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INTRODUCTION
KZ contains Ketoconazole which belongs to the group of medicines called antifungals. It is used to treat infections such as athlete's foot, jock itch, ringworm, and seborrhea (dry, flaking skin or dandruff). This medicine works by binding to the fungal p450 enzymes and stops the cells making ergosterol of the cell wall which is necessary for them to grow.
Apply the medicine onto to the affected area or as directed by physician. It is for external use only. It is recommended for the use in children and adolescents. Do not take this medicine, if you have eye infections. It should be used in pregnant or breastfeeding women, consult your doctor before taking this medicine. Tell your doctor if you are using any of the other topical medicines. The most common side effects include burning sensation, irritation and reddening of the skin.
USES OF KZ
- Treat infections such as athlete's foot, jock itch, ringworm, and seborrhea (dry, flaking skin or dandruff)
HOW KZ WORKS
KZ binds to the fungal p450 enzymes and stops the cells making ergosterol of the cell wall which is necessary for them to grow.
DIRECTIONS FOR USE
Apply the medicine onto the affected area or as directed by physician. It is for external use only.
SIDE EFFECTS OF KZ
SERIOUS
- severe irritation or reddening of the skin
- peeling or blistering of the skin
COMMON
- burning sensation
HOW TO MANAGE SIDE EFFECTS
Skin irritation:
Avoid bath in hot water because hot water can irritate the skin. Moisturizers can be used regular basis to soothe and hydrate the affected area.
WARNING & PRECAUTIONS
PREGNANCY
KZ is considered safe for use by pregnant women. It is advised to consult your doctor before taking this medicine.
BREASTFEEDING
KZ is safe to use during breastfeeding. It is advised to consult your doctor before taking this medicine.
ALLERGY
Do not take if you are allergic to the medicine.
INTERACTIONS
Tell your doctor if you are using any other cream, ointment or lotion on your skin infection that contains a steroids.
SYNOPSIS
| Drug | : | Ketoconazole |
| Pharmacological Category | : | Antifungal |
| Therapeutic Indication | : | Treat fungal infection |
| Dosage Forms | : | Tablet, Cream, Gel, Ointment, Lotion, Soap, Dusting powder |
MORE INFORMATION
Store at room temperature 15-25°C and keep out of reach of children.
FAQs ABOUT KZ
Can KZ be used in pregnant women?
Yes. It is safe for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
How does KZ kill fungus?
It kills fungi by binding to the fungal p450 enzymes and stops the cells making ergosterol of the cell wall.
REFERENCES
1. Hadeer Sinawe; Damian Casadesus, Ketoconazole, [Revised on Jun 2020] [Accessed 11 Dec 2020] https://www.ncbi.nlm.nih.gov/books/NBK559221/
2. Jan van cutsem; The antifungal activity of ketoconazole; [Revised on Jan 1983] [Accessed 11 Dec 2020] https://www.amjmed.com/article/0002-9343(83)90508-9/fulltext
3. K.D.Tripathi, Essentials of medical pharmacology, ANTIMICROBIAL DRUGS, Chapter 57 – ANTIFUNGAL DRUGS, 7th edition 2013, Page – 792.
4. Glenmark Pharmaceuticals s.r.o., U.S. Food and Drug Administration; [Revised on July 2013] [Accessed 11 Dec 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/018533s040lbl.pdf
5. Janssen Pharmaceutica NV; Electronic Medicines Compendium (EMC); [Revised on Mar 2019] [Accessed 11 Dec 2020] https://www.medicines.org.uk/emc/files/pil.970.pdf
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