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INTRODUCTION
ETOCEL P TABLET is a combination of Etoricoxib and Paracetamol which belongs to the group of medicines called Nonsteroidal Anti-inflammatory Drugs (NSAIDs) and Analgesics respectively. It is used to treat pain and inflammation in conditions like ankylosing spondylitis (inflammation of the spine), osteoarthritis and rheumatoid arthritis.
Osteoarthritis is defined as a progressive disorder affecting primarily weight-bearing joints, characterized by progressive worsening and loss of cartilage that join bones, pain, motion restriction, deformity and disability. Rheumatoid arthritis is a long-term, progressive inflammatory disorder of unknown cause characterized by involvement of five or more joints and systemic symptoms like tiredness, weakness, fever, loss of appetite and joint pain.
During course of the treatment your doctor might regularly monitor your liver and kidney function test to avoid any untoward side effects.
Before taking ETOCEL P TABLET, inform your doctor if you have kidney, liver or heart problems, stomach ulcer or bleeding, high blood pressure, stroke, diabetes, peripheral arterial disease and inflammatory bowel disease such as ulcerative colitis or colitis.
ETOCEL P TABLET is not recommended for use in pregnant and breast-feeding women. This medicine is not recommended for use in children and adolescents (aged less than 16 years) and it should be used with caution in elderly patients.
The most common side effect of taking ETOCEL P TABLET are stomach pain, constipation, flatulence, acid reflux, diarrhea, stomach discomfort, nausea and mouth ulcer. Consult your doctor if any of the side effects worsen.
USES OF ETOCEL P TABLET
- Treats pain and inflammation in conditions like ankylosing spondylitis, osteoarthritis, and rheumatoid arthritis
HOW ETOCEL P TABLET WORKS
ETOCEL P TABLET helps to relieve pain and inflammation, where etoricoxib inhibits cyclo-oxygenase enzyme (COX-2) and reduces prostaglandins (PGs) generation from arachidonic acid and paracetamol appears to relieve pain by elevation of the pain threshold.
DIRECTIONS FOR USE
Take ETOCEL P TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF ETOCEL P TABLET
COMMON
- stomach pain, constipation, gas
- gastritis, acid reflux
- diarrhea, stomach discomfort, nausea, vomiting
- inflammation of food pipe
- mouth ulcer
- swelling of the legs and/or feet due to fluid retention
- dizziness, headache
- irregular heart rhythm
- wheezing or shortness of breath
- weakness and fatigue, flu-like illness
UNCOMMON
- gastroenteritis (inflammation of the stomach and small intestine)
- urinary tract infection
- appetite increases or decreases, weight gain
- taste alteration, inability to sleep, numbness or tingling, sleepiness
- blurred vision, eye irritation and redness
- ringing in the ears, vertigo (spinning sensation of head)
- feeling of tightness, pressure or heaviness in the chest, heart attack
- flushing, stroke, mini-stroke
- severe increase in blood pressure
- cough, breathlessness, nosebleed
- dry mouth
- swelling of the face, skin rash or itchy skin, redness of the skin
- muscle cramp/spasm, muscle pain/stiffness
RARE
- confusion, restlessness
- severe skin reactions (these reactions can involve ulcers of the mouth, throat, nose and genitals)
Stop taking ETOCEL P TABLET and contact your doctor immediately if you experience any of the following side effects:
- shortness of breath, chest pain, or ankle swelling appear or if they get worse
- signs of liver problems such as yellowing of the skin and eyes (jaundice)
- severe or continual stomach pain or your stools become black
- allergic reaction (signs include skin problems such as ulcers or blistering or swelling of the face, lips, tongue or throat which may cause difficulty in breathing)
HOW TO MANAGE SIDE EFFECTS
Nausea:
Try to take ETOCEL P TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating oil rich or spicy food. Consult your doctor if the symptom gets worse.
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables, cereals and drink plenty of water. Exercise more regularly. If constipation does not improve, contact your doctor.
Diarrhoea:
Drink lot of fluids such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor. If diarrhea does not improve, contact your doctor.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heat pad on your stomach. If the stomach pain does not improve, contact your doctor.
Flatulence:
Eat smaller and frequent meals. Eat and drink slowly and exercise regularly. If flatulence does not improve, contact your doctor.
WARNING & PRECAUTIONS
PREGNANCY
ETOCEL P TABLET is not recommended for use in pregnant women. Consult your doctor before taking ETOCEL P TABLET.
BREASTFEEDING
ETOCEL P TABLET is not recommended for use in breast-feeding women. Consult your doctor before taking ETOCEL P TABLET.
DRIVING AND USING MACHINES
Do not drive or operate any machines while taking ETOCEL P TABLET since it may cause dizziness or sleepiness.
KIDNEY
ETOCEL P TABLET is not recommended for use in patients with serious kidney disease. It should be used with caution in patients with a history of kidney disease. Consult your doctor before taking ETOCEL P TABLET.
LIVER
ETOCEL P TABLET is not recommended for use in patients with serious liver disease. It should be used with caution in patients with a history of liver disease. Consult your doctor before taking ETOCEL P TABLET.
ALLERGY
Do not take ETOCEL P TABLET if you are allergic to Etoricoxib, Paracetamol or any of the other ingredients of this medicine.
HEART DISEASE
ETOCEL P TABLET is not recommended for use in patients with heart problems including heart failure (moderate or severe types), chest pain, heart attack or bypass surgery. It should be used with caution in patients with any other heart disease. Consult your doctor before taking ETOCEL P TABLET.
OTHERS
ETOCEL P TABLET is not recommended for use if you:
- have active stomach ulcer or gastrointestinal bleeding
- have inflammatory bowel disease, such as Crohn’s Disease, ulcerative colitis, or colitis
- have high blood pressure that has not been controlled by treatment
- peripheral arterial disease (poor circulation in legs or feet due to narrow or blocked arteries)
- have had any kind of stroke (including mini-stroke, transient ischaemic attack or TIA)
Before taking ETOCEL P TABLET, inform your doctor if you:
- have a history of gastrointestinal disease like ulceration and bleeding
- are dehydrated (prolonged bout of vomiting or diarrhoea)
- have swelling due to fluid retention
- have a history of high blood pressure
- are being treated for an infection
- have diabetes, high cholesterol or a smoker
Use in pediatrics:
ETOCEL P TABLET is not recommended for use in children and adolescents (under 16 years of age). Consult your child’s doctor for advice.
Use in geriatrics:
ETOCEL P TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking ETOCEL P TABLET.
INTERACTIONS
A. Drug-Drug interactions:
Before taking ETOCEL P TABLET, inform your doctor if you are taking any of the following medicines:
- other medicines used to treat pain and inflammation (Ex. celecoxib, acetylsalicylic acid)
- warfarin (used for blood thinning)
- methotrexate (used to suppress immune system)
- ciclosporin or tacrolimus (used to prevent organ rejection after transplant)
- lithium (used to treat depression)
- medicines used to help control high blood pressure and heart failure (enalapril, ramipril, minoxidil, losartan and valsartan)
- diuretics such as furosemide, chlorthalidone (used to treat fluid retention)
- digoxin (a medicine for heart failure and irregular heart rhythm)
- salbutamol (used to treat asthma)
- hormonal replacement therapy (such as estrogen) (used to treat symptoms of menopause)
- birth control pills (such as mifepristone) (used to prevent pregnancy)
Overdosage:
If you or anyone else accidentally take too much of ETOCEL P TABLET, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Etoricoxib, Paracetamol |
| Pharmacological Category | : | Nonsteroidal anti-inflammatory drug (NSAID), Analgesics |
| Therapeutic Indication | : | Pain and inflammation associated with other conditions |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep ETOCEL P TABLET out of reach of children
- Store ETOCEL P TABLET at room temperature
FAQs ABOUT ETOCEL P TABLET
Q: Can ETOCEL P TABLET be used in children?
A: No, ETOCEL P TABLET is not recommended for children and adolescents younger than 16 years of age. Your child’s doctor will decide a suitable alternative therapy for your child to treat pain and inflammation.
Q: Is ETOCEL P TABLET safe during pregnancy?
A: No, ETOCEL P TABLET is not recommended for use during pregnancy. If you are pregnant, think you may be pregnant or are planning to get pregnant, inform your doctor before taking ETOCEL P TABLET.
Q: Can ETOCEL P TABLET be stopped on my own?
A: Continue taking ETOCEL P TABLET until your doctor tells you to stop, unless you experience any unwanted effects, worsening of your condition or any new symptoms. In such cases, contact your doctor right away.
Q: What precautions do I need to follow while taking ETOCEL P TABLET?
A: Patients taking ETOCEL P TABLET must inform their doctor about their pre-existing disease conditions like kidney, liver or heart problems. Patients should also inform if they are pregnant, breast-feeding, having any allergies, stomach ulcers or bleeding problems. Contact your doctor immediately if you have any abnormal symptoms.
Q: Does ETOCEL P TABLET cause nausea?
A: Yes, ETOCEL P TABLET may cause nausea in some individuals. If you feel nauseous, take this medicine with or just after meals. Stick to simple meals. Avoid eating oily or spicy food. Consult your doctor if you experience persistent nausea.
Q: What if I forget to take a dose of ETOCEL P TABLET?
A: If you forget to take a dose of ETOCEL P TABLET, take it as soon as you remember and then continue your treatment as usual. Do not take the medicine twice to make up for the forgotten dose. If you have any further doubts, contact your doctor.
REFERENCES
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Osteoarthritis. Rheumatoid Arthritis. Pharmacotherapy handbook. Ninth edition. Page- 9, 26.
2. Brooks P, Kubler P. Etoricoxib for arthritis and pain management. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. March 2006. [Accessed on 30th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1661646/
3. Micro Labs Ltd. (Etorica P Tablets) Etoricoxib + Paracetamol. [Accessed on 30th June 2022] https://www.microlabsltd.com/elibrary/node/1745
4. Central Drugs Standard Control Organization (CDSCO). [Accessed on 30th June 2022] https://cdscoonline.gov.in/CDSCO/Drugs
USEFUL DIAGNOSTIC TESTS
- Liver function test
- Kidney function test
AUTHOR DETAILS
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 24 Dec 2022 | 06:06 PM(IST)
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