INTRODUCTION

CYCLOMUNE 0.1% contains Cyclosporin which belongs to the group of medicines called immunosuppressive agents. It is used to treat severe keratitis (inflammation of the cornea) in adults. It can also increase tear production in a condition called dry eyes where the tear produced is suppressed due to ocular inflammation associated with keratoconjunctivitis sicca.

Cyclosporin works by decreasing inflammation in the eye and by increasing tear production. It lubricates your eye and reduces discomfort. Wash your hands before and after application. Make sure to remove your contact lenses before application of eye drops. It can be reinserted 15 minutes after application. Patients with decreased tear production should typically avoid wearing contact lenses, because it can further damage your cornea.

Apply this medicine as directed by your physician. It is for ophthalmic use only. The most common side effects of using this medicine are eye irritation, pain and itching and blurred vision. Avoid travelling or driving until your vision becomes clear. Before taking this medicine, inform your doctor if you are pregnant, breastfeeding or if you have any eye infection or cancer in eye. This medicine is not recommended for use in children aged below 18 years of age.

USES OF CYCLOMUNE 0.1%

• Treats severe keratitis
• Treats dry eye

HOW CYCLOMUNE 0.1% WORKS

Cyclosporin is a calcineurin inhibitor that inhibits the activation of T-lymphocytes (cells catalyzing immune reaction) and various cytokines (e.g. IL-1, IL-2) involved in the regulation of T-cell activation. Decreased T-cell activation reduces inflammation or swelling in the eye, increases tear production and lubricates your eye and reduces discomfort.

DIRECTIONS FOR USE

Apply this medicine as directed by your physician. It is for ophthalmic use only. The recommended dose is 1 drop in each affected eye, once daily at bedtime. However, your doctor will decide the correct dose and duration for you depending upon your condition. Wash your hands thoroughly. If you are wearing contact lenses, remove them before using the drops. Pull down your lower eyelid and tilt your head backwards. Gently squeeze a drop of medicine onto your eye.

If required, repeat the steps for another eye. Avoid touching the tip of the container with your hand or eye to avoid contamination. Continue to take this medicine, as prescribed by your doctor to obtain better results.

SIDE EFFECTS OF CYCLOMUNE 0.1%

HOW TO MANAGE SIDE EFFECTS

Blurred vision:

This is a common side effect after using this medicine and usually disappears within few minutes. Close your eyes and rest for few minutes. Avoid travelling or driving with blurred vision. Wait until your vision clears before you drive or use machines.

WARNING & PRECAUTIONS

INTERACTIONS

Talk to your doctor, if you are taking,

• other steroid medicine used to treat eye inflammation (e.g. betamethasone, dexamethasone)
• medicines used to treat glaucoma (e.g. lantanoprost)

SYNOPSIS

MORE INFORMATION

Store below 20-25°C and keep out of reach of children.

FAQs ABOUT CYCLOMUNE 0.1%

Can CYCLOMUNE 0.1% cause eye problems?

Yes. This medicine may cause certain eye problems like eye irritation, pain, redness of eye and swelling. Contact your doctor if your symptom worsens.

Can CYCLOMUNE 0.1% be used in children?

No. This medicine is not recommended for use in children and in adolescents aged below 18 years of age.

Can CYCLOMUNE 0.1% be used during pregnancy?

No. This medicine is strictly not recommended for use in pregnant women. Consult your doctor before taking.

REFERENCES

1. Jeffrey D. Henderer and Christopher J. Rapuano. Ocular pharmacology. Goodman & Gilman’s: The pharmacological basics of therapeutics. 12th Edition. New York, New York: McGraw-Hill Medical, 2011. Page – 1790.

2. National Eye Institute (NEI). Treatment of Dry Eye Syndrome with Cyclosporin a Eye Drops. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on March 2008] [Accessed 29th October 2020] https://clinicaltrials.gov/ct2/show/NCT00001731

3. Clyde Schultz. Safety and Efficacy of Cyclosporine in the Treatment of Chronic Dry Eye. NCBI; PMC US National Library of Medicine, National Institute of Health. June 2014. [Accessed 29th October 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4076204/

4. EXCELVISION, SANTEN Oy. Electronic Medicines Compendium (EMC); [Revised on March 2020] [Accessed 29th October 2020] https://www.medicines.org.uk/emc/files/pil.6937.pdf

5. Allergan, Inc. U.S. Food & Drug Administration; [Revised on November 2012] [Accessed 29th October 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050790s020lbl.pdf