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Introduction About DEGAPRIDE 80MG INJECTION
DEGAPRIDE 80MG INJECTION is used to manage adult patients with advanced hormone dependent prostate cancer. It contains Degarelix which belongs to the group of medicines called Gonadotrophin-releasing hormone antagonist or GnRH blocker. DEGAPRIDE 80MG INJECTION works by blocking messages from a part of the brain called the hypothalamus that tells the pituitary gland to produce luteinising hormone. Luteinising hormone tells the testicles to produce testosterone. So degarelix stops the testicles making testosterone. Prostate cancer depends on testosterone to grow. Hormone therapy blocks or lowers the amount of testosterone in the body.
DEGAPRIDE 80MG INJECTION should be used with caution in patients have low bone density, glucose intolerance, diabetes mellitus, liver, kidney or cardiovascular diseases. DEGAPRIDE 80MG INJECTION is not recommended for use in pregnant women. It is not recommended for use in children and adolescents. Consult your doctor before receiving the medicine.
DEGAPRIDE 80MG INJECTION should be used with caution in elderly patients, therefore consult your doctor before receiving. The most common side effects after receiving DEGAPRIDE 80MG INJECTION are hot flushes and inflammation around the injection site, dizziness, weight gain, headache, diarrhoea. Consult your doctor immediately in case any of the side effects worsen or you experience an allergic reaction after receiving DEGAPRIDE 80MG INJECTION.
Uses Of DEGAPRIDE 80MG INJECTION
- It is used to manage adult patients with advanced hormone dependent prostate cancer
How DEGAPRIDE 80MG INJECTION Works
DEGAPRIDE 80MG INJECTION contains Degarelix which works by blocking messages from a part of the brain called the hypothalamus that tells the pituitary gland to produce luteinising hormone. Luteinising hormone tells the testicles to produce testosterone. So degarelix stops the testicles making testosterone.
How to use DEGAPRIDE 80MG INJECTION
DEGAPRIDE 80MG INJECTION will be administered by a healthcare professional only. It is for subcutaneous administration only and is not to be administered intravenously. DEGAPRIDE 80MG INJECTION is for subcutaneous administration to the abdominal region only. As with other medicines administered by subcutaneous injection, the injection site should vary periodically. Injections should be given in areas of the abdomen that will not be exposed to pressure. (e.g., not close to waistband or belt nor close to the ribs. It should be reconstituted before use.
Side Effects Of DEGAPRIDE 80MG INJECTION
Common
- hot flushes and inflammation around the injection site
- a drop in red blood cells that can cause breathlessness, tiredness and looking pale
- weight gain
- difficulty sleeping or getting to sleep
- headaches
- feeling dizzy
- diarrhoea
- feeling sick
- excessive sweating including night sweats
- rash
- discomfort or pain in muscles, bones, or joints
- growth of breast tissue
- problems getting or maintaining an erection (erectile dysfunction)
- high temperature
- chills
- tiredness
- flu like symptoms such as high temperature, feeling achy, cough, sore throat, and headache
How To Manage Side Effects
Diarrhea
Drink plenty of water or fruit juices to keep yourself hydrated. Don’t take any medicine on your own for managing diarrhoea however, contact your doctor if your diarrhoea worsens.
Dizziness Or Drowsiness
Lie down until the dizziness is gone and get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and medicine, however, consult your doctor if the symptom gets worse.
Headache
Drink lots of water and avoid skipping meals. Try to be relaxed and avoid stress. Apply pain relieving balm on your forehead if necessary and consult your doctor if the symptom does not improve.
Warning & Precautions
Pregnancy
ContraindicatedDEGAPRIDE 80MG INJECTION is not indicated in women. In addition, due to its pharmacological effects can cause fetal harm when administered to a pregnant woman. Consult your doctor before receiving the medicine.
Breastfeeding
Consult your doctorThere is no relevant indication for use of DEGAPRIDE 80MG INJECTION in women. Consult your doctor before receiving the medicine.
Driving and Using Machines
Use with CautionThere is no relevant indication for use of DEGAPRIDE 80MG INJECTION in women. Consult your doctor before receiving the medicine.
Kidney
Use with CautionDEGAPRIDE 80MG INJECTION should be used with caution in patient with kidney problems, therefore consult your doctor before receiving.
Liver
Use with CautionDEGAPRIDE 80MG INJECTION should be used with caution in patient with liver problems, therefore consult your doctor before receiving.
Allergy
ContraindicatedDo not receive DEGAPRIDE 80MG INJECTION if you are allergic or hypersensitive to Degarelix or any of the ingredients of this medicine.
Heart Disease
Use with CautionDEGAPRIDE 80MG INJECTION should be used with caution in patients with cardiovascular disease such as stroke and myocardial infarction therefore consult your doctor before receiving the medicine.
Use In Pediatrics
ContraindicatedDEGAPRIDE 80MG INJECTION is not recommended for use in children and adolescents. Consult your doctor before receiving the medicine.
Use In Geriatrics
Use with CautionThere is no need to adjust the dose for the elderly or in patients with mild or moderate liver or kidney function impairment. Consult your doctor before receiving the medicine.
Others
Before receiving DEGAPRIDE 80MG INJECTION inform your doctor if you have:
- have changes in bone density
- have glucose intolerance
- have diabetes mellitus
Interactions
A. Drug-Drug interactions:
Before receiving DEGAPRIDE 80MG INJECTION, inform your doctor if you are taking any of the following medicine:
- Antiarrhythmic agents (Ex. Quinidine, procainamide, amiodarone and sotalol)
- Opiate (narcotic) analgesics (Ex. Methadone)
- Antibiotics (Ex. Moxifloxacin)
- Antipsychotics
Overdosage:
There is no clinical experience with the effects of an acute overdose with DEGAPRIDE 80MG INJECTION. In the event of an overdose the patient should be monitored and appropriate supportive treatment should be given, if considered necessary.
Synopsis
| Drug | : | Degarelix |
| Pharmacological Category | : | Gonadotrophin-Releasing Hormone Antagonist or GnRH blocker |
| Therapeutic Indication | : | Used to manage adult patients with advanced hormone dependent prostate cancer |
| Dosage Forms | : | Injection |
More Information
Storage
- Keep DEGAPRIDE 80MG INJECTION out of reach of children
- Store at temperature between 2°C to 8°C
FAQs About DEGAPRIDE 80MG INJECTION
Q: What happens if I stop my management with DEGAPRIDE 80MG INJECTION suddenly?
A: Patients who are receiving DEGAPRIDE 80MG INJECTION for a longer duration should not stop the management with DEGAPRIDE 80MG INJECTION suddenly or without consulting your doctor. Your doctor will slowly reduce your dosage, to avoid withdrawal symptoms.
Q: What are the precautions need to be followed while receiving DEGAPRIDE 80MG INJECTION?
A: DEGAPRIDE 80MG INJECTION should be used with caution in patients have low bone density, glucose intolerance, diabetes mellitus, liver, kidney or cardiovascular diseases.
Q: What are the methods of after reconstitution of DEGAPRIDE 80MG INJECTION?
A: The reconstituted solution must be clear liquid free from any undissolved matter. Chemical and physical in-use stability of the reconstituted solution has been demonstrated for 2 hours at 25°C after solvent addition. From a microbiological point of view, once reconstituted, the product should be administered immediately.
Q: What are the common side effects while receiving DEGAPRIDE 80MG INJECTION?
A: The most common side effects after receiving DEGAPRIDE 80MG INJECTION are hot flushes and inflammation around the injection site, dizziness, weight gain, headache, diarrhoea. Consult your doctor immediately in case any of the side effects worsen or you experience an allergic reaction after receiving DEGAPRIDE 80MG INJECTION.
Q: What DEGAPRIDE 80MG INJECTION is used for?
A: DEGAPRIDE 80MG INJECTION is used to manage adult patients with advanced hormone dependent prostate cancer.
Q: Can DEGAPRIDE 80MG INJECTION be used during pregnancy?
A: DEGAPRIDE 80MG INJECTION is not recommended for use in pregnant women, as it may cause harm to the growing baby.
Q: Who should avoid taking DEGAPRIDE 80MG INJECTION?
A: DEGAPRIDE 80MG INJECTION is not recommended for use if you are allergic or hypersensitive to Degarelix or any other ingredients of this medicine.
Q: What is advanced prostate cancer?
A: Prostate cancer is considered advanced when it breaches the prostate's border. As it advances, the cancer may also spread (metastasize) to other areas of the body. Men with advanced prostate cancer typically start treatment with hormone therapy.
Q: Should I follow any special diet if I have advanced prostate cancer?
A: Small changes in your diet can lead to healthier living and maintaining overall health. Fruits and vegetables, especially dark, leafy greens, are recommended. Try to reduce fats from red meat and dairy. Instead, choose fish, lean poultry, or plant-based proteins from nuts and beans. Before making changes to your diet, be sure to talk to your doctor.
References
1. CDSCO. [Accessed on September 11th 2024] https://cdscoonline.gov.in/CDSCO/Drugs
2. Ferring Pharmaceuticals. [Revised on March 18, 2016] [Accessed on September 11th 2024] https://pdf.hres.ca/dpd_pm/00034229.PDF
3. FIRMAGON. [Accessed on September 11th 2024] https://firmagon.com/hcp/
4. Ferring Pharmaceuticals A/S. Food and Drug Administration. [Revised on November 13, 2013] [Accessed on September 11th 2024] https://www.ema.europa.eu/en/documents/product-information/firmagon-epar-product-information_en.pdf
Useful Diagnostic Tests
- Prostate Specific Antigen - Psa (Total)
- Healthians Prostate Cancer Package
- Prostate Specific Antigen - Psa (Free)
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