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HEALTROXIN 75 Tablet 120's
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INTRODUCTION
HEALTROXIN 75 TABLET contains Thyroxine which belongs to the group of medicines called Thyroid hormone receptors. It is used as a replacement therapy in the treatment of primary (thyroidal), secondary (pituitary) and tertiary (hypothalamic) congenital or acquired hypothyroidism.
It is also used as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated papillary or follicular carcinoma (a differentiated thyroid cancer where cancer develops from the follicular cells and grow slowly) of thyroid gland.
Hypothyroidism is a condition in which the thyroid gland doesn't produce enough thyroid hormone in the blood stream. It is characterized by symptoms such as weakness, increased sensitivity to cold, constipation, dry skin, weight gain, puffy face, hoarseness and muscle weakness.
HEALTROXIN 75 TABLET is not recommended for use if you had a heart attack, acute myocarditis (inflammation/swelling of the heart muscle) or acute pancarditis (general inflammation/ swelling of the heart) recently.
Before taking this medicine, inform your doctor if you are having severe liver disease such as liver cirrhosis, kidney problems such as renal impairment, end-stage renal disease, nephrotic syndrome, renal failure, other heart problems, history of heart attack and/or history of kidney transplant.
It is not recommended for use in patients with overactive thyroid gland or untreated adrenal insufficiency (inability of adrenal glands to make enough of the hormone cortisol).
HEALTROXIN 75 TABLET should be used with caution in pregnant and breastfeeding women. It should be used with caution in children and adolescents (aged below 18 years) and elderly patients (aged above 65 years).
The most common side effects associated with the use of HEALTROXIN 75 TABLET are skin rash, itching and mild leucopenia (reduced white blood cell count). Consult your doctor if any of these symptoms worsens.
USES OF HEALTROXIN 75 TABLET
- Treats primary, secondary and tertiary congenital or acquired hypothyroidism.
- To manage thyrotropin-dependent well-differentiated papillary or follicular carcinoma of thyroid gland (with adjunct to surgery and radioiodine therapy)
HOW HEALTROXIN 75 TABLET WORKS
HEALTROXIN 75 TABLET works by replacing the thyroid hormone which thyroid gland fails to produce in sufficient quantity in body thus treating the symptoms of hypothyroidism.
DIRECTIONS FOR USE
Take HEALTROXIN 75 TABLET as advised by your physician. Swallow the medicine with a glass of water on an empty stomach. Administer HEALTROXIN 75 TABLET to infants and children who are unable to swallow the intact tablets by crushing it and suspending the freshly crushed tablet in a small amount of water and immediately administering the fresh suspension by dropper or spoon. Do not store the suspension.
Your doctor will decide the correct dose and duration of HEALTROXIN 75 TABLET for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF HEALTROXIN 75 TABLET
COMMON
- skin rash
- itching
- mild leucopenia (reduced white blood cell count)
UNCOMMON
- signs of agranulocytosis (deficiency of certain white blood cells) such as increased vulnerability to infection
RARE
- hair loss
- seizures (fits)
Stop taking HEALTROXIN 75 TABLET and contact your doctor if you experience any of the following side effects:
- signs of heart problems such as chest pain, rapid/irregular heartbeat, pounding heartbeat and shortness of breath
- signs of heart attack such as crushing chest pain that radiates to the left arm and/or jaw, sweating, nausea, vomiting and shortness of breath
- signs of serious allergic reactions such as rash, raised red patches, swelling of the face, lips, tongue, or throat and difficulty swallowing or breathing
- signs of seizure (fits) such as muscle twitching, changes in emotions, confusion or loss of consciousness with uncontrollable shaking
- signs of increased pressure in the brain (in children) such as headaches, vison problems or complete loss of vision, double vision, ringing in the ears or pain in the arms
- signs of slipped capital femoral epiphysis (condition marked by weakened hip joint in children) such as stiffness/pain in the knee or groin, walking with a limp, inability to bear weight on the affected side.
- signs of osteoporosis (condition marked by decreased bone density) such as back pain, loss of height over time, stooped posture, broken bones
WARNING & PRECAUTIONS
PREGNANCY
HEALTROXIN 75 TABLET should be used with caution during pregnancy. Consult your doctor before taking HEALTROXIN 75 TABLET.
BREASTFEEDING
HEALTROXIN 75 TABLET should be used with caution in breastfeeding women as it may pass through breast milk. Consult your doctor before taking HEALTROXIN 75 TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines as it may affect your ability to drive and use machines while taking HEALTROXIN 75 TABLET. Consult your doctor before taking HEALTROXIN 75 TABLET.
KIDNEY
HEALTROXIN 75 TABLET is used with caution in patients with kidney problems such as renal impairment, end-stage renal disease, nephrotic syndrome, renal failure or patients with kidney transplant. Consult your doctor before taking HEALTROXIN 75 TABLET.
LIVER
HEALTROXIN 75 TABLET should be used with caution in patients with severe liver disease such as severe cirrhosis and other liver problems such as hepatic impairment. Consult your doctor before taking HEALTROXIN 75 TABLET.
ALLERGY
Do not take HEALTROXIN 75 TABLET if you are allergic to thyroxine sodium or any other ingredients of this medicine.
HEART DISEASE
HEALTROXIN 75 TABLET is not recommended for use if you had a recent heart attack, acute myocarditis (inflammation/swelling of the heart muscle) or acute pancarditis (general inflammation/swelling of the heart). It should be used with caution in patients with other heart problems such as coronary artery disease, angina or have a history of heart attack, heart disease or hardening of the arteries. Consult your doctor before taking HEALTROXIN 75 TABLET.
OTHERS
HEALTROXIN 75 TABLET is not recommended for use if you:
- have signs of overactive thyroid gland such as nervousness, anxiety and irritability, mood swings and difficulty sleeping
- have untreated adrenal insufficiency (a disorder marked by insufficient production of certain hormones)
- myxoedema coma (a rare life-threatening condition of untreated hypothyroidism)
Before taking HEALTROXIN 75 TABLET, inform your doctor if you:
- have high blood pressure
- have blood clotting disorders
- have psychotic disorders such as schizophrenia
- are a post-menopausal woman and have been on long-term thyroxine sodium therapy
- signs of malabsorption syndrome (condition marked by inability of small intestine to absorb sufficient nutrients) such as abdominal pain and distension, bloating and flatulence
- have diabetes
- are scheduled for any surgery
- have nontoxic diffuse goitre (enlarged thyroid gland) or nodular thyroid disease (condition marked by thyroid lumps)
- have hypothalamic/pituitary hormone deficiencies
- have autoimmune polyglandular syndrome (autoimmune disorder) such as adrenal insufficiency, pernicious anaemia
- are in weight control programme
Use in Paediatrics
HEALTROXIN 75 TABLET should be used with caution in children and adolescents (below 18 years of age). Consult your child’s doctor before administration of HEALTROXIN 75 TABLET to your child.
Use in Geriatrics
HEALTROXIN 75 TABLET should be used with caution in elderly patients (aged above 65 years). Consult your doctor before taking HEALTROXIN 75 TABLET.
INTERACTIONS
A. Drug-Drug Interactions
Before taking HEALTROXIN 75 TABLET, inform your doctor, if you are taking any of the following medicines:
- nutritional supplements Ex. calcium carbonate, ferrous sulfate, vitamin B3 (niacin/ nicotinic acid)
- medicines used to treat heart problems such as digitalis glycosides (Ex. digoxin), ketamine
- medicines used to lower blood pressure such as beta blockers Ex. propranolol, atenolol and metoprolol
- medicines used to prevent blood clotting such as blood thinners Ex. warfarin, heparin
- medicines used to treat abnormal heart rhythm Ex. amiodarone
- medicines used to dilate blood vessels to reduce blood pressure Ex. nitroprusside
- medicines used to increase urine output to reduce blood pressure such as diuretics Ex. furosemide
- medicines used to treat diabetes Ex. insulin, tolbutamide
- medicines used to treat digestion problems such as antacids (Ex. aluminium and magnesium hydroxides, simethicone), proton pump inhibitors (Ex. omeprazole), metoclopramide, sucralfate
- medicines used to lower high cholesterol levels Ex. colestipol, cholestyramine, lovastatin, colesevelam
- medicines to lower levels of phosphorus in the blood Ex. polystyrene sulfonate, sevelamer, lanthanum carbonate, sevelamer
- medicines used to treat mental health problems and seizures such antidepressants (Ex. sertraline, maprotiline, amitriptyline), lithium, perphenazine, carbamazepine, diazepam, methadone, heroin, phenobarbital, amionoglutethemide or hydantoins
- medicines used to treat certain cancers such as tyrosine kinase inhibitors (Ex. imatinib, sunitinib), tamoxifen, 5-flurouracil, mitotane, mercaptopurine, octreotide, interferon alpha (IFN-a), interleukin-2
- medicines used for weight loss Ex. orlistat, other diet pills
- medicines used to treat inflammatory conditions such as corticosteroids (Ex. dexamethasone and prednisone), non-steroidal anti-inflammatory drugs (Ex. fenamic acid, phenylbutazone and salicylates)
- X-ray contrast agents Ex. iodide
- medicines used to treat asthma or other breathing problems Ex. salbutamol
- medicines used to treat colds, sinus problems, hay fever or other allergies Ex. cetirizine
- medicine used to treat Parkinson’s disease and restless leg syndrome Ex. dopamine
- medicines used to treat bacterial, viral or fungal infections such as sulfamethoxazole, rifampin and resorcinol
- medicine used to treat HIV infection Ex. ritonavir
- medicines used to treat tuberculosis such as ethionamide
- synthetic hormones Ex. estrogens, somatotropin (a growth hormone), anabolic steroids or muscle building hormones Ex. asparaginase
- other medicines used to treat thyroid problems Ex. methimazole, carbimazole, propylthiouracil (PTU)
B. Drug-Food Interactions
Avoid taking consumption of grapefruit juice and food containing soybean flour, cottonseed meal, walnuts or dietary fibre while taking HEALTROXIN 75 TABLET, as these may bind and decrease the absorption of this medicine in the body.
Overdosage:
If you or anyone else accidentally takes too much of HEALTROXIN 75 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are weakness, increased appetite, weight loss, heat intolerance, fever, excessive sweating, headache, hyperactivity, nervousness, anxiety, irritability, emotional lability, sleeplessness, tremors, muscle weakness, muscle spasm, awareness of heartbeat, fast or irregular heartbeat, increased pulse rate, high blood pressure, heart failure, angina, heart attack, cardiac arrest, breathlessness, diarrhoea, vomiting, abdominal cramps, hair loss, flushing, rashes, decreased bone mineral density, menstrual irregularities, impaired fertility, seizures (life-threatening emergency characterized by poor circulation and decreased metabolic rate), confusion, disorientation, cerebral embolism (blockage of blood supply to brain), shock, coma, exophthalmic goitre (autoimmune disease), sleeplessness or acute psychosis.
SYNOPSIS
| Drug | : | Thyroxine sodium |
| Pharmacological Category | : | Thyroid hormone receptors |
| Therapeutic Indication | : | Hypothyroidism, papillary or follicular carcinoma of the thyroid gland |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep the medicine out of reach of children
- Store HEALTROXIN 75 TABLET at room temperature
FAQs ABOUT HEALTROXIN 75 TABLET
What is HEALTROXIN 75 TABLET used for?
HEALTROXIN 75 TABLET is used as a replacement therapy in the treatment of primary (thyroidal), secondary (pituitary) and tertiary (hypothalamic) congenital or acquired hypothyroidism. It is also used as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated papillary/follicular carcinoma of the thyroid gland.
Who should avoid taking HEALTROXIN 75 TABLET?
HEALTROXIN 75 TABLET is not recommended for use if you had a recent heart attack, acute myocarditis (inflammation/swelling of the heart muscle) or acute pancarditis (general inflammation/swelling of the heart). It is not indicated for use in patients with overactive thyroid gland or untreated adrenal insufficiency (inability of adrenal glands to make enough of the hormone cortisol). Consult your doctor before taking HEALTROXIN 75 TABLET.
How does HEALTROXIN 75 TABLET work?
HEALTROXIN 75 TABLET works by replacing the thyroid hormone which thyroid gland fails or unable to produce in sufficient quantity in body thus treating the symptoms of hypothyroidism.
What is the method of taking HEALTROXIN 75 TABLET?
Take HEALTROXIN 75 TABLET as advised by your physician. Swallow the medicine with a glass of water on an empty stomach. Administer HEALTROXIN 75 TABLET to infants and children who are unable to swallow the intact tablets by crushing it and suspending the freshly crushed tablet in a small amount of water and immediately administering the fresh suspension by dropper or spoon. Do not store the suspension. Your doctor will decide the correct dose and duration of HEALTROXIN 75 TABLET for you depending upon your age, body weight and disease condition.
Can [GBNKEYWORD] be used in heart patients?
HEALTROXIN 75 TABLET is not recommended for use if you had a heart attack, acute myocarditis (inflammation/ swelling of the heart muscle) or acute pancarditis (general inflammation/ swelling of the heart) recently. It should be used with caution in patients with other heart problems such as coronary artery disease and/or angina. Consult your doctor for advice before taking HEALTROXIN 75 TABLET.
What should I avoid eating while taking HEALTROXIN 75 TABLET?
Avoid taking food containing soybean flour, cottonseed meal, walnuts, grapefruit juice or dietary fibre while taking HEALTROXIN 75 TABLET as these may bind and decrease the absorption of this medicine in the body.
What if I forget to take a dose of HEALTROXIN 75 TABLET?
If you forget to take HEALTROXIN 75 TABLET dose, take it as early as possible, unless it is nearly the time for the next dose. If you skip the missed dose, then continue with your regular dosing schedule. Do not double up the dose to make up for the forgotten one. Consult your doctor if you miss 2 or more doses in a row.
When to stop taking HEALTROXIN 75 TABLET?
Do not stop taking this medicine unless your doctor instructs you to for stopping the intake of this medicine. However, stop taking HEALTROXIN 75 TABLET and contact your doctor if you experience any of the side effects such as chest pain, rapid or irregular heartbeat, awareness of heartbeat, shortness of breath, crushing chest pain, sweating, nausea, vomiting, shortness of breath, serious allergic reactions or increased pressure in the brain (in children).
Can HEALTROXIN 75 TABLET be used in pregnant or breastfeeding women?
HEALTROXIN 75 TABLET should be used with caution in pregnant women to avoid any potential side effects that can cause foetal abnormalities. It should be used with caution in breastfeeding women as it may pass into the breast milk. Consult your doctor before taking HEALTROXIN 75 TABLET.
Can I drive or use machines while taking HEALTROXIN 75 TABLET?
Do not drive or operate any machines as it may affect your ability to drive and use machines while taking HEALTROXIN 75 TABLET until you know how this medicine affects you. Consult your doctor before taking HEALTROXIN 75 TABLET.
Can HEALTROXIN 75 TABLET be used in children?
Yes, HEALTROXIN 75 TABLET can be used with caution in children and adolescents (below 18 years of age) after consulting the doctor. This medicine on indication can be given to infants and children (who are unable to swallow intact tablets) by crushing it and suspending the freshly crushed tablet in a small amount of water. Consult your child’s doctor for advice before administration of HEALTROXIN 75 TABLET to your child.
REFERENCES
1. Laurence L. Brunton. Goodman and Gilman’s; The Pharmacological Basics of Therapeutics. Twelfth edition. 2017. Page 1142-1143.
2. Philippe Colucci, Corinne Seng Yue, Murray Ducharme, Salvatore Benvenga. A Review of the Pharmacokinetics of Levothyroxine for the Treatment of Hypothyroidism. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. March 2013. [Accessed on 11th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193522/
3. L Bartalena, F Bogazzi, E Martino. Adverse effects of thyroid hormone preparations and antithyroid drugs. NIH National Library of Medicine. National Centre for Biotechnology Information. PubMed.gov. July 1996. [Accessed on 11th October 2022] https://pubmed.ncbi.nlm.nih.gov/8862963/
4. Neolpharma, Inc. Food and Drug Administration. [Revised in December 2017] [Accessed on 11th October 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021342s023lbl.pdf
5. BGP Pharma ULC. Synthroid. [Revised in September 2020] [Accessed on 11th October 2022] https://www.mylan.ca/-/media/mylanca/documents/english/product-pdf/synthroid-pm-en.pdf?la=en-ca
6. Steris Healthcare Pvt Ltd. Thyrorise. [Accessed on 11th October 2022] https://www.sterisindia.com/latest-update/thyroxine-sodium-t/1454
7. Macleods Pharmaceuticals Ltd. Thyrox. [Accessed on 11th October 2022] https://www.macleodspharma.com/products/
USEFUL DIAGNOSTIC TESTS
- Thyroid Function Test
- Thyroid Profile Free
- Thyroid Stimulating Hormone
- Anti-Thyroglobulin Antibody
AUTHOR DETAILS
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 19 Oct 2022 | 06:25 PM(IST)
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.