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INTRODUCTION
CLOSAL GM CREAM is a combination of Clobetasol, Miconazole and Neomycin which belongs to the group of medicines called Corticosteroids, Antifungals and Antibiotics. It is used to treat resistant dermatoses (skin infections) with secondary bacterial or fungal infection.
CLOSAL GM CREAM is not recommended for use in patients with rosacea, acne vulgaris, perioral dermatitis, perianal and genital pruritus, viral infections (ex. herpes simplex, chickenpox) and perforated eardrum. Contact your doctor before applying. CLOSAL GM CREAM should be used with caution in patients with liver or kidney disease. Contact your doctor before applying.
CLOSAL GM CREAM is generally not recommended for use in pregnancy unless considered clearly necessary. CLOSAL GM CREAM should be used with caution in breastfeeding women as it is not known whether it may pass through the breast milk. Contact your doctor before applying. CLOSAL GM CREAM is not recommended for use in children under 2 years of age. Contact your doctor before applying.
Dosage adjustment is not required for CLOSAL GM CREAM in the geriatric population. However, greater sensitivity of some older individuals cannot be ruled out. Contact your doctor before applying. The most common side effects of this medicine are skin rash, itching, redness, burning sensation and contact dermatitis. Contact your physician if any of the symptoms worsen.
USES OF CLOSAL GM CREAM
- Used to treat resistant dermatoses (skin infections) with secondary bacterial or fungal infection
HOW CLOSAL GM CREAM WORKS
CLOSAL GM CREAM helps to treat infection, where Clobetasol have anti-inflammatory, antipruritic, and vasoconstrictive properties, which blocks the production of certain chemical messengers (prostaglandins) that make the skin red, swollen, and itchy. Miconazole belongs to antifungal which stops the growth of fungi while Neomycin belongs to antibiotic which stops the growth of bacteria in the skin.
DIRECTIONS FOR USE
Apply CLOSAL GM CREAM as directed by your physician. It is for external use only. Wash your hands with soap and water and apply a thin layer of the medicine to the affected area of the skin and rub it gently. Avoid contact with eyes, face, groin or in the skin folds.
SIDE EFFECTS OF CLOSAL GM CREAM
COMMON
- skin rash, itching, redness
- burning sensation
- contact dermatitis
RARE
Stop applying CLOSAL GM CREAM and contact your physician immediately if you experience any of the following side effects:
- severe allergic reactions such as anaphylaxis or angioedema (skin rash, swelling of the face, lips, tongue, or throat causing breathing difficulty)
HOW TO MANAGE SIDE EFFECTS
Skin Rash Or Itching
Avoid hot showers because hot water can irritate the skin. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use unscented moisturizers to soothe and hydrate the affected area. Contact your doctor if itching worsens.
WARNING & PRECAUTIONS
PREGNANCY
Monitoring requiredCLOSAL GM CREAM is not recommended for use in pregnancy unless considered clearly necessary. Contact your doctor before applying.
BREASTFEEDING
Use with CautionCLOSAL GM CREAM should be used with caution in breastfeeding women as it is not known whether it may pass through the breast milk. Contact your doctor before applying.
KIDNEY
Use with CautionCLOSAL GM CREAM should be used with caution in patients with kidney disease. Contact your doctor before applying.
LIVER
Use with CautionCLOSAL GM CREAM should be used with caution in patients with liver disease. Contact your doctor before applying.
ALLERGY
ContraindicatedDo not use CLOSAL GM CREAM if you are allergic to Clobetasol, Miconazole, Neomycin, or to any other ingredients of this medicine.
USE IN PEDIATRICS
ContraindicatedCLOSAL GM CREAM is not recommended for use in children under 2 years of age. Contact your doctor before applying.
USE IN GERIATRICS
Use with CautionDosage adjustment is not required for CLOSAL GM CREAM in the geriatric population. However, greater sensitivity of some older individuals cannot be ruled out. Contact your doctor before applying.
OTHERS
CLOSAL GM CREAM is not recommended for use if you have:
- rosacea
- acne vulgaris
- perioral dermatitis
- perianal and genital pruritus
- viral infections (ex. herpes simplex, chickenpox)
- perforated eardrum
INTERACTIONS
A. Drug-Drug interactions:
Before applying CLOSAL GM CREAM tell your doctor if you are taking,
- ritonavir (medicines used for HIV infections)
- itraconazole (medicines used for fungal infections)
- amikacin, gentamicin (medicines used for bacterial infections)
- neuromuscular blocking agents like atracurium, pancuronium (medicines used in anaesthesia)
- warfarin (medicines used to treat or prevent blood clots)
Overdosage:
If you or anyone else accidentally uses too much of CLOSAL GM CREAM, consult your doctor immediately or visit the nearby hospital.
SYNOPSIS
| Drug | : | Clobetasol, Miconazole, Neomycin |
| Pharmacological Category | : | Corticosteroids, Antifungals, Antibiotics |
| Therapeutic Indication | : | Skin infections |
| Dosage Forms | : | Cream, Lotion, Ointment |
MORE INFORMATION
- Keep out of reach of children
- Store CLOSAL GM CREAM below 25°C
FAQs ABOUT CLOSAL GM CREAM
Q: What are the possible side effects of applying CLOSAL GM CREAM?
A: The most common side effects of this medicine are skin rash, urticaria, itching, redness, burning sensation and contact dermatitis. Contact your physician if any of the symptoms worsen.
Q: Can I use CLOSAL GM CREAM in children?
A: CLOSAL GM CREAM is not recommended for use in children under 2 years of age. Contact your doctor before applying.
Q: For what conditions CLOSAL GM CREAM is used?
A: CLOSAL GM CREAM is used to treat resistant dermatoses (skin infections) with secondary bacterial or fungal infection.
Q: Does CLOSAL GM CREAM cause itching on the skin?
A: Yes, CLOSAL GM CREAM may cause skin itching at the site of application as a temporary side effect. However, if the itching persists or worsens, consult your doctor for advice.
Q: Can I stop using CLOSAL GM CREAM when my symptoms are relieved?
A: No, do not stop using CLOSAL GM CREAM and complete the full course of treatment, even if you feel better. Your symptoms may improve before the infection is completely cured.
Q: Who should not use CLOSAL GM CREAM?
A: CLOSAL GM CREAM is not recommended for use in patients with rosacea, acne vulgaris, perioral dermatitis, perianal and genital pruritus, viral infections (ex. herpes simplex, chickenpox), perforated eardrum. Contact your doctor before applying.
REFERENCES
1. K.D. Tripathi. Drugs acting on the skin and mucous membrane, Antifungal Drugs & Aminoglycoside Antibiotics. Essentials of medical pharmacology. Seventh edition. 2013. Page – 895, 792, 750.
2. Bethesda (MD). Clobetasol. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/5311051
3. Bethesda (MD). Miconazole. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/4189
4. Bethesda (MD). Neomycin. National Institute of Health. NLM. National Centre for Biotechnology Information. PubChem Compound Summary. 2004. [Accessed on 17th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Neomycin
5. Blue Cross labs. Clobetasol, Miconazole and Neomycin. [Revised on May 2020] [Accessed on 24th June 2022] https://www.bluecrosslabs.com/img/sections/SONADERM-NM-CREAM.pdf
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