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INTRODUCTION
DESDAC 100MG TABLET contains Desvenlafaxine which belongs to the group of medicines called Antidepressants. It is used in adults to treat major depressive disorder. Major depressive disorder (also known as clinical depression) is a mental health disorder characterized by persistant depressed mood, lack of interest, feeling of guilt, sleep disturbances or sucidial thoughts for a prolonged period (more than 2 weeks) that causes significant impairment in performing day-to-day activities.
Take DESDAC 100MG TABLET for the stipulated duartion mentioned by your doctor. Although, you might feel improvement in your condition after 2 weeks of therapy with DESDAC 100MG TABLET, it may take several weeks for DESDAC 100MG TABLET to deliver complete benefits. Therefore, continue to take DESDAC 100MG TABLET for the stipulated duration recommended by your doctor even if you feel better during the midway of the therapy.
Before taking DESDAC 100MG TABLET, inform your doctor if you have high blood fat levels or any liver, kidney or heart problems. You must also inform your doctor if you have or have a family history of bipolar disorder, mania or epilepsy. Do not take DESDAC 100MG TABLET if you are pregnant or breastfeeding without consulting your doctor.
Talk to your doctor if you are currently taking other antidepressant medicines (such as monoamine oxidase inhibitors (Ex. isocarboxazid, phenelzine and tranylcypromine)) while taking DESDAC 100MG TABLET. You must also inform your doctor if you have taken any antidepressant (especially monoamine oxidase inhibitor) within the last 14 days.
DESDAC 100MG TABLET may make you feel dizzy or sleepy. Therefore, do not drive or operate any heavy tools or machines that requires complete concentration.
Other side effects might include decreased sex drive, increased sweating, constipation, and dry mouth. Consult your doctor if any of these side effects worsen. Also, inform your doctor immediately if you experience any worsening or depression, unusual behaviour or have suicidal thoughts after taking DESDAC 100MG TABLET.
USES OF DESDAC 100MG TABLET
- Treats major depressive disorder (depression) in adults
HOW DESDAC 100MG TABLET WORKS
DESDAC 100MG TABLET is a potent antidepressant drug. It contains a medicine called desvenlafaxine which is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI). It acts by increasing the levels of certain chemicals (serotonin and norepinephrine) within the brain that elevates your mood and stabilizes mental health. As a result, it makes you feel active and energetic.
DIRECTIONS FOR USE
Take DESDAC 100MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine.
DESDAC 100MG TABLET can be taken with or without food. Your doctor will decide the correct dose and duration of theray for you depending upon your age, body weight and disease condition.
Continue to take DESDAC 100MG TABLET for the stipulated duration recommended by your doctor even if you feel better during the midway of the therapy.
SIDE EFFECTS OF DESDAC 100MG TABLET
COMMON
- nausea
- dizziness, tiredness
- feeling sleepy or difficulty in sleeping
- increased sweating
- constipation, decreased appetite, dry mouth, diarrhea
- anxiety
- decreased sex drive, delayed ejaculation, problems in erection
- feeling shaky
- difficulty in passing urine
- weight gain or weight loss
RARE
Stop taking DESDAC 100MG TABLET and contact your doctor immediately if you experience any of the following side effects:
- signs of serotonin syndrome (feeling agitated, hallucinations, confusion, loss of consciousness, fast heartbeat, feeling dizzy, increased sweating, flushing, tremors, stiff muscles or muscle twitching, loss of coordination, nausea, vomiting, diarrhea, or seizures)
- worsening of hypertension (high blood pressure)
- increased signs of bleeding or bruising
- problems in vision (such as blurred vision, eye swelling or pain, seeing halos around lights and glaucoma)
- fits (seizures)
- low blood sodium levels (causing headache, nausea, difficulty in concentration, memory impairment, confusion, feeling weak or unsteady, hallucinations, fainting or seizures)
- troubled breathing, chest pain or coughing
- worsening of depression, suicidal thoughts or behavior
- behavioural changes (such as anxiety, panic attacks, difficulty in sleeping, irritability, restlessness)
- severe upper abdominal pain, swollen and tender abdomen, fever
HOW TO MANAGE SIDE EFFECTS
Constipation
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Dizziness Or Drowsiness
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Consult your doctor if your dizziness worsens.
Nausea And Vomiting
Take DESDAC 100MG TABLET with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your nausea worsens.
WARNING & PRECAUTIONS
PREGNANCY
ContraindicatedDESDAC 100MG TABLET is generally not recommended for use in pregnant women. If you become pregnant while undergoing therapy with DESDAC 100MG TABLET, inform your doctor immediately.
BREASTFEEDING
ContraindicatedDESDAC 100MG TABLET is generally not recommended for use in breastfeeding women. Therefore, consult your doctor before taking it.
DRIVING AND USING MACHINES
Use with CautionDo not drive or operate any heavy tools or machines if you feel dizzy or sleepy after taking DESDAC 100MG TABLET.
ALCOHOL
Consult your doctorAvoid consumption of alcohol while taking DESDAC 100MG TABLET.
KIDNEY
Use with CautionDESDAC 100MG TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
LIVER
Use with CautionDESDAC 100MG TABLET should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.
ALLERGY
ContraindicatedDo not take DESDAC 100MG TABLET if you are allergic to Desvenlafaxine or Venlafaxine.
HEART DISEASE
Use with CautionDESDAC 100MG TABLET should be used with caution in patients with heart diseases (such as high blood pressure). Therefore, consult your doctor before taking it.
OTHERS
Before taking DESDAC 100MG TABLET, inform your doctor if you:
- have had stroke or any other circulatory disorders
- have or ever had any bleeding problems
- have or have a family history of various mental illness (such as bipolar disorder, mania and hypomania)
- have high blood cholesterols levels
- have ever felt extremely sad with suicidal thoughts or behaviour
- have or ever had seizures (fits)
- have low blood sodium levels (causing tiredness, confusion and muscle weakness)
- have glaucoma
Use in Pediatrics:
DESDAC 100MG TABLET is generally not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before administration.
Use in Geriatrics:
DESDAC 100MG TABLET should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
INTERACTIONS
A. Drug-Drug interactions:
Before taking DESDAC 100MG TABLET, inform your doctor if you are taking any of the following medicines such as:
- other medicines used to treat depression such as monoamine oxidase inhibitors (Ex. moclobemide, isocarboxazid, phenelzine and tranylcypromine), tricyclic antidepressants (Ex. amitriptyline, nortriptyline), lithium, fluoxetine, sertraline, citalopram, escitalopram etc.
- linezolid (an antibiotic used to treat bacterial infection)
- intravenous methylene blue (used to treat abnormal methemoglobin levels in blood)
- medicines used to treat migraine headaches (such as sumatriptan, zolmitriptan)
- fentanyl (an opioid analgesic used for pain relief)
- tramadol (used for pain relief)
- tryptophan (an aminoacid used for maintaing mental health)
- buspirone (a medicine used to reduce anxiety)
- amphetamines (used as CNS stimulants) Ex. dexamphetamine and lisdexamphetamine
- dextromethorphan (a cough medicine)
- methadone (a medicine used to treat pain or drug addiction)
- pentazocaine (an anesthetic used to cause numbness before surgeries)
- St. John’s Wort (a herbal medicine used to treat depression)
- medicines that can affect blood clotting (such as aspirin or warfarin)
- non-steroidal anti-inflammatory drugs (used for pain relief) Ex. paracetamol, ibuprofen, diclofenac
- medicines used to treat mood and anxiety (such as barbiturates (Ex. phenobarbital), benzodiazepines (Ex. diazepam, clonazepam, alprazolam))
- medicines used to treat psychotic disorders (Ex. chlorpromazine, prochlorperazine, trihexiphenidyl)
Overdosage:
If you or anyone else accidentally consumed more DESDAC 100MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include headache, nausea, vomiting, dizziness, feeling agitated, constipation, diarrhea, dry mouth, numbness of body parts and fast heart rate.
SYNOPSIS
| Drug | : | Desvenlafaxine |
| Pharmacological Category | : | Selective Serotonin and Norepinephrine Reuptake Inhibitor (SNRI) |
| Therapeutic Indication | : | Major depressive disorder |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep DESDAC 100MG TABLET out of reach of children
- Store DESDAC 100MG TABLET at room temperature
FAQs ABOUT DESDAC 100MG TABLET
Q: What is the use of DESDAC 100MG TABLET?
A: DESDAC 100MG TABLET is an antidepressant medicine used to treat depression in adults.
Q: How long does it take for DESDAC 100MG TABLET to work?
A: It may take several weeks for DESDAC 100MG TABLET to heal your condition. Therefore, continue to take DESDAC 100MG TABLET for the stipulated duration recommended by your doctor without any interruption.
Q: Is DESDAC 100MG TABLET a strong antidepressant?
A: Yes. DESDAC 100MG TABLET is a strong antidepressant that effectively controls signs of depression. It works by increasing the levels of certain chemicals (serotonin and noreipherine) within the brain that stabilizes mental health.
Q: What is the best time to take DESDAC 100MG TABLET?
A: Take DESDAC 100MG TABLET approximately at the same time each day. You can take DESDAC 100MG TABLET either in the morning or in the evening as per doctor’s instructions. Taking it at the same time each day will have the best effect and it would also help you remember your daily dose.
Q: What is the difference between Venlafaxine and Desvenlafaxine?
A: Both Venlafaxine and Desvenlafaxine are selective serotonin and norepinephrine reuptake inhibitor (SSNRI) used to treat depression. Desvenlafaxine is the primary active metabolite of venlafaxine. Following administration, it reaches the site of action with limited bioconversions. Whereas venlafaxine following administration must get converted into desvenlafaxine before providing necessary effects.
Q: Can DESDAC 100MG TABLET be used to reduce anxiety?
A: DESDAC 100MG TABLET is a prescription medicine used to treat depression. It has been shown to reduce anxiety. However, there are no proper evidence to prove that. If you wish to control anxiety using DESDAC 100MG TABLET, speak with your doctor for advice.
Q: How does DESDAC 100MG TABLET works?
A: DESDAC 100MG TABLET is a potent antidepressant drug. It acts by increasing the levels of certain chemicals (serotonin and norepinephrine) within the brain that elevates your mood and stabilizes mental health. As a result, it makes you feel active and energetic.
Q: Can I take DESDAC 100MG TABLET in the mornings?
A: Take DESDAC 100MG TABLET approximately at the same time each day. You can take DESDAC 100MG TABLET either in the morning or in the evening as per doctor’s instructions. Taking it at the same time each day will have the best effect and it would also help you remember your daily dose.
Q: Can DESDAC 100MG TABLET cause weight gain?
A: Yes. Weight gain is one of the common side effects of taking DESDAC 100MG TABLET. If this side effect bothers you, contact your doctor.
Q: Will DESDAC 100MG TABLET reduce my sex drive?
A: Yes. DESDAC 100MG TABLET may affect your sexual life. It may decrease sex drive or causing problems in orgasm, ejaculation or erection. Therefore, consult your doctor if you experience any such symptoms.
Q: Will the use of DESDAC 100MG TABLET make you feel sleepy or tired?
A: Yes, DESDAC 100MG TABLET can make your feel sleepy, drowsy, or tired. Do not drive or handle heavy machines or tool if you feel drowsy or sleepy. Avoid consumption of alcohol as it can aggravate your drowsiness.
Q: What precautions must be followed while taking DESDAC 100MG TABLET?
A: Before taking DESDAC 100MG TABLET, inform your doctor if you have high blood fat levels or any liver, kidney or heart problems. You must also inform your doctor if you have or have a family history of bipolar disorder, mania or epilepsy. Do not take DESDAC 100MG TABLET if you are pregnant or breastfeeding without consulting your doctor. Avoid taking other antidepressant medicines concomittantly while taking DESDAC 100MG TABLET without consulting your doctor. Take DESDAC 100MG TABLET for the stipulated duration recommended by your doctor to achieve better results. Contact your doctor immediately if you experience any worsening or depression, unusual behaviour or have suicidal thoughts or behaviour after taking DESDAC 100MG TABLET.
Q: Can DESDAC 100MG TABLET be used in children?
A: DESDAC 100MG TABLET is generally not recommended for use in children and adolescents (aged below 18 years). Therefore, consult your doctor before administration.
Q: What to do if I forget to take a dose of DESDAC 100MG TABLET?
A: If you forget to take a dose of DESDAC 100MG TABLET, take it as soon as you remember. However, if it is time to take the next dose, skip the missed dose and take the next one at regular times. Do not take a double dose of DESDAC 100MG TABLET to compensate a missed dose, as it could lead to toxicity.
Q: Will taking a higher dose of DESDAC 100MG TABLET than the prescribed one be beneficial?
A: No, taking a higher dose of DESDAC 100MG TABLET will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Q: Can I stop taking DESDAC 100MG TABLET once my symptoms subside?
A; No. Do not stop taking DESDAC 100MG TABLET without consulting your doctor even if you feel better during the mid-way of the therapy. You may feel better after 2 weeks of therapy with DESDAC 100MG TABLET, but it might take several weeks for you to experience complete benefits. Also, sudden discontinuation of therapy may cause withdrawal symptoms such as headache, dizziness, nausea, irritability, lack of sleep, diarrhea, anxiety, abnormal dreams, fatigue and increased sweating.
Q: Can DESDAC 100MG TABLET be taken daily?
A: Yes. DESDAC 100MG TABLET can be taken daily as per your doctor’s instruction. However, if you are doubtful, consult your doctor.
REFERENCES
1. Barbara G Wells, Joseph T. DiPiro, Terry L. Schwinghammer and Cecily V. DiPiro. Major Depressive Disorder. Pharmacotherapy Handbook. Nineth Edition. Page – 715 & 718.
2. Harrison’s Manual of Medicine. Psychiatric Medication. 18th Edition. Page – 1327.
3. Raheel Naseeruddin, Alan Rosani and Raman Marwaha. Desvenlafaxine. NIH. National Library of Medicine. National Center of Biotechnology Information. StatPearls. [Revised in July 2022]. [Accessed on 30th August 2022]. https://www.ncbi.nlm.nih.gov/books/NBK534829/#:~:text=Desvenlafaxine%20is%20an%20antidepressant%20that,treat%20hot%20flashes%20during%20menopause.
4. Michael R. Liebowitz and Karen A. Tourian. Efficacy, Safety, and Tolerability of Desvenlafaxine 50 mg/d for the Treatment of Major Depressive Disorder: A Systematic Review of Clinical Trials. NIH. National Library of Medicine. National Center of Biotechnology Information. PMC PubMed Central. 2010. [Accessed on 30th August 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2947544/
5. Pfizer Ltd. U.S. Food & Drug Administration. [Revised in July 2011] [Accessed on 30th August 2022]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021992s030lbl.pdf
6. Pfizer Ltd. MEDICATION GUIDE PRISTIQ® (pris-TEEK) (desvenlafaxine) extended-release tablets. [Revised in January 2022] [Accessed on 30th August 2022]. https://labeling.pfizer.com/ShowLabeling.aspx?id=14010
7. Pfizer Ltd. PACKAGE INSERT PRISTIQ® (desvenlafaxine) Extended-Release Tablets. [Revised in September 2021] [Accessed on 30th August 2022]. https://labeling.pfizer.com/ShowLabeling.aspx?id=12155
8. Pfizer Australia Pty Ltd. PRISTIQ®. Healthlinks.Net.AU. [Revised in March 2022] [Accessed on 30th August 2022]. http://secure.healthlinks.net.au/content/pf/retriever.cfm?product=pfcprist11212
AUTHOR DETAILS
Written By Srilekha. R, B.Pharm
Last updated on 31 Jan 2023 | 04:15 PM(IST)
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