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INTRODUCTION
FIXICAN DX TABLET is a combination of Cefixime and Dicloxacillin which belongs to the group of medicines called Antibiotics. It is used to treat bacterial infections such as ear (otitis media), nose (sinusitis), throat (tonsillitis, pharyngitis), chest and lung infections such as (bronchitis, pneumonia), uncomplicated urinary tract infections such as cystitis and kidney infections and uncomplicated gonorrhoea (cervical/urethral infections).
Before taking FIXICAN DX TABLET inform your doctor if you have lung diseases such as asthma, liver, kidney or heart disease.
FIXICAN DX TABLET should be used with caution in pregnant women. Contact your doctor before taking. FIXICAN DX TABLET is not recommended for use in breast feeding women as it may pass through the breast milk. Contact your doctor before taking.
FIXICAN DX TABLET is not recommended for use in children under 10 years of age. Contact our doctor before taking.
FIXICAN DX TABLET should be used with caution in elderly patients aged 65 years or above. Contact your doctor before taking.
The most common side effects of this medicine are nausea, vomiting, stomach pain, diarrhea, indigestion or headache, dizziness. Contact your doctor if any of the side effects worsen.
USES OF FIXICAN DX TABLET
It is used to treat bacterial infections such as:
- ear (otitis media), nose (sinusitis), throat (tonsillitis, pharyngitis)
- chest and lungs (bronchitis, pneumonia)
- uncomplicated urinary tract infections (cystitis and kidney infections)
- uncomplicated gonorrhoea (cervical/urethral infections)
HOW FIXICAN DX TABLET WORKS
FIXICAN DX TABLET helps to treat bacterial infections, where Cefixime and Dicloxacillin belongs to cephalosporin and penicillin antibiotics respectively. They, works by binding to penicillin-binding proteins, located inside the bacterial cell walls (which are responsible for the formation of bacterial cell wall) and inhibit the synthesis of bacterial cell wall, leading to bacterial cell death.
DIRECTIONS FOR USE
Take this medicine as advised by your physician. Swallow this medicine as whole with a glass of water and do not crush or chew the medicine. Your doctor will give the right dose depends on your age, body weight and disease condition.
SIDE EFFECTS OF FIXICAN DX TABLET
COMMON
- nausea, vomiting
- stomach pain
- diarrhoea
- indigestion
- headache
- dizziness
- genital or vaginal area itching
UNCOMMON
- change in kidney and liver function
- blood clot
RARE
Stop taking FIXICAN DX TABLET and contact your doctor immediately if you experience any of the following side effects:
- allergic reaction such as rash, joint pains, swelling of face, lips, tongue or throat causing difficulty in swallowing or breathing or anaphylactic reactions
- Stevens Johnson Syndrome or Toxic Epidermal Necrolysis symptoms such as blistering, peeling or bleeding from the lips, eyes, mouth, nose, genitals, hands or feet
- DRESS (Drug Rash with Eosinophilia and Systemic symptoms) symptoms may include flu-like symptoms and a widespread rash, high fever and enlarged lymph nodes
- abnormal blood test values may include increased levels of liver enzymes and an increase in a type of white blood cell (eosinophilia) and enlarged lymph nodes
- AGEP (Acute generalized exanthematous pustulosis) symptoms such as red, scaly, widespread rash with fever, bumps under the skin or skin folds, chest, abdomen, back and arms and blisters
- skin rash or lesions with a reddish or pink ring and a pale centre, with itching, scaly or filled with fluid
- signs of infections
- bruise or bleed more easily
- nose bleed, bleeding gums, chills, tiredness, pale skin, and shortness of breath
- blood in urine
- fits
- convulsions, feeling confused, decreased alertness or aware of things than usual, abnormal muscle movements or stiffness
- symptoms of pseudomembranous colitis such as severe watery diarrhoea, fever and weakness
HOW TO MANAGE SIDE EFFECTS
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes and apply a pain-relieving balm on the head if necessary. Do not consume alcohol. Contact your doctor if the symptom did not improve.
Nausea or Vomiting:
Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods.
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for treating diarrhea. Contact your doctor if the symptom did not improve.
Indigestion:
Eat smaller meals but take frequently. Eat and exercise regularly. Contact your doctor if the symptom did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operate any machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Contact your doctor if the symptom did not improve.
Stomach pain:
Try to rest and relax. Eat small meals but take frequently. Keep a heat pad on your stomach. Contact your doctor if the symptom did not improve.
WARNING & PRECAUTIONS
PREGNANCY
FIXICAN DX TABLET should be used with caution in pregnant women. Contact your doctor before taking.
BREASTFEEDING
FIXICAN DX TABLET is generally not recommended for use in breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you have fits (convulsions), feeling confused, decreased alertness or aware of things than usual, abnormal muscle movements or stiffness after taking [GBNEYWORD].
KIDNEY
FIXICAN DX TABLET should be used caution in patients with kidney disease. Consult your doctor before taking.
LIVER
FIXICAN DX TABLET should be used with caution in patients with liver disease. Contact your doctor before taking.
ALLERGY
Do not take FIXICAN DX TABLET if you are allergic to Cefixime, Dicloxacillin, or to Beta lactam antibiotics like cephalosporins, penicillin or to any of the other ingredients of this medicine.
LUNGS
FIXICAN DX TABLET should be used with caution in patients with lung disease like asthma. Contact your doctor before taking.
HEART DISEASE
FIXICAN DX TABLET should be used caution in patients with cardio spasm. Contact your doctor before taking.
OTHERS
Before taking FIXICAN DX TABLET, inform your doctor if you have:
- colitis
- clostridium difficle associated diarrhea (CDAD)
- coagulation disorders
- poor nutrition
- urine test for ketones, glucose
- coombs test
- phenylketonuria
- severe illness
Use in pediatrics:
FIXICAN DX TABLET is not recommended for use in children under 10 years of age. Contact your doctor before taking.
Use in geriatrics:
FIXICAN DX TABLET should be used with caution in elderly patients (aged 65 years or above). Contact your doctor before taking.
INTERACTIONS
A. Drug-Drug interactions:
Inform your physician if you are taking:
- medicines used to thin the blood (Ex. warfarin, dicumarol)
- carbamazepine (medicines used to treat epilepsy)
- probenecid (medicines used to treat gout)
- medicines used to treat bacterial infections (amikacin, gentamycin and tetracyclines like doxycycline, demeclocycline)
Overdosage:
If you or anyone else accidentally took too much of this medicine, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Cefixime, Dicloxacillin |
| Pharmacological Category | : | Cephalosporins, Penicillin Antibiotics |
| Therapeutic Indication | : | Bacterial infections |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep out of reach of children
- Store FIXICAN DX TABLET below 25°C
FAQs ABOUT FIXICAN DX TABLET
How FIXICAN DX TABLET work?
FIXICAN DX TABLET helps to treat bacterial infections, where Cefixime and Dicloxacillin belongs to cephalosporin and penicillin antibiotics respectively. They, works by binding to penicillin-binding proteins, located inside the bacterial cell walls (which are responsible for the formation of bacterial cell wall) and inhibit the synthesis of bacterial cell wall, leading to bacterial cell death.
Who should avoid taking FIXICAN DX TABLET?
FIXICAN DX TABLET is not recommended for use in patients with allergic history to Cefixime, Dicloxacillin, or to Beta lactam antibiotics like cephalosporins, penicillins or cephamycins, in breast feeding women and in children under 10 years of age. Contact your doctor before taking.
Can I use FIXICAN DX TABLET to treat cold?
No. FIXICAN DX TABLET is not used to treat viral infections like common cold. Contact your doctor before taking.
For what conditions FIXICAN DX TABLET is used?
FIXICAN DX TABLET is used to treat bacterial infections such as ear (otitis media), nose (sinusitis), throat (tonsillitis, pharyngitis), chest and lung infections such as (bronchitis, pneumonia), uncomplicated urinary tract infections such as cystitis and kidney infections and uncomplicated gonorrhoea (cervical/urethral infections). Contact your doctor before taking.
Does FIXICAN DX TABLET cause fits?
Yes. FIXICAN DX TABLET may cause fits. Stop taking FIXICAN DX TABLET and contact your doctor if you have unusual symptoms like fits.
REFERENCES
1. K.D.Tripathi. Beta-lactam Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page- 728, 721.
2. Famar Lyon. Electronic Medicines Compendium (EMC). [Revised on April 2021] [Accessed on 6th June 2022] https://www.medicines.org.uk/emc/files/pil.5534.pdf
3. Lupin Limited. U.S. Food & Drug Administration. [Revised on May 2012] [Accessed on 6th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/203195s000lbl.pdf
4. Orchid Europe Limited. Health Products Regulatory Authority (HPRA). [Revised on November 2018] [Accessed on 6th June 2022] https://www.hpra.ie/img/uploaded/swedocuments/Licence_PA1335-002-001_23112018135013.pdf
5. Lupin Pharmaceuticals, Inc. Cefixime. [Revised on November 2019] [Accessed on 6th June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=d0fd45bd-7d52-4fa6-a5f7-f46d5651ffa2
6. Sandoz Inc. Dicloxacillin. [Revised on November 2020] [Accessed on 6th June 2022] https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=65c3e99b-ec77-416c-ad70-596d6f0a9c31
7. Teva Pharmaceuticals USA, Inc. Dicloxacillin. [Revised on July 2018] [Accessed on 6th June 2022] https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=8478f242-c715-4984-ac1d-dc79dc28665e
8. Dicloxacillin. mims.com. [Accessed on 6th June 2022] https://www.mims.com/philippines/drug/info/dicloxacillin?mtype=generic
USEFUL DIAGNOSTIC TESTS
- Complete blood count
- Peripheral smear examination
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