caution in patients with mild to moderate kidney impairment and your doctor may adjust the dose depending upon your kidney function. Consult your doctor before receiving LORSAID.

REFERENCES

1. KD. Tripathi. Nonsteroidal Antiinflammatory Drugs and Antipyretic-Analgesics. Essentials of medical pharmacology. 8th Edition. 2019. Page – 211 to 223.

2. Ahmet Soylu, Mehmet Sarier, Bulent Altunoluk, Haluk Soylemez, Yasar Can Baydinc. Comparison of the Efficacy of Intravenous and Intramuscular Lornoxicam for the Initial Treatment of Acute Renal Colic. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. February 2019 [Accessed on 28th June 2022] https://pubmed.ncbi.nlm.nih.gov/30058061/

3. Nihal Basak, Yakup Akso, Ayhan Kaydu, and Omer Fatih Sahin. Lornoxicam use to reduce the pain associated with propofol injection. NIH National Library of Medicine, National center for biotechnology information. Pubmed Central. April 2017. [Accessed on 28th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418937

4. Takeda UK Limited. Health Products Regulatory Authority (HPRA). [Revised in February 2015] [Accessed on 28th June 2022] http://www.hpra.ie/img/uploaded/swedocuments/LicenseSPC_PA1547-005-003_11032015142107.pdf

USEFUL DIAGNOSTIC TESTS

  • Liver function test
  • Kidney function test
  • Bleeding/clotting time

PRODUCT DETAILS

    Net Qty
    1 N
    Shelf Life
    24 months
    Item Weight
    10 g
    Ingredient
    LORNOXICAM 8MG
    Hsn Code
    30049099
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Lorsaid Injection 2ml

Lorsaid Injection 2ml Mkt: Abbott Healthcare Pvt Ltd

M.R.P.: Rs.101.73
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