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INTRODUCTION
LIPAGLYN 4MG TABLET contains Saroglitazar which belongs to the group of medicines called Antidiabetics. It is indicated in the treatment of diabetic dyslipidaemia and hypertriglyceridemia (high levels of triglycerides) with Type 2 diabetes mellitus not controlled by statin therapy.
Diabetic Dyslipidaemia refers to a condition in which there are elevated triglycerides and LDL cholesterol, low HDL cholesterol and major presence of small LDL particles. Your doctor may ask you to undergo certain diagnostic tests before starting the treatment with this medicine.
Along with LIPAGLYN 4MG TABLET, your doctor might ask you to make certain lifestyle changes such as eating healthy, adequate sleep, weight and stress management, quitting smoking and alcohol.
LIPAGLYN 4MG TABLET should be used with caution in patients having liver, kidney or heart disease (with episodic congestive heart failure) and history of muscle diseases. LIPAGLYN 4MG TABLET should be used with caution in pregnant women and is not recommended for use in breast-feeding women.
Safety and effectiveness of this medicine has not been established in children, hence, ask for your doctor’s advice before using. LIPAGLYN 4MG TABLET should be used with caution in elderly patients. The most common side effects of taking LIPAGLYN 4MG TABLET are gastritis, weakness and fever. Consult your doctor if symptoms do not improve.
USES OF LIPAGLYN 4MG TABLET
Treats:
- diabetic dyslipidaemia
- hypertriglyceridemia (high levels of triglycerides) with Type 2 diabetes mellitus not controlled by statin therapy
HOW LIPAGLYN 4MG TABLET WORKS
LIPAGLYN 4MG TABLET influences glucose metabolism as well as fat metabolism. It acts on certain receptors and helps in lowering high blood triglycerides as well as the glucose levels in the blood and improves insulin resistance. It acts on the liver and increases the degradation of lipids (fats) and decreases their formation as well hence, resulting in reduced triglycerides.
DIRECTIONS FOR USE
Take LIPAGLYN 4MG TABLET as advised by your doctor. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, condition and body weight.
SIDE EFFECTS OF LIPAGLYN 4MG TABLET
COMMON
- gastritis
- weakness
- fever
HOW TO MANAGE SIDE EFFECTS
Fever:
Drink plenty of fluids and water. Avoid taking cold baths or showers. Consult your doctor if the symptom did not improve.
WARNING & PRECAUTIONS
PREGNANCY
LIPAGLYN 4MG TABLET should be used with caution in pregnant women or women planning to have a baby and should be given only if the potential benefits are more than the risks involved. Consult with your doctor before taking it.
BREASTFEEDING
LIPAGLYN 4MG TABLET is not recommended for use in breastfeeding women as it is not known if it passes through the breast milk. Consult your doctor before taking it.
KIDNEY
LIPAGLYN 4MG TABLET should be used with caution in patients with abnormal kidney function. Consult your doctor before taking it.
LIVER
LIPAGLYN 4MG TABLET should be used with caution in patients with abnormal liver function. Consult your doctor before taking.
ALLERGY
Do not take LIPAGLYN 4MG TABLET if you are allergic to Saroglitazar or any other ingredients of this medicine.
HEART DISEASE
LIPAGLYN 4MG TABLET should be taken with caution in patients with type 2 diabetes mellitus having heart diseases with episodic congestive heart failure. Consult your doctor before taking.
OTHERS
Before taking LIPAGLYN 4MG TABLET, inform your doctor if you:
- have muscular diseases (myopathies)
Use in paediatrics:
Safety and effectiveness of LIPAGLYN 4MG TABLET has not been established in children. Consult with your doctor before taking.
Use in geriatrics:
LIPAGLYN 4MG TABLET should be used with caution in elderly patients. Consult with your doctor before taking.
INTERACTIONS
A. Drug–Drug Interactions:
Before taking LIPAGLYN 4MG TABLET, inform your doctor if you are taking, have taken or might take any other medicine, including prescription, non-prescription or any herbal medicine.
Overdosage:
If you or anyone else accidentally take too much of LIPAGLYN 4MG TABLET, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Saroglitazar |
| Pharmacological Category | : | PPAR agonist |
| Therapeutic Indication | : | Diabetic Dyslipidaemia, Hypertriglyceridemia with Type 2 diabetes mellitus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep LIPAGLYN 4MG TABLET out of reach of children
- Store at room temperature below 25°C
FAQs ABOUT LIPAGLYN 4MG TABLET
Q: What is LIPAGLYN 4MG TABLET and why is it prescribed?
A: LIPAGLYN 4MG TABLET contains Saroglitazar which belongs to the group of medicines called Antidiabetics. It is indicated in the treatment of diabetic dyslipidaemia and hypertriglyceridemia (high levels of triglycerides) with Type 2 diabetes mellitus not controlled by statin therapy.
Q: Can LIPAGLYN 4MG TABLET be given to pregnant and breast-feeding women?
A: LIPAGLYN 4MG TABLET should be used with caution in pregnant women only if the potential benefits are more than the risks involved. It is not recommended for use in breastfeeding women as it is not known if it passes through breast milk or not. Consult your doctor before taking it.
Q: Can LIPAGLYN 4MG TABLET cause weight gain?
A: Although during the clinical studies, no significant weight gain and edema was reported with LIPAGLYN 4MG TABLET, patients who experience rapid increase in weight should be assessed for fluid accumulation and volume-related events such as excessive edema and congestive heart failure.
Q: How does LIPAGLYN 4MG TABLET work?
A: LIPAGLYN 4MG TABLET influences glucose metabolism as well as fat metabolism. It acts on certain receptors and helps in lowering high blood triglycerides as well as the glucose levels in the blood and improves insulin resistance. It acts on the liver and increases the degradation of lipids (fats) and decreases their formation as well hence, resulting in reduced triglycerides.
Q: Can LIPAGLYN 4MG TABLET be taken by patients having heart diseases?
A: LIPAGLYN 4MG TABLET should be taken with caution in patients with type 2 diabetes mellitus having heart diseases with episodic congestive heart failure. Consult your doctor before taking.
REFERENCES
1. KD. Tripathi. Hypolipidemic Drugs. Essentials of medical pharmacology. Eighth edition. 2018. Page – 688.
2. Shaival Chandalia. Hydroxychloroquine: Old wine in a new bottle & Saroglitazar: New Kid on the Block. Association of Diabetes Educators. Journal of Diabetes Education. March 2019. [Accessed on 23rd June 2022] https://www.diabeteseducatorsindia.com/uploads/Journal/pdfs/vol7-no1-jan-mar-2019-30.pdf
3. Mukul R Jain, Suresh R Giri, Chitrang Trivedi, Bibhuti Bhoi, Akshyaya Rath, Geeta Vanage, Purvi Vyas, Ramchandra Ranvir, Pankaj R Patel. Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid-lowering and insulin-sensitizing effects in preclinical models. NIH National library of medicine. National centre for biotechnology information. Pubmed.gov 2015. [Accessed on 23rd June 2022] https://pubmed.ncbi.nlm.nih.gov/26171220/
4. Cadila Healthcare Limited. Lipaglyn. [Accessed on 23rd June 2022] http://lipaglyn.com/downloads/Lipaglyn_Product_Monograph.pdf, http://www.lipaglyn.com/downloads/Lipaglyn_PI_Booklet.pdf
USEFUL DIAGNOSTIC TESTS
- Blood Glucose Levels
- Hb1AC
- Lipid Profile
AUTHOR DETAILS
Written By Dr. Shruthi M R, BDS
Last updated on 10 Jan 2023 | 04:29 PM(IST)
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