Fruselac Tablet 10'S

Introduction About FRUSELAC TABLET

FRUSELAC TABLET is a combination medication containing spironolactone (a potassium-sparing diuretic) and furosemide (a loop diuretic). It is commonly prescribed by healthcare professionals to help manage fluid retention while maintaining appropriate potassium levels. This formulation works by promoting the removal of excess fluid from the body without causing significant potassium loss.

It is recommended to take FRUSELAC TABLET in the morning with food to help reduce frequent urination during the night. For optimal results, try to take it at the same time each day. The dosage and frequency will depend on the condition being managed, as determined by your doctor. Continue taking the medication for the full duration prescribed by your doctor.

Common side effect of this medication includes dehydration, dryness of mouth, thirst, weakness, lethargy, muscle pains, low blood pressure, dizziness, headache, nausea or vomiting, gynecomastia (in males), increased urination and electrolyte imbalance. Therefore, it is important to regularly monitor kidney function and electrolyte levels while taking this medication.

Before taking FRUSELAC TABLET inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you are severely dehydrated or have diabetes, gout, prostate problems, or low blood pressure which makes you feel dizzy while standing up or changing position. It is not recommended for use in patients with severe low sodium levels in their blood. It is also not suitable for use in pregnant or breastfeeding women due to increased risk of side effects.

Uses Of FRUSELAC TABLET

• Edema (fluid retention)

Benefits of FRUSELAC TABLET

01)Supports effective management of fluid retention and swelling (edema) caused by certain conditions:

FRUSELAC TABLET is commonly prescribed to manage fluid retention and swelling (edema) caused by conditions such as heart disease, liver disease, or kidney problems. By helping the body get rid of excess fluid, it reduces swelling in areas like your legs, ankles, or abdomen, helping you feel more comfortable.

02) Helps maintain electrolyte balance, especially potassium, in the body:

One of the key functions of FRUSELAC TABLET is maintaining a healthy balance of electrolytes in your body, especially potassium. Potassium is essential for the proper functioning of your heart, muscles, and nerves. FRUSELAC TABLET helps to reduce potassium levels from dropping too low, ensuring your body stays in balance.

03) Often recommended as part of long-term wellness plans for individuals with specific fluid imbalance needs:

For people with chronic conditions like heart failure or cirrhosis, FRUSELAC TABLET can be an important part of your ongoing health management. It helps control fluid buildup over time, which can support better overall health and well-being. By preventing fluid retention, it reduces the strain on your heart and kidneys, allowing you to live a healthier life.

04) Dual-action formula combines the benefits of two active components for synergistic effectiveness

FRUSELAC TABLET combines the benefits of two active ingredients that work together to tackle both fluid retention and electrolyte imbalance. This dual-action formula provides enhanced effectiveness compared to other treatments, offering you better control over your condition.

How FRUSELAC TABLET Works

FRUSELAC TABLET works by combining two diuretics such as spironolactone and furosemide to effectively remove excess fluid from the body while maintaining electrolyte balance. Furosemide acts on the loop of Henle in the kidneys to increase the excretion of sodium, chloride, and water, leading to rapid diuresis and relief from fluid overload. Meanwhile, spironolactone blocks the action of aldosterone, reducing sodium retention and preventing the loss of potassium. Together, they promote fluid removal in conditions like heart failure, liver cirrhosis, or kidney disease while minimizing the risk of potassium deficiency.

How to use FRUSELAC TABLET

Follow your doctor's instructions regarding the exact dosage. Do not exceed the recommended daily dosage. Do not stop the medication without consulting your doctor, even if you feel better.

How to Take FRUSELAC TABLET ?

Dosage: Take exactly as prescribed by your doctor, usually once daily, preferably in the morning to avoid nighttime urination.

With or without food: It can be taken with food to reduce stomach upset.

Swallow whole: Do not crush or chew the tablet.

Stay hydrated: Drink adequate water unless otherwise advised by your doctor.

Avoid high-potassium foods (like bananas, oranges) unless directed, as spironolactone can increase potassium levels.

Regular monitoring: Your doctor may ask for periodic blood tests to monitor electrolytes and kidney function.

Practical Tips for Users:

• Setting Reminders: Consider using a daily alarm or reminder on your phone to ensure you take your medication at the same time every day.
• Track Your Doses: Keeping a simple medication log can help you track when you have taken the medication, making it easier to avoid missed doses.
• Avoid Overdosing: Do not exceed the recommended dosage. If you accidentally take more than prescribed, contact your doctor immediately.

What if I forgot to take FRUSELAC TABLET

If you forget to take a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose. Do not take two doses at once to make up for a missed dose.

Side Effects Of FRUSELAC TABLET

Like all medicines, FRUSELAC TABLET may cause certain side effects in some individuals, although not everybody gets them.

The most common side effects of taking FRUSELAC TABLET are:

• Dehydration
• Dryness of mouth
• Thirst
• Weakness
• Lethargy
• Muscle pains
• Low blood pressure
• Dizziness
• Headache
• Nausea or vomiting
• Gynecomastia (in males)
• Increased urination
• Electrolyte imbalance

When to consult your doctor?

• High potassium (hyperkalemia) symptoms such as muscle weakness, irregular heartbeat, or palpitations, tingling or numbness (especially around the mouth or in hands/feet), sudden fatigue
• Allergic reaction symptoms such as swelling of face, lips, tongue, or throat, difficulty breathing, severe skin rash or itching
• Severe dehydration or electrolyte imbalance symptoms such as dizziness or fainting, confusion or mental changes, extreme thirst or dry mouth, muscle cramps or weakness
• Kidney problems symptoms such as little or no urine output, swelling in legs or feet, rapid weight gain
• Liver problem symptoms such as yellowing of the skin or eyes (jaundice), dark urine, pale stools, abdominal pain or swelling

How To Manage Side Effects

Dizziness Or Drowsiness

• Sit or Lie Down: If you feel dizzy, sit down or lie down immediately to prevent falling. Keep your head still and close your eyes if needed.
• Hydrate: Dehydration can cause dizziness, so drink water or electrolyte-replenishing drinks like sports drinks.
• Avoid Sudden Movements: When standing or sitting, do so slowly to avoid triggering dizziness. Take your time when getting up.
• Eat Small, Regular Meals: Low blood sugar can cause dizziness, so eat small meals throughout the day and avoid skipping meals.
• Fresh Air: Sometimes dizziness can be alleviated by taking slow, deep breaths in a well-ventilated area.

Headache

• Rest in a Quiet, Dark Room: Find a calm, quiet space away from bright lights and loud noises. Lie down and close your eyes.
• Hydrate: Dehydration can contribute to headaches, so drink plenty of water.
• Apply a Cold or Warm Compress: A cold pack on your forehead may reduce pain, or a warm compress on your neck or shoulders can relieve tension.
• Over-the-Counter Pain Relief: You can take over-the-counter pain relievers like acetaminophen or ibuprofen if appropriate for you. Follow the recommended dosage.
• Practice Relaxation Techniques: Deep breathing exercises, meditation, or gentle stretching can help reduce stress and alleviate headache symptoms.

Warning & Precautions

Pregnancy

Contraindicated

FRUSELAC TABLET is not recommended for use in pregnant women. It is important to consult your doctor before taking this medication.

Breastfeeding

Contraindicated

FRUSELAC TABLET is not recommended for use in breast-feeding women. It is important to consult your doctor before taking this medication.

Driving and Using Machines

Use with Caution

Do not drive or operate any machines if you feel dizziness or unwell or tiredness after taking it.

Alcohol

Consult your doctor

Avoid consumption of alcohol while taking FRUSELAC TABLET as it might make you feel more dizziness.

Kidney

Consult your doctor

FRUSELAC TABLET is not recommended for use in patients with severe kidney diseases and should be used with caution in patients with other minor kidney problems. Consult your doctor before taking it.

Liver

Consult your doctor

FRUSELAC TABLET is not recommended for use in patients with severe liver diseases and should be used with caution in patients with other minor liver problems. Consult your doctor before taking it.

Allergy

Contraindicated

Do not take this medication if you are allergic to Frusemide or Spironolactone, or sulphonamides (Ex. sulfadiazine).

Use In Pediatrics

Contraindicated

FRUSELAC TABLET is generally not recommended for use in children and adolescents (aged below 18 years). Consult your pediatrician before giving it.

Use In Geriatrics

Use with Caution

FRUSELAC TABLET should be used with caution in elderly people (aged 65 years and above) especially in patients undergoing management for mental illness. Therefore, consult your doctor before taking it.

Other Warnings for FRUSELAC TABLET

Before taking FRUSELAC TABLET, inform your doctor if you:

• feel dizzy upon standing up or changing position
• have diabetes
• have difficulty in passing urine
• have prostate cancer or other problems in prostate
• have gout

Who should not take [GBNKEYWORD

FRUSELAC TABLET is not recommended for use if you:

• have a low blood volume (hypovolemia) or severely dehydrated
• pass scanty urine or no urine at all
• have low or high levels of sodium or potassium in the blood
• have Addison's disease (problems with adrenal glands)

Drug - Drug interaction

Inform your physician if you are taking any of the following medicine before taking FRUSELAC TABLET :

1. Potassium Supplements and Potassium-Sparing Agents

• Interaction: High risk of hyperkalemia (elevated potassium levels).
• Examples: Potassium chloride, ACE inhibitors (like enalapril), ARBs (like losartan), aliskiren.
• Effects: Muscle weakness, heart rhythm abnormalities, confusion.
• Management:
  • Monitor serum potassium and renal function regularly.
  • Avoid combining with other potassium-retaining drugs unless necessary.
  • Educate patients to avoid high-potassium foods.

2. ACE Inhibitors and ARBs

• Interaction: Increased risk of hyperkalemia and renal impairment.
• Examples: Lisinopril, Ramipril, Valsartan, Telmisartan.
• Effects: Electrolyte imbalance, reduced kidney function.
• Management:
  • Use with caution in patients with pre-existing kidney issues.
  • Start with low doses and monitor kidney function and electrolytes.

3. NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)

• Interaction: May reduce the diuretic effect of FRUSELAC TABLET and increase the risk of renal toxicity.
• Examples: Ibuprofen, Diclofenac, Naproxen.
• Effects: Fluid retention, elevated blood pressure, kidney damage.
• Management:
  • Use NSAIDs sparingly in patients on FRUSELAC TABLET.
  • Monitor blood pressure and renal function.

4. Digoxin

• Interaction: Furosemide may cause hypokalemia, which increases the risk of digoxin toxicity.
• Effects: Nausea, vision changes, arrhythmias.
• Management:
  • Monitor potassium levels and digoxin serum levels.
  • Adjust dose of digoxin as necessary.

5. Lithium

• Interaction: Diuretics can reduce lithium excretion, leading to lithium toxicity.
• Effects: Tremors, confusion, kidney dysfunction.
• Management:
  • Avoid combining if possible.
  • If combined, monitor lithium levels closely.

6. Antidiabetic Drugs (Insulin and Oral Agents)

• Interaction: Furosemide may reduce glucose tolerance, while spironolactone may enhance insulin sensitivity.
• Examples: Metformin, Glipizide, Insulin.
• Effects: Fluctuating blood sugar levels.
• Management:
  • Monitor blood sugar closely.
  • Adjust antidiabetic medication if needed.

7. Alcohol and CNS Depressants

• Interaction: Additive hypotensive effects and increased risk of dizziness or fainting.
• Management:
  • Advise patients to avoid alcohol.
  • Caution with driving or operating machinery.

Drug - Food interaction

1. High-Potassium Foods

• Interaction: Spironolactone is potassium-sparing, and consuming potassium-rich foods can increase the risk of hyperkalemia.
• Examples: Bananas, oranges, avocados, spinach, tomatoes, coconut water.
• Effects: Irregular heartbeat, muscle weakness, fatigue.
• Management:
  • Avoid or limit potassium-rich foods.
  • Monitor blood potassium levels regularly.
  • Discuss a heart-healthy diet plan with your doctor or dietitian.

2. Licorice (Natural, Not Candy)

• Interaction: Natural licorice can reduce potassium levels and counteract spironolactone, increasing the risk of hypokalemia and hypertension.
• Effects: Headache, fluid retention, high blood pressure, muscle cramps.
• Management:
  • Avoid herbal supplements or teas containing real licorice (Glycyrrhiza glabra).
  • Always check herbal product ingredients.

3. Alcohol

• Interaction: Alcohol can worsen blood pressure-lowering effects and increase the risk of dizziness or fainting.
• Effects: Light-headedness, dehydration, increased diuretic effect.
• Management:
  • Limit or avoid alcohol consumption.
  • Stay hydrated and rise slowly from sitting or lying down.

4. Salt Substitutes

• Interaction: Many salt substitutes contain potassium chloride, which may dangerously increase potassium levels.
• Effects: Hyperkalemia symptoms (e.g., slow heart rate, weakness).
• Management:
  • Avoid salt substitutes unless approved by your doctor.
  • Read food labels for potassium content.

Synopsis

More Information

1.Product Comparison

a) FRUSELAC TABLET  Vs Lasix

Why FRUSELAC TABLET Stands Out:

1. Potassium-Sparing Advantage:
   FRUSELAC TABLET  includes spironolactone, which conserves potassium—minimizing the risk of hypokalemia, a major side effect of Lasix alone.
2. Comprehensive Diuresis:
   Combines the powerful fluid-removal effect of furosemide with the aldosterone-blocking effects of spironolactone, offering broader management especially for cirrhosis-related ascites or heart failure.
3. Better Compliance:
   Two medications in a single tablet = fewer pills and better patient adherence.
4. Liver and Heart Benefits:
   Especially effective in conditions involving aldosterone excess, like liver cirrhosis or certain heart failure cases.
5. Balanced Electrolyte Management:
   Offers a more stable electrolyte profile over time compared to Lasix monotherapy.

FAQs About FRUSELAC TABLET

Q: What is FRUSELAC TABLET used for?

A: FRUSELAC TABLET is commonly used to manage fluid retention (edema) associated with heart failure, liver cirrhosis, or kidney disease. It also helps manage high blood pressure in some cases.

Q: How does FRUSELAC TABLET work?

A: It contains two active ingredients: Furosemide, a loop diuretic, and Spironolactone, a potassium-sparing diuretic. Together, they help remove excess fluid while maintaining potassium levels.

Q: How should I take FRUSELAC TABLET ?

A: Take it exactly as prescribed by your doctor, usually once daily. It is best taken in the morning to avoid frequent urination at night.

Q: Can I take FRUSELAC TABLET on an empty stomach?

A: Yes, it can be taken with or without food. However, taking it with food may help reduce stomach upset.

Q: What are the common side effects of FRUSELAC TABLET ?

A: Common side effects include increased urination, dizziness, low blood pressure, nausea, and electrolyte imbalance. Always report unusual symptoms to your doctor.

Q: Is FRUSELAC TABLET safe during pregnancy?

A: FRUSELAC TABLET is generally not recommended during pregnancy unless clearly needed. Consult your doctor before use.

Q: Can FRUSELAC TABLET cause potassium imbalance?

A: Yes, although it contains spironolactone to conserve potassium, monitoring is still necessary as both high and low potassium levels can occur.

Q: Is FRUSELAC TABLET addictive?

A: No, FRUSELAC TABLET is not habit-forming or addictive.

Q: Can I stop taking FRUSELAC TABLET if I feel better?

A: No, do not stop taking it without consulting your doctor, even if symptoms improve.

Q: What should I do if I miss a dose?

A: Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one. Do not double the dose.

Q: Can I use FRUSELAC TABLET every day?

A: FRUSELAC TABLET is often taken once daily, but this depends on your medical condition and how your body responds to management. It contains two medicines that help remove extra fluid from the body and control blood pressure. Taking it every day without medical advice can cause problems like dehydration or electrolyte imbalance. Always follow your doctor’s instructions and never change the dose or frequency on your own.

Q: Is FRUSELAC TABLET safe for elderly individuals?

A: Yes, but it must be used cautiously. Older adults are more sensitive to medications like diuretics, which can cause dizziness, low blood pressure, or changes in kidney function. Doctors usually start with a lower dose and closely monitor blood tests and blood pressure. Regular follow-ups are important to ensure the medicine is working safely.

Q: Does FRUSELAC TABLET affect potassium levels?

A: Yes, it does. FRUSELAC TABLET contains two active ingredients: furosemide, which may lower potassium levels, and spironolactone, which helps retain potassium. These effects can balance each other, but not always. That is why doctors often order blood tests to check your potassium and other electrolytes. Too little or too much potassium can cause serious issues like muscle weakness, irregular heartbeat, or fatigue.

References

1. K.D. Tripathi. Diuretics. Essentials of Medical pharmacology. Seventh edition. 2013. Page no – 579-582 & 587.

2. A.E.Birbari, M.M.Daouk, S.Mukaddam-Daher. Efficacy and safety of lasilactone, a new combination diuretic, in essential hypertension. ScienceDirect. November 2002.  [Accessed on 6th May 2025] 

3. Sanofi. Electronic Medicines Compendium (EMC) [Revised in March 2022] [Accessed on 6th May 2025] 

4. G.D. Searle U.S. Food & Drug Administration [Revised on March 2018] [Accessed on 6th May 2025]  

5. Accord Healthcare Limited Electronic Medicines Compendium (EMC) [Revised on March 2020] [Accessed on 6th May 2025]  

Useful Diagnostic Tests

• Kidney function test

Author Details

Written By Dr. Karthikeyan Rajagopal - M.Pharm (Pharmacology)

Reviewed For Accuracy By Dr. Venkatesh Poludasu - MBBS

Last updated on 23 May 2025 | 03:37 PM(IST)