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INTRODUCTION
DOXOLIN AX is a combination of Ambroxol and Doxophylline which belongs to the group of medicines called Mucolytics and Bronchodilators respectively. It is used to treat asthma (condition in which the airways become narrow, swell and produce extra mucus which leads to breathing difficulties, chest pain, severe dry cough, and increased heartbeat).
Also, used to treat chronic obstructive pulmonary disorder (lung disorder in which the flow of air to the lungs is obstructed which leads to shortness of breath, dry cough with phlegm, wheezing, fatigue and weight loss).
Limit the consumption of beverages and foods containing caffeine while taking DOXOLIN AX as it may increase the risk of side effects. DOXOLIN AX is not recommended for use in patients with acute myocardial infarction and low blood pressure. If you are pregnant or breast-feeding, consult your doctor for advice before taking DOXOLIN AX.
DOXOLIN AX is not recommended for use in children (under 6 years of age) and it should be used with caution in elderly patients. Consult your doctor before taking it. The most common side effects of taking DOXOLIN AX are taste changes, nausea, numbness in the throat and mouth. Consult your doctor if any of the symptom worsens.
USES OF DOXOLIN AX
To Treat:
- asthma
- chronic obstructive pulmonary disorder (COPD)
HOW DOXOLIN AX WORKS
DOXOLIN AX helps to treat asthma and chronic obstructive pulmonary disorder, where ambroxol stimulates the production of a substance that lowers surface tension, which keeps the air sacs in the lungs from collapsing after exhalation. Doxophylline inhibits certain enzymes in the body called phosphodiesterase, which in turn increases the substance that leads to muscle relaxation leading to dilation of the constricted airway tract. It also acts as an anti-inflammatory agent to reduce inflammation. This combined action together makes breathing easier.
DIRECTIONS FOR USE
Take DOXOLIN AX as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. The correct dose and duration will be decided by your doctor for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF DOXOLIN AX
COMMON
- changes in taste sensation
- numbness in mouth and throat
- nausea
UNCOMMON
- vomiting
- diarrhoea
- indigestion
- stomach pain
- dry mouth
RARE
- increased blood sugar
- skin rash and itchiness
Stop taking DOXOLIN AX and contact your doctor immediately if you experience any of the following side effects:
- allergic symptoms (skin itchiness, rashes, difficulty in breathing, or eye swelling)
- skin rash including lesions on the mucous membranes of the mouth, throat, nose, eyes and reproductive organs
- severe nausea, vomiting, stomach pain, headache, irritability, insomnia, increased heart rate, skipped heartbeat and fast breathing
HOW TO MANAGE SIDE EFFECTS
Nausea:
Take this medicine with, or just after meals. Stick to simple meals. Avoid eating oily, fried or spicy foods. If the symptom does not improve, consult your doctor.
Stomach pain:
Try to take rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, consult your doctor.
Dry mouth:
Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.
WARNING & PRECAUTIONS
PREGNANCY
DOXOLIN AX is generally not recommended for use in pregnant women as the medicine can cross the placental barrier. Consult your doctor for advice before taking it.
BREASTFEEDING
DOXOLIN AX is generally not recommended for use in breastfeeding women as it may pass through breast milk. Consult your doctor for advice before taking it.
DRIVING AND USING MACHINES
DOXOLIN AX does not affect the alertness of the patient and therefore does not interfere with the ability to drive and use machines.
KIDNEY
DOXOLIN AX should be taken with caution in patients with impaired kidney function. Consult your doctor before taking DOXOLIN AX.
LIVER
DOXOLIN AX should be taken with caution in patients with severe liver disease. Consult your doctor before taking DOXOLIN AX.
ALLERGY
Do not take DOXOLIN AX if you are allergic to Ambroxol, Bromhexine, Doxophylline, or other xanthine derivatives (such as methylxanthine).
LUNGS
DOXOLIN AX should be taken with caution in patients with existing lung conditions such as chronic obstructive lung disorder, severe uncontrolled asthma, pneumonia or bronchial motor activity disorder along with excessive mucous secretion (risk of a mucous plug). Consult your doctor before taking DOXOLIN AX.
HEART DISEASE
DOXOLIN AX is not recommended for use in patients with acute myocardial infarction (blockage of blood flow to the heart muscle), and low blood pressure. It should be taken with caution in patients with heart disease, high blood pressure, pulmonary heart disease, congestive heart failure (heart muscle doesn't pump blood sufficiently), and severe hypoxemia (low levels of oxygen in the blood). Consult your doctor before taking DOXOLIN AX.
OTHERS
Before taking DOXOLIN AX, inform your doctor if you have:
- hyperthyroidism
- peptic ulcer or predilection for the development of peptic ulcers
- concomitant infections
- low immune system due to other health conditions (Ex. HIV infection)
Use in pediatrics:
DOXOLIN AX is generally not recommended for use in children (under 6 years of age). Consult child’s doctor for advice.
Use in geriatrics:
DOXOLIN AX should be used with caution in elderly patients. Consult your doctor before taking DOXOLIN AX.
INTERACTIONS
A. Drug-Drug interactions:
Before taking DOXOLIN AX, inform your doctor if you have received or taking any of the following medicines:
- medicines used as antibiotics (Ex. erythromycin, troleandomycin, lincomycin, clindamycin) (used to treat bacterial infections)
- allopurinol (used to treat gout)
- cimetidine (used to treat ulcers and indigestion)
- propranolol (used to treat high blood pressure)
- influenza vaccine (protects against flu infection)
- phenytoin (used to treat epilepsy)
- medicines used to treat certain types of cancer (Ex. melphalan, busulfan, methotrexate)
B. Drug - food interaction:
Avoid consuming beverages and foods containing caffeine while taking DOXOLIN AX as it may increase the risk of side effects.
Overdosage:
If you or anyone else accidentally take too much DOXOLIN AX, consult your physician immediately or visit the nearby hospital. Symptoms of overdosage are severe cardiac arrhythmias (irregular heart rhythm) and tonic-clonic seizures.
SYNOPSIS
| Drug | : | Ambroxol, Doxophylline |
| Pharmacological Category | : | Aromatic amines, Methylxanthines |
| Therapeutic Indication | : | Asthma, Chronic obstructive pulmonary disorder (COPD) |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep DOXOLIN AX out of reach of children
- Store at room temperature
FAQs ABOUT DOXOLIN AX
What is DOXOLIN AX used for?
DOXOLIN AX is used to treat asthma (condition in which the airways become narrow, swell and produce extra mucus which leads to breathing difficulties, chest pain, severe dry cough, and increased heartbeat) and chronic obstructive pulmonary disorder (lung disorder in which the flow of air to the lungs is obstructed which leads to shortness of breath, dry cough with phlegm, wheezing, fatigue and weight loss).
What are the common side effects of DOXOLIN AX?
The most common side effects of taking DOXOLIN AX are changes in taste sensation, nausea, numbness in the throat or mouth. Consult your doctor if any of the symptom worsens.
What recommendations should be followed while taking DOXOLIN AX?
Avoid consuming beverages and foods containing caffeine while taking DOXOLIN AX as it may increase the risk of side effects. Also, avoid smoking or use of tobacco products as it may worsen the condition of the patient by reducing the lung function.
What happens if I forget to take a dose of DOXOLIN AX?
You should take DOXOLIN AX immediately when you remember. If it is time for your next dose skip the missed dose and follow your regular dose schedule. Do not double the dose to match up your missed dose.
Is DOXOLIN AX safe to use in patients with lung diseases?
DOXOLIN AX should be used with caution in patients with existing lung conditions such as chronic obstructive lung disorder, severe uncontrolled asthma, pneumonia or bronchial motor activity disorder along with excessive mucous secretion (risk of a mucous plug). Consult your doctor before taking it.
REFERENCES
1. KD. Tripathi. Drugs for Cough and Bronchial Asthma. Essentials of medical pharmacology. Seventh edition. 2013. Page – 218-219, 227.
2. Ahmad Kantar, Ludger Klimek, Dorotheea Cazan, Annette Sperl, Ulrike Sent, and Margarida Mesquita. An overview of efficacy and safety of ambroxol for the treatment of acute and chronic respiratory diseases with a special regard to children. Journal of Multidisciplinary Respiratory Medicine. March 2020. [Accessed on 15th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137760/
3. Paola Rogliani, Luigino Calzetta, Josuel Ora, Mario Cazzola and Maria Gabriella Matera. Efficacy and safety profile of doxofylline compared to theophylline in asthma: a meta-analysis. Journal of Multidisciplinary Respiratory Medicine. August 2019. [Accessed on 15th June 2022] https://mrmjournal.biomedcentral.com/articles/10.1186/s40248-019-0189-0
4. Mario Cazzola, Maria Gabriella Matera. The effect of doxofylline in asthma and COPD. Journal of Respiratory Medicine. April 2020. [Accessed on 15th June 2022] https://www.resmedjournal.com/article/S0954-6111(20)30044-5/fulltext
5. Vibcare Pharma Pvt. Ltd. Vibodoxo AM (Doxofylline and Ambroxol). [Accessed on 15th June 2022] https://vibcare.co.in/doxofylline-ambroxol/#!/SIDEEFFECTS
6. Pharmaceutical Society of Singapore. Ambroxol Tablets. hsa.gov. [Revised in April 2017] [Accessed on 15th June 2022] https://www.hsa.gov.sg/docs/default-source/announcements/prescription-only-medicines-(pom)/ambroxol-pil-26-04-2017.pdf
7. Abc FarMaceutici. Ansimar (Doxofylline Tablets). [Revised in March 2011] [Accessed on 15th June 2022] https://www.abcfarmaceutici.it/uploads/news/40_file3_en.pdf
PRODUCT DETAILS
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.