Gluconorm G 1mg Tablet 15'S

Introduction About GLUCONORM G 1MG TABLET

Gluconorm G 1mg Tablet is a commonly used oral antidiabetic medication that combines Glimepiride 1mg and Metformin 500mg. It is mainly prescribed for adults with type 2 diabetes mellitus, especially when diet, exercise, or a single medicine are not enough to control blood sugar levels. This combination works through a dual-action mechanism, helping to manage blood glucose effectively and safely.

Gluconorm G 1mg Tablet should be taken with food, at the same time each day for best effectiveness. Your doctor will prescribe the appropriate dose for you and may adjust it over time depending on how well your blood sugar is managed.

Continue taking this medication as directed, even if you feel well or your blood sugar appears controlled. Stopping it without medical advice can cause your blood sugar to rise, increasing the risk of serious complications such as kidney damage, vision loss, nerve problems, and amputation. Remember, this medicine is just one part of your diabetes management plan, which should also include a healthy diet, regular physical activity, and weight management as recommended by your doctor. Your lifestyle choices play a crucial role in effectively managing diabetes.

The most common side effects of Gluconorm G 1mg Tablet include nausea, vomiting, diarrhea, stomach pain, dizziness, changes in taste, headache, upper respiratory tract infection and hypoglycemia (low blood sugar) with symptoms such as sweating, shakiness, headache, and confusion. To reduce the risk of low blood sugar, ensure you eat regular meals and always carry a quick source of glucose, such as sugary food or fruit juice, in case symptoms occur. Consuming alcohol can further increase your risk of hypoglycemia and should be avoided.

You should not use this medication if you have type 1 diabetes mellitus, diabetic ketoacidosis (a condition where there is too much acid in your blood), or if you suffer from severe kidney or liver problems. Inform your doctor if you have a history of heart disease, as this medication may not be appropriate for you. Pregnant or breastfeeding women should consult their doctor before starting this management. It is important to have your blood sugar checked regularly. Your doctor may also recommend blood tests to monitor your blood cell counts and liver function during management.

Uses Of GLUCONORM G 1MG TABLET

• Type 2 diabetes mellitus

Benefits of GLUCONORM G 1MG TABLET

1) Supports improved blood sugar control: Gluconorm G 1mg Tablet helps manage type 2 diabetes by improving the body’s sensitivity to insulin, reducing the amount of sugar produced by the liver, and enhancing glucose utilization. This contributes to more stable and balanced blood sugar levels.

2) Combination therapy for enhanced effect: This tablet combines Glimepiride and Metformin, which work together to both stimulate the pancreas to release more insulin and help the body use insulin efficiently. This dual action ensures more effective control of high blood sugar when diet, exercise, or a single medication is not enough.

3) Reduces the risk of diabetes-related complications: By controlling blood sugar levels, Gluconorm G 1mg Tablet lowers the risk of serious complications such as heart disease, kidney damage, eye problems, and nerve issues often associated with poorly managed diabetes.

4) Complements a healthy lifestyle: The medication supports the benefits of proper diet, regular exercise, and weight management, making it easier for patients to achieve and maintain their blood sugar targets as part of a comprehensive diabetes care plan.

5) May enable improved quality of life: Regular use as prescribed can help people with type 2 diabetes enjoy a more active, healthy lifestyle by minimizing fluctuations in blood glucose and supporting the lowering of long-term complications.

How GLUCONORM G 1MG TABLET Works

Gluconorm G 1mg Tablet contains two active ingredients: Glimepiride and Metformin, which work together to lower and control blood sugar in people with type 2 diabetes.

Mechanism of Action and Regulation of Insulin and Glucose:

Glimepiride belongs to the sulfonylurea class. It acts primarily by stimulating the beta cells of the pancreas to release more insulin. The increased insulin helps transport glucose from the blood into cells, lowering blood sugar levels. This effect is glucose-dependent, meaning more insulin is released in response to higher blood glucose.

Metformin works mainly by three mechanisms:

• It reduces glucose production in the liver (hepatic gluconeogenesis).
• It delays absorption of glucose from the intestines into the bloodstream.
• It increases the sensitivity of muscle and fat cells to insulin, allowing better uptake and utilization of glucose, further lowering blood sugar.

What Happens Inside the Body:

• After taking Gluconorm G 1mg, your pancreas produces more insulin (due to glimepiride), and your body's cells become more responsive to insulin (due to metformin).
• The liver slows down its release of glucose into the bloodstream, and your intestines absorb sugar from food more slowly.
• The combination provides better blood sugar control than either medicine alone, reducing the risk of high blood sugar complications and hypoglycemia if taken as directed.

Cellular Effects:

• At a cellular level, glimepiride engages with pancreatic potassium channels to trigger insulin release.
• Metformin acts at the liver cells (hepatocytes) by activating AMPK (AMP-activated protein kinase), a key cellular energy sensor, suppressing synthesis of glucose and fat, and increasing insulin sensitivity in peripheral tissues.

How to use GLUCONORM G 1MG TABLET

Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage.

Dosage and Administration:

• The dosage is individualized and determined by your doctor based on your blood sugar levels and response to management.
• Typically, it is taken once or twice daily with meals, but always follow your doctor’s specific instructions.
• Do not take more than the prescribed dose, as this increases the risk of low blood sugar (hypoglycemia).

How to Take:

• Swallow the tablet whole with a sufficient amount of water. Do not break, chew, or crush the tablet.
• For best results, take it at the same time each day to maintain an even level of the medicine in your body.

Food and Timing Guidelines:

• Always take with food to minimize the risk of stomach upset and low blood sugar.
• Avoid alcohol, as it can increase the risk of hypoglycemia.

Tips for Swallowing and Handling:

• Swallow the tablet whole with water. Do not split, cut, or crush the tablet.
• Store at room temperature in a dry place, away from moisture, and out of reach of children.

Maximum Daily Dose and Safety Considerations:

• The maximum daily dose depends on the combination of glimepiride and metformin in the tablet (typically not exceeding 2 mg glimepiride and 2000 mg metformin in split doses per day, but always follow your healthcare provider’s recommendation).
• Overdose can cause serious complications like severe hypoglycemia and lactic acidosis. If you suspect an overdose, seek immediate medical attention.
• Regular monitoring of blood sugar is essential while on this medication.
• Do not stop taking the medicine without consulting your doctor, even if you feel well

Side Effects Of GLUCONORM G 1MG TABLET

Like all medicines, Gluconorm G 1mg Tablet may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking Gluconorm G 1mg Tablet are:

• Nausea
• Vomiting
• Diarrhea
• Stomach pain
• Dizziness
• Changes in taste
• Headache
• Upper respiratory tract infection
• Hypoglycemia (low blood sugar) symptoms such as sweating, shakiness, headache, confusion

When to consult your doctor?

• Severe hypoglycemia (very low blood sugar) symptoms such as confusion, loss of consciousness, seizures, severe dizziness, sweating, shakiness, rapid heartbeat, or fainting.
• Lactic acidosis symptoms such as severe nausea or vomiting, persistent abdominal pain, muscle cramps, profound weakness or fatigue, difficulty breathing, a feeling of being severely unwell, slow, or irregular heartbeat, or a drop in body temperature.
• Severe allergic reactions symptoms such as sudden difficulty breathing, swelling of the face, lips, tongue, or throat, and widespread skin rash or hives.
• Serious liver or blood problems symptoms such as yellowing of the skin/eyes (jaundice), unusual bleeding or bruising, or severely decreased alertness.

How To Manage Side Effects

Headache

• Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
• Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
• Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
• Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
• Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.

Nausea And Vomiting

• Eat Small, Frequent Meals: Avoid heavy or greasy foods. Opt for bland foods like crackers, toast, or bananas.
• Stay Hydrated: Sip on clear fluids like water, ginger tea, or electrolyte drinks, Avoid caffeinated and carbonated beverages.
• Ginger: Ginger is a natural remedy for nausea. Try ginger tea, ginger candies, or ginger ale (ensure it contains real ginger).
• Avoid Strong Odors: Minimize exposure to smells that might trigger nausea, such as perfumes or cooking odors.

Warning & Precautions

Pregnancy

Consult your doctor

Gluconorm G 1mg Tablet should not be taken during pregnancy unless specifically advised by your doctor. If you are pregnant or planning to become pregnant, consult your doctor before taking this medicine.                                     

Breastfeeding

Consult your doctor

It is not known if Gluconorm G 1mg Tablet passes into human milk. Discuss with your doctor about the safest options for controlling your blood glucose while breastfeeding. Consult your doctor before taking it.   

Driving and Using Machines

Use with Caution

Do not drive or operate heavy machinery if you feel dizziness or weakness or confused on this medication, as these may be signs of low blood sugar (hypoglycemia). If you experience such symptoms, avoid activities that require full attention.

Alcohol

Contraindicated

Avoid alcohol consumption while taking Gluconorm G 1mg Tablet as it may increase your risk of hypoglycemia and lactic acidosis. 

Kidney

Consult your doctor

Gluconorm G 1mg Tablet is not recommended for use in patients with severe kidney problems and should be used cautiously in those with mild to moderate kidney impairment. Kidney function should be monitored regularly. Consult your doctor before taking it.

Liver

Consult your doctor

Gluconorm G 1mg Tablet is not recommended for use in patients with severe liver problems and should be used caution in patients with other liver problems. Liver function may need to be checked during management. Consult your doctor before taking it.  

Allergy

Contraindicated

Do not take this medicine if you are allergic to Glimepiride or Metformin, or any other ingredient in the tablet. 

Heart Disease

Consult your doctor

Gluconorm G 1mg Tablet is not recommended for patients with severe heart conditions such as recent heart attack or heart failure and should be used with caution in other heart conditions. Consult your doctor before taking this medicine.

Use In Pediatrics

Contraindicated

Gluconorm G 1mg Tablet is not recommended for use in children and adolescents under 18 years, as safety and efficacy have not been established in this age group. Consult your pediatrician before giving it.  

Use In Geriatrics

Use with Caution

Elderly patients (65 years and above) should use this medicine with caution, as they may be more susceptible to side effects like low blood sugar or kidney problems. Closer monitoring may be needed. Consult your doctor before taking it. 

Other Warnings for GLUCONORM G 1MG TABLET

Before taking GLUCONORM G 1MG TABLET inform your doctor if you:

• are recovering from injury, operation, infections with fever, or from other forms of stress
• have glucose-6-phosphate dehydrogenase (G6PD) deficiency
• have various factors which could increase the risk of low blood sugar levels (such as undernourishment, irregular mealtime, missed or delayed meal or period of fasting, change in diet, hormone-induced disorders)

Who should not take [GBNKEYWORD

GLUCONORM G 1MG TABLET is not recommended for use, if you have:  

• type 1 diabetes mellitus
• diabetic ketoacidosis 
• uncontrolled diabetes or ketoacidosis 
• dehydration 
• severe infection

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking Gluconorm G 1mg Tablet:

1. Diuretics (e.g., Thiazides like Hydrochlorothiazide)
   • Interaction: Thiazide diuretics can impair kidney function and may increase blood sugar levels, which can reduce the blood sugar-lowering effect of Gluconorm G.
   • Effects: Elevated blood sugar, dehydration, and increased risk of electrolyte imbalances such as low potassium (hypokalemia).
   • Management: Monitor blood glucose levels closely, adjust Gluconorm G dosage if needed, and monitor electrolytes (potassium and sodium). Consider potassium-sparing diuretics if appropriate.
      
2. Other Antidiabetic Medications (e.g., Insulin, Pioglitazone)
   • Interaction: Concurrent use increases the risk of hypoglycemia (low blood sugar).
   • Effects: Symptoms of hypoglycemia such as sweating, shakiness, dizziness, confusion, headache.
   • Management: Frequent blood sugar monitoring, adjusting doses to reduce hypoglycemia, carry fast-acting glucose sources like sugary food or fruit juice.
      
3. Blood Pressure Medicines (e.g., ACE inhibitors like Captopril, Beta-blockers like Atenolol)
   • Interaction: Some blood pressure drugs may enhance or reduce Gluconorm G’s effects or mask hypoglycemia symptoms.
   • Effects: Altered blood sugar control and possible unrecognized hypoglycemia due to masked symptoms like tremors or palpitations.
   • Management: Regular glucose monitoring and informing your doctor about all medications; adjust doses accordingly.
      
4. Antibiotics (e.g., Clarithromycin)
   • Interaction: May potentiate hypoglycemia risk when used with Gluconorm G.
   • Effects: Increased likelihood of low blood sugar episodes.
     • Management: Closely monitor blood glucose and seek medical advice if symptoms appear.
        
5. Drugs Affecting Liver or Kidney Function (e.g., Diclofenac, Ibuprofen, some diuretics)
   • Interaction: These may worsen kidney or liver function, increasing the risk of adverse effects or lactic acidosis.
   • Effects: Potential for serious toxicities and metabolic imbalances.
   • Management: Regular monitoring of liver and kidney function; adjust medication use carefully under medical supervision.
      
6. Oral Contraceptives, Phenytoin, Rifampicin
   • Interaction: These may decrease the blood sugar-lowering effect of Gluconorm G.
   • Effects: Possible loss of glycemic control with elevated blood sugar.
   • Management: Blood sugar monitoring and dose adjustment or alternative therapies as recommended by the doctor.

Drug - Food interaction

1. Alcohol
   • Interaction: Alcohol can increase the risk of hypoglycemia (low blood sugar) and lactic acidosis when taken with Gluconorm G.
   • Effects: Risk of very low blood sugar causing dizziness, confusion, sweating; and potentially life-threatening lactic acidosis. 
   • Management: Avoid all alcohol consumption while on this medication. If alcohol intake occurs, monitor blood sugar closely and seek medical advice if symptoms develop.
      
2. High-Carbohydrate Meals (Sugary or Starchy Foods)
   • Interaction: Consuming large amounts of sugar or carbohydrates can counteract the blood sugar-lowering effects of Gluconorm G.
   • Effects: Elevated post-meal blood glucose levels, reduced efficacy of the medication.
   • Management: Maintain a balanced, diabetes-appropriate diet with consistent carbohydrate intake as advised by your healthcare provider.
      
3. Foods High in Fiber (e.g., whole grains, vegetables)
   • Interaction: High-fiber foods can slow glucose absorption, which may alter the timing of blood sugar reduction by the medication.
   • Effects: More gradual lowering of blood sugar, potentially affecting timing of hypoglycemia risk.
   • Management: Continue a high-fiber diet as recommended, but closely monitor blood glucose to adjust medication timing if necessary.
      
4. Grapefruit and Grapefruit Juice
   • Interaction: Although not a major concern for glimepiride or metformin specifically, grapefruit may interfere with some medications' metabolism and could theoretically affect blood sugar control.
   • Effects: Potential change in drug blood levels causing altered effectiveness or side effects.
   • Management: Avoid or limit grapefruit products unless your doctor says otherwise.
      
5. Caffeine (Coffee, Tea, Energy Drinks)
   • Interaction: Caffeine may temporarily raise blood sugar levels or affect insulin sensitivity in some individuals.
   • Effects: Possible minor increases in blood glucose or fluctuations.
   • Management: Monitor your response to caffeine and maintain consistent intake; discuss with your doctor if unsure.
      
6. Vitamin B12-Rich Foods/Supplements
   • Interaction: Long-term use of metformin (part of Gluconorm G) can reduce vitamin B12 absorption.
   • Effects: Risk of B12 deficiency leading to anemia or neuropathy if not managed.
   • Management: Ensure adequate dietary intake of vitamin B12 or consider supplements after consulting your doctor.

Synopsis

More Information

01. What diet and exercise habits should I follow when taking Gluconorm G 1mg Tablet?

Additional Tips:

• Always carry a fast-acting sugar source (like fruit juice or glucose tablets) to raise blood sugar if hypoglycemia symptoms occur.
• Monitor your blood glucose regularly before and after exercise to understand how activity affects your sugar levels.
• Consistency in diet and exercise along with Gluconorm G 1mg enhances overall diabetes management and reduces complication risks.

2. How does Gluconorm G 1mg Tablet compare to other antidiabetic medications with similar ingredients?

Conclusion:

• Gluconorm G 1mg Tablet offers a convenient and effective dual therapy option with glimepiride and metformin, suitable for many type 2 diabetes patients needing combination therapy.
• Other brands with the same active ingredients work similarly; differences mainly lie in dosing, formulation, and price.
• Triple combination pills that add a DPP-4 inhibitor (e.g., sitagliptin) to glimepiride and metformin may offer improved glycemic control in patients inadequately controlled by dual therapy but with increased considerations for side effects and cost.

3. Why do doctors recommend combination medicines like Gluconorm G 1mg Tablet for certain diabetes patients?

• Improved Blood Sugar Control: Combination therapy uses drugs that work by different mechanisms to more effectively lower and stabilize blood glucose levels compared to using a single medication alone. For example, Gluconorm G combines Glimepiride (stimulates insulin secretion) and Metformin (reduces liver glucose production and improves insulin sensitivity), providing a more comprehensive approach.
• Address Multiple Pathways: Diabetes is a complex condition affecting various metabolic pathways. Combining medications targets multiple aspects of the disease simultaneously, compensating for limitations of single drugs and enhancing overall efficacy.
• Reduce Drug Dosage and Side Effects: By using lower doses of two or more drugs, combination therapy can minimize the adverse effects associated with higher doses of single drugs, improving tolerability and patient adherence.
• Delay or reduce Complications: Better glycemic control through combination therapy reduces the risk or progression of diabetes-related complications such as heart disease, kidney damage, and nerve problems.
• Simplify management Regimen: Fixed-dose combination pills reduce the number of tablets a patient must take daily, improving medication adherence and convenience.
• Personalized management: Combination medicines enable doctors to tailor therapy to the specific needs, health status, and risk profile of the patient, including those with existing heart or kidney disease, or those who do not achieve targets with monotherapy.
• Recommended for Patients with High Blood Sugar or Complications Risk: For patients with type 2 diabetes inadequately controlled by monotherapy or at higher risk of complications, combination therapy is often necessary to achieve and maintain target glucose levels.

FAQs About GLUCONORM G 1MG TABLET

References

1. KD Tripathi MD. Hormones and related drugs. Essentials of medical pharmacology. Seventh edition. New Delhi, May 2013. Page – 274.

2. Rakesh Kumar Sahay, Vinod Mittal, G Raja Gopal, Sunil Kota, Ghanshyam Goyal, Mahesh Abhyankar, Santosh Revenkar. Glimepiride and Metformin Combinations in Diabetes Comorbidities and Complications: Real-World Evidence. September 2020. [Accessed on July 30th 2025]

3. Sanofi. Efficacy and Safety Comparison of Metformin/Glimepiride Combination Versus Each Compound Alone in New Diagnosed Type 2 Diabetes Patients (RECOMMEND). NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in January 2015] [Accessed on July 30th 2025] 

4. Torrent pharmaceuticals Ltd. Azulix MF. Metformin Hydrochloride Prolonged Release and Glimepiride Tablets I.P. [Revised in July 2019] [Accessed on July 30th 2025] 

5. Sanofi-aventis group. Amaryl M. Glimepiride + Metformin. [Revised in May 2015] [Accessed on July 30th 2025]

Useful Diagnostic Tests

• Random Blood Sugar (RBS)
• Fasting Blood Sugar (FBS)
• Post Prandial Blood Sugar (PPBS)
• Sugar Risk Package
• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Jaya Prabakaran - MBBS, MD (Diabetology and Family Medicine)

Last updated on 05 Aug 2025 | 09:39 AM(IST)