INTRODUCTION

LACOXA 15MG SYRUP contains Lacosamide which belongs to the group of medicines called Antiepileptics. It is used to treat a certain type of epilepsy characterised by the occurrence of partial onset seizure with or without secondary generalisation.

In this type of epilepsy, fits first affect only one side of your brain. However, these may then spread to larger areas on both sides of your brain. It may be used on its own or with other antiepileptic medicines.

Epilepsy is a neurological disorder of the central nervous system in which the brain activity becomes abnormal, causing seizures or periods of unusual behavior, sensations and sometimes loss of awareness.

Before taking LACOXA 15MG SYRUP, inform your doctor if you have or ever had a certain type of heartbeat problem called second or third-degree AV block.

LACOXA 15MG SYRUP is not recommended to use among women who are pregnant or breastfeeding. Your doctor will prescribe the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before taking.

The most common side effects of taking LACOXA 15MG SYRUP are headache, feeling dizzy or sick, nausea and double vision. Contact your doctor if any of the above symptoms worsen.

USES OF LACOXA 15MG SYRUP

• Used as an adjunctive treatment of partial onset seizures in patients above 17 years of age

HOW LACOXA 15MG SYRUP WORKS

LACOXA 15MG SYRUP works slowly by inactivating the sodium gated channels, which decreases the abnormal and excessive activity of the nerve cells in the brain and controls seizures or fits.

DIRECTIONS FOR USE

Take LACOXA 15MG SYRUP as advised by your physician. Shake well before use. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF LACOXA 15MG SYRUP

HOW TO MANAGE SIDE EFFECTS

Nausea or Vomiting:

Take this medicine with or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods.

Diarrhea:

Drink a lot of fluids such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.

Constipation:

Eat plenty of fiber-rich foods such as fresh fruits, vegetables and cereals and drink plenty of water. Exercise more regularly.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug interactions:

Before taking LACOXA 15MG SYRUP, inform your doctor if you are taking any of the following medicine:

• medicines used to treat heart problems
• medicines used to treat epilepsy or pain (Ex. carbamazepine, lamotrigine or pregabalin)
• medicines used for fungal infections (Ex. fluconazole, itraconazole or ketoconazole)
• medicine used to treat HIV (Ex. ritonavir)
• medicines used to treat bacterial infections (Ex. clarithromycin or rifampicin)
• herbal medicine used to treat mild anxiety and depression (Ex. St. John’s wort)

Overdosage:

If you or anyone else accidentally takes too much of LACOXA 15MG SYRUP, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are dizziness, nausea, vomiting, fits (seizures), heartbeat problems such as a slow, fast or irregular heartbeat or a fall in blood pressure with rapid heartbeat and sweating.

SYNOPSIS

MORE INFORMATION

• Keep LACOXA 15MG SYRUP out of reach of children
• Store at a temperature not exceeding 30°C

FAQs ABOUT LACOXA 15MG SYRUP

What are the symptoms of overdose of LACOXA 15MG SYRUP?

Symptoms of overdose of LACOXA 15MG SYRUP are dizziness, nausea, vomiting, fits (seizures), heartbeat problems such as a slow, fast or irregular heartbeat. Consult your doctor immediately if you experience these unusual reactions.

How to take LACOXA 15MG SYRUP?

Take LACOXA 15MG SYRUP as advised by your physician. Shake well before use. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Is it safe to use LACOXA 15MG SYRUP in patients with kidney problems?

LACOXA 15MG SYRUP should be used with caution in patients with kidney problems. Consult your doctor before taking it.

How do LACOXA 15MG SYRUP work?

LACOXA 15MG SYRUP works slowly by inactivating the sodium gated channels, which decreases the abnormal and excessive activity of the nerve cells in the brain and controls seizures or fits.

Is it safe to take LACOXA 15MG SYRUP during pregnancy?

LACOXA 15MG SYRUP is generally not recommended to use in pregnant women unless clearly considered necessary. Consult your doctor before taking it.

What are the common side effects of LACOXA 15MG SYRUP?

The common side effects of LACOXA 15MG SYRUP are headache, feeling dizzy or sick (nausea) and double vision (diplopia). Consult your doctor for advice.

REFERENCES

1. Misty D. Smith, Cameron S. Metcalf and Karen S. Wilcox. Pharmacotherapy of the Epilepsies. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018 Page – 303-326.

2. Liyan Hou, Bingjie Peng, Defu Zhang, Jingjing Yang, Ying Wang, Li Tong, Sheng Li, Qingshan Wang1 and Jie Zhao. Clinical Efficacy and Safety of Lacosamide as an Adjunctive Treatment in Adults With Refractory Epilepsy. Frontiers in neurology. December 2021. [Accessed on 21st May] https://www.frontiersin.org/articles/10.3389/fneur.2021.712717/full

3. Jon Allard, William Henley, Brendan Mclean, Sunil Ram, Manny Bagary, Rohit Shankar. Lacosamide in the general population and in people with intellectual disability: Similar responses? European Journal of Epilepsy. March 2020. [Accessed on 21st May] https://www.seizure-journal.com/article/S1059-1311(20)30054-6/fulltext

4. G. L. Krauss. Lacosamide for the treatment of epilepsy. Taylor and Francis online. June 2011. [Accessed on 21st May] https://www.tandfonline.com/doi/full/10.3109/07853890.2011.603700

5. Torrent pharmaceutical LTD. [Revised in April 2021] [Accessed on 21st May] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2867.pdf