Entacom 200mg Tablet 10'S

Parkinsonism Rx required

Best Price*  ₹ 56.00
MRP ₹70.00
(Inclusive of all taxes) *10 Tablet(s) in a Strip * Mkt: Intas Pharmaceuticals Ltd * Country of Origin: India * Delivery charges if applicable will be applied at checkout

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INTRODUCTION

ENTACOM contains Entacapone which belongs to a group of medicines called Anti-Parkinson agent and COMT Inhibitor. It is used together with levodopa to treat Parkinson’s disease. This medicine increases the activity of levodopa in relieving the symptoms of Parkinson's disease.

Entacapone is used in the treatment of Parkinson’s disease as an adjunct to levodopa/carbidopa therapy. When ENTACOM is taken with levodopa, it results in more sustained levodopa serum levels. These sustained levels of levodopa provides increased levels of dopamine in CNS, which is an active metabolite of levodopa. 

Always take this ENTACOM exactly as directed by your doctor. Before taking this medicine, tell your doctor if you have liver, kidney or heart problems. It is not suitable for children and adolescents below 18 years of age. The common side effects are nausea, vomiting, diarrhoea and uncontrolled movements.

USES OF ENTACOM

  • treat parkinson’s disease with levodopa

HOW ENTACOM WORKS

ENTACOM works by inhibiting a chemical messenger catechol-O-methyltransferase (COMT), which helps in increasing the amount of dopamine in the brain. An adequate amount of dopamine in the brain helps to coordinate body movements to control symptoms of Parkinson's disease.

DIRECTIONS FOR USE

Always take ENTACOM exactly as your doctor has told you. Swallow as a whole, do not crush or chew. It can be taken with or without food.

SIDE EFFECTS OF ENTACOM

COMMON

  • uncontrollable movements (difficulty in performing voluntary movements)
  • nausea, vomiting
  • reddish-brown discoloration of urine
  • excessive movements (hyperkinesias)
  • worsening of symptoms of Parkinson’s disease
  • prolonged muscle cramps (dystonia)
  • diarrhoea, abdominal pain, constipation
  • dry mouth
  • dizziness, tiredness, increased sweating, falling
  • hallucinations 
  • sleeplessness
  • vivid dreams and confusion
  • heart or artery disease events (chest pain, angina)

RARE

  • rashes, redness or bumps on the skin
  • abnormal results in liver function tests
  • agitation
  • decreased appetite
  • weight loss
  • hives

HOW TO MANAGE SIDE EFFECTS

Nausea:

Stick to simple normal meals and do not eat rich or spicy foods.

Diarrhoea:

Drink plenty of fluids to avoid dehydration. ORS should be used to prevent dehydration.

Vomiting:

Drink clear or ice-cold drinks. Eat light, bland foods and avoid fried, greasy, or sweet foods.

Constipation:

Add fruits, vegetables whole grains and other high-fiber foods to your normal diet.

Dizziness:

Get up and move around to feel awake, take small naps to edge off the sleepiness. Give your eyes a break to avoid fatigue and eat a healthy food to boost energy.

Abdominal pain:

Place a warm water bottle on your abdomen. Soak in a warm bath. Drink plenty of clear fluids and water.

Dry mouth:

Chew sugar-free gum or candies to stimulate the flow of saliva and limit your caffeine intake. Drink small sips of water regularly.

WARNING & PRECAUTIONS

PREGNANCY

ENTACOM is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.

BREASTFEEDING

ENTACOM is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor. 

DRIVING AND USING MACHINES

Do not drive or operate machinery while taking this medicine, since it may cause light-headedness or dizziness.

KIDNEY

ENTACOM should be used with caution in patients suffering from active kidney diseases. Consult your doctor for advice.

LIVER

ENTACOM is not recommended in patients with active liver diseases. Discuss the risks and benefits with your doctor.

ALLERGY

Do not take if you are allergic (hypersensitive) to Entacapone.

HEART DISEASE

ENTACOM should be used with caution if you ever had a heart attack or any other active heart diseases. Consult your doctor for advice.

OTHERS

Inform your doctor if you have or had,

  • phaeochromocytoma (a tumour of the adrenal gland)
  • rhabdomyolysis (a rare muscle disorder)
  • low blood pressure
  • unexplained muscle pain, tenderness or weakness, or sensitivity to pressure
  • prolonged diarrhoea (inflammation of the colon)
  • neuroleptic malignant syndrome (NMS)

INTERACTIONS

Inform your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription or the following,

  • phenelzine, moclobemide, tranylcypromine, amitriptyline, maprotiline, venlafaxine, paroxetine and desipramine (used to treat depression)
  • moclobemide and selegiline (monoamine oxidase inhibitors type A&B)
  • rimiterole, isoprenaline, adrenaline, noradrenaline, dopamine, dobutamine, alpha-methyldopa, apomorphine
  • warfarin (used to thin the blood)
  • iron supplements

SYNOPSIS

Drug :   Entacapone
Pharmacological Category :   Anti-Parkinson Agent, COMT Inhibitor
Therapeutic Indication :   Parkinson disease
Dosage Forms :   Tablet

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT ENTACOM

Does ENTACOM have any effect on urine color?

Yes, it may cause urine to change to a brownish-orange color. This effect is common and is not harmful.

Does ENTACOM affect fertility?

No, it does not affect fertility, it is not recommended for pregnant and breastfeeding women.

What is the mechanism of action of ENTACOM?

It has ability to inhibit COMT and alter the plasma pharmacokinetics of levodopa.

REFERENCES

1. KD Tripathi MD. Drugs acting on central nervous system. Essentials of Medical Pharmacology 7th ed. New Delhi, May 2013. Page – 432.

2. Thomas and David westfall. Neurotransmission: The Autonomic and somatic motor nervous system. Goodman & Gilman’s: The Pharmacological Basis of Therapeutics. 12th ed. New York, New York: McGraw-Hill Medical; 2011. Page – 212.

3. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 473-474.

4 Li J. Lou Z. Liu X. Sun Y. Chen J. Efficacy and Safety of Adjuvant Treatment with Entacapone in Advanced Parkinson’s disease with Motor Fluctuation: A Systematic Meta-Analysis. Aug 16, 2017; [Accessed Jan 11, 2021] karger.com/Article/Pdf/479555

5. Mylan Potters Bar (UK). Gerard Laboratories. Electronic Medicines Compendium (EMC); [Revised Feb, 2017] [Accessed Jan 11, 2021] https://www.medicines.org.uk/emc/files/pil.8818.pdf

6. Novartis Pharmaceuticals Corporation. Orion Corporation. Sep 28, 2010; U.S. Food & Drug Administration; [Accessed Jan 11, 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020796s15lbl.pdf

PRODUCT DETAILS

    Net Qty
    1
    Item Weight
    17.5
    Ingredient
    ENTACAPONE 200MG
    Hsn Code
    30049099
ALTERNATE BRANDS
Adcapone Tablet 10'S
Prescription Parkinsonism Rx required
Rs.88.00
DISCLAIMER

The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.

Entacom 200mg Tablet 10'S

Entacom 200mg Tablet 10'S Mkt: Intas Pharmaceuticals Ltd

M.R.P.: Rs.70.00
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