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INTRODUCTION
GLIPTIRRYL V 50 TABLET contains Vildagliptin which belongs to group of medicines called Oral Anti-diabetics. It is used in adults to treat type 2 diabetes which helps to control the blood sugar level when diet and exercise becomes insufficient to control the disease.
Type 2 diabetes mellitus is a medical condition in which the body does not make enough insulin or if the insulin that the body makes is insufficient leading to high blood sugar level in the body. It is generally characterized by symptoms such as excessive thirst, frequent urination, excessive hunger, unintended weight loss and tiredness.
Along treatment with GLIPTIRRYL V 50 TABLET, your doctor might advise you to follow the diet and/or exercise which is beneficial. Avoid consumption of alcohol while taking GLIPTIRRYL V 50 TABLET because it might lead to low blood glucose levels.
Before taking GLIPTIRRYL V 50 TABLET, inform your doctor if you are on dialysis or have diabetic ketoacidosis (serious complication of diabetes), pancreatic disease, heart failure and liver or kidney disease.
GLIPTIRRYL V 50 TABLET is not recommended for use in pregnant and breast-feeding women, which is also not recommended for use in children and adolescents (aged below 18 years). It should be used with caution in elderly patients (aged 65 years and above).
The side effects of taking GLIPTIRRYL V 50 TABLET are dizziness, headache, joint pain and constipation. Consult your doctor if any of the side effects worsen.
USES OF GLIPTIRRYL V 50 TABLET
- Treats type 2 diabetes
HOW GLIPTIRRYL V 50 TABLET WORKS
GLIPTIRRYL V 50 TABLET controls blood glucose level by acting on the pancreas to produce more insulin and less glucagon which leads to low production of blood sugar levels resulting in controlled blood glucose levels.
DIRECTIONS FOR USE
Take GLIPTIRRYL V 50 TABLET as advised by your physician. Do not crush or chew GLIPTIRRYL V 50 TABLET. Swallow the medicine with a glass of water. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF GLIPTIRRYL V 50 TABLET
COMMON
- dizziness
UNCOMMON
- headache
- constipation
- swollen hands, ankle or feet (oedema)
- joint pain
- signs of low blood glucose levels such as excessive hunger, sweating, tiredness
RARE
Stop taking GLIPTIRRYL V 50 TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of angioedema (such as swollen face, tongue or throat, difficulty swallowing, difficulty in breathing, sudden onset rash or hives)
- signs of liver disease (hepatitis) such as loss of appetite or dark-coloured urine, yellow skin and eyes, nausea
- signs of inflammation of the pancreas such as severe and persistent pain in the abdomen (stomach area), nausea and vomiting
HOW TO MANAGE SIDE EFFECTS
Constipation
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. If the symptom does not improve, consult your doctor.
Dizziness Or Drowsiness
Lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol and drugs. Consult your doctor if the symptom gets worse.
Headache
Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedGLIPTIRRYL V 50 TABLET is not recommended for use in pregnant women. Consult your doctor before taking it.
BREASTFEEDING
ContraindicatedGLIPTIRRYL V 50 TABLET is not recommended for use in breastfeeding women or women who plan to breast-feed. Consult your doctor before taking it.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any machines if you feel dizziness after taking GLIPTIRRYL V 50 TABLET.
ALCOHOL
ContraindicatedAvoid consumption of alcohol while taking GLIPTIRRYL V 50 TABLET because it might lead to hypoglycemia (lowering of blood glucose levels).
KIDNEY
Use with CautionGLIPTIRRYL V 50 TABLET should be used with caution in patients with moderate or severe kidney disease and in patients who are undergoing dialysis. Consult your doctor before taking it.
LIVER
Use with CautionGLIPTIRRYL V 50 TABLET should be used with caution in patients with liver disease. Consult your doctor before taking it.
ALLERGY
ContraindicatedDo not take GLIPTIRRYL V 50 TABLET if you are allergic to Vildagliptin or any other ingredients of this medicine.
HEART DISEASE
Use with CautionGLIPTIRRYL V 50 TABLET should be used with caution in patients suffering from heart failure. Consult your doctor before taking it.
USE IN PEDIATRICS
ContraindicatedGLIPTIRRYL V 50 TABLET is generally not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.
USE IN GERIATRICS
Use with CautionGLIPTIRRYL V 50 TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking it.
OTHERS
Before taking GLIPTIRRYL V 50 TABLET, inform your doctor if you:
- have type 1 diabetes (i.e. your body does not produce insulin)
- have a condition called diabetic ketoacidosis (serious complication of diabetes)
- have intolerance to certain sugars
- had or have a disease of the pancreas
INTERACTIONS
A. Drug - Drug interactions:
Before taking GLIPTIRRYL V 50 TABLET, inform your doctor if you are taking any of the following medicines:
- oral antidiabetics (medicine used to treat type 2 diabetes) Ex. sulphonylureas such as gliclazide, glipizide
- digoxin (used to treat heart failure)
- warfarin (used to treat blood clot)
- amlodipine, ramipril, valsartan and angiotensin-converting enzyme (ACE) inhibitors (used to treat high blood pressure) such as captopril, enalapril, fosinopril
- simvastatin (used to reduce high cholesterol levels)
- thiazides or other diuretics (medicines used to treat high blood pressure) Ex. chlorothiazide, chlorthalidone, hydrochlorothiazide
- corticosteroids (used to treat inflammation) Ex. prednisolone
- certain medicines affecting nervous system such as antidepressants Ex. clomipramine, amitriptyline
- thyroid medicines (used to lower thyroid levels) Ex. levothyroxine
Over dosage:
If you or anyone else accidentally takes too much of GLIPTIRRYL V 50 TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of GLIPTIRRYL V 50 TABLET are muscle pain, mild and transient paraesthesia (burning and prickling sensation in hands and legs), fever, oedema (swelling in arms and legs) and laboratory abnormalities such as transient increase in lipase levels, increases in creatine phosphokinase (CPK), aspartate aminotransferase (AST), C-reactive protein (CRP) and myoglobin levels.
SYNOPSIS
| Drug | : | Vildagliptin |
| Pharmacological Category | : | Dipeptidyl peptidase-4 (DPP-4) inhibitors |
| Therapeutic Indication | : | Type II diabetes mellitus |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep GLIPTIRRYL V 50 TABLET out of reach of children
- Store at room temperature
FAQs ABOUT GLIPTIRRYL V 50 TABLET
Q: Can GLIPTIRRYL V 50 TABLET be used to treat diabetes mellitus?
A: Yes, GLIPTIRRYL V 50 TABLET lowers blood glucose levels and it is specifically used to treat type II diabetes mellitus which is a medical condition where the body does not make enough insulin or if the produced insulin that the body makes is not optimal leading to increased blood glucose levels in the body. Consult your doctor before taking GLIPTIRRYL V 50 TABLET.
Q: Can I take GLIPTIRRYL V 50 TABLET along with other hypoglycemic drugs like metformin or glimepiride?
A: Using GLIPTIRRYL V 50 TABLET along with other hypoglycemic drugs like metformin, glimiperide may drastically lower your blood glucose levels. So, be cautious and inform your doctor before taking any other anti-diabetic medicines.
Q: Does taking GLIPTIRRYL V 50 TABLET cause weight gain?
A: No, GLIPTIRRYL V 50 TABLET has no effect on weight gain. Moreover, these kinds of medicines delay gastric emptying and make you feel satiety (stomach fullness). These further decreases hunger. So, basically GLIPTIRRYL V 50 TABLET has no effect or it does not influence weight gain.
Q: How does GLIPTIRRYL V 50 TABLET work?
A: GLIPTIRRYL V 50 TABLET controls blood glucose level by acting on the pancreas to produce more insulin and less glucagon which leads to low production of blood sugar levels resulting in controlled blood glucose levels.
Q: Does GLIPTIRRYL V 50 TABLET cause dizziness?
A: Yes, GLIPTIRRYL V 50 TABLET may cause dizziness in some individuals. To manage this effect, lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol and drugs. Consult your doctor if the symptom gets worse.
REFERENCES
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 275
2. B Ahren , A Schweizer, S Dejager, E B Villhauer, B E Dunning, J E Foley. Mechanisms of action of the dipeptidyl peptidase-4 inhibitor vildagliptin in humans. NIH National Library of Medicine. National Center for Biotechnology Information.PubMed.gov. [Revised in September 2011] [Accessed on 14th April 2022] https://pubmed.ncbi.nlm.nih.gov/21507182/
3. Kalyan Kumar Gangopadhyay and Parminder Singh. Consensus Statement on Dose Modifications of Antidiabetic Agents in Patients with Hepatic Impairment. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. [Revised in March 2017] [Accessed on 14th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367241/
4. Novartis Europharm Limited. Electronic Medicines Compendium (EMC) [Revised in October 2020] [Accessed on 14th April 2022] https://www.medicines.org.uk/emc/files/pil.6225.pdf
5. Novartis Pharma GmbH. European Medicines Agency (EMA). [Revised in July 2012] [Accessed on 14th April 2022] https://ec.europa.eu/health/documents/community-register/2007/2007092629572/anx_29572_en.pdf
USEFUL DIAGNOSTIC TESTS
- HA1C Test
- Fasting Blood Sugar Test
- Random Blood Sugar Test
- Glucose Tolerance Test
AUTHOR DETAILS
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 19 Oct 2023 | 06:02 PM(IST)
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