Fungisome 10mg Injection 10ml

Fungal Rx required
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INTRODUCTION

FUNGISOME 10MG contains Amphotericin B which belongs to a group of medicines known as anti-fungal antibiotics. It is indicated for severe life threatening fungal infections and visceral leishmaniasis (developed by parasite).

Amphotericin B is an antifungal medicine, which can be fungistatic or fungicidal, depends on its concentration and fungal susceptibility, which acts by binding to ergosterol in the fungal cell membrane eventually causes membrane damage.  This results in cell contents leak from the fungal cell and cell death happens. It has greater affinity for fungal ergosterol than for the cholesterol of human cells. Amphotericin B is a macrocyclic which is created from a strain of Streptomyces nodosus.

FUNGISOME 10MG will be administered by physician or nurse, inform your physician if you have or had liver, kidney or heart problems, are pregnant women or breastfeeding mothers. This medicine is not suitable for babies less than 1 month old. The common side effects are nausea, vomiting, fever, chills and decrease in potassium levels.

USES OF FUNGISOME 10MG

  • Treats severe life threatening fungal infections and Leishmaniasis

HOW FUNGISOME 10MG WORKS

Amphotericin B works by slowing the growth of fungi that causes infection.

DIRECTIONS FOR USE

FUNGISOME 10MG will be administered as an infusion into a vein (drip) by physician or nurse.

SIDE EFFECTS OF FUNGISOME 10MG

COMMON

  • fever, chills
  • decrease in blood potassium levels
  • nausea or vomiting
  • increase in blood sugar levels
  • headache
  • fast heart rate
  • decrease in blood pressure and flushing
  • breathlessness
  • diarrhoea
  • stomach pain
  • rash
  • chest and back pain
  • abnormal liver or kidney test results

HOW TO MANAGE SIDE EFFECTS

Nausea:

Stick to regular meals and avoid spicy foods.

Diarrhoea:

Take large amount of fluids to avoid dehydration. ORS can also be used to prevent dehydration.

Vomiting:

Drink ice-cold drinks and eat light foods and avoid sweets.

Abdominal pain:

Place a warm water bottle on your abdomen or soak in a warm bath. Drink sufficient amount of water.

Headache:

Rest in a quiet, comfortable, and dark room with a cold or wet cloth on your temple.

WARNING & PRECAUTIONS

PREGNANCY

FUNGISOME 10MG should be used with caution in pregnant women. Consult your doctor before taking this medicine.

BREASTFEEDING

FUNGISOME 10MG should be used with caution in breastfeeding mothers. Consult your doctor before taking this medicine.

DRIVING AND USING MACHINES

Do not drive or operate any machines, FUNGISOME 10MG could affect your ability to drive or use machines safely.

KIDNEY

FUNGISOME 10MG should be used with caution if you are suffering from kidney failure or undergoing dialysis. Consult your doctor for advice.

ALLERGY

Do not take if you are allergic (hypersensitive) to Amphotericin B.

OTHERS

Tell your physician if you have or had a condition, such as,

  • severe allergic reaction (anaphylactic or anaphylactoid)
  • low potassium levels
  • white blood cell transfusion
  • diabetes

INTERACTIONS

Tell your doctor if you are taking,

  • ciclosporin and tacrolimus (suppress the immune system)
  • gentamicin, neomycin, streptomycin and polymixin (treats infection)
  • pentamidine (treats pneumonia along with AIDS and leishmaniasis)
  • corticosteroids
  • corticotropin (controls the amount of corticosteroid produced by your body)
  • furosemide  
  • digitalis glycosides (treats heart failure)
  • tubocurarine  
  • flucytosine (treats fungal infection)
  • methotrexate, doxorubicin, carmustine and cyclophosphamide (treats cancer)
  • white blood cell transfusions

SYNOPSIS

Drug :   Amphotericin B
Pharmacological Category :   Antifungal Agent
Therapeutic Indication :   Life-threatening fungal infections, Leishmaniasis
Dosage Forms :   Injection, Topical gel

MORE INFORMATION

Store at 2 - 8°C and keep out of reach of children.

FAQs ABOUT FUNGISOME 10MG

How long will it take FUNGISOME 10MG to be administered?

It usually takes 30 to 60 minutes. In case of high doses it may take up to 2 hours.

Does FUNGISOME 10MG a fungicidal?

Yes, this medicine is fungicidal in nature, which kills the fungi.

Is FUNGISOME 10MG testing dose needed?

Yes, testing dose is needed, to check if you have any allergic condition before starting the treatment.

REFERENCES

1. KD Tripathi MD. General considerations. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 689.

2. Phillips MA, Stanley SL Jr. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page - 1424.

3. Bennett JE. Antifungal Agents. In: Brunton LL, Chabner BA, Knollmann BC, editors. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. New York, New York: McGraw-Hill Medical; 2011. Page: 1571-1575.

4. Sheppard D, Lampiris HW. Antifungal Agents. In: Katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. 11th ed. New Delhi, India: Tata McGraw Hill Education Private Limited; 2009. Page: 836-838.

5. Neil RH Stone, Tihana Bicanic, Rahuman Salim, and William Hope. Liposomal Amphotericin B: A review of the pharmacokinetics, pharmacodynamics, clinical experience and future directions. March, 2016. [Accessed May 25, 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856207/

6. Gilead Sciences International Ltd. Electronic Medicines Compendium (EMC); [Revised Sep, 2020] [Accessed May 25, 2021] https://www.medicines.org.uk/emc/files/pil.1022.pdf

7. Teva Pharma B.V. Millmount Healthcare Limited. Electronic Medicines Compendium (EMC); [Revised Dec, 2020] [Accessed May 25, 2021] https://www.medicines.org.uk/emc/files/pil.5407.pdf

8. Cipla. [Revised Sep, 2013] [Accessed May 25, 2021] https://www.ciplamed.com/content/phosome-injection

USEFUL DIAGNOSTIC TESTS

  • Complete Blood Count
  • Peripheral Smear Examination

PRODUCT DETAILS

    Net Qty
    1
    Item Weight
    20
    Ingredient
    AMPHOTERICIN B 10MG
    Hsn Code
    30049029
ALTERNATE BRANDS
Lambin 10mg Injection 10ml
Prescription Fungal Fungal Infections Rx required
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