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Introduction About HAEM UP INJECTION
HAEM UP INJECTION contains Elemental Iron, which belongs to the group of medicines called Iron replacement medicines. It is used to manage iron deficiency anaemia (IDA) in adults and in children (above 14 years of age).
Your doctor may advise you to take relevant tests to understand your existing condition. Before receiving HAEM UP INJECTION inform your doctor if you are pregnant, planning to get pregnant, or breast-feeding women. HAEM UP INJECTION is not recommended for use in children and adolescents (under 14 years of age), and it should be used with caution in elderly patients (aged 65 years or older). Consult your doctor before receiving the HAEM UP INJECTION.
The most common side effects of receiving HAEM UP INJECTION may cause headache, dizziness, flushing, high blood pressure, nausea, and injection or infusion site reactions. Consult your physician if any of the above side effects worsen.
Uses Of HAEM UP INJECTION
- Used to manage iron deficiency anaemia
How HAEM UP INJECTION Works
HAEM UP INJECTION contains iron (III) hydroxide complexed with a carbohydrate polymer called carboxymaltose, which is capable of releasing iron. The iron released from the complex helps in the synthesis of haemoglobin and increases the red blood cell count. As a result, it manages iron-deficiency anaemia.
How to use HAEM UP INJECTION
HAEM UP INJECTION will be administered to you only by a doctor or a nurse into a vein as an intravenous injection or infusion. Your physician will decide the correct dose and duration for you depending on your age, body weight, and severity of the condition.
Side Effects Of HAEM UP INJECTION
Common
- headache
- dizziness
- flushing
- high blood pressure
- nausea
- injection/infusion site reactions
- low levels of phosphorous in the blood
Uncommon
- numbness, prickling or tingling sensation of the skin
- change in taste sensation
- difficulty breathing
- indigestion
- constipation
- diarrhoea
- skin rash
- muscle or joint pain, back pain, pain in the arms or the legs
- swelling of the hands and feet, and chills
Rare
- inflammation of the vein
- flatulence
Contact your doctor immediately if you experience any of the following side effects:
- Symptoms of a serious allergic reaction or Kounis syndrome (such as rashes, itching, swelling of the face, lips, mouth, tongue, throat, or body, causing difficulty breathing or wheezing, and chest pain)
- Severe or life-threatening allergic reactions are called anaphylactic reactions, which can be associated with heart problems, circulation problems (low blood pressure), and loss of consciousness
- Signs of a decrease in blood phosphorus causing softening of bones (osteomalacia) symptoms include worsening of tiredness, muscle or bone pain (pain in arms or legs, joints, or back), and may lead to fractures
- Signs of high blood pressure (such as facial flushing, dizziness, or nausea)
- Skin irritation and brownish discolouration of the skin at the injected site
How To Manage Side Effects
Constipation
Include fiber-rich foods in your diet, such as fresh fruits, vegetables, and whole grain cereals, and drink plenty of fluids. Consult your doctor if the symptom does not improve.
Diarrhea
Drink a lot of fluids, such as water or fruit juices, to keep yourself hydrated. Avoid eating high-fat or spicy foods. If the symptom does not improve, consult your doctor.
Headache
Take a rest and relax. Drink plenty of fluids, such as water. Apply a pain-relieving balm to the forehead if necessary. Consult your doctor if your headache does not improve.
Nausea And Vomiting
Stick to simple meals. Avoid eating oily, fried, or spicy foods. Do not lie down or go to sleep immediately after eating. Consult your doctor if the symptom does not improve.
Stomach Pain
Try to take a rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, consult your doctor.
Warning & Precautions
Pregnancy
Monitoring requiredHAEM UP INJECTION should be used with caution in pregnant women only if considered clearly necessary. Inform your doctor if you are pregnant, think you may be pregnant, or are planning to have a baby. Consult your doctor before receiving HAEM UP INJECTION.
Breastfeeding
Consult your doctorIf you are breastfeeding, consult your doctor for advice before receiving an HAEM UP INJECTION. It is unlikely that an HAEM UP INJECTION represents a risk to a breast-fed child.
Driving and Using Machines
Use with CautionHAEM UP INJECTION is unlikely to impair the ability to drive or operate machines.
Kidney
Use with CautionHAEM UP INJECTION should be used with caution in patients with chronic kidney disease who are dependent on haemodialysis management. Consult your doctor before receiving HAEM UP INJECTION.
Liver
Use with CautionHAEM UP INJECTION should be used with caution in patients with liver disease. Before receiving HAEM UP INJECTION, consult with your doctor.
Allergy
ContraindicatedDo not receive HAEM UP INJECTION if you are allergic to Elemental Iron or any of the other ingredients of this medicine or if you have experienced serious allergic reactions to other injectable iron preparations.
Lungs
Use with CautionHAEM UP INJECTION should be used with caution in patients with severe asthma. Consult your doctor before receiving the HAEM UP INJECTION.
Use In Pediatrics
ContraindicatedHAEM UP INJECTION is not recommended for use in children (under 14 years of age). Consult the child's doctor for advice on how to manage the condition.
Use In Geriatrics
Use with CautionHAEM UP INJECTION should be used with caution in elderly patients (aged 65 years or older). Consult your doctor before receiving the HAEM UP INJECTION.
Others
HAEM UP INJECTION is not recommended for use if you have:
- anaemia not caused by iron deficiency
- iron overload (too much iron in your body) or disturbances in the utilization of iron
Before receiving HAEM UP INJECTION inform your doctor if you have:
- systemic lupus erythematosus
- rheumatoid arthritis
- eczema or other allergies
- an infection
- low levels of phosphate in the blood
- high blood pressure
Interactions
A. Drug-Drug interactions:
Before receiving HAEM UP INJECTION, inform your doctor if you are using or have recently taken any other medicines, including prescription and non-prescription medicines, vitamins, or herbal supplements.
- Oral iron preparations such as ferrous ascorbate, ferrous sulphate, and ferric citrate (used to manage low levels of iron in the body)
Overdosage:
HAEM UP INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
Synopsis
| Drug | : | Elemental Iron |
| Pharmacological Category | : | Iron replacement medicines |
| Therapeutic Indication | : | Iron Deficiency Anemia (IDA) |
| Dosage Forms | : | Injection |
More Information
Storage
- Keep HAEM UP INJECTION out of reach of children
- Store at room temperature
FAQs About HAEM UP INJECTION
Q: What is the use of HAEM UP INJECTION?
A: HAEM UP INJECTION is used in the management of iron deficiency anaemia. Consult your doctor before receiving the medicine.
Q: How does HAEM UP INJECTION work?
A: HAEM UP INJECTION contains iron (III) hydroxide complexed with a carbohydrate polymer called carboxymaltose, which is capable of releasing iron. The iron released from the complex helps in the synthesis of haemoglobin and increases the red blood cell count. As a result, it manages iron-deficiency anaemia.
Q: Is HAEM UP INJECTION safe to use in patients with kidney problems?
A: HAEM UP INJECTION should be used with caution in patients with chronic kidney disease who are dependent on haemodialysis management. Consult your doctor before receiving HAEM UP INJECTION.
Q: Who should avoid taking HAEM UP INJECTION?
A: HAEM UP INJECTION is not recommended for use in patients with evidence of iron overload or disturbances in the utilization of iron, anaemia not caused by iron deficiency, known allergies to Elemental Iron, or serious allergies to other parenteral iron products.
Q: Is HAEM UP INJECTION safe to use with elderly patients?
A: HAEM UP INJECTION should be used with caution in elderly patients (aged 65 years or older). Your doctor may monitor you carefully during administration and at a certain time after administration of HAEM UP INJECTION. Consult your doctor before receiving the medicine.
Q: Can HAEM UP INJECTION be used during pregnancy?
A: [GNKEYWORD] should be used with caution in pregnant women only if clearly advised by your doctor. Inform your doctor if you are pregnant, think you may be pregnant, or are planning to have a baby. Consult your doctor before receiving HAEM UP INJECTION.
Q: Can HAEM UP INJECTION interact with other medications?
A: Yes, HAEM UP INJECTION can interact with other medications, including certain antibiotics, antifungals, antidepressants, and medications that affect heart rhythm. It's crucial to inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting HAEM UP INJECTION therapy to avoid potential interactions.
Q: How often do I need to take HAEM UP INJECTION?
A: The frequency of HAEM UP INJECTION will depend on your specific condition and management plan. Your healthcare provider will determine the appropriate dosing schedule for your condition.
Q: What should I do if I miss a dose of HAEM UP INJECTION?
A: It's crucial to follow your healthcare provider's instructions regarding management. If you miss a dose, contact your healthcare provider for guidance.
Q: What are the side effects of receiving HAEM UP INJECTION?
A: The most common side effects of receiving HAEM UP INJECTION includes headache, dizziness, flushing, high blood pressure, and nausea. Consult your physician if any of the side effects worsen.
Q: What precautions must be taken while receiving HAEM UP INJECTION?
A: Before receiving HAEM UP INJECTION, inform your doctor if you have liver, kidney disease, severe asthma, systemic lupus erythematosus, rheumatoid arthritis, eczema or other allergies, infections, low levels of phosphate in the blood, or high blood pressure.
Q: If a higher dose of HAEM UP INJECTION is administered, will I get faster results?
A: No. Do not receive more than the recommended dose of HAEM UP INJECTION, as it may increase the risk of unwanted side effects. Your doctor will decide the correct dose and duration depending on age, body weight, and disease conditions.
References
1. KD. Tripathi. Haematinics and Erythropoietin. Essentials of medical pharmacology. Seventh edition. 2013. Page-605.
2. Joao Ricardo Friedrischa and Rodolfo Delfini Cancadob. Intravenous Elemental Iron for the treatment of iron deficiency anemia. NIH. National Library of Medicine, National Center for Biotechnology Information. PMC PubMed Central. October 2015. [Accessed on 4th April 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4678908/
3. American Regent, Inc. Safety and Tolerability of Elemental Iron (FCM) Versus Standard of Care in Treating Iron Deficiency Anemia. NIH. U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in February 2018] [Accessed on 4th April 2024] https://clinicaltrials.gov/ct2/show/NCT00703937
4. Vifor France. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 4th April 2024] https://www.medicines.org.uk/emc/files/pil.5910.pdf
5. Vifor (International) Inc. U.S. Food & Drug Administration. [Revised in April 2021] [Accessed on 4th April 2024] https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/203565s014lbl.pdf
Useful Diagnostic Tests
- Complete Blood Count (CBC)/ Hemogram
- Ferritin /Iron Serum
- Iron Studies
- Iron Deficiency Profile
- Iron
- Total Iron Binding Capacity- TIBC
- Unsaturated Iron Binding Capacity (UIBC)
- Ferritin
- Anemia Basic Panel (Nutritional)
- Iron Deficiency Panel
- Iron Studies With Ferritin
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